The Wertheim hysterectomy: Development, modifications, and impact in the present day.


:Ernst Wertheim was a pioneer in the history of the surgical treatment of cervical cancer. His English-language manuscript "The extended abdominal operation for carcinoma uteri (based on 500 operative cases)," which was published in 1912, detailed his standardization of the radical hysterectomy and formed the basis of the current treatment for early stage cervical cancer. We contextualize the Wertheim hysterectomy, emphasizing medical advances that allowed for its development and subsequent modification. We then discuss modifications to the originally proposed procedure, including a maximally extended parametrical resection pioneered by Takayama, and the addition of the Taussig en bloc lymph node dissection by Meigs, both of which afforded an improved mortality profile due to decreased disease recurrence. Finally, we discuss progress that has been made in the present day, such as the development of nerve-sparing and fertility-sparing surgeries, as well as the introduction of the robotic platform. In this way, we hope to provide a historical background for the Wertheim hysterectomy-a cornerstone of gynecologic oncology.


Gynecol Oncol


Gynecologic oncology


Swailes AL,Gockley A,Phaëton R,Kesterson JP




Has Abstract


2017-04-01 00:00:00














  • The prescription or proscription of exercise in endometrial cancer care.

    abstract:OBJECTIVE:To determine the proportion of endometrial cancer patients who can be safely prescribed community/home based unsupervised exercise. A better understanding of the physical dysfunction secondary to comorbidities among endometrial cancer patients would assist clinicians in delineating which patients to send to m...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Zhang X,Haggerty AF,Brown JC,Giuntoli R 2nd,Lin L,Simpkins F,Dean LT,Ko E,Morgan MA,Schmitz KH

    更新日期:2015-10-01 00:00:00

  • The role of interstitial brachytherapy using template in locally advanced gynecological malignancies.

    abstract:OBJECTIVE:Brachytherapy plays a major role in the treatment of patients with carcinoma of the cervix. However, routine intracavitary brachytherapy may not be feasible or adequate to treat locally advanced disease. The purpose of this prospective study was to assess treatment outcome for patients with locally advanced g...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Agrawal PP,Singhal SS,Neema JP,Suryanarayan UK,Vyas RK,Rathi AK,Bahadur AK

    更新日期:2005-10-01 00:00:00

  • The opioid growth factor (OGF) and low dose naltrexone (LDN) suppress human ovarian cancer progression in mice.

    abstract:OBJECTIVE:The opioid growth factor (OGF) and its receptor, OGFr, serve as a tonically active inhibitory axis regulating cell proliferation in normal cells and a variety of cancers, including human ovarian cancer. Blockade of OGF and OGFr with the nonselective opioid receptor antagonist naltrexone (NTX) upregulates expr...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Donahue RN,McLaughlin PJ,Zagon IS

    更新日期:2011-08-01 00:00:00

  • Stage I uterine carcinosarcoma: Matched cohort analyses for lymphadenectomy, chemotherapy, and brachytherapy.

    abstract:OBJECTIVE:To determine if lymphadenectomy, chemotherapy and radiotherapy are associated with survival benefit among women with stage I uterine carcinosarcoma. METHODS:Women with stage I uterine carcinosarcoma (n=5614) were identified from the 1998-2013 National Cancer Data Base. Kaplan-Meier survival estimates and Cox...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Seagle BL,Kanis M,Kocherginsky M,Strauss JB,Shahabi S

    更新日期:2017-04-01 00:00:00

  • POSTN/TGFBI-associated stromal signature predicts poor prognosis in serous epithelial ovarian cancer.

    abstract:OBJECTIVE:To identify molecular prognosticators and therapeutic targets for high-grade serous epithelial ovarian cancers (EOCs) using genetic analyses driven by biologic features of EOC pathogenesis. METHODS:Ovarian tissue samples (n = 172; 122 serous EOCs, 30 other EOCs, 20 normal/benign) collected prospectively from...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Karlan BY,Dering J,Walsh C,Orsulic S,Lester J,Anderson LA,Ginther CL,Fejzo M,Slamon D

    更新日期:2014-02-01 00:00:00

  • Endocrine therapy in endometrial cancer: An old dog with new tricks.

    abstract::One of the most prevalent potential therapeutic targets for women with endometrioid endometrial cancer (EC) is the estrogen receptor (ER)/progesterone receptor (PR) pathway. Despite a high proportion of endometrioid ECs being ER and/or PR positive, endocrine therapy is only effective in a minority of women with EC and...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Jerzak KJ,Duska L,MacKay HJ

    更新日期:2019-04-01 00:00:00

  • PD-1 blockade in recurrent or metastatic cervical cancer: Data from cemiplimab phase I expansion cohorts and characterization of PD-L1 expression in cervical cancer.

