5-Fluorouracil (5-FU) and leucovorin in platinum-refractory advanced stage ovarian carcinoma.


:Twenty-nine patients with recurrent advanced stage ovarian cancer were treated with 5-fluorouracil (5-FU) and leucovorin by intravenous bolus on 5 consecutive days, repeated every 3 weeks. Twenty-one of these patients had experienced disease progression while receiving a cisplatin- or carboplatin-based regimen. There were 2 clinical complete responders and 1 partial responder to therapy (10% response rate; 95% confidence interval, 2 to 27%) and 11 individuals who experienced stable disease for periods ranging from 5 to 27 months. Of 204 cycles of therapy administered, 9 cycles were associated with hospitalization. These occurred in the more heavily pretreated members of the cohort. 5-FU and leucovorin appear to have activity in platinum-refractory ovarian cancer and form a well-tolerated regimen in most patients.


Gynecol Oncol


Gynecologic oncology


Reed E,Jacob J,Ozols RF,Young RC,Allegra C




Has Abstract


1992-09-01 00:00:00












  • Phase II study of vinorelbine in the treatment of platinum-resistant ovarian carcinoma.

    abstract:OBJECTIVE:The purpose of this phase II study was to evaluate on an intent-to-treat basis the activity and toxicity of single-agent vinorelbine (VRL) as second-line chemotherapy of patients with platinum-resistant ovarian cancer. Platinum-resistant disease was defined as disease refractory to or relapsing within 12 mont...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Sørensen P,Høyer M,Jakobsen A,Malmström H,Havsteen H,Bertelsen K

    更新日期:2001-04-01 00:00:00

  • Sensitization of cervical cancer cell lines to low-dose radiation by retinoic acid does not require functional p53.

    abstract:OBJECTIVE:Current therapy for cervical cancer includes radiation therapy. Retinoic acid (RA) can increase the sensitivity of cervical cancer cell lines to radiation. The mechanism of this sensitization may not involve the p53 protein because the human papillomavirus (HPV) E6 protein, which is present in the majority of...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Tillmanns TD,Kamelle SA,Guruswamy S,Gould NS,Rutledge TL,Benbrook DM

    更新日期:2005-04-01 00:00:00

  • Carboplatin and paclitaxel for advanced and recurrent cervical carcinoma: the British Columbia Cancer Agency experience.

    abstract:BACKGROUND:One of the most active chemotherapy combinations in advanced or recurrent cervical cancer is cisplatin-paclitaxel. However, this palliative regimen is associated with significant toxicity. Carboplatin-paclitaxel is thus an attractive option. METHODS:Patients with advanced or recurrent carcinoma of the cervi...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Tinker AV,Bhagat K,Swenerton KD,Hoskins PJ

    更新日期:2005-07-01 00:00:00

  • Ovarian cancer linked to Lynch syndrome typically presents as early-onset, non-serous epithelial tumors.

    abstract:OBJECTIVE:Heredity is a major cause of ovarian cancer and during recent years the contribution from germline mismatch repair (MMR) gene mutations linked to Lynch syndrome has gradually been recognized. METHODS:We characterized clinical features, tumor morphology and mismatch repair defects in all ovarian cancers ident...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Ketabi Z,Bartuma K,Bernstein I,Malander S,Grönberg H,Björck E,Holck S,Nilbert M

    更新日期:2011-06-01 00:00:00

  • Carboplatin/gemcitabine alternating with carboplatin/pegylated liposomal doxorubicin and carboplatin/cyclophosphamide in platinum-refractory/resistant paclitaxel - pretreated ovarian carcinoma.

    abstract:OBJECTIVE:In this phase II study the efficacy and toxicity of an alternating chemotherapy regimen was examined in platinum-resistant relapsed epithelial ovarian cancer (EOC) patients. METHODS:Forty-five patients with platinum-refractory/resistant relapsed EOC, previously treated with carboplatin+paclitaxel+/-epirubici...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Pectasides D,Pectasides E,Papaxoinis G,Psyrri A,Pliarchopoulou K,Koumarianou A,Macheras A,Athanasas G,Xiros N,Economopoulos T

    更新日期:2010-07-01 00:00:00

  • Prognostic significance of growth characteristics of xenotransplanted ovarian carcinomas into nude mice.

    abstract::Human ovarian carcinomas (n = 215) were xenotransplanted into thymus-aplastic female nu/nu mice (NMRI). Growth of transplants was defined as take-off rate, growth rapidity, and feasibility of passages. In 204 cases these growth characteristics could be correlated with survival time of the individual tumor-donor patien...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kleine W

    更新日期:1986-09-01 00:00:00

  • Adenovirus-mediated thymidine kinase gene therapy in combination with topotecan for patients with recurrent ovarian cancer: 2.5-year follow-up.

    abstract:OBJECTIVE:Patients with recurrent ovarian cancer were treated intraperitoneally (ip) with a replication-deficient recombinant adenovirus (ADV) containing the herpes simplex virus thymidine kinase gene. Vector delivery was followed by intravenous administration of an antiherpetic prodrug and a topoisomerase I inhibitor....

