Phase II trial of etoposide in leiomyosarcoma of the uterus: a Gynecologic Oncology Group study.

abstract：OBJECTIVE:To profile long non-coding RNA (lncRNA) expression at the various anatomic sites of high-grades serous carcinoma (HGSC) and in effusion-derived exosomes. METHODS:LncRNA profiling was performed on 60 HGSC specimens, including 10 ovarian tumors, 10 solid metastases and 10 malignant effusions, as well as exosom...

journal_title：Gynecologic oncology

authors： Filippov-Levy N,Cohen-Schussheim H,Tropé CG,Hetland Falkenthal TE,Smith Y,Davidson B,Reich R

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:To compare the detection rate of genital human papillomavirus (HPV) infection in self- and physician-obtained samples. DESIGN:Systematic review and meta-analysis. DATA SOURCES:Studies published between 1966 and November 2005 identified through Medline and Embase that compared both sampling methods. MAIN OU...

journal_title：Gynecologic oncology

authors： Petignat P,Faltin DL,Bruchim I,Tramèr MR,Franco EL,Coutlée F

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVES:(1) To determine the response rate of advanced, recurrent, or persistent carcinoma of the cervix to ifosfamide, paclitaxel, and carboplatin chemotherapy; (2) to determine the progression free interval and survival rate in patients treated with this regimen; (3) to describe the toxicities associated with this...

journal_title：Gynecologic oncology

authors： Downs LS Jr,Chura JC,Argenta PA,Judson PL,Ghebre R,Geller MA,Carson LF

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVES:Determinants of endometrial cancer grade have not been precisely defined, however, cell cycle control is considered to be integrally involved in endometrial cancer development. TP53 and MDM2 are essential components for cell cycle arrest and apoptosis. Polymorphisms in these genes cause TP53 inactivation and...

journal_title：Gynecologic oncology

authors： Ashton KA,Proietto A,Otton G,Symonds I,McEvoy M,Attia J,Gilbert M,Hamann U,Scott RJ

更新日期：2009-04-01 00:00:00

abstract：:We examined the efficacy of CA125 and urinary gonadotropin fragment (UGF) measurements for differentiating benign from malignant pelvic masses. CA125, at a cutoff of greater than or equal to 35 U/ml, detected 82% (n = 71) of ovarian malignancies, but also falsely detected 14% of (n = 332) patients with benign pelvic m...

journal_title：Gynecologic oncology

authors： Cole LA,Nam JH,Chambers JT,Schwartz PE

更新日期：1990-03-01 00:00:00

abstract：:A phase II trial of ifosfamide (IFX) and mesna was conducted by the GOG in patients with recurrent or advanced nonsquamous carcinoma of the cervix. A starting dose of 1.5 g/m2 IFX iv daily for 5 days and 300 mg/m2 mesna iv every 4 hr with three doses daily after IFX were given. In patients who had received prior radio...

journal_title：Gynecologic oncology

authors： Sutton GP,Blessing JA,DiSaia PJ,McGuire WP

更新日期：1993-04-01 00:00:00

abstract：:The common epithelial tumors of the human ovary have rarely been found in the gonads of intersex patients with gonadal dysgenesis or true hermaphroditism. This report describes a patient with ovarian serous cystadenocarcinoma and mixed gonadal dysgenesis (45,X/46,XY) and reviews other reported cases. Intersex patients...

journal_title：Gynecologic oncology

authors： Miller DS,Teng NN,Ballon SC

更新日期：1986-07-01 00:00:00

abstract：:From 1980 to 1987, 30 patients with FIGO clinical Stage II carcinoma of the endometrium were treated with 5000 cGy preoperative pelvic radiation therapy at Thomas Jefferson University Hospital. Patients with gross cervical disease received additional intracavitary irradiation with a tandem and ovoids for a combined to...

journal_title：Gynecologic oncology

authors： Reisinger SA,Staros EB,Feld R,Mohiuddin M,Lewis GC

更新日期：1992-05-01 00:00:00

abstract：OBJECTIVE:Preoperative leukocytosis is known to be a negative prognostic factor for several gynecologic malignancies, but its relationship with epithelial ovarian carcinoma (EOC) is unknown. We sought to evaluate the prognostic implications of preoperative leukocytosis for women with EOC. METHODS:We retrospectively re...

journal_title：Gynecologic oncology

authors： So KA,Hong JH,Jin HM,Kim JW,Song JY,Lee JK,Lee NW

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVE:To estimate the frequency of cervical cytologic/histologic discrepancies in a group of obstetric patients diagnosed as HIV infected by routine prenatal screening. Also, to determine if serum CD4 levels or sexually transmitted diseases (STDs) are associated with the occurrence of preinvasive cervical disease i...

