Diagnostic utility of Müllerian inhibiting substance determination in patients with primary and recurrent granulosa cell tumors.

abstract：OBJECTIVE:Increased Vascular Endothelial Growth Factor Receptor (VEGF) expression in endometrial cancer (EC) is associated with a poor prognosis. Preliminary clinical data reported Bevacizumab effectiveness in EC both as single agent and in combination with chemotherapy. METHODS:In a phase II trial, patients with adva...

journal_title：Gynecologic oncology

authors： Lorusso D,Ferrandina G,Colombo N,Pignata S,Pietragalla A,Sonetto C,Pisano C,Lapresa MT,Savarese A,Tagliaferri P,Lombardi D,Cinieri S,Breda E,Sabatucci I,Sabbatini R,Conte C,Cecere SC,Maltese G,Scambia G

更新日期：2019-12-01 00:00:00

abstract：:Thirty-two patients with Stage III or IV epithelial ovarian cancer and residual tumor volumes in excess of 2 cm in diameter after initial debulking were treated with platinum and cyclophosphamide chemotherapy. Twenty-seven patients (84%) received at least six courses of chemotherapy. Six patients developed grade 3 or ...

journal_title：Gynecologic oncology

authors： Gallion HH,van Nagell JR,Donaldson ES,Hanson MB,Kryscio RJ

更新日期：1987-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess whether microvessel density (measured by CD31), vascular endothelial growth factor (VEGF) or multidrug resistance (MDR1) could determine the response to chemotherapy or act as prognostic factors in ovarian cancer. METHODS:Seventy-nine ovarian specimens were immunostained. ...

journal_title：Gynecologic oncology

authors： O'Toole SA,Sheppard BL,Laios A,O'Leary JJ,McGuinness EP,D'Arcy T,Bonnar J

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVES:To evaluate the CINtec PLUS assay (mtm laboratories), a new immunocytochemical method for the simultaneous detection of p16(INK4a) and Ki-67, in liquid-based cervico-vaginal cytology, investigating the association of the dual staining with HPV infection and genotyping as well as cytological and histological ...

journal_title：Gynecologic oncology

authors： Donà MG,Vocaturo A,Giuliani M,Ronchetti L,Rollo F,Pescarmona E,Carosi M,Vocaturo G,Benevolo M

更新日期：2012-08-01 00:00:00

abstract：:Two cases with squamous cell carcinoma of the cervix stage IIB with primary tumor mass about 2 X 2 X 2 cm were treated with primary chemotherapy of cis-platinum, 20 micrograms/m2 body surface intravenously daily for 5 consecutive days. Papanicolaou smear turned negative after two courses of chemotherapy in both cases....

journal_title：Gynecologic oncology

authors： Kim DS,Moon H,Kang KJ

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:Malignant struma ovarii is a rare tumor, consisting of a struma ovarii with malignant change. Because of the rarity of the tumor, only a few reports with detailed data of thyroid function of the patient have been published. CASE:Medical and surgical treatments were performed in a case of malignant struma ov...

journal_title：Gynecologic oncology

authors： Kano H,Inoue M,Nishino T,Yoshimoto Y,Arima R

更新日期：2000-12-01 00:00:00

abstract：:This study evaluated the effects of cisplatin on 18 nerve conduction parameters of median, ulnar, peroneal, and sural nerves in relation to age, magnesium nadir, average magnesium, and magnesium replacement in gynecologic oncology patients. The 37 patients in this study received cisplatin (70 mg/m2) at 4-week interval...

journal_title：Gynecologic oncology

authors： Ashraf M,Riggs JE,Wearden S,Scotchel P

更新日期：1990-04-01 00:00:00

abstract：OBJECTIVE:Doxorubicin has reported activity in advanced and recurrent cervical cancer but hematologic toxicity has limited its use in some combinations. To determine the level of activity and potential for use in future combinations, a phase II trial of pegylated liposomal doxorubicin as second-line therapy in advanced...

journal_title：Gynecologic oncology

authors： Rose PG,Blessing JA,Lele S,Abulafia O

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:To compare the oncologic outcomes of women who underwent a fertility-sparing radical trachelectomy (RT) to those who underwent a radical hysterectomy (RH) for stage IB1 cervical carcinoma. METHODS:We performed a case-control study of all patients with stage IB1 cervical carcinoma who underwent a vaginal or a...

journal_title：Gynecologic oncology

authors： Diaz JP,Sonoda Y,Leitao MM,Zivanovic O,Brown CL,Chi DS,Barakat RR,Abu-Rustum NR

更新日期：2008-11-01 00:00:00

abstract：:Pelvic washings for cytologic analysis have become an accepted diagnostic procedure in the management of endometrial carcinoma. A retrospective study was performed in 163 consecutive patients with FIGO Stage I and II endometrial carcinoma to assess the significance and value of the washings. Abnormal results were obta...