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Hasenburg A,Tong XW,Fischer DC,Rojas-Martinez A,Nyberg-Hoffman C,Kaplan AL,Kaufman RH,Ramzy I,Aguilar-Cordova E,Kieback DG

    更新日期:2001-12-01 00:00:00

  • Durability of clinical performance afforded by self-collected HPV testing: A 15-year cohort study in China.

    abstract:OBJECTIVE:Self-collected HPV testing could substantially reduce disparities in cervical cancer screening, with slightly lower sensitivity compared to physician-collected specimens cross-sectionally. We aimed to evaluate the comprehensive long-term performance of self-collected HPV testing prospectively. METHODS:In 199...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Zhang L,Xu XQ,Hu SY,Chen F,Zhang X,Pan QJ,Zhang WH,Feng RM,Dong L,Zhang Q,Ma JF,Sauvaget C,Zhao FH,Qiao YL,Sankaranarayanan R

    更新日期:2018-11-01 00:00:00

  • DNA aneuploidy is associated with increased mortality for stage I endometrial cancer.

    abstract:OBJECTIVE:The current study was undertaken to determine if DNA ploidy is a useful prognostic variable for predicting recurrence in stage I endometrial cancer. For cancer of the endometrium, survival following recurrence may depend on a number of factors, including the pattern of recurrence and the response to second li...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Terada K,Mattson D,Goo D,Shimizu D

    更新日期:2004-12-01 00:00:00

  • Activation of androgen receptor-associated protein 70 (ARA70) mRNA expression in ovarian cancer.

    abstract:OBJECTIVE:Androgens have been implicated in ovarian cancer and androgen receptor expression has been reported in 70-95% of ovarian adenocarcinomas, implying a role in ovarian cancer cell biology. Androgen receptor-associated protein 70 (ARA70) is a reported androgen receptor coactivator that enhances the transactivatio...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Shaw PA,Rittenberg PV,Brown TJ

    更新日期:2001-02-01 00:00:00

  • Pilomatricoma-like endometrioid adenosquamous carcinoma of the ovary with neuroendocrine differentiation.

    abstract::A case of high-grade endometrioid adenosquamous carcinoma of the ovary showing pilomatricoma-like areas and neuroendocrine differentiation is presented. The pilomatricoma-like areas were strongly positive for cytokeratin and vimentin, whereas the poorly differentiated areas of the tumor were positive for cytokeratin, ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Fang J,Keh P,Katz L,Rao MS

    更新日期:1996-05-01 00:00:00

  • Long term follow-up of a large series of stage-II/III atypical proliferative serous ovarian tumors.

    abstract:BACKGROUND:The aim of this study was to assess prognostic factors and implications on further management in a large series of stage-II or III Atypical Proliferative Serous Tumors (APST) with a long-term follow-up. PATIENTS AND METHODS:Patients with APSTs and peritoneal implants treated in, or referred to, our institut...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Maria S,Faron M,Maulard A,Pautier P,Leary A,Chargari C,Genestie C,Gouy S,Morice P

    更新日期:2020-09-01 00:00:00

  • Endometrial histopathology in 700 patients treated with tamoxifen for breast cancer.

    abstract:OBJECTIVE:The aim of this study was the evaluation of endometrial histopathologic findings from 700 patients treated with tamoxifen (Tx) for breast cancer from two medical centers (United States and France). METHODS:A retrospective review of data including histologic slides from 134 hysterectomies and 566 endometrial ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Deligdisch L,Kalir T,Cohen CJ,de Latour M,Le Bouedec G,Penault-Llorca F

    更新日期:2000-08-01 00:00:00

  • Consolidation paclitaxel is more cost-effective than bevacizumab following upfront treatment of advanced epithelial ovarian cancer.

    abstract:INTRODUCTION:Randomized trials have demonstrated significant improvements in progression-free survival (PFS) with consolidation paclitaxel (P) and bevacizumab (B) following cytoreduction and adjuvant carboplatin/paclitaxel (CP) for advanced epithelial ovarian cancer (EOC). We sought to evaluate the cost-effectiveness (...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Lesnock JL,Farris C,Krivak TC,Smith KJ,Markman M

