Detection of human papillomavirus genome and analysis of expression of c-myc and Ha-ras oncogenes in invasive cervical carcinomas.


:Invasive carcinomas of the uterine cervix of 38 patients were examined for the presence of human papillomavirus (HPV) genomes and for the state of the c-myc and Ha-ras oncogenes. A combination of Southern blot hybridization and polymerase chain reaction revealed the presence of the genome of HPV type 16 in 17 tumors (45%), that of HPV type 18 in 3 tumors (8%), and that of unknown types in 16 others (42%), while no viral DNA sequences were detected in 2 tumors. Of the 38 tumors, c-myc amplification was found in only 1 tumor, while there was no Ha-ras amplification. Overexpression of the c-myc gene was observed in 15 (44%) of the 34 tumors analyzed, while there was no overexpression of Ha-ras. Of the 23 squamous cell carcinomas analyzed, relapse-free rates at 24 months were 55% in tumors with c-myc overexpression and 100% in case of tumors with no c-myc overexpression, respectively. The results suggest the possibility that activation of the c-myc oncogene is involved in tumor progression.


Gynecol Oncol


Gynecologic oncology


Iwasaka T,Yokoyama M,Oh-uchida M,Matsuo N,Hara K,Fukuyama K,Hachisuga T,Fukuda K,Sugimori H




Has Abstract


1992-09-01 00:00:00












  • High-risk metastatic gestational trophoblastic disease: further stratification into two clinical entities.

    abstract::Forty-two of sixty-seven patients (62.7%) treated for high-risk metastatic trophoblastic disease achieved and maintained complete remissions. The survival rate was significantly improved in those patients with scores lower than 8 according to a modification of the World Health Organization (WHO) prognostic scoring sys...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Gordon AN,Gershenson DM,Copeland LJ,Stringer CA,Morris M,Wharton JT

    更新日期:1989-07-01 00:00:00

  • Radiotherapy of primary carcinoma of the vagina: management and results of different therapy schemes.

    abstract::Three hundred and sixty-two cases of primary vaginal carcinoma were treated at the Irradiation Department of the University Clinic for Obstetrics and Gynecology, Vienna, from 1950 to 1977. As the method of choice an individually dosed, fractioned, and protracted radium-telecobalt therapy was employed. Comparing the la...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kucera H,Langer M,Smekal G,Weghaupt K

    更新日期:1985-05-01 00:00:00

  • Quality of life in cervical cancer survivors: patient and provider perspectives on common complications of cervical cancer and treatment.

    abstract:OBJECTIVE:This study's objective was to quantify the impact (utility) of common complications of early cervical cancer treatment on quality of life (QOL). Utilities assigned by survivors were compared to those assigned by providers. METHODS:30 survivors of early cervical cancer identified from our Tumor Registry and 1...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Einstein MH,Rash JK,Chappell RJ,Swietlik JM,Hollenberg JP,Connor JP

    更新日期:2012-04-01 00:00:00

  • Standardization of lower extremity quantitative lymphedema measurements and associated patient-reported outcomes in gynecologic cancers.

    abstract::Practice changing standardization of lower extremity lymphedema quantitative measurements with integrated patient reported outcomes will likely refine and redefine the optimal risk-reduction strategies to diminish the devastating limb-related dysfunction and morbidity associated with treatment of gynecologic cancers. ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Russo S,Walker JL,Carlson JW,Carter J,Ward LC,Covens A,Tanner EJ 3rd,Armer JM,Ridner S,Hayes S,Taghian AG,Brunelle C,Lopez-Acevedo M,Davidson BA,Schaverien MV,Ghamande SA,Bernas M,Cheville AL,Yost KJ,Schmitz K,Coy

    更新日期:2021-02-01 00:00:00

  • Clinical validation of the Cervista HPV HR and 16/18 genotyping tests for use in women with ASC-US cytology.

    abstract:OBJECTIVE:High-risk (HR) human papillomavirus (HPV) testing is important in cervical cancer screening for triage to colposcopy. This study evaluated the clinical performance of the Cervista HPV HR and 16/18 genotyping tests for detection of HPV in cervical cytology specimens. METHODS:The tests were prospectively evalu...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Einstein MH,Martens MG,Garcia FA,Ferris DG,Mitchell AL,Day SP,Olson MC

    更新日期:2010-08-01 00:00:00

  • Complete molar pregnancy in adolescents from North and South America: Clinical presentation and risk of gestational trophoblastic neoplasia.

    abstract:OBJECTIVES:To compare complete hydatidiform mole (CHM) clinical presentation and risk factors associated with GTN development between North American and South American adolescents. METHODS:This non-concurrent cohort study was undertaken including adolescents with CHM referred to centers in North America (New England T...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Soares RR,Maestá I,Colón J,Braga A,Salazar A,Charry RC,Sun SY,Goldstein DP,Berkowitz RS

