Comparison of dilatation & curettage and endometrial aspiration biopsy accuracy in patients treated with high-dose oral progestin plus levonorgestrel intrauterine system for early-stage endometrial cancer.


OBJECTIVE:To compare the diagnostic accuracy of dilatation & curettage (D&C) vs. endometrial aspiration biopsy in follow-up evaluation of patients treated with high-dose oral progestin plus levonorgestrel intrauterine system (LNG-IUS) for early-stage endometrial cancer (EC). METHOD:A prospective observational study was conducted with 11 patients with FIGO grade 1 or 2, clinical stage IA endometrioid adenocarcinoma. Patients were aged up to 40 years wishing to preserve fertility treated with high-dose oral progestin plus LNG-IUS. Treatment response assessment was done at three month intervals. Endometrial tissues were obtained via endometrial aspiration biopsy with LNG-IUS in place and D&C after removal of LNG-IUS. We identified 28 cases; the histologic results were compared. Kappa statistics were used to assess the agreement of two methods. RESULTS:Diagnostic concordance between examinations was assessed for 9 out of 28 cases examined (32.1%). These consisted of three cases with both examination results of normal, 3 cases with endometrioid adenocarcinoma, 1 case with complex endometrial hyperplasia, 2 cases with material insufficient for diagnosis. Endometrioid adenocarcinoma on D&C was diagnosed in 9 out of 28 cases, but from endometrial aspiration biopsy, only 3 of these 9 cases were diagnosed with endometrioid adenocarcinoma, giving the diagnostic concordance at 33% (kappa value=0.27). From endometrial aspiration biopsy, 17 out of 28 cases (60.7%) had material insufficiency for diagnosis. CONCLUSION:In patients treated with high-dose oral progestin plus LNG-IUS for early-stage EC, endometrial aspiration biopsy with LNG-IUS in place may be not reliable as a follow-up evaluation method.


Gynecol Oncol


Gynecologic oncology


Kim MK,Seong SJ,Song T,Kim ML,Yoon BS,Jun HS,Lee GH,Lee YH




Has Abstract


2013-09-01 00:00:00














  • The increase of mitochondrial DNA content in endometrial adenocarcinoma cells: a quantitative study using laser-captured microdissected tissues.

    abstract:OBJECTIVE:Microsatellite instability (MSI) is a frequent genetic event in the D-loop region (which controls mitochondrial DNA (mtDNA) replication) of mitochondrial genome of endometrial cancer. We therefore investigated the relationship between mtMSI and mtDNA content in endometrial cancer. METHODS:Tumor tissues from ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Wang Y,Liu VW,Xue WC,Tsang PC,Cheung AN,Ngan HY

    更新日期:2005-07-01 00:00:00

  • Parametrial invasion of uterine cervical cancer assessed by transrectal ultrasonography: preliminary report.

    abstract::Transrectal ultrasonographic examinations were performed on 30 patients with uterine cervical cancer to assess parametrial invasion. The findings were compared with data obtained by manual rectal examination. Forty-six parametria in 23 patients were histologically examined following surgery. Sensitivity, specificity, ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Aoki S,Hata T,Senoh D,Makihara K,Hata K,Takamiya O,Kitao M

    更新日期:1990-01-01 00:00:00

  • Multicenter phase II trial of topotecan, cisplatin and bevacizumab for recurrent or persistent cervical cancer.

    abstract:OBJECTIVE:We evaluated the activity and safety of the combination of topotecan, cisplatin and bevacizumab in patients with recurrent or persistent carcinoma of the cervix. METHODS:Eligible patients had persistent or recurrent cervical cancer not amenable to curative intent treatment. No prior chemotherapy for recurren...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Zighelboim I,Wright JD,Gao F,Case AS,Massad LS,Mutch DG,Powell MA,Thaker PH,Eisenhauer EL,Cohn DE,Valea FA,Alvarez Secord A,Lippmann LT,Dehdashti F,Rader JS

