当前位置： SCI文献检索 > GYNECOLOGIC ONCOLOGY期刊下所有文献 > Simple extrafascial trachelectomy and pelvic bilateral lymphadenectomy in early stage cervical cancer.

Simple extrafascial trachelectomy and pelvic bilateral lymphadenectomy in early stage cervical cancer.

Abstract：

OBJECTIVE:To determine the feasibility and safety of simple extra-fascial trachelectomy plus pelvic lymphadenectomy in young patients affected by early stage cervical cancer. METHODS:We have prospectively identified all patients with early-stage cervical cancer (stages IA2-IB1) referred to our department. Inclusion criteria were: age ≤ 38 years, strong desire to maintain fertility, FIGO stage ≤ IB1, tumor size<2 cm, no LVSI, no evidence of nodal metastasis. Surgical technique included two steps: laparoscopic pelvic lymphadenectomy and vaginal simple extrafascial trachelectomy. Patients were followed up for oncological and obstetrical outcomes. RESULTS:Fourteen patients were enrolled in the study. Median age was 32 years (range 28-37); histotype was squamous in 11/14 (79%) cases and adenocarcinoma in 3/14 cases (21%); FIGO stage was IA2 in 5/14 (36%) patients, IB1 in 9/14 (64%) patients; median tumor size was 17 mm (range 14-19); median operative time was 120 min (range 95-210). No severe intraoperative complications were recorded. Postoperative complications were observed in two patients. No recurrences were detected. One patient died for other disease. Eight patients became pregnant and 3 of them had a term delivery. CONCLUSION:Low risk early-cervical cancer patients could be safely treated by simple extrafascial trachelectomy in order to maintain fertility. More studies are needed to better define the role of conservative and ultraconservative surgical approaches (i.e. conization) in this setting, either for fertility purposes or to minimize surgical complications.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Palaia I,Musella A,Bellati F,Marchetti C,Di Donato V,Perniola G,Benedetti Panici P

doi

10.1016/j.ygyno.2012.04.004

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

78-81

issue

1

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(12)00256-9

journal_volume

126

pub_type

临床试验,杂志文章

相关文献

GYNECOLOGIC ONCOLOGY文献大全
  • Characterization of the protein synthesis independent TNFalpha lytic mechanism in human ovarian and cervical carcinoma cell lines.

    abstract：:The analysis of the lytic mechanism initiated by TNFalpha in three human ovarian cell lines (CAOV-3, SK-OV-3, and OVCAR-3) and in three human cervical cell lines (SIHa, HT-3, and ME-180) in the presence of inhibitors of protein synthesis indicates that this lytic mechanism is similar to the protein synthesis-independe...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.1996.0187

    authors： Powell CB,Scott JH,Collins JL

    更新日期：1996-07-01 00:00:00

  • Quality of life in long-term survivors of ovarian germ cell tumors: a Gynecologic Oncology Group study.

    abstract：PURPOSE:This report describes the strength and significance of the association between antecedent and mediating variables across four categories of quality of life (QOL) outcomes in 132 disease free women with ovarian germ cell survivors. METHODS:Survivors (n=132) participated in a mailed questionnaire and computer-as...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2007.01.042

    authors： Champion V,Williams SD,Miller A,Reuille KM,Wagler-Ziner K,Monahan PO,Zhao Q,Gershenson D,Cella D,Gynecologic Oncology Group.

    更新日期：2007-06-01 00:00:00

  • Expression of Bcl-xL in ovarian carcinoma is associated with chemoresistance and recurrent disease.

    abstract：OBJECTIVE:The long-term survival of patients with epithelial ovarian cancer is limited by the emergence of tumor cells that are resistant to chemotherapy. We hypothesized that expression of Bcl-x(L), a homologue of Bcl-2 that confers protection from chemotherapy-induced apoptosis, may be predictive of patients' clinica...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2004.10.026

    authors： Williams J,Lucas PC,Griffith KA,Choi M,Fogoros S,Hu YY,Liu JR

    更新日期：2005-02-01 00:00:00

  • Limits of lymphoscintigraphy for sentinel node biopsy in women with endometrial cancer.