    更新日期:2016-09-01 00:00:00

  • Conservative management in primary genital lymphomas: the role of chemotherapy.

    abstract:BACKGROUND:The female genital lymphomas are an extremely rare disease accounting for less than 0.5% of gynecological cancers and for 1.5% of all NHL. Because of their low incidence there is no widely accepted consensus on its treatment. Literature data support a radiotherapy-based treatment in case of primary genital l...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Signorelli M,Maneo A,Cammarota S,Isimbaldi G,Garcia Parra R,Perego P,Maria Pogliani E,Mangioni C

    更新日期:2007-02-01 00:00:00

  • Transvaginal ultrasound-guided fine needle sampling of deep cancer recurrences in the pelvis: usefulness and limitations.

    abstract::The usefulness of fine needle sampling (FNS) under transvaginal ultrasound guidance in gynecologic oncology patients is evaluated in this study. Between 1990 and 1993, 101 FNS under transvaginal ultrasound guidance were performed in 88 sessions. All targets were located deep in the pelvis and their median diameter was...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Zanetta G,Brenna A,Pittelli M,Lissoni A,Trio D,Riotta S

    更新日期:1994-07-01 00:00:00

  • Ifosfamide, paclitaxel, and carboplatin, a novel triplet regimen for advanced, recurrent, or persistent carcinoma of the cervix: a phase II trial.

    abstract:OBJECTIVES:(1) To determine the response rate of advanced, recurrent, or persistent carcinoma of the cervix to ifosfamide, paclitaxel, and carboplatin chemotherapy; (2) to determine the progression free interval and survival rate in patients treated with this regimen; (3) to describe the toxicities associated with this...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Downs LS Jr,Chura JC,Argenta PA,Judson PL,Ghebre R,Geller MA,Carson LF

    更新日期:2011-02-01 00:00:00

  • A clinicopathological analysis of 40 cases of ovarian Sertoli-Leydig cell tumors.

    abstract:OBJECTIVE:To evaluate the clinicopathological features of ovarian Sertoli-Leydig cell tumors (SLCTs) and to explore the reasonable therapy. METHODS:A total of 40 cases of SLCTs were retrospectively reviewed. RESULTS:The incidence of SLCTs was 0.41%, with a median age of 28 years. All tumors were confined to one ovary...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Gui T,Cao D,Shen K,Yang J,Zhang Y,Yu Q,Wan X,Xiang Y,Xiao Y,Guo L

    更新日期:2012-11-01 00:00:00

  • Survival of women diagnosed with malignant, mixed mullerian tumors of the ovary (OMMMT).

    abstract:OBJECTIVE:To analyze the survival of women with malignant, mixed mullerian tumors of the ovary (OMMMT) compared to women with epithelial ovarian cancer (EOC). METHODS:Data from the Surveillance, Epidemiology and End Results (SEER) Program on 14025 women diagnosed with primary invasive ovarian cancer between 1988 and 1...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Barnholtz-Sloan JS,Morris R,Malone JM Jr,Munkarah AR

    更新日期:2004-05-01 00:00:00

  • Stage II endometrial carcinoma: prognostic factors and the results of treatment.

    abstract::Results of treatment and potential prognostic factors in 54 patients with clinical stage II endometrial carcinoma were analyzed. During the period analyzed, three different treatment techniques were used. The highest cure rate (70.6%) was observed in patients treated with simple hysterectomy and bilateral salpingo-oop...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Andersen ES

    更新日期:1990-08-01 00:00:00

  • Low-dose oral granisetron (1 mg) plus intravenous dexamethasone: efficacy in gynecologic cancer patients receiving carboplatin-based chemotherapy.

    abstract:OBJECTIVE:The objective of this study was to determine the efficacy of a low-dose oral granisetron plus intravenous dexamethasone prophylactic antiemetic regimen in patients receiving carboplatin-based chemotherapy. PATIENTS AND METHODS:Patients with gynecologic malignancies being treated with either single-agent carb...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Markman M,Kennedy A,Webster K,Kulp B,Peterson G,Belinson J

    更新日期:1998-10-01 00:00:00

  • Utility of pre-operative serum CA-125 in the management of uterine papillary serous carcinoma.

    abstract:OBJECTIVE:To evaluate the usefulness of pre-operative serum CA-125 in the management of women diagnosed with uterine papillary serous carcinoma (UPSC). We hypothesized that elevated pre-operative levels of serum CA-125 correlate with higher disease stage and poorer prognosis. METHODS:Patients diagnosed with UPSC and m...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Olawaiye AB,Rauh-Hain JA,Withiam-Leitch M,Rueda B,Goodman A,del Carmen MG

    更新日期:2008-09-01 00:00:00

  • Correlation of CA125 and CA19-9 serum levels with clinical course and second-look findings in patients with ovarian carcinoma.