journal_title：Gynecologic oncology

authors： Robinson WR,Barnes SE,Adams S,Perrin MS

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVES:Limited knowledge exists about the value of tumor size in surgically treated cervical cancer (CX) using a tumor size of 2 cm as cut-off value. METHODS:A total of 366 cases of CX FIGO stage IB who received upfront surgery were evaluated regarding tumor size, the prediction of pelvic lymph node involvement, a...

journal_title：Gynecologic oncology

authors： Horn LC,Bilek K,Fischer U,Einenkel J,Hentschel B

更新日期：2014-07-01 00:00:00

abstract：:From January 1, 1946, through January 1, 1986, at the University of Michigan, 60 patients were treated with Stage IB (FIGO) carcinoma of the cervix with lymph node metastases. Clinical variables were examined with regard to long-term survival. Prognostically significant variables were (1) highest level of lymph node i...

journal_title：Gynecologic oncology

authors： Terada KY,Morley GW,Roberts JA

更新日期：1988-11-01 00:00:00

abstract：OBJECTIVE:Chemoradiation based on cisplatin is the standard treatment for locally advanced cervical carcinoma; however, the optimal scheduling and dosing have still not been established. This study was conducted to determine the maximum-tolerated dose (MTD) of cisplatin for daily administration during pelvic radiothera...

journal_title：Gynecologic oncology

authors： Mitsuhashi A,Uno T,Tanaka N,Suzuka K,Tate S,Yamazawa K,Matsui H,Yamamoto S,Ito H,Sekiya S

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:The purpose of the present study is to prospectively evaluate the effects of tamoxifen on the pathological behavior of endometrial hyperplasias without atypia, diagnosed before the start of adjuvant endocrine therapy, in menopausal patients suffering from breast cancer. METHODS:Twenty-six patients suffering ...

journal_title：Gynecologic oncology

authors： Garuti G,Cellani F,Centinaio G,Sita G,Nalli G,Luerti M

更新日期：2006-05-01 00:00:00

abstract：:Lynch syndrome II was diagnosed when two sisters manifested early-onset synchronous carcinomas of the ovary and endometrium and a third sister was found to have Duke's A carcinoma of the cecum. A detailed cancer family history indicated paternal transmission of the deleterious genotype. The pattern of carcinoma of the...

journal_title：Gynecologic oncology

authors： Lynch HT,Cavalieri RJ,Lynch JF,Casey MJ

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND:A case of primary neuroblastoma arising from the broad ligament with excellent response to neoadjuvant bleomycin, etoposide, and cisplatin (BEP) is reported. CASE:A 48-year-old woman, G0, who presented with acute renal failure, an enlarged pelvic mass, and abdominal pain was diagnosed with adult neuroblasto...

journal_title：Gynecologic oncology

authors： Milam MR,Gabel SF,Milam RA,Liu J,Ramirez PT

更新日期：2007-11-01 00:00:00

abstract：:A patient with malignant struma ovarii who had elevated thyroglobulin levels at the time of her original surgery was diagnosed with recurrence on the basis of progressive thyroglobulin level elevation while on thyroid suppressive therapy. Subsequent treatment with therapeutic doses of iodine-137 resulted in normalizat...

journal_title：Gynecologic oncology

authors： Rose PG,Arafah B,Abdul-Karim FW

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a classical glycolytic protein. A higher level of GAPDH mRNA was found in lung, pancreas, and prostate cancers, but in cervical carcinoma there have not been any reports about the level of GAPDH gene expression. So, we tried to investigate the GAPDH gene exp...

journal_title：Gynecologic oncology

authors： Kim JW,Kim SJ,Han SM,Paik SY,Hur SY,Kim YW,Lee JM,Namkoong SE

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE AND METHODS:Ten vulvar squamous cell carcinoma cell lines established at the University of Michigan (UM-SCV-1A, -1B, -2, -3, -4, -6, -7) and at the University of Turku (UT-SCV-1, -2, -3) were characterized by G-banding karyotyping, comparative genomic hybridization (CGH), and deoxyribonucleic acid (DNA) flow ...

journal_title：Gynecologic oncology

authors： Raitanen M,Worsham MJ,Lakkala T,Carey TE,Van Dyke DL,Grénman R,Klemi P,Rantanen V,Isola J,Grénman S

更新日期：2004-04-01 00:00:00

abstract：:Over a 20-year period, 34 patients with FIGO stage II ovarian carcinoma were treated with postoperative pelvic irradiation at the University of Michigan. Complications of radiation treatment were minimal. The overall actuarial disease-free 5-year survival was 53%. This was not significantly different for substages IIA...

