The prognostic significance of preoperative leukocytosis in epithelial ovarian carcinoma: a retrospective cohort study.

abstract：OBJECTIVE:Potential predictive/prognostic angiogenic markers were prospectively examined in a phase II trial of bevacizumab in epithelial ovarian cancer (EOC)/primary peritoneal cancer (PPC). METHODS:Recurrent/persistent EOC/PPC patients were treated with bevacizumab (15 mg/kg IV q21days) until disease progression. Va...

journal_title：Gynecologic oncology

authors： Han ES,Burger RA,Darcy KM,Sill MW,Randall LM,Chase D,Parmakhtiar B,Monk BJ,Greer BE,Connelly P,Degeest K,Fruehauf JP

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the usefulness of pre-operative serum CA-125 in the management of women diagnosed with uterine papillary serous carcinoma (UPSC). We hypothesized that elevated pre-operative levels of serum CA-125 correlate with higher disease stage and poorer prognosis. METHODS:Patients diagnosed with UPSC and m...

journal_title：Gynecologic oncology

authors： Olawaiye AB,Rauh-Hain JA,Withiam-Leitch M,Rueda B,Goodman A,del Carmen MG

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Granulosa cell tumors of the ovary are rare, primarily treated surgically. In advanced or recurrent disease, data are inconclusive regarding the benefit of either primary or adjuvant chemotherapy. Hormonal therapy has been suggested as an alternative treatment. CASE:Our patient had three recurrences of estr...

journal_title：Gynecologic oncology

authors： Hardy RD,Bell JG,Nicely CJ,Reid GC

更新日期：2005-03-01 00:00:00

abstract：:Endometrial carcinoma is the most common gynecologic malignancy and the fourth most prevalent cancer in women in the modern world. Despite a relatively high chance of surgical cure, for patients with advanced or recurrent disease there are few therapeutic options. Angiogenesis has been extensively studied ever since v...

journal_title：Gynecologic oncology

authors： Berger AA,Dao F,Levine DA

更新日期：2020-12-26 00:00:00

abstract：OBJECTIVE:To evaluate the survival impact of residual disease at the time of primary surgery for patients with Stage III and IV endometrial carcinoma; to assess morbidity associated with surgical cytoreduction. METHOD:All patients with endometrial carcinoma who underwent primary surgical therapy at the University of M...

journal_title：Gynecologic oncology

authors： Lambrou NC,Gómez-Marín O,Mirhashemi R,Beach H,Salom E,Almeida-Parra Z,Peñalver M

更新日期：2004-06-01 00:00:00

abstract：:Invasive carcinomas of the uterine cervix of 38 patients were examined for the presence of human papillomavirus (HPV) genomes and for the state of the c-myc and Ha-ras oncogenes. A combination of Southern blot hybridization and polymerase chain reaction revealed the presence of the genome of HPV type 16 in 17 tumors (...

journal_title：Gynecologic oncology

authors： Iwasaka T,Yokoyama M,Oh-uchida M,Matsuo N,Hara K,Fukuyama K,Hachisuga T,Fukuda K,Sugimori H

更新日期：1992-09-01 00:00:00

abstract：:Three hundred sixty-one patients with FIGO stage III and IV ovarian cancer were treated with cis-platinum combination chemotherapy in a Danish multicenter trial. Primary surgery was performed at 58 different departments; 32% of the patients were operated at a department associated with an oncologic center, 50% at a ge...

journal_title：Gynecologic oncology

authors： Bertelsen K

更新日期：1990-08-01 00:00:00

abstract：:Verrucous carcinoma is a rare variant of epidermoid carcinoma with distinct clinical and histopathologic features. To date, 31 cases have been reported in the cervix. They are typically slow-growing, locally invasive tumors with low potential for lymphatic metastasis and appear to be radioresistant. We report a case w...

journal_title：Gynecologic oncology

authors： de Jesus M,Tang W,Sadjadi M,Belmonte AH,Poon TP

更新日期：1990-02-01 00:00:00

abstract：OBJECTIVE:To evaluate safety, tolerability, and antitumor activity of pembrolizumab monotherapy in patients with programmed death ligand 1 (PD-L1)-expressing advanced ovarian cancer enrolled in the multicohort, phase Ib KEYNOTE-028 trial. METHODS:Key inclusion criteria were age ≥18 years; advanced ovarian epithelial, ...

journal_title：Gynecologic oncology

authors： Varga A,Piha-Paul S,Ott PA,Mehnert JM,Berton-Rigaud D,Morosky A,Yang P,Ruman J,Matei D