    更新日期:2011-09-01 00:00:00

  • Bilateral ultrastaging of sentinel lymph node in cervical cancer: Lowering the false-negative rate and improving the detection of micrometastasis.

    abstract:OBJECTIVE:To evaluate the sensitivity of sentinel node (SN) ultrastaging and to define parameters that may reduce the overall false-negative rate in women with early-stage cervical cancer. METHODS:We analyzed data from a large retrospective multicenter cohort group with FIGO stages IA-IIB cervical cancer in whom at le...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Cibula D,Abu-Rustum NR,Dusek L,Slama J,Zikán M,Zaal A,Sevcik L,Kenter G,Querleu D,Jach R,Bats AS,Dyduch G,Graf P,Klat J,Meijer CJ,Mery E,Verheijen R,Zweemer RP

    更新日期:2012-12-01 00:00:00

  • Death from anaphylaxis to cisplatin: a case report.

    abstract::A patient with a history of ovarian carcinoma that had responded well to cisplatin was treated with platinum agents for a recurrence. She had a seizure while receiving carboplatin and was switched to cisplatin. The patient was premedicated with antihistamines and steroids. After approximately 400 micrograms of cisplat...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Zweizig S,Roman LD,Muderspach LI

    更新日期:1994-04-01 00:00:00

  • Pre-operative imaging, surgery and adjuvant therapy for women diagnosed with cancer of the corpus uteri in community practice in the United States.

    abstract:INTRODUCTION:Non-Hispanic black women are less often diagnosed with endometrial cancer than are non-Hispanic white women, but are more likely to die of their disease. Reasons for this disparity in outcome are not well understood. METHODS:The Surveillance, Epidemiology, and End-Results Program data were used to sample ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Trimble EL,Harlan LC,Clegg LX,Stevens JL

    更新日期:2005-03-01 00:00:00

  • A phase II trial of cisplatin, ifosfamide, and mesna in patients with advanced or recurrent uterine malignant mixed müllerian tumors with evaluation of potential molecular targets.

    abstract:OBJECTIVE:The aim of this study was to determine the efficacy of cisplatin, ifosfamide, and mesna in uterine malignant mixed müllerian tumor (MMMT) and to evaluate the expression of clinically relevant molecular markers. METHODS:Women with advanced or recurrent MMMT were treated every 28 days with cisplatin (75 mg/m(2...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Ramondetta LM,Burke TW,Jhingran A,Schmandt R,Bevers MW,Wolf JK,Levenback CF,Broaddus R

    更新日期:2003-09-01 00:00:00

  • Cytidine deaminase Apobec3a induction in fallopian epithelium after exposure to follicular fluid.

    abstract:OBJECTIVE:Ovarian carcinomas that originate from fallopian epithelial cells are suggested to arise due to repeated exposure to ovulatory follicular fluid (FF). Mechanistic explanation(s) for how this occurs are unknown. Here, we sought to understand if FF exposure to fallopian epithelial cells could induce DNA damage a...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Brachova P,Alvarez NS,Van Voorhis BJ,Christenson LK

    更新日期:2017-06-01 00:00:00

  • Gamma-knife radiosurgery for the treatment of ovarian cancer metastatic to the brain.

    abstract:BACKGROUND:Central nervous system (CNS) metastases from an ovarian malignancy are uncommon. The long-term prognosis for these patients is poor, with studies reporting a mean survival of less than 12 months. CASES:We present three ovarian cancer patients who developed metastatic disease to the brain. All patients were ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Brown JV 3rd,Goldstein BH,Duma CM,Rettenmaier MA,Micha JP

    更新日期:2005-06-01 00:00:00

  • Bolus mitomycin C and 5-FU with sequential radiation for poor-prognosis locally advanced cervical cancer.

    abstract::Forty patients with locally advanced cervical carcinoma were entered into a protocol utilizing the bolus administration of both mitomycin C (10 or 15 mg) on Day 1 and 5-fluorouracil (400 mg) on Day 1-5 followed by sequential pelvic irradiation on Day 6 between September 1980 and October 1985. All patients had poor-pro...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,评审


    authors: Denehy TR,Eastman R,SanFilippo L,Gregori CA,Breen JL

    更新日期:1996-01-01 00:00:00

  • Docetaxel plus trabectedin appears active in recurrent or persistent ovarian and primary peritoneal cancer after up to three prior regimens: a phase II study of the Gynecologic Oncology Group.

    abstract:OBJECTIVE:This study aims to estimate the activity of docetaxel 60mg/m(2) IV over 1h followed by trabectedin 1.1mg/m(2) over 3h with filgrastim, pegfilgrastim, or sargramostim every 3weeks (one cycle). METHODS:Patients with recurrent and measurable disease, acceptable organ function, PS≤2, and ≤3 prior regimens were e...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Monk BJ,Sill MW,Hanjani P,Edwards R,Rotmensch J,De Geest K,Bonebrake AJ,Walker JL