    abstract::CA125 and CA19-9 levels were serially evaluated in blood samples from 21 patients during and after integrated surgical and chemotherapeutic treatment for ovarian carcinoma. Serial measurement of CA125 and CA19-9 correlated with clinical course of disease in 89.7 and 72.7% of instances, respectively. The decrease of se...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Fioretti P,Gadducci A,Ferdeghini M,Bartolini T,Bianchi R,Facchini V

    更新日期:1987-11-01 00:00:00

  • A comparison of modified MonoPrep2 of liquid-based cytology with ThinPrep Pap test.

    abstract:OBJECTIVE:The purpose of this study is to evaluate a modified MonoPrep2 (MP) of liquid-based cytology (LBC) to search for a less expensive alternative technique usable for screening of cervical cancers. STUDY DESIGN:Cervicovaginal direct-to-vial samples from 1218 consecutive patients were processed with the modified M...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Nam JH,Kim HS,Lee JS,Choi HS,Min KW,Park CS

    更新日期:2004-09-01 00:00:00

  • A phase II study of gemcitabine in combination with tanespimycin in advanced epithelial ovarian and primary peritoneal carcinoma.

    abstract:OBJECTIVE:To evaluate the efficacy and biological effects of the gemcitabine/tanespimycin combination in patients with advanced ovarian and peritoneal cancer. To assess the effect of tanespimycin on tumor cells, levels of the chaperone proteins HSP90 and HSP70 were examined in peripheral blood mononuclear cells (PBMC) ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Hendrickson AE,Oberg AL,Glaser G,Camoriano JK,Peethambaram PP,Colon-Otero G,Erlichman C,Ivy SP,Kaufmann SH,Karnitz LM,Haluska P

    更新日期:2012-02-01 00:00:00

  • Analysis of common variations in tumor-suppressor genes on chr1p36 among Caucasian women with endometriosis.

    abstract:OBJECTIVE:Epidemiological data indicate that endometriosis increases the risk of epithelial ovarian cancer (EOC), but the mechanism of cancer transition is unknown. Results from genome-wide association studies (GWAS) and transcriptome sequencing have demonstrated that genes located in the 1p36 region are important in b...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Falconer H,Sundqvist J,Xu H,Vodolazkaia A,Fassbender A,Kyama C,Bokor A,D'Hooghe TM

    更新日期:2012-11-01 00:00:00

  • Participation of the general gynecologist in surgical staging of endometrial cancer: analysis of cost and perioperative outcomes.

    abstract:OBJECTIVE:To compare the cost and perioperative outcomes of endometrial cancer staging when the procedure is performed by a gynecologic oncologist alone or when a general gynecologist participates in the procedure. METHODS:A retrospective analysis was performed on a series of women with clinical stage I endometrial ca...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Hoekstra A,Singh DK,Garb M,Arekapudi S,Rademaker A,Lurain JR

    更新日期:2006-12-01 00:00:00

  • High homogeneity of MMR deficiency in ovarian cancer.

    abstract:OBJECTIVE:Mismatch repair (MMR) deficiency and Bethesda panel microsatellite instability (MSI) are increasingly analyzed to identify tumors that might benefit from immune checkpoint inhibitors, but tumor heterogeneity is a potential obstacle for such analyses. In ovarian cancer, data on intratumoral heterogeneity of MM...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Fraune C,Rosebrock J,Simon R,Hube-Magg C,Makrypidi-Fraune G,Kluth M,Büscheck F,Höflmayer D,Schmalfeldt B,Müller V,Wölber L,Witzel I,Paluchowski P,Wilke C,Heilenkötter U,von Leffern I,Clauditz TS,Wilczak W,Sauter G,S

    更新日期:2020-03-01 00:00:00

  • Development of a prediction model for residual disease in newly diagnosed advanced ovarian cancer.

    abstract:OBJECTIVES:To construct a tool, using computed tomography (CT) imaging and preoperative clinical variables, to estimate successful primary cytoreduction for advanced epithelial ovarian cancer (EOC). METHODS:Women who underwent primary cytoreductive surgery for stage IIIC/IV EOC at Mayo Clinic between 1/2/2003 and 12/3...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Janco JM,Glaser G,Kim B,McGree ME,Weaver AL,Cliby WA,Dowdy SC,Bakkum-Gamez JN

    更新日期:2015-07-01 00:00:00

  • Abnormal cervical cytology leading to the diagnosis of gastric cancer.

    abstract::There have been nine cases reported in the English literature in which the finding of malignant cells on cervical/vaginal cytology led to the diagnosis of primary gastric cancer. We report on a patient with gastric carcinoma, metastatic to the cervix, in which the diagnosis was suspected by the finding of signet ring ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: McGill F,Adachi A,Karimi N,Wadler S,Kim ES,Greston WM,Kleiner GJ

    更新日期:1990-01-01 00:00:00

  • Adjuvant chemotherapy does not improve disease-free survival in FIGO stage IC ovarian granulosa cell tumors: The MITO-9 study.

    abstract:OBJECTIVE:Evidence-based management of granulosa cell tumors of the ovary (GCT) has been not yet standardized: surgery, including fertility-sparing procedures for young women, has been traditionally the standard treatment; on the other hand, chemotherapy has been used for treatment of advanced and/or recurrent disease....

