Vulvar intraepithelial neoplasia in women infected with human immunodeficiency virus-1.


:The purpose of this study was to determine the response of vulvar intraepithelial neoplasia (VIN) lesions to standard treatment methods in women infected with human immunodeficiency virus (HIV). We reviewed all cases of VIN over a 4-year period at an inner-city hospital. We reviewed the clinical records of these women to abstract demographic information as well as information about tobacco use, injection drug use, results of HIV testing, T cell count, stage of HIV infection, colposcopic and cytologic findings, treatment of lesions, and follow-up. Eight of the 28 women (29%) with VIN were infected with HIV. The relative risk for recurrence or persistence of VIN after treatment was 3.3 (95% confidence interval, 1.4-7.4; P = 0.01) in the HIV+ compared with the HIV- group. The high rate of HIV infection among women with VIN supports recommendation of HIV testing for women with VIN. Women known to have HIV infection should be carefully examined for vulvar lesions. Further study is needed to determine the optimum treatment for VIN in women infected with HIV.


Gynecol Oncol


Gynecologic oncology


Korn AP,Abercrombie PD,Foster A




Has Abstract


1996-06-01 00:00:00














  • Increased serum levels of 5-S-cysteinyldopa and intercellular adhesion molecule-1 in a patient with a uterine amelanotic metastasis from a primary vaginal malignant melanoma.

    abstract::A 75-year-old Japanese woman, who had an enlarged uterus and two nodules on the anterior vaginal wall, underwent wide excision of the anterior vaginal wall, bilateral inguinal lymphadenectomy, modified radical hysterectomy, and pelvic lymph node dissection. Her serum level of 5-S-cysteinyldopa (5-S-CD) was elevated, b...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Suenaga Y,Katabuchi H,Okamura H,Kageshita T,Ono T

    更新日期:1999-01-01 00:00:00

  • Etiologic heterogeneity in endometrial cancer: evidence from a Gynecologic Oncology Group trial.

    abstract:OBJECTIVE:Although the epidemiology of typical endometrial carcinomas (grades 1-2 endometrioid or Type I) is well established, less is known regarding higher grade endometrioid or non-endometrioid carcinomas (Type II). Within a large Gynecologic Oncology Group trial (GOG-210), which included central pathology review, w...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Brinton LA,Felix AS,McMeekin DS,Creasman WT,Sherman ME,Mutch D,Cohn DE,Walker JL,Moore RG,Downs LS,Soslow RA,Zaino R

    更新日期:2013-05-01 00:00:00

  • Angiographic-guided embolization of metastatic invasive mole.

    abstract:BACKGROUND:The friable and hypervascular nature of a metastatic invasive mole places the patient at risk for significant hemorrhage. Bleeding is the chief cause of morbidity and mortality in patients with a histopathological diagnosis of invasive mole. Bleeding from vaginal metastatic lesions can be controlled by packi...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Method MW,Hirschfield M,Everette HE

    更新日期:1996-06-01 00:00:00

  • Neurotropic desmoplastic melanoma: a rare vulvar malignancy.

    abstract::Melanoma represents the second most frequent vulvar malignancy, and yet is still considered to be an uncommon neoplasm. Several varieties of melanoma exist. A patient who was diagnosed with a rare subtype of melanoma as a primary vulvar process is presented here. To date, there is only one other reported case of neuro...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Byrne PR,Maiman M,Mikhail A,Harris M,Rosen Y

    更新日期:1995-02-01 00:00:00

  • Voiding recovery after radical parametrectomy in cervical cancer patients: An international prospective multicentre trial - SENTIX.

    abstract:OBJECTIVE:Voiding dysfunctions represent a leading morbidity after radical hysterectomy performed in patients with early-stage cervical cancer. The aim of this study was to perform ad hoc analysis of factors influencing voiding recovery in SENTIX (SENTinel lymph node biopsy in cervIX cancer) trial. METHODS:The SENTIX ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Zapardiel I,Kocian R,Köhler C,Klat J,Germanova A,Jacob A,Bajsova S,Böhmer G,Lay L,Gil-Ibañez B,Havelka P,Kipp B,Szewczyk G,Toth R,Staringer JC,De Santiago J,Coronado PJ,Poka R,Laky R,Luyckx M,Fastrez M,Dusek L,

    更新日期:2021-01-05 00:00:00

  • The accuracy of magnetic resonance imaging in staging of vulvar cancer: a retrospective multi-centre study.