    abstract:OBJECTIVES:To characterize the safety, tolerability, and anti-tumor activity of cemiplimab as monotherapy or in combination with hypofractionated radiation therapy (hfRT) in patients with recurrent or metastatic cervical cancer. To determine the association between histology and programmed death-ligand 1 (PD-L1) expres...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Rischin D,Gil-Martin M,González-Martin A,Braña I,Hou JY,Cho D,Falchook GS,Formenti S,Jabbour S,Moore K,Naing A,Papadopoulos KP,Baranda J,Fury W,Feng M,Stankevich E,Li J,Yama-Dang NA,Yoo SY,Lowy I,Mathias M,Fury

    更新日期:2020-11-01 00:00:00

  • Expression and localization of aquaporin-5 in the epithelial ovarian tumors.

    abstract:OBJECTIVE:To investigate the expression and localization of aquaporin-5 (AQP5) in epithelial ovarian tumors and its clinic significance. METHODS:The expression of AQP5 protein and mRNA in 65 cases epithelial ovarian tumors and 13 cases normal tissue were measured by immunohistochemical technique, Western blotting and ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Yang JH,Shi YF,Cheng Q,Deng L

    更新日期:2006-02-01 00:00:00

  • Treatment of malignant ascites with allogeneic and autologous lymphokine-activated killer cells.

    abstract::Two cases of peritonitis carcinomatosa with gynecological cancer, which did not respond to conventional treatment, were treated by intraperitoneal adoptive immunotherapy with allogeneic or autologous lymphokine-activated killer (LAK) cells plus interleukin-2. In case 1, reduction of acute ascites and disappearance of ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kamada M,Sakamoto Y,Furumoto H,Mori K,Daitoh T,Irahara M,Aono T,Nii A,Yanagawa H,Sone S

    更新日期:1989-07-01 00:00:00

  • The effects of size and shape of the ovarian cancer spheroids on the drug resistance and migration.

    abstract:BACKGROUND:High fatality in ovarian cancer is attributed to metastasis, propagated by the release of multi-cellular aggregates/spheroids into the peritoneal cavity and their subsequent mesothelial invasion of peritoneal organs. Spheroids are therefore a common and clinically relevant in vitro model for ovarian cancer r...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Gunay G,Kirit HA,Kamatar A,Baghdasaryan O,Hamsici S,Acar H

    更新日期:2020-11-01 00:00:00

  • Nomograms to predict isolated loco-regional or distant recurrence among women with uterine cancer.

    abstract:OBJECTIVE:While there is ample literature on prognostic factors for uterine cancer, currently there are nomeans to estimate an individual's risk for recurrence or to differentiate the risk of loco-regional recurrence from distant recurrence. We addressed this gap by developing nomograms to individualize the risk of rec...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kondalsamy-Chennakesavan S,Yu C,Kattan MW,Leung Y,Sykes P,Nascimento M,Nicklin J,Perrin L,Crandon A,Chetty N,Land R,Garrett A,Obermair A

    更新日期:2012-06-01 00:00:00

  • Racial disparities in surgical care for uterine cancer.

    abstract:OBJECTIVE:To evaluate the association of race and surgical approach for women who underwent surgical treatment for uterine cancer. METHODS:The design was a retrospective cohort study of discharge data from nonfederal acute care hospitals in Maryland from 2000 to 2009. Women aged 18 and older who underwent hysterectomy...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Fleury AC,Ibeanu OA,Bristow RE

    更新日期:2011-06-01 00:00:00

  • Bolus mitomycin C and 5-FU with sequential radiation for poor-prognosis locally advanced cervical cancer.

    abstract::Forty patients with locally advanced cervical carcinoma were entered into a protocol utilizing the bolus administration of both mitomycin C (10 or 15 mg) on Day 1 and 5-fluorouracil (400 mg) on Day 1-5 followed by sequential pelvic irradiation on Day 6 between September 1980 and October 1985. All patients had poor-pro...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,评审


    authors: Denehy TR,Eastman R,SanFilippo L,Gregori CA,Breen JL

    更新日期:1996-01-01 00:00:00

  • Risk of malignancy index in the preoperative evaluation of patients with adnexal masses.

    abstract:OBJECTIVE:The aim of this study was to evaluate the use of a Risk of Malignancy Index (RMI) in primary evaluation of patients with adnexal masses. METHODS:The RMI is based on menopausal status, ultrasonographic findings, and serum CA 125 level. A cutoff level of 200 was chosen as the threshold for referral for central...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Andersen ES,Knudsen A,Rix P,Johansen B

    更新日期:2003-07-01 00:00:00

  • The use of CT findings to predict extent of tumor at primary surgery for ovarian cancer.