journal_title：Gynecologic oncology

authors： Kennedy AW,Peterson GL,Becker SN,Nunez C,Webster KD

更新日期：1987-09-01 00:00:00

abstract：:Forty-one eligible patients with metastatic or recurrent carcinoma of the uterine cervix received 149 courses of carboplatin. The drug was administered at a starting dosage of 400 mg/m2 IV every 28 days. The overall response rate was 15% (two complete responses, four partial responses; 95% confidence interval 6-29%) a...

journal_title：Gynecologic oncology

authors： Weiss GR,Green S,Hannigan EV,Boutselis JG,Surwit EA,Wallace DL,Alberts DS

更新日期：1990-12-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the efficacy of cisplatin, ifosfamide, and mesna in uterine malignant mixed müllerian tumor (MMMT) and to evaluate the expression of clinically relevant molecular markers. METHODS:Women with advanced or recurrent MMMT were treated every 28 days with cisplatin (75 mg/m(2...

journal_title：Gynecologic oncology

authors： Ramondetta LM,Burke TW,Jhingran A,Schmandt R,Bevers MW,Wolf JK,Levenback CF,Broaddus R

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to profile cervical squamous cell carcinoma in elderly patients undergoing radiation therapy and to study the treatment outcome and side effects of therapy. MATERIALS AND METHODS:A retrospective analysis was carried out from the records of 380 patients with squamous cell carcino...

journal_title：Gynecologic oncology

authors： Sakurai H,Mitsuhashi N,Takahashi M,Yamakawa M,Akimoto T,Hayakawa K,Niibe H

更新日期：2000-04-01 00:00:00

abstract：OBJECTIVE:To determine the effectiveness of chemotherapy alone as postoperative adjuvant therapy for intermediate- and high-risk cervical cancer. METHODS:The study group comprised of 65 consecutive patients with stage IB or IIA squamous cell or adenosquamous cervical cancer who were initially treated with radical hyst...

journal_title：Gynecologic oncology

authors： Takeshima N,Umayahara K,Fujiwara K,Hirai Y,Takizawa K,Hasumi K

更新日期：2006-11-01 00:00:00

abstract：:Results of treatment and potential prognostic factors in 54 patients with clinical stage II endometrial carcinoma were analyzed. During the period analyzed, three different treatment techniques were used. The highest cure rate (70.6%) was observed in patients treated with simple hysterectomy and bilateral salpingo-oop...

journal_title：Gynecologic oncology

authors： Andersen ES

更新日期：1990-08-01 00:00:00

abstract：OBJECTIVE:Small cell carcinoma (SmCC) of the female genital tract constitutes a diagnostic and clinical challenge given its rarity and the lack of standardized therapeutic approaches. Here we review the morphological, clinical and molecular features of gynecologic SmCCs and discuss potential areas for future research. ...

journal_title：Gynecologic oncology

authors： Atienza-Amores M,Guerini-Rocco E,Soslow RA,Park KJ,Weigelt B

更新日期：2014-08-01 00:00:00

abstract：:Surgical treatment including total abdominal hysterectomy+bilateral salpingo oopherectomy (TAH+BSO) with pelvic and para-aortic lymphadenectomy may not be sufficient to treat cases with advanced endometrial adenocarcinoma (EAC), and in these cases, adjuvant treatments including radiotherapy and/or chemotherapy, are em...

journal_title：Gynecologic oncology

authors： Thangaraju S,Subramani E,Chakravarty B,Chaudhury K

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Practitioners and researchers require an outcome measure that accurately identifies the range of common treatment-induced changes in sexual function and well-being experienced by women after cervical or endometrial cancer. This systematic review critically appraised the measurement properties and clinical ut...

journal_title：Gynecologic oncology

authors： White ID,Sangha A,Lucas G,Wiseman T

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:Primary debulking surgery (PDS) has historically been the standard treatment for advanced ovarian cancer. Recent data appear to support a paradigm shift toward neoadjuvant chemotherapy with interval debulking surgery (NACT-IDS) for a subset of women with advanced ovarian cancer. It remains unresolved whether ...

journal_title：Gynecologic oncology

authors： Rauh-Hain JA,Nitschmann CC,Worley MJ Jr,Bradford LS,Berkowitz RS,Schorge JO,Campos SM,del Carmen MG,Horowitz NS

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:To determine the impact of geographic location on advanced-stage ovarian cancer care adherence to the National Comprehensive Cancer Network (NCCN) guidelines in relation to race and socioeconomic status (SES). METHODS:Patients diagnosed with stage IIIC/IV epithelial ovarian cancer (1/1/96-12/31/06) were iden...