    abstract：OBJECTIVE:Lymph node status in endometrial cancer is a major prognostic factor. Sentinel lymph node (SLN) biopsy using radiocolloid and blue dye labeling has emerged as an alternative to systematic lymphadenectomy. This technique requires a preoperative lymphoscintigraphy. The aim of this study was to evaluate the limi...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2008.11.004

    authors： Ballester M,Rouzier R,Coutant C,Kerrou K,Daraï E

    更新日期：2009-02-01 00:00:00

  • Clinical characteristics and treatment of gestational trophoblastic tumor with vaginal metastasis.

    abstract：OBJECTIVE:The aim of this study was to evaluate clinical manifestations, management options, and prognosis for women presenting with gestational trophoblastic tumors with vaginal metastasis. METHOD:Fifty-one patients with vaginal metastases were analyzed retrospectively between January 1985 and September 2000. Vaginal...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.2001.6540

    authors： Yingna S,Yang X,Xiuyu Y,Hongzhao S

    更新日期：2002-03-01 00:00:00

  • Extraperitoneal versus transperitoneal selective paraaortic lymphadenectomy in the pretreatment surgical staging of advanced cervical carcinoma (a Gynecologic Oncology Group study).

    abstract：:Two-hundred and eighty-eight patients with predominately stage IIB or IIIB cervical carcinoma underwent pretreatment surgical staging including selective paraaortic lymphadenectomy (SPAL), followed by pelvic irradiation with or without paraaortic irradiation (RT). Four patients were excluded from analysis (two receive...

    journal_title：Gynecologic oncology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0090-8258(89)90513-1

    authors： Weiser EB,Bundy BN,Hoskins WJ,Heller PB,Whittington RR,DiSaia PJ,Curry SL,Schlaerth J,Thigpen JT

    更新日期：1989-06-01 00:00:00

  • Placental leucine aminopeptidase (P-LAP) expression is associated with chemosensitivity in human endometrial carcinoma.

    abstract：OBJECTIVE:Although treatment for advanced or recurrent endometrial carcinoma has improved over recent years with the introduction of paclitaxel- and platinum-based chemotherapy, in most, the disease remains incurable because of resistance to chemotherapy. In the previous study, we have shown that placental leucine amin...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2004.07.054

    authors： Shibata K,Kikkawa F,Kondo C,Mizokami Y,Kajiyama H,Ino K,Nomura S,Mizutani S

    更新日期：2004-11-01 00:00:00

  • Pathways to a cancer-free future: A protocol for modelled evaluations to maximize the future impact of interventions on cervical cancer in Australia.

    abstract：OBJECTIVE:Australia's HPV vaccination and HPV-based cervical screening programs are changing the landscape in cervical cancer prevention. We aim to identify areas which can make the biggest further impact on cervical cancer burden. This protocol describes the first stage of a program of work called Pathways-Cervix that...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2018.12.019

    authors： Velentzis LS,Smith MA,Simms KT,Lew JB,Hall M,Hughes S,Yuill S,Killen J,Keane A,Butler K,Darlington-Brown J,Hui H,Brotherton JML,Skinner R,Brand A,Roeske L,Heley S,Carter J,Bateson D,Frazer I,Garland SM,Guy R,H

    更新日期：2019-03-01 00:00:00

  • Evaluation of pegylated liposomal doxorubicin (Doxil) as second-line chemotherapy of squamous cell carcinoma of the cervix: a phase II study of the Gynecologic Oncology Group.

    abstract：OBJECTIVE:Doxorubicin has reported activity in advanced and recurrent cervical cancer but hematologic toxicity has limited its use in some combinations. To determine the level of activity and potential for use in future combinations, a phase II trial of pegylated liposomal doxorubicin as second-line therapy in advanced...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ygyno.2005.11.048

    authors： Rose PG,Blessing JA,Lele S,Abulafia O

    更新日期：2006-08-01 00:00:00

  • Prospective study of nerve conduction parameters and serum magnesium following cisplatin therapy.

    abstract：:This study evaluated the effects of cisplatin on 18 nerve conduction parameters of median, ulnar, peroneal, and sural nerves in relation to age, magnesium nadir, average magnesium, and magnesium replacement in gynecologic oncology patients. The 37 patients in this study received cisplatin (70 mg/m2) at 4-week interval...

    journal_title：Gynecologic oncology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0090-8258(90)90302-2

    authors： Ashraf M,Riggs JE,Wearden S,Scotchel P

    更新日期：1990-04-01 00:00:00

  • Activation of androgen receptor-associated protein 70 (ARA70) mRNA expression in ovarian cancer.