    abstract:BACKGROUND:High tumor dissemination (HTD) is a major risk factor for serious morbidity after primary ovarian cancer (OC) surgery, particularly in medically compromised patients. We performed a pilot study of whether CT findings could predict extent of disease and surgical complexity necessary in advanced OC. METHODS:P...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Glaser G,Torres M,Kim B,Aletti G,Weaver A,Mariani A,Hartmann L,Cliby W

    更新日期:2013-08-01 00:00:00

  • Percutaneous nephrostomy catheter use in gynecologic malignancy: M.D. Anderson Hospital experience.

    abstract::The clinical courses of 30 patients with 41 nephrostomy catheters were followed. Duration of drainage ranged from 2 days to 15 months with a mean of 3.7 months. The most common complications were hemorrhage (28%), infection (70%), and blockage of catheter (65%). No deaths occurred as a result of these complications. R...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Dudley BS,Gershenson DM,Kavanagh JJ,Copeland LJ,Carrasco CH,Rutledge FN

    更新日期:1986-07-01 00:00:00

  • Antiemetic treatment of chemotherapy-induced nausea in ovarian carcinoma patients.

    abstract::In a prospective, randomized, double-blind trial the combination betamethasone-dixyrazine was compared with high-dose metoclopramide as antiemetic treatment during combination chemotherapy (melphalan-doxorubicin and cisplatin) of ovarian carcinoma. Of 40 evaluable patients, 15 (38%) had previous experience with chemot...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sorbe B,Hallén C

    更新日期:1989-08-01 00:00:00

  • Ifosfamide, paclitaxel, and carboplatin, a novel triplet regimen for advanced, recurrent, or persistent carcinoma of the cervix: a phase II trial.

    abstract:OBJECTIVES:(1) To determine the response rate of advanced, recurrent, or persistent carcinoma of the cervix to ifosfamide, paclitaxel, and carboplatin chemotherapy; (2) to determine the progression free interval and survival rate in patients treated with this regimen; (3) to describe the toxicities associated with this...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Downs LS Jr,Chura JC,Argenta PA,Judson PL,Ghebre R,Geller MA,Carson LF

    更新日期:2011-02-01 00:00:00

  • Adriamycin and cis-diamminedichloroplatinum in the treatment of metastatic endometrial adenocarcinoma.

    abstract::Adriamycin (50 mg/m2) and cis-diamminedichloroplatinum (50 mg/m2) were administered every 21 days to treat metastatic endometrial adenocarcinoma. This regimen resulted in three responses (one complete and two partial) in nine women (33%). Most patients had moderate or severe hematologic and gastrointestinal toxicity. ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Seltzer V,Vogl SE,Kaplan BH

    更新日期:1984-11-01 00:00:00

  • Immunization with adenoviral vectors carrying recombinant IL-12 and E7 enhanced the antitumor immunity to human papillomavirus 16-associated tumor.

    abstract:OBJECTIVE:Human papillomavirus (HPV) infection play a significant role in cervical carcinogenesis, and HPV oncoprotein E7 has important functions in the formation and maintenance of cervical cancers. Interleukin-12 (IL-12) has been reported to induce cellular immune responses, and has also been demonstrated to suppress...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Jin HS,Park EK,Lee JM,NamKoong SE,Kim DG,Lee YJ,Jun HJ,Han BD,Bae SM,Ahn WS

    更新日期:2005-05-01 00:00:00

  • Oncolytic adenovirus Ad5/3-delta24 and chemotherapy for treatment of orthotopic ovarian cancer.

    abstract:OBJECTIVE:Oncolytic adenoviruses capable of replication selectively in tumor cells are an appealing approach for the treatment of neoplastic diseases refractory to conventional therapies. The aim of this study was to evaluate the effect of dose and scheduling of a tropism-modified, adenovirus serotype 3 receptor-target...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Raki M,Särkioja M,Desmond RA,Chen DT,Bützow R,Hemminki A,Kanerva A

    更新日期:2008-01-01 00:00:00

  • Platelets promote invasion and induce epithelial to mesenchymal transition in ovarian cancer cells by TGF-β signaling pathway.

    abstract:OBJECTIVE:To test whether platelets could increase invasion potential and initiate EMT in ovarian cancer cells via a TGF-β signaling pathway. METHODS:Blood samples were collected in 69 patients with ovarian cancer, 16 patients with benign ovarian tumor and 64 healthy donors. SK-OV-3 and OVCAR-3 ovarian cancer cells we...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Guo Y,Cui W,Pei Y,Xu D

    更新日期:2019-06-01 00:00:00

  • Relationship of margin status and radiation dose to recurrence in post-operative vulvar carcinoma.

