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A phase II trial of dolastatin-10 in recurrent platinum-sensitive ovarian carcinoma: a Gynecologic Oncology Group study.

Abstract：

OBJECTIVE:To estimate the antitumor efficacy of dolastatin-10 in patients with measurable recurrences of platinum-sensitive ovarian carcinoma and to determine the nature and degree of toxicity of dolastatin-10 in these patients. METHODS:Patients received dolastatin-10 400 microg/m(2) intravenously every 3 weeks and tumor measurements were performed every one to two cycles. RESULTS:Of 28 patients evaluable for response, there were no complete or partial responses. Seven patients had stable disease and 21 patients had increasing disease. CONCLUSION:Dolastatin-10 has minimal activity in recurrent platinum-sensitive ovarian carcinoma at the dose and schedule tested.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Hoffman MA,Blessing JA,Lentz SS,Gynecologic Oncology Group Study.

doi

10.1016/s0090-8258(03)00007-6

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

95-8

issue

1

eissn

0090-8258

issn

1095-6859

pii

S0090825803000076

journal_volume

89

pub_type

临床试验,杂志文章,多中心研究

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