    更新日期:2011-03-01 00:00:00

  • Psychological adjustment to familial-genetic risk assessment for ovarian cancer: predictors of nonadherence to surveillance recommendations.

    abstract:OBJECTIVE:To evaluate whether self-report measures of psychological distress and perceived risk were associated with nonadherence to recommended ovarian cancer surveillance. METHODS:Eighty-three patients attending the Familial Ovarian Cancer Clinic (FOCC) at Princess Margaret Hospital were assessed psychosocially prio...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Ritvo P,Irvine J,Robinson G,Brown L,Murphy KJ,Matthew A,Rosen B

    更新日期:2002-01-01 00:00:00

  • Close relationship between removal of circumflex iliac nodes to distal external iliac nodes and postoperative lower-extremity lymphedema in uterine corpus malignant tumors.

    abstract:OBJECTIVE:The aim of this study was to confirm a causal relationship between removal of circumflex iliac nodes to the distal external iliac nodes (CINDEIN) and lower-extremity lymphedema after systematic lymphadenectomy in patients with uterine corpus malignancies. METHODS:A retrospective chart review was carried out ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Todo Y,Yamazaki H,Takeshita S,Ohba Y,Sudo S,Minobe S,Okamoto K,Kato H

    更新日期:2015-10-01 00:00:00

  • Validation of the accuracy of the sentinel lymph node procedure in patients with vulvar cancer: results of a multicenter study in Germany.

    abstract:OBJECTIVE:To investigate the diagnostic accuracy of the sentinel node procedure in patients with vulvar cancer, a multicenter study was launched in Germany in 2003 involving 7 oncology centers. PATIENTS AND METHODS:Between 2003 and 2006, 127 women with primary T1-T3 vulvar cancer were entered in the study and treated ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Hampl M,Hantschmann P,Michels W,Hillemanns P,German Multicenter Study Group.

    更新日期:2008-11-01 00:00:00

  • The malignant potential of small cystic ovarian tumors in women over 50 years of age.

    abstract:OBJECTIVE:The aim of this study was to determine the risk of malignancy in cystic ovarian tumors < 10 cm in diameter in asymptomatic postmenopausal women or women >or =50 years of age. METHODS:All cystic ovarian tumors detected by transvaginal sonography screening in asymptomatic postmenopausal women or women > or =50...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Bailey CL,Ueland FR,Land GL,DePriest PD,Gallion HH,Kryscio RJ,van Nagell JR Jr

    更新日期:1998-04-01 00:00:00

  • Pelvic exenteration in the age of modern chemoradiation.

    abstract:BACKGROUND:To examine outcomes after pelvic exenteration in women treated with modern chemoradiation and surgical techniques. METHODS:All patients at our institution with a diagnosis of gynecologic malignancy who underwent pelvic exenteration after treatment with chemoradiation between 1/90 and 6/08 were evaluated wit...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: McLean KA,Zhang W,Dunsmoor-Su RF,Shah CA,Gray HJ,Swensen RE,Goff BA

    更新日期:2011-04-01 00:00:00

  • Surgical approach to diaphragmatic metastases from ovarian cancer.

    abstract::Fourteen patients underwent surgical debulking of diaphragmatic metastases as part of cytoreductive surgery for advanced ovarian epithelial cancer from 1983 to 1984. The surgical technique is described. Morbidity from this approach was not excessive in this small series of patients. It is suggested that this technique...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Deppe G,Malviya VK,Boike G,Hampton A

    更新日期:1986-06-01 00:00:00

  • Skull metastasis in primary vulvar adenocarcinoma of the Bartholin's gland: a case report.

    abstract:BACKGROUND:Metastatic bone involvement in vulvar squamous carcinoma is very rare. Here, we present a case of primary adenocarcinoma of the Bartholin's gland giving rise to isolated skull metastasis. CASE:A 74-year-old woman was referred with a diagnosis of primary vulvar adenocarcinoma of the right labium minus. A rig...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Ferrandina G,Testa AC,Zannoni GF,Poerio A,Scambia G

    更新日期:2005-08-01 00:00:00

  • Gemcitabine in cervical cancer.

    abstract:OBJECTIVE:Recurrent and advanced cervical cancers are associated with high mortality and a lack of effective treatment options, especially for women who are poor candidates for surgery or radiation therapy. The broad clinical effectiveness and low toxicity of gemcitabine in other human malignancies suggest that it migh...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Mutch DG,Bloss JD

    更新日期:2003-08-01 00:00:00