    abstract:OBJECTIVE:To evaluate the effect of margin status and radiation dose in patients treated with radiation therapy (RT) for vulvar cancer. Clinical outcomes included vulvar recurrence (VR), relapse-free survival (RFS) and overall survival (OS). METHODS:We retrospectively reviewed the records of 300 patients with Stage I-...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Viswanathan AN,Pinto AP,Schultz D,Berkowitz R,Crum CP

    更新日期:2013-09-01 00:00:00

  • Sarcoma in association with multimodality management of vulvar cancer: two case reports.

    abstract:BACKGROUND:Radiation-induced or -associated sarcoma is a rare event which has been well described in the literature. However, this entity has been infrequently described in association with genital tract malignancies. To our knowledge it has never been described in association with the management of vulvar cancer. CAS...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Hyde S,Uitterhoeve LJ,Schilthuis MS,ten Kate FJ,van der Velden J

    更新日期:2001-05-01 00:00:00

  • The prognostic value of residual disease after neoadjuvant chemotherapy in advanced ovarian cancer; A systematic review.

    abstract:INTRODUCTION:The ability to minimize residual disease during primary cytoreductive surgery is the strongest predictor for improved overall survival in advanced ovarian cancer. But while the probability to achieve a macroscopic complete resection increases if surgery is preceded by neoadjuvant chemotherapy (NACT), survi...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Timmermans M,van der Hel O,Sonke GS,Van de Vijver KK,van der Aa MA,Kruitwagen RF

    更新日期:2019-05-01 00:00:00

  • Spatial analysis of adherence to treatment guidelines for advanced-stage ovarian cancer and the impact of race and socioeconomic status.

    abstract:OBJECTIVE:To determine the impact of geographic location on advanced-stage ovarian cancer care adherence to the National Comprehensive Cancer Network (NCCN) guidelines in relation to race and socioeconomic status (SES). METHODS:Patients diagnosed with stage IIIC/IV epithelial ovarian cancer (1/1/96-12/31/06) were iden...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Bristow RE,Chang J,Ziogas A,Anton-Culver H,Vieira VM

    更新日期:2014-07-01 00:00:00

  • Prognostic implications of histological tumor regression (Böhm's score) in patients receiving neoadjuvant chemotherapy for high grade serous tubal & ovarian carcinoma.

    abstract:OBJECTIVE:Primary objective of this study was to determine prognostic significance of Bohm's histopathological regression score in patients who received neoadjuvant chemotherapy (NACT) for treatment of high grade serous (HGS) tubal & ovarian carcinoma. METHODS:This was a retrospective cohort study of patients who rece...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Rajkumar S,Polson A,Nath R,Lane G,Sayasneh A,Jakes A,Begum S,Mehra G

    更新日期:2018-11-01 00:00:00

  • Clinical characteristics and treatment of gestational trophoblastic tumor with vaginal metastasis.

    abstract:OBJECTIVE:The aim of this study was to evaluate clinical manifestations, management options, and prognosis for women presenting with gestational trophoblastic tumors with vaginal metastasis. METHOD:Fifty-one patients with vaginal metastases were analyzed retrospectively between January 1985 and September 2000. Vaginal...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Yingna S,Yang X,Xiuyu Y,Hongzhao S

    更新日期:2002-03-01 00:00:00

  • Defining the survival benefit of adjuvant pelvic radiotherapy and chemotherapy versus chemotherapy alone in stages III-IVA endometrial carcinoma.

    abstract:OBJECTIVES:To determine which patients with locoregionally advanced endometrial cancer may benefit from pelvic external beam radiotherapy (EBRT) in addition to chemotherapy compared to chemotherapy alone. METHODS:Patients with FIGO stages III-IVA endometrial carcinoma between 2004 and 2016 who underwent at least total...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Xiang M,English DP,Kidd EA

    更新日期:2019-09-01 00:00:00

  • PI3K oncogenic mutations mediate resistance to afatinib in HER2/neu overexpressing gynecological cancers.

    abstract:OBJECTIVE:Aberrant expression of HER2/neu and PIK3CA gene products secondary to amplification/mutations are common in high-grade-serous-endometrial (USC) and ovarian-cancers (HGSOC). Because scant information is currently available in the literature on the potential negative effect of PIK3CA mutations on the activity o...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Bonazzoli E,Cocco E,Lopez S,Bellone S,Zammataro L,Bianchi A,Manzano A,Yadav G,Manara P,Perrone E,Haines K,Espinal M,Dugan K,Menderes G,Altwerger G,Han C,Zeybek B,Litkouhi B,Ratner E,Silasi DA,Huang GS,Azodi M,

    更新日期:2019-04-01 00:00:00