    abstract:OBJECTIVE:To retrospectively evaluate the diagnostic accuracy and clinical relevance of magnetic resonance imaging (MRI) in the management of primary and recurrent vulvar cancer and to examine the added value of contrast-enhanced MRI (CE-MRI). METHODS:The research ethics committee waived informed consent for this stud...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Kataoka MY,Sala E,Baldwin P,Reinhold C,Farhadi A,Hudolin T,Hricak H

    更新日期:2010-04-01 00:00:00

  • Strategies in late stage cervix carcinoma.

    abstract::Stage IIB-IV squamous cell carcinoma of the cervix when treated by irradiation has a significant failure rate. Causes of pelvic and distant failure are discussed. New techniques employed to improve local control and decrease distant metastasis are presented. Data on morbidity, mortality, and survival will be reviewed ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Krochak R

    更新日期:1986-03-01 00:00:00

  • Incidence and risk factors for lower limb lymphedema associated with endometrial cancer: Results from a prospective, longitudinal cohort study.

    abstract:BACKGROUND:Evidence on the incidence and risk factors for lower limb lymphedema (LLL) associated with endometrial cancer is limited. Our objective was to use data from a prospective, longitudinal gynecological cancer cohort study to determine LLL incidence up to 24 months post-diagnosis of endometrial cancer and to exp...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Pigott A,Obermair A,Janda M,Vagenas D,Ward LC,Reul-Hirche H,Hayes SC

    更新日期:2020-08-01 00:00:00

  • Comparison of dilatation & curettage and endometrial aspiration biopsy accuracy in patients treated with high-dose oral progestin plus levonorgestrel intrauterine system for early-stage endometrial cancer.

    abstract:OBJECTIVE:To compare the diagnostic accuracy of dilatation & curettage (D&C) vs. endometrial aspiration biopsy in follow-up evaluation of patients treated with high-dose oral progestin plus levonorgestrel intrauterine system (LNG-IUS) for early-stage endometrial cancer (EC). METHOD:A prospective observational study wa...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kim MK,Seong SJ,Song T,Kim ML,Yoon BS,Jun HS,Lee GH,Lee YH

    更新日期:2013-09-01 00:00:00

  • Moving forward with actionable therapeutic targets and opportunities in endometrial cancer: A NCI clinical trials planning meeting report.

    abstract::The incidence of endometrial cancer (EC) in the U.S. has been rising, from an estimated annual incidence of 49,560 in 2013 to 61,380 in 2017. Meanwhile, the SEER-based relative survival of women with EC in the U.S. has remained flat [82.3% from 1987 to 1989, 82.8% from 2007 to 2013] and our recent increased understand...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Lheureux S,McCourt C,Rimel BJ,Duska L,Fleming G,Mackay H,Mutch D,Temkin SM,Lynn J,Kohn EC

    更新日期:2018-02-22 00:00:00

  • Implementation of a standardized voiding management protocol to reduce unnecessary re-catheterization - A quality improvement project.

    abstract:OBJECTIVE:To design and implement a standardized postoperative voiding management protocol that accurately identifies patients with urinary retention and reduces unnecessary re-catheterization. METHODS:A postoperative voiding management protocol was designed and implemented in patients undergoing major, inpatient, non...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Brackmann M,Carballo E,Uppal S,Torski J,Reynolds RK,McLean K

    更新日期:2020-05-01 00:00:00

  • The antiestrogen tamoxifen in the treatment of recurrent benign cystic mesothelioma.

    abstract::Benign cystic mesothelioma is a tumor characteristically found in women during the reproductive years. These tumors are infrequently found after castration or menopause, suggesting some degree of hormonal sensitivity. Such aspects of the tumor suggest a potential role for antiestrogens as medical management and an alt...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Letterie GS,Yon JL

    更新日期:1998-07-01 00:00:00

  • Efficacy and hematologic toxicity of salvage chemotherapy following stem cell-supported high-dose chemotherapy in women with recurrent ovarian cancer.

    abstract:OBJECTIVE:The objective of this study was to determine the efficacy and hematologic toxicity of salvage chemotherapy in patients with recurrent ovarian cancer following high-dose chemotherapy and peripheral blood stem cell transplantation (PBSCT). METHODS:A retrospective analysis of 19 Massachusetts General Hospital c...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Cook S,Penson R,Duska L,Nikrui N,Goodman A,Fuller A,Seiden M

    更新日期:2000-04-01 00:00:00

  • Reliability of frozen section examination in identifying poor prognostic indicators in stage I endometrial adenocarcinoma.