    更新日期:2013-07-01 00:00:00

  • Three-dimensional power Doppler ultrasound improves the diagnostic accuracy for ovarian cancer prediction.

    abstract:OBJECTIVE:The goal of this study was to determine if three-dimensional power Doppler ultrasound improves the specificity for ovarian cancer detection as compared with two-dimensional ultrasound. METHODS:Seventy-one women with a known complex pelvic mass were referred for a preoperative ultrasound evaluation with both ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Cohen LS,Escobar PF,Scharm C,Glimco B,Fishman DA

    更新日期:2001-07-01 00:00:00

  • Uterine papillary serous carcinoma (UPSC): a clinicopathologic study of 30 cases.

    abstract::Between 1975 and 1989, 896 patients were treated for endometrial carcinoma at the Massachusetts General Hospital. Thirty patients were identified from the tumor registry as having uterine papillary serous carcinomas. The survival for all patients and for groups of patients stratified on clinical and pathological param...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kato DT,Ferry JA,Goodman A,Sullinger J,Scully RE,Goff BA,Fuller AF Jr,Rice LW

    更新日期:1995-12-01 00:00:00

  • Malignant melanoma of the vulva: an extension of cutaneous melanoma?

    abstract:OBJECTIVE:To determine the prognostic significance of the 2002 revisions of the American Joint Committee on Cancer (AJCC) Staging System for cutaneous melanoma in melanoma of the vulva and review the current surgical utilized for treatment of this neoplasm. METHODS:Demographic, surgical and outcomes data were obtained...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Moxley KM,Fader AN,Rose PG,Case AS,Mutch DG,Berry E,Schink JC,Kim CH,Chi DS,Moore KN

    更新日期:2011-09-01 00:00:00

  • Vulvar reconstruction using a mons pubis pedicle flap.

    abstract::The treatment of early vulvar carcinoma has moved toward less radical surgery with reconstruction. This report describes our preliminary experience with a mons pubis flap that is simple and appears safe, reliable, and gives excellent cosmetic and functional results following radical hemivulvectomy. Four patients have ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Potkul RK,Barnes WA,Barter JF,Delgado G,Spear SL

    更新日期:1994-10-01 00:00:00

  • Types of pelvic exenterations: a reappraisal.

    abstract::Subgrouping of pelvic exenterations as supralevator (type I), infralevator (type II), with vulvectomy (type III), and, an added category, extended can be helpful to facilitate communication when referring to these patients. It also can facilitate a more detailed analysis of operative risk factors, complications, and r...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Magrina JF

    更新日期:1990-06-01 00:00:00

  • Nucleolar organizer regions in endometriosis, atypical endometriosis, and clear cell and endometrioid carcinomas.

    abstract::Nucleolar Organizer Regions (NORs) code for ribosomal RNA and are thought to be an accurate representation of the percentage of cells in S-phase. NORs are associated with nonhistone nucleoproteins, which can be stained with silver (AgNORs). An increased number of AgNORs has been observed in many malignancies. AgNORs w...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Chalas E,Chumas J,Barbieri R,Mann WJ

    更新日期:1991-03-01 00:00:00

  • A small molecule Smac mimic potentiates TRAIL-mediated cell death of ovarian cancer cells.

    abstract:OBJECTIVES:Ovarian cancer remains a leading cause of death in women and development of new therapies is essential. Second mitochondria derived activator of caspase (Smac) has been described to sensitize for apoptosis. We have explored the proapoptotic activity of a small molecule mimic of Smac/DIABLO on ovarian cancer ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Petrucci E,Pasquini L,Petronelli A,Saulle E,Mariani G,Riccioni R,Biffoni M,Ferretti G,Benedetti-Panici P,Cognetti F,Scambia G,Humphreys R,Peschle C,Testa U

    更新日期:2007-05-01 00:00:00

  • Epithelial ovarian carcinoma in patients with intersex disorders: the role of pituitary gonadotropins in ovarian tumorigenesis.

