Abstract:
OBJECTIVE:To compare the diagnostic accuracy of dilatation & curettage (D&C) vs. endometrial aspiration biopsy in follow-up evaluation of patients treated with high-dose oral progestin plus levonorgestrel intrauterine system (LNG-IUS) for early-stage endometrial cancer (EC). METHOD:A prospective observational study was conducted with 11 patients with FIGO grade 1 or 2, clinical stage IA endometrioid adenocarcinoma. Patients were aged up to 40 years wishing to preserve fertility treated with high-dose oral progestin plus LNG-IUS. Treatment response assessment was done at three month intervals. Endometrial tissues were obtained via endometrial aspiration biopsy with LNG-IUS in place and D&C after removal of LNG-IUS. We identified 28 cases; the histologic results were compared. Kappa statistics were used to assess the agreement of two methods. RESULTS:Diagnostic concordance between examinations was assessed for 9 out of 28 cases examined (32.1%). These consisted of three cases with both examination results of normal, 3 cases with endometrioid adenocarcinoma, 1 case with complex endometrial hyperplasia, 2 cases with material insufficient for diagnosis. Endometrioid adenocarcinoma on D&C was diagnosed in 9 out of 28 cases, but from endometrial aspiration biopsy, only 3 of these 9 cases were diagnosed with endometrioid adenocarcinoma, giving the diagnostic concordance at 33% (kappa value=0.27). From endometrial aspiration biopsy, 17 out of 28 cases (60.7%) had material insufficiency for diagnosis. CONCLUSION:In patients treated with high-dose oral progestin plus LNG-IUS for early-stage EC, endometrial aspiration biopsy with LNG-IUS in place may be not reliable as a follow-up evaluation method.
journal_name
Gynecol Oncoljournal_title
Gynecologic oncologyauthors
Kim MK,Seong SJ,Song T,Kim ML,Yoon BS,Jun HS,Lee GH,Lee YHdoi
10.1016/j.ygyno.2013.06.035subject
Has Abstractpub_date
2013-09-01 00:00:00pages
470-3issue
3eissn
0090-8258issn
1095-6859pii
S0090-8258(13)00868-8journal_volume
130pub_type
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journal_title:Gynecologic oncology
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journal_title:Gynecologic oncology
pub_type: 临床试验,杂志文章
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journal_title:Gynecologic oncology
pub_type: 杂志文章
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journal_title:Gynecologic oncology
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pub_type: 杂志文章,随机对照试验
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journal_title:Gynecologic oncology
pub_type: 杂志文章,多中心研究
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pub_type: 临床试验,杂志文章
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journal_title:Gynecologic oncology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Gynecologic oncology
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journal_title:Gynecologic oncology
pub_type: 杂志文章,多中心研究
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更新日期:2019-07-01 00:00:00
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journal_title:Gynecologic oncology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,多中心研究
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