A phase I clinical trial of Ad5/3-Δ24, a novel serotype-chimeric, infectivity-enhanced, conditionally-replicative adenovirus (CRAd), in patients with recurrent ovarian cancer.

abstract：OBJECTIVES:Molecular markers associated with tumor progression in uterine carcinoma are poorly defined. In this study, we determine whether upregulation of LAMC1, a gene encoding extracellular matrix protein, laminin γ1, is associated with various uterine carcinoma subtypes and stages of tumor progression. METHODS:An ...

journal_title：Gynecologic oncology

authors： Kashima H,Wu RC,Wang Y,Sinno AK,Miyamoto T,Shiozawa T,Wang TL,Fader AN,Shih IeM

更新日期：2015-11-01 00:00:00

abstract：:Clear cell carcinoma of the ovary accounts for 2 to 3% of all epithelial ovarian neoplasms. Patient profiles, pathological characteristics, and results of treatment are reviewed for 59 patients. The median age was 51. Disease extent at diagnosis was as follows: stage I, 18 patients (31%); stage II, 20 patients (34%); ...

journal_title：Gynecologic oncology

authors： Crozier MA,Copeland LJ,Silva EG,Gershenson DM,Stringer CA

更新日期：1989-11-01 00:00:00

abstract：:Ovarian germ cell tumors (GCTs) are rare in adults, but are more common in adolescents and young adults. Contemporary management of ovarian GCTs is evolving as collaboration among pediatric, medical, and gynecologic oncologists increases, and studies increasingly incorporate female adult patients. Despite an improved ...

journal_title：Gynecologic oncology

authors： Veneris JT,Mahajan P,Frazier AL

更新日期：2020-08-01 00:00:00

abstract：:Nineteen patients with stage III or IV epithelial ovarian cancer treated on a prospective randomized protocol with either adriamycin and cis-diamminedichloroplatinum or tamoxifen, adriamycin, and cis-diamminedichloroplatinum received a modified "CHAP II" regimen at the time of clinical progression of disease or the fi...

journal_title：Gynecologic oncology

authors： Schwartz PE,Keating G,Kohorn EI,Chambers JT

更新日期：1986-11-01 00:00:00

abstract：OBJECTIVE:Metformin is one of the most widely used drugs for the treatment of type 2 diabetes. Recent investigations demonstrated that application of metformin reduces cancer risk. The present study aimed to determine the role of liver kinase B1 (LKB1) in the response of cervical cancer cells to metformin. METHODS:LKB...

journal_title：Gynecologic oncology

authors： Xiao X,He Q,Lu C,Werle KD,Zhao RX,Chen J,Davis BC,Cui R,Liang J,Xu ZX

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:In the US, second non-ocular malignancies are the primary cause of death in retinoblastoma survivors with the germline RB1 mutation. Soft tissue sarcomas are one of the most likely malignancies to pose a risk to these patients, with leiomyosarcoma (LMS) being the most common subtype. As our cohort is followed...

journal_title：Gynecologic oncology

authors： Francis JH,Kleinerman RA,Seddon JM,Abramson DH

更新日期：2012-02-01 00:00:00

abstract：:Only one case of endometrial transitional cell carcinoma (TCC) has been previously reported in the literature. We report a second case. In both the previously reported case and in this case there was a separate focus of TCC in the adnexa. Both patients were treated with adjuvant whole pelvic radiation and are alive an...

journal_title：Gynecologic oncology

authors： Spiegel GW,Austin RM,Gelven PL

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVE:To assess and characterize the temporal variation in ovarian cancer incidence and mortality by age within countries in the Americas, Europe, Asia, and Oceania. METHODS/MATERIALS:Data from the National Cancer Institute's Surveillance, Epidemiology, and End Results Program in the United States (U.S.) were used...

journal_title：Gynecologic oncology

authors： Lowe KA,Chia VM,Taylor A,O'Malley C,Kelsh M,Mohamed M,Mowat FS,Goff B

更新日期：2013-07-01 00:00:00

abstract：:Open biopsy of the left scalene lymph nodes has been utilized to identify distant spread of cervical carcinoma in selected groups of patients who do not have other clinical evidence of disseminated disease. Twenty-one patients with primary cervical carcinoma and histologically proven para-aortic lymph node metastases ...

journal_title：Gynecologic oncology

authors： Burke TW,Heller PB,Hoskins WJ,Weiser EB,Nash JD,Park RC

更新日期：1987-11-01 00:00:00

abstract：OBJECTIVE:To compare the frequencies of somatic homologous recombination (HR) gene mutations identified in next-generation sequencing (NGS) genomic profiling of uterine serous carcinomas (USCs) and high-grade serous ovarian carcinomas (HGSOCs). METHODS:Data for this analysis was obtained from AACR Project GENIE, a mul...