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Mangili G,Ottolina J,Cormio G,Loizzi V,De Iaco P,Pellegrini DA,Candiani M,Giorda G,Scarfone G,Cecere SC,Frigerio L,Gadducci A,Marchetti C,Ferrandina G

    更新日期:2016-11-01 00:00:00

  • Efficacy of acupuncture in prevention of delayed chemotherapy induced nausea and vomiting in gynecologic cancer patients.

    abstract:OBJECTIVE:To compare the efficacy between acupuncture and ondansetron in the prevention of delayed chemotherapy induced nausea and vomiting (CINV). METHODS:70 patients were randomized to receive either 1) acupuncture at P6 point before chemotherapy infusion or 2) ondansetron 8 mg intravenously 30 min before chemothera...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,随机对照试验


    authors: Rithirangsriroj K,Manchana T,Akkayagorn L

    更新日期:2015-01-01 00:00:00

  • Applicability of the concept of "platinum sensitivity" to recurrent endometrial cancer: the SGSG-012/GOTIC-004/Intergroup study.

    abstract:OBJECTIVE:The concept of "platinum sensitivity" has been widely applied in the management of recurrent ovarian cancer. This study aimed to evaluate the applicability of this concept to recurrent endometrial cancer. PATIENTS AND METHODS:In this multicenter retrospective cohort study, the clinical data of patients with ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Nagao S,Nishio S,Michimae H,Tanabe H,Okada S,Otsuki T,Tanioka M,Fujiwara K,Suzuki M,Kigawa J

    更新日期:2013-12-01 00:00:00

  • High grade undifferentiated uterine sarcoma: surgery, treatment, and survival outcomes.

    abstract:OBJECTIVES:High grade undifferentiated uterine sarcomas (HGUS) are rare, aggressive malignancies. Data regarding management are limited. We aimed to describe disease stage, response to treatment, and survival outcomes among patients with HGUS at our institution. METHODS:We identified all patients with HGUS who receive...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Tanner EJ,Garg K,Leitao MM Jr,Soslow RA,Hensley ML

    更新日期:2012-10-01 00:00:00

  • The benefits of low anterior en bloc resection as part of cytoreductive surgery for advanced primary and recurrent epithelial ovarian cancer patients outweigh morbidity concerns.

    abstract:OBJECTIVES:The aim of this study was to assess the safety, efficacy and impact on survival of low anterior resection and primary anastomosis at the time of en bloc resection for primary and recurrent epithelial ovarian carcinoma. METHODS:We performed a retrospective review of 46 primary and 14 recurrent epithelial ova...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Park JY,Seo SS,Kang S,Lee KB,Lim SY,Choi HS,Park SY

    更新日期:2006-12-01 00:00:00

  • Conservative surgery for borderline ovarian tumors: a review.

    abstract:OBJECTIVE:Borderline tumor of the ovary is an epithelial tumor with a low rate of growth and a low potential to invade or metastasize. This review will outline the most recent information regarding the molecular pathogenesis, pathology, fertility and tumor recurrence rate after conservative management of young women wi...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Tinelli R,Tinelli A,Tinelli FG,Cicinelli E,Malvasi A

    更新日期:2006-01-01 00:00:00

  • Aberrant expression of cyclin D1 is associated with poor prognosis in early stage cervical cancer of the uterus.

    abstract:OBJECTIVE:Many investigators have studied the expression of G1 phase regulatory protein in uterine cervical cancer. However, it is unclear which step of the genetic expression participates in cyclin D1 expression and what its prognostic meaning is. The aims of this study were to evaluate the regulatory level of cyclin ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Bae DS,Cho SB,Kim YJ,Whang JD,Song SY,Park CS,Kim DS,Lee JH

    更新日期:2001-06-01 00:00:00

  • Detection of chromogranin in argyrophil cells of endometrial carcinoma.

    abstract::Normal and neoplastic endometrial tissues were examined immunohistochemically for chromogranin which was shown to be a specific marker for neuroendocrine cells. All 20 normal endometriums and 20 endometrial carcinomas without argyrophilia were chromogranin negative. Endometrial carcinomas with argyrophilia tested were...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Ueda G,Nishino T,Saito J,Abe Y,Shimizu H,Tanizawa O

    更新日期:1987-06-01 00:00:00