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Mutations in TAP genes are common in cervical carcinomas.

Abstract：

OBJECTIVE:To determine whether squamous cervical cancers exhibit mutations or deletions in MHC class I genes or transport-associated protein (TAP) genes. METHODS:Polymerase chain reaction based protocols were used to examine HLA class I and TAP genes in a panel of cervical tumours, using DNA from corresponding blood samples as controls. SSP-PCR protocols were similarly used for examination of all TAP alleles in tumour and blood samples. RESULTS:In a series of cervical carcinomas, 7 of 27 (26%) exhibited mutations in HLA-A genes, while 12 of 23 (52%) exhibited mutations in TAP genes. HLA gene mutations were detected in 2 of 14 CIN2-3 lesions, and TAP gene mutations in none of 14, a frequency significantly less than observed in the cervical carcinoma samples (P<0.01). The TAP 2A/2B heterozygous genotype was observed with increased frequency in patients with cervical cancer compared to population controls (P<0.02). CONCLUSION:These data suggest that TAP genes may be relevant to evolution of cervical cancer from precursor lesions.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Fowler NL,Frazer IH

doi

10.1016/j.ygyno.2003.11.037

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

914-21

issue

3

eissn

0090-8258

issn

1095-6859

pii

S0090825803008679

journal_volume

92

pub_type

杂志文章

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