Characterization of the protein synthesis independent TNFalpha lytic mechanism in human ovarian and cervical carcinoma cell lines.

abstract：OBJECTIVE:The current study was undertaken to determine if DNA ploidy is a useful prognostic variable for predicting recurrence in stage I endometrial cancer. For cancer of the endometrium, survival following recurrence may depend on a number of factors, including the pattern of recurrence and the response to second li...

journal_title：Gynecologic oncology

authors： Terada K,Mattson D,Goo D,Shimizu D

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVES:(1) To determine the response rate of advanced, recurrent, or persistent carcinoma of the cervix to ifosfamide, paclitaxel, and carboplatin chemotherapy; (2) to determine the progression free interval and survival rate in patients treated with this regimen; (3) to describe the toxicities associated with this...

journal_title：Gynecologic oncology

authors： Downs LS Jr,Chura JC,Argenta PA,Judson PL,Ghebre R,Geller MA,Carson LF

更新日期：2011-02-01 00:00:00

abstract：:Favorable responses to hexamethylmelamine (HMM) have been documented in untreated as well as in alkylating agent-resistant ovarian epithelial adenocarcinoma (OvCa). Platinum-based combination therapy for OvCa has been used since 1976. Eighteen patients with OvCa were treated with HMM as salvage therapy between Februar...

journal_title：Gynecologic oncology

authors： Stehman FB,Ehrlich CE,Callangan MF

更新日期：1984-02-01 00:00:00

abstract：PURPOSE:There are extremely limited data available in the general oncology or gynecologic cancer literature to document the effectiveness of antiemetic therapy over multiple courses of cytotoxic chemotherapy. METHODS:To examine this highly clinically relevant issue, we analyzed the complete treatment course of patient...

journal_title：Gynecologic oncology

authors： Markman MR,Peterson G,Kulp B,Markman M

更新日期：2002-06-01 00:00:00

abstract：:Twenty-five patients underwent adjunctive extrafascial hysterectomy 14-60 days following completion of external and intracavitary irradiation for bulky carcinoma of the uterine cervix. Review of the operative histopathology and correlation with subsequent patient outcomes suggests that morphologically persistent cance...

journal_title：Gynecologic oncology

authors： Russell AH,Burt AR,Ek M,Russell KJ,Cain JM,Greer BE,Tamimi HK,Figge DC

更新日期：1987-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the 5-year survival probability (SP) of patients treated for ovarian clear cell adenocarcinoma (OCCA) at a single tertiary institution and to compare it to the 5-year SP of patients with other histologic subtypes of epithelial ovarian cancer. METHODS:Sixty-four patients ...

journal_title：Gynecologic oncology

authors： Kennedy AW,Markman M,Biscotti CV,Emery JD,Rybicki LA

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVES:To assess the utility of tumor diameter (TD) for predicting lymphatic dissemination (LD) and determining need for lymphadenectomy following diagnosis of endometrioid endometrial cancer. METHODS:Patients diagnosed with stage I-III endometrioid endometrial cancer during 2003-2013 who underwent pelvic or para-...

journal_title：Gynecologic oncology

authors： Cox Bauer CM,Greer DM,Kram JJF,Kamelle SA

更新日期：2016-05-01 00:00:00

abstract：:Three hundred sixty-one patients with FIGO stage III and IV ovarian cancer were treated with cis-platinum combination chemotherapy in a Danish multicenter trial. Primary surgery was performed at 58 different departments; 32% of the patients were operated at a department associated with an oncologic center, 50% at a ge...

journal_title：Gynecologic oncology

authors： Bertelsen K

更新日期：1990-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of orally administered medroxyprogesterone acetate upon angiogenesis in the myometrium of patients with complex endometrial hyperplasia. METHODS:Microvessel counts in the myometrium of consecutive patients with complex endometrial hyperplasia, treated with oral medroxyprogesterone acet...

journal_title：Gynecologic oncology

authors： Abulafia O,Triest WE,Adcock JT,Sherer DM

更新日期：1999-02-01 00:00:00

abstract：OBJECTIVE:Many gynecologic oncology (GO) patients in Virginia are low income and their care is supplemented by Disproportionate Share Hospital (DSH) funds. Our objective is to estimate how many new GO patients may lose access to care if the state forgoes Medicaid expansion. METHODS:New patients referred to the GO serv...

journal_title：Gynecologic oncology

authors： Courtney-Brooks M,Pelkofski EB,Engelhard CL,Duska LR

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:To evaluate the long-term disease control, survival and complication rates using high-dose-rate intracavitary brachytherapy (HDRB) and external beam radiotherapy (EBRT) for patients found to have isolated vaginal recurrences from early-stage endometrial adenocarcinoma following total abdominal hysterectomy and ...