journal_title：Gynecologic oncology

authors： Wallbillich JJ,Morris RT,Ali-Fehmi R

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:To determine the relationship between history of cervical dysplasia or carcinoma and the development of cervical dysplasia or adenocarcinoma in women who have a diagnosis of atypical glandular cells of undetermined significance (AGUS), favor endocervical origin, or AGUS, not otherwise specified. METHODS:A 6-...

journal_title：Gynecologic oncology

authors： Raab SS,Bishop NS,Zaleski MS

更新日期：1999-09-01 00:00:00

abstract：:Cyclin E1 (CCNE1) gene amplification occurs in approximately 20% of ovarian high grade serous carcinoma (HGSC) and is associated with chemotherapy resistance and, in some studies, overall poor prognosis. The role of cyclin E1 in inducing S phase entry relies upon its interactions with cyclin dependent kinases (CDK), s...

journal_title：Gynecologic oncology

authors： Kanska J,Zakhour M,Taylor-Harding B,Karlan BY,Wiedemeyer WR

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:To determine the relationship between chemotherapy dose modification (dose adjustment or treatment delay), overall survival (OS) and progression-free survival (PFS) for women with advanced-stage epithelial ovarian carcinoma (EOC) and primary peritoneal carcinoma (PPC) who receive carboplatin and paclitaxel. ME...

journal_title：Gynecologic oncology

authors： Olawaiye AB,Java JJ,Krivak TC,Friedlander M,Mutch DG,Glaser G,Geller M,O'Malley DM,Wenham RM,Lee RB,Bodurka DC,Herzog TJ,Bookman MA

更新日期：2018-10-01 00:00:00

abstract：:Between October 1985 and January 1989, 33 patients with stage I (31) or clinically occult stage II (2) endometrial cancer at a high risk for recurrence were entered in a prospective study evaluating adjuvant cisplatin, doxorubicin, and cyclophosphamide (PAC) chemotherapy. Eligibility criteria included grade 2 tumors w...

journal_title：Gynecologic oncology

authors： Stringer CA,Gershenson DM,Burke TW,Edwards CL,Gordon AN,Wharton JT

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVES:A prior clinical trial on early-stage high risk ovarian cancer showed a lower recurrence rate in those treated with six vs. three cycles of chemotherapy. We proposed to identify subsets of patients who may benefit from more cycles of chemotherapy. METHODS:Outcomes of patients who underwent six vs. three cyc...

journal_title：Gynecologic oncology

authors： Chan JK,Tian C,Fleming GF,Monk BJ,Herzog TJ,Kapp DS,Bell J

更新日期：2010-03-01 00:00:00

abstract：:Classification of ovarian tumors according to FIGO does not take into account involvement of spleen. A patient who appears to be the first reported case of widespread carcinoma of the ovary with involvement of the splenic parenchyma is presented. ...

journal_title：Gynecologic oncology

authors： Glezerman M,Yanai-Inbar I,Charuzi I,Katz M,Glasner M,Piura B

更新日期：1988-05-01 00:00:00

abstract：:Gynecologic oncology patients are at a high-risk of postoperative venous thromboembolism and these events are a source of major morbidity and mortality. Given the availability of prophylaxis regimens, a structured comprehensive plan for prophylaxis is necessary to care for this population. There are many prophylaxis s...

journal_title：Gynecologic oncology

authors： Barber EL,Clarke-Pearson DL

更新日期：2017-02-01 00:00:00

abstract：:Angiomyofibroblastoma is a rare, myxoid tumor of the vulva. To date only 12 cases have been reported in the world literature. Patients are usually premenopausal and present with a vulval mass initially diagnosed as a Bartholin's cyst. The lesions are well circumscribed and range from 0.5 to 12 cm in size. Microscopica...

journal_title：Gynecologic oncology

authors： Van der Griend MD,Burda P,Ferrier AJ

更新日期：1994-09-01 00:00:00

abstract：:The purpose of this study was to determine the response of vulvar intraepithelial neoplasia (VIN) lesions to standard treatment methods in women infected with human immunodeficiency virus (HIV). We reviewed all cases of VIN over a 4-year period at an inner-city hospital. We reviewed the clinical records of these women...

journal_title：Gynecologic oncology

authors： Korn AP,Abercrombie PD,Foster A

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:Although renal cell carcinoma (RCC) is characterized with unpredictable clinical presentation, multiple genital tract metastases are still surprising and mode of spread is obscure. CASE:We report a case of RCC metastases to uterine cervix and vagina 1 year after radical nephrectomy in a 19-year-old virgin. ...