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:This study analyzed a model for the identification of specific epitopes recognized by autologous tumor-reactive humoral responses of endometrial cancer patients as potential markers for the monitoring of cancer. METHODS:The presence of circulating pro- and mature forms of cathepsin D and antibodies reactive ...

journal_title：Gynecologic oncology

authors： Bosscher JR,Gerçel-Taylor C,Watkins CS,Taylor DD

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:Therapy related acute myeloid leukemia (t-AML) is a potential late complication of cytotoxic therapy, and it is of particular concern in the treatment of patients with epithelial ovarian carcinoma (EOC) exposed to multiple courses of chemotherapy during the course of their disease. This study examines the inc...

journal_title：Gynecologic oncology

authors： Vay A,Kumar S,Seward S,Semaan A,Schiffer CA,Munkarah AR,Morris RT

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Chemotherapy remains an essential part of the treatment of advanced ovarian cancer. Intraperitoneal (IP) administration has been demonstrated to provide a survival advantage over intravenous chemotherapy in three phase 3 studies. However, IP catheter complications have been a significant factor in aborting I...

journal_title：Gynecologic oncology

authors： Bryant CS,Shah JP,Triest JA,Schimp VL,Morris RT

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVES:A phase II trial was conducted to evaluate the anti-tumor activity and adverse effects of thalidomide in persistent or recurrent endometrial cancer refractory to cytotoxic chemotherapy and to correlate angiogenesis biomarker expression with clinical outcome. METHODS:Consenting patients were treated until pr...

journal_title：Gynecologic oncology

authors： McMeekin DS,Sill MW,Benbrook D,Darcy KM,Stearns-Kurosawa DJ,Eaton L,Yamada SD,Gynecologic Oncology Group.

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Ovarian cancer arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy is rare. CASE:We herein report the case of a 67-year-old woman with a history of breast cancer, taking tamoxifen citrate 20 mg/day for 4 years, who underwent an operation for left ovarian tumor. The postopera...

journal_title：Gynecologic oncology

authors： Okugawa K,Hirakawa T,Ogawa S,Kaku T,Nakano H

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Traditionally, hysterectomy is considered definitive therapy for cervical adenocarcinoma in situ (AIS) in women beyond childbearing. CASE:A 45-year-old gravida 2, para 2 patient presented with cervical dysplasia and on pathology review of the large loop excision procedure cervical adenocarcinoma in situ was...

journal_title：Gynecologic oncology

authors： Miller B,Dunn J,Dalrymple J,Krivak TC

更新日期：2005-11-01 00:00:00

abstract：:Twelve patients with recurrent squamous cell carcinoma of the cervix restricted to the pelvis were treated with intra-arterial infusion of carboplatin. The initial carboplatin dose was 300 mg/m2, every 4 weeks, and the dose was escalated to 450 mg/m2. Myelosuppression was the dose-limiting toxicity at the 450 mg/m2 do...

journal_title：Gynecologic oncology

authors： Verma S,Prefontaine M,Bertrand M,Genest P,Dahrouge S

更新日期：1994-06-01 00:00:00

abstract：OBJECTIVE:The aim of our study was to retrospectively examine the proliferating cell nuclear antigen (PCNA) immunoreactivity of tumor cells in curettage specimens containing endometrioid adenocarcinoma and obtained immediately before definitive surgical staging. This PCNA index was compared with the one subsequently de...

journal_title：Gynecologic oncology

authors： Garzetti GG,Ciavattini A,Goteri G,De Nictolis M,Romanini C

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVES:We aimed to determine the sentinel lymph node detection rates, accuracy in predicting the status of lymph node metastasis, and if pathologic ultrastaging improves the detection of micrometastases and isolated tumor cells at the time of primary surgery for cervical cancer. METHODS:A prospective, non-randomiz...

journal_title：Gynecologic oncology

authors： Diaz JP,Gemignani ML,Pandit-Taskar N,Park KJ,Murray MP,Chi DS,Sonoda Y,Barakat RR,Abu-Rustum NR

更新日期：2011-03-01 00:00:00

abstract：:Melanoma represents the second most frequent vulvar malignancy, and yet is still considered to be an uncommon neoplasm. Several varieties of melanoma exist. A patient who was diagnosed with a rare subtype of melanoma as a primary vulvar process is presented here. To date, there is only one other reported case of neuro...

journal_title：Gynecologic oncology

authors： Byrne PR,Maiman M,Mikhail A,Harris M,Rosen Y

更新日期：1995-02-01 00:00:00

abstract：:Three cases of papillary villoglandular carcinoma of the cervix are presented. Each patient was multiparous and presented with abnormal vaginal bleeding. The mean age at presentation was 35 years (range 28-42 years). All patients were staged as FIGO IB and underwent radical Wertheim hysterectomy and bilateral pelvic l...