journal_title：Gynecologic oncology

authors： Bristow RE,Chang J,Ziogas A,Anton-Culver H,Vieira VM

更新日期：2014-07-01 00:00:00

abstract：:Steroid cell tumors, not otherwise specified, are rare ovarian sex cord-stromal tumors with malignant potential. The majority of these tumors produce steroids with testosterone being the most common. A case of a 46-year-old woman who presented with sudden onset of virilization and a pelvic mass is reported. Various as...

journal_title：Gynecologic oncology

authors： Reedy MB,Richards WE,Ueland F,Uy K,Lee EY,Bryant C,van Nagell JR Jr

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:In cervical cancer patients, dose-volume relationships have been demonstrated for tumor and organs-at-risk, but not for pathologic nodes. The nodal control probability (NCP) according to dose/volume parameters was investigated. MATERIAL AND METHODS:Patients with node-positive cervical cancer treated curative...

journal_title：Gynecologic oncology

authors： Bacorro W,Dumas I,Escande A,Gouy S,Bentivegna E,Morice P,Haie-Meder C,Chargari C

更新日期：2018-03-01 00:00:00

abstract：:Taxol is one of the more significant advances in cancer chemotherapy in the last 10-15 years with a 30-50% response rate in both breast and ovarian cancers. The toxicity profile of taxol is still evolving as changes in the dosing and scheduling of the drug are instituted. We herein present the first evidence of taxol-...

journal_title：Gynecologic oncology

authors： Jerian SM,Sarosy GA,Link CJ Jr,Fingert HJ,Reed E,Kohn EC

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVE:The present study was undertaken to analyze the impact of epigenetic alterations with a main focus on nuclear area, aneuploidy, hyperploidy, and proliferation in 70 ovarian cancer specimens. METHODS:Morphometric changes and somatic chromosomal ploidy status were assessed by Feulgen spectrophotometry. DNA-hyp...

journal_title：Gynecologic oncology

authors： Zeimet AG,Fiegl H,Goebel G,Kopp F,Allasia C,Reimer D,Steppan I,Mueller-Holzner E,Ehrlich M,Marth C

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVES:Mature cystic teratoma of the ovary transforms into malignant tumors, mostly squamous cell carcinomas, at an incidence of approximately 2%. Preoperative diagnosis of squamous cell carcinoma arising in mature cystic teratoma of the ovary is a difficult task. The present study aims to assess whether combined u...

journal_title：Gynecologic oncology

authors： Suzuki M,Tamura N,Kobayashi H,Ohwada M,Terao T,Sato I

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to retrospectively analyze the prognostic importance of age, histologic type and grade, ascites, lymph node status, size and type of postoperative residual disease, and radiation dose on disease-specific (DSS) and progression-free survival (PFS) in stage III epithelial ovarian cancer...

journal_title：Gynecologic oncology

authors： Kapp KS,Kapp DS,Poschauko J,Stücklschweiger GF,Hackl A,Pickel H,Petru E,Winter R

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:To prospectively evaluate tumor control, survival, and toxic effects in patients with International Federation of Gynecology and Obstetrics (1988) stage I-IIIA papillary serous carcinoma of the endometrium treated with concurrent chemoradiation and adjuvant chemotherapy. METHODS:Thirty-two patients were enro...

journal_title：Gynecologic oncology

authors： Jhingran A,Ramondetta LM,Bodurka DC,Slomovitz BM,Brown J,Levy LB,Garcia ME,Eifel PJ,Lu KH,Burke TW

更新日期：2013-05-01 00:00:00

abstract：:From 1970 to 1992, 136 patients with a histologic diagnosis of endometrial hyperplasia underwent total abdominal hysterectomy at the University of Kentucky Medical Center. Slides of the curettage or biopsy specimens were reviewed and classified according to the International Society of Gynecologic Pathologists System ...

journal_title：Gynecologic oncology

authors： Hunter JE,Tritz DE,Howell MG,DePriest PD,Gallion HH,Andrews SJ,Buckley SB,Kryscio RJ,van Nagell JR Jr

更新日期：1994-10-01 00:00:00

abstract：:Malignant ovarian germ cell tumors (OGCT) and sex cord-stromal tumors (OSCST), each of which account for less than 5% of all ovarian malignancies, are much less common than epithelial ovarian cancer. In young patients suspected of having an OGCT, laparotomy is initially indicated for both diagnosis and treatment. For ...

journal_title：Gynecologic oncology

authors： Gershenson DM

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVE:The opioid growth factor (OGF) and its receptor, OGFr, serve as a tonically active inhibitory axis regulating cell proliferation in normal cells and a variety of cancers, including human ovarian cancer. Blockade of OGF and OGFr with the nonselective opioid receptor antagonist naltrexone (NTX) upregulates expr...

journal_title：Gynecologic oncology

authors： Donahue RN,McLaughlin PJ,Zagon IS

更新日期：2011-08-01 00:00:00