journal_title：Gynecologic oncology

authors： Terada KY,Morley GW,Roberts JA

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:Bilateral oophorectomy (BOE) is often recommended in order to prevent cancer at hysterectomy for non-malignant diseases and when familial risk of ovarian and breast cancer has been identified. Surgical menopause increases the risk of cardiovascular mortality, however, the intervening mechanisms are not clear....

journal_title：Gynecologic oncology

authors： Dørum A,Tonstad S,Liavaag AH,Michelsen TM,Hildrum B,Dahl AA

更新日期：2008-06-01 00:00:00

abstract：:An unusual case of Stage IB moderately well-differentiated endometrial adenocarcinoma that was confined to a polyp and recurred only in the abdominal wound is presented. Eighteen months following complete excision, local electron beam therapy, and the institution of hormonal therapy, the patient is alive and without o...

journal_title：Gynecologic oncology

authors： Barter JF,Hatch KD,Orr JW Jr,Shingleton HM

更新日期：1986-11-01 00:00:00

abstract：:Ovarian carcinoma usually presents in an indolent manner, most often nonspecifically with complaints of abdominal pain or swelling, bloating, constipation, anorexia, early satiety, and evidence of ascites. We present a case of ovarian cancer with a cerebrovascular accident (CVA) as the presenting symptom, with minimal...

journal_title：Gynecologic oncology

authors： Shamonki MI,Squatrito RC,Welander CE

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVE:To determine the effectiveness of chemotherapy alone as postoperative adjuvant therapy for intermediate- and high-risk cervical cancer. METHODS:The study group comprised of 65 consecutive patients with stage IB or IIA squamous cell or adenosquamous cervical cancer who were initially treated with radical hyst...

journal_title：Gynecologic oncology

authors： Takeshima N,Umayahara K,Fujiwara K,Hirai Y,Takizawa K,Hasumi K

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Treatment with weekly cisplatin (CDDP) plus radiotherapy (RT) is the standard regimen for stage IB to stage IVA cervical carcinoma (CC). We performed a systematic review and meta-analysis of published studies to evaluate whether CDDP-based doublet therapy improves survival compared to weekly CDDP plus RT in ...

journal_title：Gynecologic oncology

authors： Petrelli F,De Stefani A,Raspagliesi F,Lorusso D,Barni S

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:The present study was undertaken to analyze the impact of epigenetic alterations with a main focus on nuclear area, aneuploidy, hyperploidy, and proliferation in 70 ovarian cancer specimens. METHODS:Morphometric changes and somatic chromosomal ploidy status were assessed by Feulgen spectrophotometry. DNA-hyp...

journal_title：Gynecologic oncology

authors： Zeimet AG,Fiegl H,Goebel G,Kopp F,Allasia C,Reimer D,Steppan I,Mueller-Holzner E,Ehrlich M,Marth C

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVES:In this study we evaluated changes in serum Müllerian inhibiting substance (MIS) concentration in a large number of patients with granulosa cell tumors (GCT) to determine whether MIS is elevated at the time of presentation and whether MIS is an index of successful surgical resection and management of recurre...

journal_title：Gynecologic oncology

authors： Lane AH,Lee MM,Fuller AF Jr,Kehas DJ,Donahoe PK,MacLaughlin DT

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:All non-invasive diagnostic algorithms suffer from diagnostic uncertainty in discriminating benign from malignant adnexal masses. CASE:We present a case where the identification of a large solitary multiloculated pelvic cyst in a woman with postmenopausal bleeding was shown to be multifocal multicystic beni...

journal_title：Gynecologic oncology

authors： Varma R,Wallace R

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:There is a need to find agents with activity in platinum and taxane refractory ovarian cancer to be employed as second-line therapy in the malignancy. Limited clinical trial experience has suggested that gemcitabine possesses activity in this clinical setting. We wished to further define the level of activity...

journal_title：Gynecologic oncology

authors： Markman M,Webster K,Zanotti K,Kulp B,Peterson G,Belinson J

更新日期：2003-09-01 00:00:00

abstract：:In patients with small central recurrences following radiation therapy for cervical cancer the surgeon may have to make a judgment as to when radical hysterectomy is preferable to exenteration. During the years 1968-1984 there were 21 radical hysterectomies performed at Memorial Sloan-Kettering Cancer Center for recur...

journal_title：Gynecologic oncology

authors： Rubin SC,Hoskins WJ,Lewis JL Jr

更新日期：1987-07-01 00:00:00