    abstract::The common epithelial tumors of the human ovary have rarely been found in the gonads of intersex patients with gonadal dysgenesis or true hermaphroditism. This report describes a patient with ovarian serous cystadenocarcinoma and mixed gonadal dysgenesis (45,X/46,XY) and reviews other reported cases. Intersex patients...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Miller DS,Teng NN,Ballon SC

    更新日期:1986-07-01 00:00:00

  • Survival impact of multiple bowel resections in patients undergoing primary cytoreductive surgery for advanced ovarian cancer: a case-control study.

    abstract:OBJECTIVE:To evaluate clinicopathological factors and survival outcome of patients with advanced epithelial ovarian carcinoma undergoing multiple bowel resections to achieve optimal (< or = 1 cm) cytoreduction. METHODS:A case-control study was performed identifying patients undergoing optimal primary cytoreductive sur...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Salani R,Zahurak ML,Santillan A,Giuntoli RL 2nd,Bristow RE

    更新日期:2007-12-01 00:00:00

  • The efficacy of complex decongestive physiotherapy (CDP) and predictive factors of response to CDP in lower limb lymphedema (LLL) after pelvic cancer treatment.

    abstract:OBJECTIVE:The aim of this study was to estimate the efficacy of an intensive CDP program, as well as to identify the predictors associated with lymphedema severity and response to CDP in lower limb lymphedema (LLL) after pelvic cancer therapy. METHODS:We performed a retrospective review of post-pelvic cancer LLL patie...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Liao SF,Li SH,Huang HY

    更新日期:2012-06-01 00:00:00

  • Phase II study of medroxyprogesterone acetate plus tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study.

    abstract:OBJECTIVES:The objectives of this study were to estimate the clinical response rate and toxicity of daily tamoxifen combined with intermittent weekly medroxyprogesterone acetate (MPA). METHODS:This study reports the results of 61 patients with measurable advanced or recurrent endometrial carcinoma enrolled on this stu...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Whitney CW,Brunetto VL,Zaino RJ,Lentz SS,Sorosky J,Armstrong DK,Lee RB,Gynecologic Oncology Group study.

    更新日期:2004-01-01 00:00:00

  • Perineural invasion (PNI) in vulvar carcinoma: A review of 421 cases.

    abstract:OBJECTIVES:To evaluate the prevalence and associated prognostic indicators in patients with vulvar carcinoma with and without evidence of perineural invasion (PNI). METHODS:A retrospective review identified 421 patients with invasive vulvar carcinoma evaluated at a single institution between 1993 and 2011. Medical rec...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Salcedo MP,Sood AK,Dos Reis R,Ramalingam P,Chen C,Frumovitz M,Jhingran A,Pitcher B,Ramirez PT,Schmeler KM

    更新日期:2019-01-01 00:00:00

  • Factors predicting human papillomavirus clearance in cervical intraepithelial neoplasia lesions treated by conization.

    abstract:OBJECTIVE:The objective was to identify the factors, if any, that may predict long-term results of CIN treatment and HPV clearance/persistence after locally excisional therapy. METHODS:A series of 252 women with CIN lesions treated by conization were subjected to sequential HPV detection by repeated PCR during the pro...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Costa S,De Simone P,Venturoli S,Cricca M,Zerbini ML,Musiani M,Terzano P,Santini D,Cristiani P,Syrjänen S,Syrjänen K

    更新日期:2003-08-01 00:00:00

  • Phase II evaluation of oxaliplatin in previously treated squamous cell carcinoma of the cervix: a gynecologic oncology group study.

    abstract:OBJECTIVE:A phase II study was conducted to determine the efficacy of oxaliplatin therapy in patients with previously treated squamous cell carcinoma of the cervix. METHODS:Eligible patients were to have measurable disease and not more than one prior chemotherapy regimen that could include carboplatin or cisplatin but...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Fracasso PM,Blessing JA,Wolf J,Rocereto TF,Berek JS,Waggoner S

    更新日期:2003-07-01 00:00:00

  • High-risk metastatic gestational trophoblastic disease: further stratification into two clinical entities.