journal_title：Gynecologic oncology

authors： Bozaci EA,Atabekoğlu C,Sertçelik A,Unlü C,Ortaç F

更新日期：2005-10-01 00:00:00

abstract：:Less extensive surgical treatment has become possible for limited vulvar cancer. However, primary closure is advisable only when the defect is minimal and tissue replacement is always needed in radical excisions. Local flaps are always considered the first choice because of their characteristics of similarity to the r...

journal_title：Gynecologic oncology

authors： Tateo A,Tateo S,Bernasconi C,Zara C

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVE:Overexpression of the tyrosine kinase receptor erbB-2 is important in the pathogenesis of a variety of neoplasms including ovarian cancer. As a strategy to selectively eradicate erbB-2-overexpressing tumor cells, an anti-erbB-2 single-chain immunoglobin (sFv) gene was constructed to direct expression of intra...

journal_title：Gynecologic oncology

authors： Deshane J,Cabrera G,Grim JE,Siegal GP,Pike J,Alvarez RD,Curiel DT

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Five-Year survival after pelvic exenteration for gynecologic malignancies has been reported as high as 60%. The objective of this study was to determine overall survival (OS) after pelvic exenteration and evaluate factors impacting outcome. METHODS:A retrospective review of all women who underwent pelvic ex...

journal_title：Gynecologic oncology

authors： Westin SN,Rallapalli V,Fellman B,Urbauer DL,Pal N,Frumovitz MM,Ramondetta LM,Bodurka DC,Ramirez PT,Soliman PT

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:To test if TP53 hot spot mutations (HSMs) confer differential chemotherapy resistance or survival outcomes, the effects of microtubule stabilizers on human ovarian carcinoma cells (OCCs) expressing TP53 HSMs were studied in vitro. Survival outcomes of patients with high grade serous epithelial ovarian carcino...

journal_title：Gynecologic oncology

authors： Seagle BL,Yang CP,Eng KH,Dandapani M,Odunsi-Akanji O,Goldberg GL,Odunsi K,Horwitz SB,Shahabi S

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:Based on previous studies, standard gynecological screening consisting of annual transvaginal ultrasonography (TVU) was added with endometrial sampling in women with Lynch syndrome (LS). The aim of this study was to evaluate the additional value of endometrial sampling in detecting (pre)malignancies of the en...

journal_title：Gynecologic oncology

authors： Helder-Woolderink JM,De Bock GH,Sijmons RH,Hollema H,Mourits MJ

更新日期：2013-11-01 00:00:00

abstract：:Fourteen patients underwent surgical debulking of diaphragmatic metastases as part of cytoreductive surgery for advanced ovarian epithelial cancer from 1983 to 1984. The surgical technique is described. Morbidity from this approach was not excessive in this small series of patients. It is suggested that this technique...

journal_title：Gynecologic oncology

authors： Deppe G,Malviya VK,Boike G,Hampton A

更新日期：1986-06-01 00:00:00

abstract：OBJECTIVES:We aimed to evaluate whether carboplatin has a comparable efficacy with cisplatin as part of weekly concurrent chemoradiotherapy for cervical cancer (Car-RT vs. Cis-RT). METHODS:A literature search was conducted and both prospective and retrospective studies that evaluated the efficacy of Car-RT for cervica...

journal_title：Gynecologic oncology

authors： Xue R,Cai X,Xu H,Wu S,Huang H

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:Caregiver burden, quality of life (QOL) and unmet needs are poorly understood, particularly at the end of life. We explored these issues in caregivers of women with ovarian cancer. PATIENTS AND METHODS:The Australian Ovarian Cancer Study (AOCS) is a prospective population-based study of women newly diagnosed w...

journal_title：Gynecologic oncology

authors： Butow PN,Price MA,Bell ML,Webb PM,deFazio A,Australian Ovarian Cancer Study Group.,Australian Ovarian Cancer Study Quality Of Life Study Investigators.,Friedlander M

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVE:The ABC transporter MRP2 (ABCC2) can mediate cisplatin efflux, and over-expression of MRP2 has been associated with cisplatin resistance in cancer cell lines. The aim of this study was to determine the role of MRP2 in modulating cisplatin cytotoxicity in normal cells as well as the relationship between MRP2 e...

journal_title：Gynecologic oncology

authors： Guminski AD,Balleine RL,Chiew YE,Webster LR,Tapner M,Farrell GC,Harnett PR,Defazio A

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Gestational choriocarcinoma is a malignant tumor that frequently metastasizes to the highly vascularized organs such as the lung, brain, and liver via hematogenous spread. However, this tumor rarely metastasizes to the eye and only a few cases of metastasis to the choroid have been reported. CASE:A 17-year-...

journal_title：Gynecologic oncology

authors： Ino K,Mitsui T,Nomura S,Kikkawa F,Mizutani S

更新日期：2001-12-01 00:00:00