    abstract：OBJECTIVE:Androgens have been implicated in ovarian cancer and androgen receptor expression has been reported in 70-95% of ovarian adenocarcinomas, implying a role in ovarian cancer cell biology. Androgen receptor-associated protein 70 (ARA70) is a reported androgen receptor coactivator that enhances the transactivatio...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.2000.6068

    authors： Shaw PA,Rittenberg PV,Brown TJ

    更新日期：2001-02-01 00:00:00

  • Expression of DNA repair proteins in endometrial cancer predicts disease outcome.

    abstract：OBJECTIVE:The consequences of defective homologous recombination and other DNA repair pathways are important in disease outcomes of numerous tumor types. The objective of this study was to explore BRCA1, PARP, FANCD2, PTEN, H2AX, and ATM protein expression in endometrial cancer (EC). METHODS:PARP1, γH2AX, ATM, FANCD2,...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2014.02.002

    authors： Mhawech-Fauceglia P,Wang D,Kim G,Sharifian M,Chen X,Liu Q,Lin YG,Liu S,Pejovic T

    更新日期：2014-03-01 00:00:00

  • Mesenchymal molecular subtype is an independent predictor of severe postoperative complications after primary debulking surgery for advanced ovarian cancer.

    abstract：OBJECTIVE:To evaluate the contribution of molecular subtype to 30-day postoperative complications and 90-day mortality after primary debulking surgery (PDS) in advanced stage high-grade serous ovarian cancer (HGSOC). METHODS:Patients with stages III-IV HGSOC undergoing PDS from 1994 to 2011 with available molecular su...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2018.11.019

    authors： Torres D,Kumar A,Bakkum-Gamez JN,Weaver AL,McGree ME,Wang C,Langstraat CL,Cliby WA

    更新日期：2019-02-01 00:00:00

  • Clinical outcomes in patients with isolated serous tubal intraepithelial carcinoma (STIC): A comprehensive review.

    abstract：:OBJECTIVE. Serous tubal intraepithelial carcinoma (STIC) is currently considered the precursor lesion of pelvic (i.e., ovarian or peritoneal) high-grade serous carcinoma. The incidence of STIC has been reported to range from 0.6% to 7% in BRCA mutations carriers. However, the clinical outcome of patients with 'isolate...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ygyno.2015.09.018

    authors： Patrono MG,Iniesta MD,Malpica A,Lu KH,Fernandez RO,Salvo G,Ramirez PT

    更新日期：2015-12-01 00:00:00

  • Brain metastasis in epithelial ovarian cancer by BRCA1/2 mutation status.

    abstract：OBJECTIVE:To evaluate clinical outcomes of patients with BRCA-associated ovarian cancer who developed brain metastases (BM). METHODS:Patients with epithelial ovarian, fallopian tube, and primary peritoneal cancer (EOC) and BM, treated at a single institution from 1/1/2008-7/1/2018, were identified from two institution...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2019.05.004

    authors： Stasenko M,Cybulska P,Feit N,Makker V,Konner J,O'Cearbhaill RE,Alektiar KM,Beal K,Gardner GJ,Long Roche KC,Sonoda Y,Chi DS,Zivanovic O,Leitao MM Jr,Cadoo KA,Tew WP

    更新日期：2019-07-01 00:00:00

  • The haplotype of two FSHR polymorphisms in ovarian cancer--a potential role of ethnology in risk modification.

    abstract：OBJECTIVES:The precise role of gonadotropins in the carcinogenesis of epithelial ovarian cancer remains uncertain. Recently, the haplotype of two single nucleotide polymorphisms, Thr307Ala (rs6165) and Asn680Ser (rs6166), has been described as a risk factor for ovarian cancer in Chinese women. In this study we investig...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2008.12.011

    authors： Heubner M,Riemann K,Otterbach F,Kimmig R,Kasimir-Bauer S,Siffert W,Wimberger P

    更新日期：2009-03-01 00:00:00

  • Analysis of gastric-type mucinous carcinoma of the uterine cervix - An aggressive tumor with a poor prognosis: A multi-institutional study.