    abstract::Management of Stage I adenocarcinoma of the uterus includes hysterectomy, bilateral salpingo-oophorectomy, and selective paraaortic and pelvic lymphadenectomy. Postoperative radiation therapy (RT) is selectively employed in patients with histologically defined poor prognostic indicators. We attempted to identify these...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Malviya VK,Deppe G,Malone JM Jr,Sundareson AS,Lawrence WD

    更新日期:1989-09-01 00:00:00

  • Impact of obesity on surgical and oncologic outcomes in ovarian cancer.

    abstract:OBJECTIVES:The aim of this study is to determine the impact of obesity on surgical and oncologic outcomes after primary debulking surgery (PDS) in advanced epithelial ovarian cancer (EOC). METHODS:Women with stage IIIC/IV EOC who underwent PDS with curative intent between 1/2/2003 and 12/30/2011 were included. Patient...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kumar A,Bakkum-Gamez JN,Weaver AL,McGree ME,Cliby WA

    更新日期:2014-10-01 00:00:00

  • Brain metastasis in epithelial ovarian cancer by BRCA1/2 mutation status.

    abstract:OBJECTIVE:To evaluate clinical outcomes of patients with BRCA-associated ovarian cancer who developed brain metastases (BM). METHODS:Patients with epithelial ovarian, fallopian tube, and primary peritoneal cancer (EOC) and BM, treated at a single institution from 1/1/2008-7/1/2018, were identified from two institution...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Stasenko M,Cybulska P,Feit N,Makker V,Konner J,O'Cearbhaill RE,Alektiar KM,Beal K,Gardner GJ,Long Roche KC,Sonoda Y,Chi DS,Zivanovic O,Leitao MM Jr,Cadoo KA,Tew WP

    更新日期:2019-07-01 00:00:00

  • Does the interval from primary surgery to chemotherapy influence progression-free survival in ovarian cancer?

    abstract:OBJECTIVES:The objective of this study was to determine whether the length of the interval from primary surgery to commencement of chemotherapy has any direct effect on progression-free survival in ovarian cancer. METHODS:The progression-free survival of 472 patients enrolled in four trials who had all received platin...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Flynn PM,Paul J,Cruickshank DJ,Scottish Gynaecological Cancer Trials Group.

    更新日期:2002-09-01 00:00:00

  • Increased risk of secondary uterine leiomyosarcoma in hereditary retinoblastoma.

    abstract:OBJECTIVE:In the US, second non-ocular malignancies are the primary cause of death in retinoblastoma survivors with the germline RB1 mutation. Soft tissue sarcomas are one of the most likely malignancies to pose a risk to these patients, with leiomyosarcoma (LMS) being the most common subtype. As our cohort is followed...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Francis JH,Kleinerman RA,Seddon JM,Abramson DH

    更新日期:2012-02-01 00:00:00

  • Malignant pericardial effusion in ovarian carcinoma cured by systemic chemotherapy.

    abstract::A case of malignant pericardial effusion in a 67-year-old patient with serous ovarian cystadenocarcinoma is presented. Pericardial effusion was treated successfully with cyclophosphamide, doxorubicin, and cisplatin. The primary tumor had previously been assumed to be sensitive to this combination by using an in vivo p...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Mäenpää J,Taina E,Erkkola R

    更新日期:1988-06-01 00:00:00

  • Alterations in SPARC and VEGF immunoreactivity in epithelial ovarian cancer.

    abstract:OBJECTIVE:Secreted protein, acidic and rich in cysteine (SPARC), is a matricellular protein that modulates cell adhesion and growth. It is thought to play a decisive role in tissue remodeling and angiogenesis. Alterations in SPARC expression have been observed in a variety of solid tumors; however, no consistent patter...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Paley PJ,Goff BA,Gown AM,Greer BE,Sage EH

    更新日期:2000-09-01 00:00:00

  • Phase II evaluation of oxaliplatin in previously treated squamous cell carcinoma of the cervix: a gynecologic oncology group study.

    abstract:OBJECTIVE:A phase II study was conducted to determine the efficacy of oxaliplatin therapy in patients with previously treated squamous cell carcinoma of the cervix. METHODS:Eligible patients were to have measurable disease and not more than one prior chemotherapy regimen that could include carboplatin or cisplatin but...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Fracasso PM,Blessing JA,Wolf J,Rocereto TF,Berek JS,Waggoner S

    更新日期:2003-07-01 00:00:00

  • The performance of Dynamic Spectral Imaging colposcopy depends on indication for referrals.

