5-Fluorouracil (5-FU) and leucovorin in platinum-refractory advanced stage ovarian carcinoma.

Abstract:

:Twenty-nine patients with recurrent advanced stage ovarian cancer were treated with 5-fluorouracil (5-FU) and leucovorin by intravenous bolus on 5 consecutive days, repeated every 3 weeks. Twenty-one of these patients had experienced disease progression while receiving a cisplatin- or carboplatin-based regimen. There were 2 clinical complete responders and 1 partial responder to therapy (10% response rate; 95% confidence interval, 2 to 27%) and 11 individuals who experienced stable disease for periods ranging from 5 to 27 months. Of 204 cycles of therapy administered, 9 cycles were associated with hospitalization. These occurred in the more heavily pretreated members of the cohort. 5-FU and leucovorin appear to have activity in platinum-refractory ovarian cancer and form a well-tolerated regimen in most patients.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Reed E,Jacob J,Ozols RF,Young RC,Allegra C

doi

10.1016/0090-8258(92)90226-9

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

326-9

issue

3

eissn

0090-8258

issn

1095-6859

journal_volume

46

pub_type

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