    abstract：OBJECTIVE:Gastric-type mucinous carcinoma (GAS) is a novel variant of mucinous carcinoma of the uterine cervix. As shown in the original Japanese group description, in recent studies, GAS represents a more aggressive disease than the usual-type endocervical adenocarcinoma (UEA). Detailed clinicopathological features of...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ygyno.2019.01.022

    authors： Nishio S,Mikami Y,Tokunaga H,Yaegashi N,Satoh T,Saito M,Okamoto A,Kasamatsu T,Miyamoto T,Shiozawa T,Yoshioka Y,Mandai M,Kojima A,Takehara K,Kaneki E,Kobayashi H,Kaku T,Ushijima K,Kamura T

    更新日期：2019-04-01 00:00:00

  • Does adjuvant chemotherapy dose modification have an impact on the outcome of patients diagnosed with advanced stage ovarian cancer? An NRG Oncology/Gynecologic Oncology Group study.

    abstract：PURPOSE:To determine the relationship between chemotherapy dose modification (dose adjustment or treatment delay), overall survival (OS) and progression-free survival (PFS) for women with advanced-stage epithelial ovarian carcinoma (EOC) and primary peritoneal carcinoma (PPC) who receive carboplatin and paclitaxel. ME...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ygyno.2018.07.021

    authors： Olawaiye AB,Java JJ,Krivak TC,Friedlander M,Mutch DG,Glaser G,Geller M,O'Malley DM,Wenham RM,Lee RB,Bodurka DC,Herzog TJ,Bookman MA

    更新日期：2018-10-01 00:00:00

  • The association between endometriosis and gynecological cancers and breast cancer: a review of epidemiological data.

    abstract：OBJECTIVE:This article critically reviews the literature on the association between endometriosis and gynecological cancers and breast cancer, based on epidemiologic data. METHODS:Literature review of the English language literature based on searching in the MEDLINE (PubMed) database and additional collection of repor...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ygyno.2011.06.017

    authors： Munksgaard PS,Blaakaer J

    更新日期：2011-10-01 00:00:00

  • Phase II study of axalimogene filolisbac (ADXS-HPV) for platinum-refractory cervical carcinoma: An NRG oncology/gynecologic oncology group study.

    abstract：OBJECTIVE:Women with persistent, recurrent, and/or metastatic cervical cancer have a poor prognosis. Even with the availability of cisplatin plus paclitaxel and bevacizumab, median overall survival (OS) is only 17.0 months, with median post-progression survival of approximately seven months. We studied the therapeutic ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2020.06.493

    authors： Huh WK,Brady WE,Fracasso PM,Dizon DS,Powell MA,Monk BJ,Leath CA 3rd,Landrum LM,Tanner EJ,Crane EK,Ueda S,McHale MT,Aghajanian C

    更新日期：2020-09-01 00:00:00

  • Associations between etiologic factors and mortality after endometrial cancer diagnosis: the NRG Oncology/Gynecologic Oncology Group 210 trial.

    abstract：BACKGROUND:Few studies have analyzed relationships between risk factors for endometrial cancer, especially with regard to aggressive (non-endometrioid) histologic subtypes, and prognosis. We examined these relationships in the prospective NRG Oncology/Gynecologic Oncology Group 210 trial. METHODS:Prior to surgery, par...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2015.08.022

    authors： Felix AS,Scott McMeekin D,Mutch D,Walker JL,Creasman WT,Cohn DE,Ali S,Moore RG,Downs LS,Ioffe OB,Park KJ,Sherman ME,Brinton LA

    更新日期：2015-10-01 00:00:00

  • Low-grade ovarian cancer in an adolescent patient.

    abstract：BACKGROUND:Ovarian tumors in the pediatric population are most likely to be of germ cell origin. However, serous tumors have also been reported in adolescent patients. CASE:A 14-year-old girl was diagnosed with stage IIIc low-grade ovarian cancer. Her serum CA-125 was elevated preoperatively and was a marker for recur...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.2000.6020

    authors： Parker LP,Ramirez PT,Broaddus R,Sightler S,Wolf JK

    更新日期：2001-01-01 00:00:00

  • Gene expression profiling in two morphologically different uterine cervical carcinoma cell lines derived from a single donor using a human cancer cDNA array.

    abstract：PURPOSE:To examine the differentially expressed cancer-related genes in two morphologically different uterine cervical carcinoma cell lines derived from the same patient by an Affymetrix Human Cancer G110 Array carrying 1700 cancer-associated genes. In addition, to investigate specific gene expression depending on hist...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2004.02.012

    authors： Fujimoto T,Nishikawa A,Iwasaki M,Akutagawa N,Teramoto M,Kudo R

    更新日期：2004-05-01 00:00:00

  • Detection of disseminated tumor cells in patients with gynecological cancers.

