Detection of human papillomavirus genome and analysis of expression of c-myc and Ha-ras oncogenes in invasive cervical carcinomas.

Abstract:

:Invasive carcinomas of the uterine cervix of 38 patients were examined for the presence of human papillomavirus (HPV) genomes and for the state of the c-myc and Ha-ras oncogenes. A combination of Southern blot hybridization and polymerase chain reaction revealed the presence of the genome of HPV type 16 in 17 tumors (45%), that of HPV type 18 in 3 tumors (8%), and that of unknown types in 16 others (42%), while no viral DNA sequences were detected in 2 tumors. Of the 38 tumors, c-myc amplification was found in only 1 tumor, while there was no Ha-ras amplification. Overexpression of the c-myc gene was observed in 15 (44%) of the 34 tumors analyzed, while there was no overexpression of Ha-ras. Of the 23 squamous cell carcinomas analyzed, relapse-free rates at 24 months were 55% in tumors with c-myc overexpression and 100% in case of tumors with no c-myc overexpression, respectively. The results suggest the possibility that activation of the c-myc oncogene is involved in tumor progression.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Iwasaka T,Yokoyama M,Oh-uchida M,Matsuo N,Hara K,Fukuyama K,Hachisuga T,Fukuda K,Sugimori H

doi

10.1016/0090-8258(92)90220-d

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

298-303

issue

3

eissn

0090-8258

issn

1095-6859

journal_volume

46

pub_type

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