    abstract::Forty-two of sixty-seven patients (62.7%) treated for high-risk metastatic trophoblastic disease achieved and maintained complete remissions. The survival rate was significantly improved in those patients with scores lower than 8 according to a modification of the World Health Organization (WHO) prognostic scoring sys...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Gordon AN,Gershenson DM,Copeland LJ,Stringer CA,Morris M,Wharton JT

    更新日期:1989-07-01 00:00:00

  • Society of Gynecologic Oncology recommendations for fellowship education during the COVID-19 pandemic and beyond: Innovating programs to optimize trainee success.

    abstract::In approximately ten months' time, the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected over 34 million people and caused over one million deaths worldwide. The impact of this virus on our health, relationships, and careers is difficult to overstate. As the economic realiti...

    journal_title:Gynecologic oncology

    pub_type: 指南,杂志文章,评审


    authors: Ferriss JS,Rose S,Rungruang B,Urban R,Spencer R,Uppal S,Sinno AK,Duska L,Walsh C

    更新日期:2021-01-01 00:00:00

  • DNA flow cytometry and morphometry as prognostic indicators in advanced ovarian cancer: a step forward in predicting the clinical outcome.

    abstract::In 74 patients with advanced ovarian cancer, the value of DNA flow cytometry and morphometry was evaluated and compared with histological grading and clinical outcome. By means of both DNA flow cytometry and morphometry a clear distinction was found between a favorable group of 15 patients, with a median survival of m...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Rodenburg CJ,Cornelisse CJ,Hermans J,Fleuren GJ

    更新日期:1988-02-01 00:00:00

  • Therapeutic potential of the new TRIB3-mediated cell autophagy anticancer drug ABTL0812 in endometrial cancer.

    abstract:OBJECTIVES:The PI3K/AKT/mTOR pathway is frequently overactivated in endometrial cancer (EC). We assessed the efficacy of ABTL0812, a novel first-in-class molecule presenting a unique mechanism of action inhibiting this pathway. METHODS:We investigated the effects of ABTL0812 on proliferation, cell death and modulation...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Felip I,Moiola CP,Megino-Luque C,Lopez-Gil C,Cabrera S,Solé-Sánchez S,Muñoz-Guardiola P,Megias-Roda E,Pérez-Montoyo H,Alfon J,Yeste-Velasco M,Santacana M,Dolcet X,Reques A,Oaknin A,Rodríguez-Freixinos V,Lizcano JM,Domèn

    更新日期:2019-05-01 00:00:00

  • Malignant mixed mullerian tumor arising in extragenital endometriosis: report of a case and review of the literature.

    abstract::A primary malignant mixed Mullerian tumor (MMMT) was found in the wall of the rectum of a 67-year-old female. The uterus, fallopian tubes, and ovaries had been previously excised for benign disease. The tumor was associated with foci of benign endometriosis. A literature review of extragenital MMMTs indicates that the...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Chumas JC,Thanning L,Mann WJ

    更新日期:1986-02-01 00:00:00

  • Intraoperative hypothermia during primary surgical cytoreduction for advanced ovarian cancer: risk factors and associations with postoperative morbidity.

    abstract:OBJECTIVE:The objective of this study was to evaluate the risk factors and potential morbidity associated with intraoperative hypothermia (IH) during cytoreductive surgery (CRS) for advanced ovarian cancer. METHODS:Demographic and perioperative data were collected for all patients with stage IIIC-IV ovarian, fallopian...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Long KC,Tanner EJ,Frey M,Leitao MM Jr,Levine DA,Gardner GJ,Sonoda Y,Abu-Rustum NR,Barakat RR,Chi DS

    更新日期:2013-12-01 00:00:00

  • Role of toll-like receptors in cervical, endometrial and ovarian cancers: a review.

    abstract:OBJECTIVE:The Toll-like receptors (TLRs) have been implicated in inflammation, innate immunity and cancer. The goal of this paper is to review the available published research about Toll-like receptors and their roles in gynecologic malignancies. METHODS:A Medline search was conducted and published articles from the l...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Husseinzadeh N,Davenport SM