    abstract：OBJECTIVES:The presence of disseminated tumor cells (DTC) in breast cancer patients is associated with poor prognosis. However, there are limited data about the prevalence and prognostic impact of DTC in patients with gynecological tumors. The aim of this study was to evaluate the presence of DTC in the bone marrow (BM...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2006.05.049

    authors： Fehm T,Becker S,Bachmann C,Beck V,Gebauer G,Banys M,Wallwiener D,Solomayer EF

    更新日期：2006-12-01 00:00:00

  • Hormonal treatment of a recurrent granulosa cell tumor of the ovary: case report and review of the literature.

    abstract：BACKGROUND:Granulosa cell tumors of the ovary are rare, primarily treated surgically. In advanced or recurrent disease, data are inconclusive regarding the benefit of either primary or adjuvant chemotherapy. Hormonal therapy has been suggested as an alternative treatment. CASE:Our patient had three recurrences of estr...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ygyno.2004.10.042

    authors： Hardy RD,Bell JG,Nicely CJ,Reid GC

    更新日期：2005-03-01 00:00:00

  • Metastatic endometrial cancer in lung and liver: complete and prolonged response to hormonal therapy with progestins.

    abstract：:A double complete and prolonged response of metastatic endometrial carcinoma to medroxyprogesterone is reported. A 61-year-old woman with metastatic endometrial carcinoma in lung and liver achieved a complete clinical response with medroxyprogesterone lasting for 2 years. She discontinued the therapy by herself and de...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.1998.5229

    authors： Crespo C,González-Martín A,Lastra E,García-López J,Moyano A

    更新日期：1999-02-01 00:00:00

  • The significance of cone biopsy resection margins.

    abstract：:This 12-year retrospective study examines the significance of margin involvement with dysplasia at cone biopsy in relation to follow-up. Of 300 cone biopsies, 123 (41%) had margin involvement. These cases of margin involvement were associated with more severe dysplasia (P less than 0.0001) and a higher chance of subse...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/0090-8258(92)90252-e

    authors： Paterson-Brown S,Chappatte OA,Clark SK,Wright A,Maxwell P,Taub NA,Raju KS

    更新日期：1992-08-01 00:00:00

  • Phase II trial of doxorubicin, 5-fluorouracil, etoposide, and cisplatin in advanced or recurrent endometrial carcinoma.

    abstract：:We have previously reported an overall response rate of 41% and a median survival duration of 14 months in a series of 49 patients with metastatic or recurrent endometrial carcinoma treated by a combination of etoposide, 5-fluorouracil, and cisplatin. In order to increase response rate and survival duration, doxorubic...

    journal_title：Gynecologic oncology

    pub_type： 临床试验,杂志文章

    doi：10.1006/gyno.1997.4749

    authors： Pierga JY,Diéras V,Beuzeboc P,Dorval T,Palangié T,Jouve M,Scholl SM,Garcia-Giralt E,Pouillart P

    更新日期：1997-08-01 00:00:00

  • Human papillomavirus analysis as a prognostic marker following conization of the cervix uteri.

    abstract：:Cervical intraepithelial neoplasia grade 3 (CIN 3) is treated surgically. Follow-up of these patients is important to ensure successful treatment. The present study was undertaken to determine whether human papillomavirus (HPV) testing can be used to discriminate patients who will have recurrences from those who will ...

    journal_title：Gynecologic oncology

    pub_type： 临床试验,杂志文章

    doi：10.1006/gyno.1997.4753

    authors： Chua KL,Hjerpe A

    更新日期：1997-07-01 00:00:00

  • Angiogenesis in endometrial carcinoma: Therapies and biomarkers, current options, and future perspectives.

    abstract：:Endometrial carcinoma is the most common gynecologic malignancy and the fourth most prevalent cancer in women in the modern world. Despite a relatively high chance of surgical cure, for patients with advanced or recurrent disease there are few therapeutic options. Angiogenesis has been extensively studied ever since v...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ygyno.2020.12.016

    authors： Berger AA,Dao F,Levine DA

    更新日期：2020-12-26 00:00:00