journal_title：Gynecologic oncology

authors： Pai HH,Souhami L,Clark BG,Roman T

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVES:The objectives of this study were twofold: (1) to estimate the anti-tumor efficacy of CI-958 in patients with measurable platinum-resistant ovarian cancer; (2) to determine the nature and degree of toxicity of CI-958 in these patients. METHODS:Patients received CI-958 560 mg/m(2) intravenously every 3 weeks...

journal_title：Gynecologic oncology

authors： Hoffman MA,Blessing JA,Morgan M

更新日期：2000-12-01 00:00:00

abstract：OBJECTIVE:To determine the feasibility and safety of simple extra-fascial trachelectomy plus pelvic lymphadenectomy in young patients affected by early stage cervical cancer. METHODS:We have prospectively identified all patients with early-stage cervical cancer (stages IA2-IB1) referred to our department. Inclusion cr...

journal_title：Gynecologic oncology

authors： Palaia I,Musella A,Bellati F,Marchetti C,Di Donato V,Perniola G,Benedetti Panici P

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVES:We assessed the efficacy and toxicity of once-weekly topotecan (Hycamtin; GlaxoSmithKline) for relapsed or persistent epithelial ovarian cancer (EOC) and primary peritoneal carcinoma (PPC). METHODS:Patients with recurrent or persistent EOC and PPC previously treated with > or = 1 course of platinum-based ch...

journal_title：Gynecologic oncology

authors： Safra T,Menczer J,Bernstein R,Shpigel S,Inbar MJ,Grisaru D,Golan A,Levy T

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:To compare outcomes of patients undergoing continent or incontinent urinary diversion after pelvic exenteration for gynecologic malignancies. METHODS:Data on patients who underwent pelvic exenteration for gynecologic malignancies at The University of Texas MD Anderson Cancer Center between January 1993 and D...

journal_title：Gynecologic oncology

authors： Urh A,Soliman PT,Schmeler KM,Westin S,Frumovitz M,Nick AM,Fellman B,Urbauer DL,Ramirez PT

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess the long-term effect of gonadotropin-releasing hormone analogues (GnRH-a) in combination with high-dose progestogens in the treatment of atypical endometrial hyperplasia in selected surgical high-risk patients and in women desiring reproductive potential. We hypothesized th...

journal_title：Gynecologic oncology

authors： Pérez-Medina T,Bajo J,Folgueira G,Haya J,Ortega P

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVE:To estimate the likelihood of occult cancer diagnosis at prophylactic oophorectomy in BRCA1 and BRCA2 carriers in different age groups and to determine the histopathology of these lesions. METHODS:We describe a series of 159 female BRCA1 or BRCA2 carriers who underwent prophylactic oophorectomy at the Univer...

journal_title：Gynecologic oncology

authors： Finch A,Shaw P,Rosen B,Murphy J,Narod SA,Colgan TJ

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the cost-effectiveness of selective lymphadenectomy using a preoperative prediction model compared to routine lymphadenectomy for patients undergoing surgery for endometrial cancer in the US and Korea. METHODS:We used a modified Markov model to estimate clinical and eco...

journal_title：Gynecologic oncology

authors： Lee JY,Cohn DE,Kim Y,Lee TJ,Barnett JC,Kim JW,Jeon YW,Kim K,Park SM,Kang S

更新日期：2014-12-01 00:00:00

abstract：:In epithelial ovarian cancer, solitary metastasis to and recurrences in the parenchyma of the spleen are rare in the absence of apparent disease in other sites. We report four patients who developed isolated, solitary splenic parenchymal recurrences of their epithelial ovarian adenocarcinomas and underwent a splenecto...

journal_title：Gynecologic oncology

authors： Farias-Eisner R,Braly P,Berek JS

更新日期：1993-03-01 00:00:00

abstract：:During the period 1977 to 1985, 12 patients with FIGO stage II and III epithelial ovarian carcinoma failed to achieve a pathologic complete response with chemotherapy and underwent salvage whole-abdominal irradiation (WAXRT). Six of these patients had gross residual disease present at the time of irradiation, and thre...

journal_title：Gynecologic oncology

authors： Linstadt DE,Stern JL,Quivey JM,Leibel SA,Lacey CG

更新日期：1990-03-01 00:00:00

abstract：OBJECTIVE:Human leukocyte antigens (HLA) play an important role in presenting virus antigens to immune cells that are responsible for the clearance of virus-infected cells and tumor cells. Herein, we evaluated whether genetic variants of HLA-DP and HLA-DQ are associated with cervical cancer risk. METHODS:We genotyped ...