    更新日期:2014-11-01 00:00:00

  • Targeted eradication of ovarian cancer mediated by intracellular expression of anti-erbB-2 single-chain antibody.

    abstract:OBJECTIVE:Overexpression of the tyrosine kinase receptor erbB-2 is important in the pathogenesis of a variety of neoplasms including ovarian cancer. As a strategy to selectively eradicate erbB-2-overexpressing tumor cells, an anti-erbB-2 single-chain immunoglobin (sFv) gene was constructed to direct expression of intra...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Deshane J,Cabrera G,Grim JE,Siegal GP,Pike J,Alvarez RD,Curiel DT

    更新日期:1995-10-01 00:00:00

  • A phase I clinical trial of Ad5/3-Δ24, a novel serotype-chimeric, infectivity-enhanced, conditionally-replicative adenovirus (CRAd), in patients with recurrent ovarian cancer.

    abstract:OBJECTIVE:The conditionally replicative adenovirus Ad5/3-Δ24 has a type-3 knob incorporated into the type-5 fiber that facilitates enhanced ovarian cancer infectivity. Preclinical studies have shown that Ad5/3-Δ24 achieves significant oncolysis and anti-tumor activity in ovarian cancer models. The purpose of this study...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kim KH,Dmitriev IP,Saddekni S,Kashentseva EA,Harris RD,Aurigemma R,Bae S,Singh KP,Siegal GP,Curiel DT,Alvarez RD

    更新日期:2013-09-01 00:00:00

  • The role of neoadjuvant chemotherapy in the management of patients with advanced stage ovarian cancer: survey results from members of the Society of Gynecologic Oncologists.

    abstract:OBJECTIVE:Recent randomized controlled data suggest that neoadjuvant chemotherapy (NACT) with interval debulking (ID) may produce similar overall survival and progression free survival compared to standard primary cytoreduction followed by chemotherapy. The object of our study was to assess current patterns of care amo...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Dewdney SB,Rimel BJ,Reinhart AJ,Kizer NT,Brooks RA,Massad LS,Zighelboim I

    更新日期:2010-10-01 00:00:00

  • Granulosa cell tumor of ovary: a clinicopathologic and flow cytometric DNA analysis.

    abstract::Flow cytometric DNA ploidy and S-phase fraction (SPF) analysis was performed on 18 granulosa cell tumors of the ovary. Clinical and pathologic data from patients followed for an average of 10 years were compared to flow cytometry ploidy to determine its prognostic usefulness. Eleven (62%) tumors were diploid and seven...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Roush GR,el-Naggar AK,Abdul-Karim FW

    更新日期:1995-03-01 00:00:00

  • A ten year experience of cecal neovagina procedures for the restoration of sexual function on a gynecology oncology service.

    abstract:OBJECTIVE:We seek to describe the procedure, complications, and functional outcomes of utilizing the cecum and ascending colon for creation of a neovagina on a gynecologic oncology service. METHODS:A search of all the cases on the gynecologic oncology service over a ten year period yielded fourteen cases of cecal neov...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Khulpateea BR,Silver DF

    更新日期:2014-07-01 00:00:00

  • Immunogenomic landscape of gynecologic carcinosarcoma.

    abstract:OBJECTIVE:Carcinosarcoma (CS) of the uterus or ovary is a rare, biphasic tumor comprising epithelial and mesenchymal elements, and exhibits more aggressive clinical features than its carcinoma counterpart. Four molecular subtypes of CS were recently established based on genomic aberration profiles (POLE, MSI, CNH, and ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Gotoh O,Kiyotani K,Chiba T,Sugiyama Y,Takazawa Y,Nemoto K,Kato K,Tanaka N,Nomura H,Hasegawa K,Fujiwara K,Takamatsu S,Matsumura N,Noda T,Mori S

    更新日期:2021-02-01 00:00:00