    abstract::OBJECTIVE. A previous study has shown that Dynamic Spectral Imaging (DSI) colposcopy increases the sensitivity of the colposcopic examination in women referred with abnormal cytology. In this study we have reanalyzed the performance of DSI and conventional colposcopy for new referral conditions and for low-grade cytol...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Louwers JA,Zaal A,Kocken M,Berkhof J,Papagiannakis E,Snijders PJ,Meijer CJ,Verheijen RH

    更新日期:2015-12-01 00:00:00

  • Updates and emerging therapies for rare epithelial ovarian cancers: one size no longer fits all.

    abstract::Epithelial ovarian carcinoma consists of not one, but several, entities. A number of subtypes exist, including high-grade and low-grade serous carcinomas, clear cell, endometrioid carcinoma and mucinous carcinoma. Historically, women with epithelial ovarian cancer have been treated similarly and "lumped" in the same c...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Groen RS,Gershenson DM,Fader AN

    更新日期:2015-02-01 00:00:00

  • Placebo-controlled trial of indole-3-carbinol in the treatment of CIN.

    abstract:OBJECTIVE:Most precancerous lesions of the cervix are treated with surgery or ablative therapy. Chemoprevention, using natural and synthetic compounds, may intervene in the early precancerous stages of carcinogenesis and prevent the development of invasive disease. Our trial used indole-3-carbinol (I-3-C) administered ...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bell MC,Crowley-Nowick P,Bradlow HL,Sepkovic DW,Schmidt-Grimminger D,Howell P,Mayeaux EJ,Tucker A,Turbat-Herrera EA,Mathis JM

    更新日期:2000-08-01 00:00:00

  • Clinical outcome of patients with FIGO stage IA2 squamous cell carcinoma of the uterine cervix.

    abstract:OBJECTIVE:The objective of this analysis was to present the clinical outcome of the patients with FIGO stage IA2 squamous cell cervical cancer treated at the Department of Obstetrics and Gynecology between 1973 and 2009, and to clarify the discrepancies in clinical guidelines regarding the radicality of treatment appli...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Smrkolj S,Pogačnik RK,Slabe N,Rakar S

    更新日期:2012-01-01 00:00:00

  • Detection of disseminated tumor cells in patients with gynecological cancers.

    abstract:OBJECTIVES:The presence of disseminated tumor cells (DTC) in breast cancer patients is associated with poor prognosis. However, there are limited data about the prevalence and prognostic impact of DTC in patients with gynecological tumors. The aim of this study was to evaluate the presence of DTC in the bone marrow (BM...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Fehm T,Becker S,Bachmann C,Beck V,Gebauer G,Banys M,Wallwiener D,Solomayer EF

    更新日期:2006-12-01 00:00:00

  • The opioid growth factor (OGF) and low dose naltrexone (LDN) suppress human ovarian cancer progression in mice.

    abstract:OBJECTIVE:The opioid growth factor (OGF) and its receptor, OGFr, serve as a tonically active inhibitory axis regulating cell proliferation in normal cells and a variety of cancers, including human ovarian cancer. Blockade of OGF and OGFr with the nonselective opioid receptor antagonist naltrexone (NTX) upregulates expr...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Donahue RN,McLaughlin PJ,Zagon IS

    更新日期:2011-08-01 00:00:00

  • Intestinal complications associated with use of the Dexon mesh sling in gynecologic oncology patients.

    abstract::Three cases of postoperative enterocutaneous fistula formation following use of the Dexon mesh sling are reported from two gynecologic oncology services. Two patients had intestinal trauma or bowel resection at the time of mesh placement. Postoperative submesh abscess formation was noted in only one patient. Factors w...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Patsner B,Mann WJ Jr,Chalas E,Orr JW Jr

    更新日期:1990-07-01 00:00:00

  • Analysis of the cost effectiveness of concurrent cisplatin-based chemoradiation in cervical cancer: implications from five randomized trials.

    abstract:PURPOSE:Five recent phase III trials provide strong evidence that a new alternative therapy, cisplatin-based chemoradiation, is more effective than standard therapy using radiation alone in the treatment of advanced cervical cancer. We conducted a pharmacoeconomic analysis to determine whether the alternative cisplatin...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rose PG,Lappas PT

    更新日期:2000-07-01 00:00:00

  • Mucinous adenocarcinoma arising in rectovaginal fistulas associated with Crohn's disease.

    abstract:BACKGROUND:Crohn's disease is a chronic inflammatory disorder characterized by focal, transmural inflammation of the intestine. Gynecologic involvement, including rectovaginal fistula formation, is frequent. Case #1. A 53-year-old female with a 30-year history of Crohn's disease and numerous perirectal fistulas develop...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Moore-Maxwell CA,Robboy SJ

    更新日期:2004-04-01 00:00:00