journal_title：Gynecologic oncology

authors： Jiang J,Li N,Shen Y,Liu J,Liu L,Du J,Lei Y,Wen Y,Yang L,Guo L,Zhang K,Qiang F,Wang S,Hu Z,Dai M,Shen H

更新日期：2013-05-01 00:00:00

abstract：:A patient with malignant struma ovarii who had elevated thyroglobulin levels at the time of her original surgery was diagnosed with recurrence on the basis of progressive thyroglobulin level elevation while on thyroid suppressive therapy. Subsequent treatment with therapeutic doses of iodine-137 resulted in normalizat...

journal_title：Gynecologic oncology

authors： Rose PG,Arafah B,Abdul-Karim FW

更新日期：1998-09-01 00:00:00

abstract：:The usefulness of fine needle sampling (FNS) under transvaginal ultrasound guidance in gynecologic oncology patients is evaluated in this study. Between 1990 and 1993, 101 FNS under transvaginal ultrasound guidance were performed in 88 sessions. All targets were located deep in the pelvis and their median diameter was...

journal_title：Gynecologic oncology

authors： Zanetta G,Brenna A,Pittelli M,Lissoni A,Trio D,Riotta S

更新日期：1994-07-01 00:00:00

abstract：:Radical vulvectomy using warm-knife and open-wound techniques was performed as the first step in a two-phase surgical approach in 274 patients with malignant vulvar tumors. Crude 5-year survival was registered in 133/223 (60%) patients. The complication rate was low and the hospitalization period was short (mean 16 da...

journal_title：Gynecologic oncology

authors： Simonsen E,Johnsson JE,Tropé C

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the sensitivity of sentinel node (SN) ultrastaging and to define parameters that may reduce the overall false-negative rate in women with early-stage cervical cancer. METHODS:We analyzed data from a large retrospective multicenter cohort group with FIGO stages IA-IIB cervical cancer in whom at le...

journal_title：Gynecologic oncology

authors： Cibula D,Abu-Rustum NR,Dusek L,Slama J,Zikán M,Zaal A,Sevcik L,Kenter G,Querleu D,Jach R,Bats AS,Dyduch G,Graf P,Klat J,Meijer CJ,Mery E,Verheijen R,Zweemer RP

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Granulosa cell tumors of the ovary are rare, primarily treated surgically. In advanced or recurrent disease, data are inconclusive regarding the benefit of either primary or adjuvant chemotherapy. Hormonal therapy has been suggested as an alternative treatment. CASE:Our patient had three recurrences of estr...

journal_title：Gynecologic oncology

authors： Hardy RD,Bell JG,Nicely CJ,Reid GC

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:To develop a nomogram for predicting the probability of 5year survival after definitive concurrent chemoradiotherapy (CCRT) in locally advanced cervical cancer (LACC). METHODS:Between 1998 and 2008, 209 patients with LACC were treated with definitive CCRT. Multivariate analysis using Cox proportional hazards...

journal_title：Gynecologic oncology

authors： Shim SH,Lee SW,Park JY,Kim YS,Kim DY,Kim JH,Kim YM,Kim YT,Nam JH

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:The aim of our study was to retrospectively examine the proliferating cell nuclear antigen (PCNA) immunoreactivity of tumor cells in curettage specimens containing endometrioid adenocarcinoma and obtained immediately before definitive surgical staging. This PCNA index was compared with the one subsequently de...

journal_title：Gynecologic oncology

authors： Garzetti GG,Ciavattini A,Goteri G,De Nictolis M,Romanini C

更新日期：1996-04-01 00:00:00

abstract：:For the past several years, all women with epithelial ovarian cancer have been treated identically, whether in a clinical trial or off protocol. Over the past decade, we have come to appreciate the magnitude of the heterogeneity of ovarian cancer. The development of the binary grading system for serous carcinoma was a...

journal_title：Gynecologic oncology

authors： Romero I,Sun CC,Wong KK,Bast RC Jr,Gershenson DM

更新日期：2013-09-01 00:00:00

abstract：:Twenty cases of gestational trophoblastic disease in women aged 50 or more are reported. The lesions were 7 hydatidiform mole (35%), 8 invasive mole (40%), and 5 choriocarcinoma (25%). The most common presenting symptom was abnormal vaginal bleeding. Three choriocarcinoma patients were postmenopausal and all of them h...

journal_title：Gynecologic oncology

authors： Tsukamoto N,Iwasaka T,Kashimura Y,Uchino H,Kashimura M,Matsuyama T

更新日期：1985-01-01 00:00:00