journal_title：Gynecologic oncology

authors： Hopson L,Jones MA,Boyce CR,Tarraza HM Jr

更新日期：1990-11-01 00:00:00

abstract：OBJECTIVE:To determine if lymphadenectomy, chemotherapy and radiotherapy are associated with survival benefit among women with stage I uterine carcinosarcoma. METHODS:Women with stage I uterine carcinosarcoma (n=5614) were identified from the 1998-2013 National Cancer Data Base. Kaplan-Meier survival estimates and Cox...

journal_title：Gynecologic oncology

authors： Seagle BL,Kanis M,Kocherginsky M,Strauss JB,Shahabi S

更新日期：2017-04-01 00:00:00

abstract：:Twenty-six drug-resistant choriocarcinoma patients were treated with a PEBA regimen (cisplatin, etoposide, bleomycin, and adriamycin), supplemented by radiotherapy or surgery, from January 1988 to June 1992. A total of 80.8% of the patients had received at least four drugs, and 69.2% had received six or more cycles of...

journal_title：Gynecologic oncology

authors： Chen LP,Cai SM,Fan JX,Li ZT

更新日期：1995-02-01 00:00:00

abstract：OBJECTIVE:Microsatellite instability (MSI) is a frequent genetic event in the D-loop region (which controls mitochondrial DNA (mtDNA) replication) of mitochondrial genome of endometrial cancer. We therefore investigated the relationship between mtMSI and mtDNA content in endometrial cancer. METHODS:Tumor tissues from ...

journal_title：Gynecologic oncology

authors： Wang Y,Liu VW,Xue WC,Tsang PC,Cheung AN,Ngan HY

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVES:Chemotherapy is the preferred therapeutic approach for the therapy of advanced ovarian cancer, but a successful long-term treatment is prevented by the development of drug resistance. Recent works have underlined the involvement of non-coding RNAs, microRNAs (miRNAs) in cancer development, with several conje...

journal_title：Gynecologic oncology

authors： Sorrentino A,Liu CG,Addario A,Peschle C,Scambia G,Ferlini C

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:To review the clinical features, diagnosis, management, and outcomes for the 50 cases of Paget's disease (PD) of the vulva referred to Queensland Centre for Gynaecological Cancer between 1986 and 2009. METHODS:Vulvar PD cases from QCGC were reviewed and analyzed using the computer software Statistical Packag...

journal_title：Gynecologic oncology

authors： Jones IS,Crandon A,Sanday K

更新日期：2011-07-01 00:00:00

abstract：:Fifty patients with cervical cancer were treated with radical hysterectomy and lymphadenectomy followed by postoperative radiation therapy for high risk factors (nodal metastases, lymphvascular space invasion, close or involved margins) at the University of Alabama at Birmingham Medical Center from 1969 to 1984. Fifte...

journal_title：Gynecologic oncology

authors： Barter JF,Soong SJ,Shingleton HM,Hatch KD,Orr JW Jr

更新日期：1989-03-01 00:00:00

abstract：:Phase 2 trials employing several antineoplastic agents have demonstrated that surgically documented responses, including complete responses, can result when patients with ovarian cancer are treated by the intraperitoneal route in the salvage setting following initial systemic chemotherapy. Activity is essentially limi...

journal_title：Gynecologic oncology

authors： Markman M

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:To define a prognostic score based on pretreatment values of leucocyte, platelet and hemoglobin in locally advanced cervical cancer (LACC). MATERIAL AND METHODS:We conducted a prospective study of 238 patients for LACC with negative PET imaging in the para-aortic (PA) area and who were undergoing laparoscopi...

journal_title：Gynecologic oncology

authors： Maulard A,Chargari C,Faron M,Alwohaibi A,Leary A,Pautier P,Genestie C,Morice P,Gouy S

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:To describe our early experience with robotic-assisted laparoscopy for extraperitoneal para-aortic lymphadenectomy up to the left renal vein, including Da Vinci robot positioning. METHODS:Six patients underwent robotic-assisted laparoscopy using the Da Vinci apparatus. The patients included a man with a pT2 ...

journal_title：Gynecologic oncology

authors： Narducci F,Lambaudie E,Houvenaeghel G,Collinet P,Leblanc E

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:Based on previous studies, standard gynecological screening consisting of annual transvaginal ultrasonography (TVU) was added with endometrial sampling in women with Lynch syndrome (LS). The aim of this study was to evaluate the additional value of endometrial sampling in detecting (pre)malignancies of the en...

journal_title：Gynecologic oncology

authors： Helder-Woolderink JM,De Bock GH,Sijmons RH,Hollema H,Mourits MJ

更新日期：2013-11-01 00:00:00