Invasive adenocarcinoma of the cervix following LLETZ (large loop excision of the transformation zone) for adenocarcinoma in situ.


:Adenocarcinoma in situ (AIS) of the cervix is a controversial entity which is being encountered with increasing frequency. Current critical issues in its management are the safety of uterine preservation in younger patients and the use of LLETZ conization. A 28-year-old patient was diagnosed with AIS and managed with LLETZ. Despite apparently negative margins of resection in the initial conizations, the patient was found to have invasive adenocarcinoma 1 year later. It is concluded, after review of the pathologic features of AIS, that if conservative management of AIS is elected, then standard cold knife conization should be performed and not LLETZ. Further study is required to establish the overall safety of conservative treatment of cervical AIS, including the use of LLETZ.


Gynecol Oncol


Gynecologic oncology


Kennedy AW,elTabbakh GH,Biscotti CV,Wirth S




Has Abstract


1995-08-01 00:00:00














  • The significance of perineural invasion in early-stage cervical cancer.

    abstract:INTRODUCTION:Cervical cancer spreads directly and through lymphatic and vascular channels. Perineural invasion is an alternative method of spread. Several risk factors portend poor prognosis and inform management decisions regarding adjuvant therapy. OBJECTIVE:To evaluate the incidence and significance of PNI in early...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Elsahwi KS,Barber E,Illuzzi J,Buza N,Ratner E,Silasi DA,Santin AD,Azodi M,Schwartz PE,Rutherford TJ

    更新日期:2011-12-01 00:00:00

  • HPV status in sentinel nodes might be a prognostic factor in cervical cancer.

    abstract:OBJECTIVE:Although there have been studies that focused on the correlation between the HPV presence of pelvic lymph nodes and pathological metastasis in patients with cervical cancer, the biologic role of HPV DNA in lymph nodes still remains uncertain. We performed this study to investigate the correlation between the ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Lee YS,Rhim CC,Lee HN,Lee KH,Park JS,Namkoong SE

    更新日期:2007-05-01 00:00:00

  • Distribution of intraperitoneally injected microspheres labeled with the alpha-emitter astatine (211At) compared with phosphorus (32P) and yttrium (90Y) colloids in mice.

    abstract::The alpha-emitter 211At was bound to polymer microspheres with a diameter of 1.8 microns. The distributions in mice of intraperitoneally injected 211At microspheres, 90Y silicate colloid, and 32P chromic phosphate colloid were compared. The microspheres with 211At spread rapidly in the peritoneal cavity and remained m...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Vergote I,Larsen RH,De Vos L,Winderen M,Ellingsen T,Bjørgum J,Hoff P,Aas M,Tropé C,Nustad K

    更新日期:1992-12-01 00:00:00

  • Targeting CD133 in an in vivo ovarian cancer model reduces ovarian cancer progression.

    abstract:OBJECTIVES:While most women with ovarian cancer will achieve complete remission after treatment, the majority will relapse within two years, highlighting the need for novel therapies. Cancer stem cells (CSC) have been identified in ovarian cancer and most other carcinomas as a small population of cells that can self-re...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Skubitz AP,Taras EP,Boylan KL,Waldron NN,Oh S,Panoskaltsis-Mortari A,Vallera DA

    更新日期:2013-09-01 00:00:00

  • Endometrial histopathology in 700 patients treated with tamoxifen for breast cancer.

    abstract:OBJECTIVE:The aim of this study was the evaluation of endometrial histopathologic findings from 700 patients treated with tamoxifen (Tx) for breast cancer from two medical centers (United States and France). METHODS:A retrospective review of data including histologic slides from 134 hysterectomies and 566 endometrial ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Deligdisch L,Kalir T,Cohen CJ,de Latour M,Le Bouedec G,Penault-Llorca F

    更新日期:2000-08-01 00:00:00

  • Utility of pre-operative serum CA-125 in the management of uterine papillary serous carcinoma.

    abstract:OBJECTIVE:To evaluate the usefulness of pre-operative serum CA-125 in the management of women diagnosed with uterine papillary serous carcinoma (UPSC). We hypothesized that elevated pre-operative levels of serum CA-125 correlate with higher disease stage and poorer prognosis. METHODS:Patients diagnosed with UPSC and m...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Olawaiye AB,Rauh-Hain JA,Withiam-Leitch M,Rueda B,Goodman A,del Carmen MG

    更新日期:2008-09-01 00:00:00

  • High cyclooxygenase-2 expression in cervical adenocarcinomas.

    abstract:OBJECTIVE:The purpose of this study was to examine the relationships between cyclooxygenase-2 (COX-2) expression and prognostic factors in cervical carcinomas. METHODS:We studied COX-2 expression in 53 women with cervical cancers, including 35 squamous cell carcinomas (SCCs), 1 adenosquamous cell carcinoma (ASCC), and...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Chen YJ,Wang LS,Wang PH,Lai CR,Yen MS,Ng HT,Yuan CC

    更新日期:2003-03-01 00:00:00

  • Progress in endometrial cancer: Contributions of the former Gynecologic Oncology Group.

    abstract::For over forty years, the Gynecologic Oncology Group drove progress in treating endometrial cancer. The first decades of investigation began with a meticulous prospective, surgicopathologic staging study that was the platform for development of all subsequent trials. The resultant statistical model of low risk, interm...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Miller DS,Randall ME,Filiaci V

    更新日期:2020-05-01 00:00:00

  • Mortality reduction and cost-effectiveness of performing hysterectomy at the time of risk-reducing salpingo-oophorectomy for prophylaxis against serous/serous-like uterine cancers in BRCA1 mutation carriers.

    abstract:OBJECTIVE:To estimate the survival benefit and cost-effectiveness of performing hysterectomy during risk-reducing salpingo-oophorectomy (RRSO) for BRCA1 mutation carriers. METHODS:Based on a recent prospective cohort study indicating an elevated incidence of serous/serous-like uterine cancers among BRCA1 mutation carr...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Havrilesky LJ,Moss HA,Chino J,Myers ER,Kauff ND

    更新日期:2017-06-01 00:00:00

  • Incidence of vulvar high-grade precancerous lesions and cancer in Denmark before and after introduction of HPV vaccination.

    abstract:OBJECTIVE:To assess the incidence of vulvar high-grade precancerous lesions and cancer in Denmark during 1997-2018. METHODS:We identified incident vulvar cancer cases in the Danish Cancer Registry and incident cases of vulvar precancerous lesions in the Danish Pathology Register. We calculated age-standardized inciden...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Rasmussen CL,Thomsen LT,Aalborg GL,Kjaer SK

    更新日期:2020-06-01 00:00:00

  • Use of complementary and alternative medicine among women with gynecologic cancers.

    abstract:OBJECTIVE:The aim of this study was to determine the prevalence and types of complementary and alternative medicine (CAM) usage by women with gynecologic cancer in an outpatient midwestern university practice. METHODS:Any patient with a gynecologic cancer seen in the outpatient clinic of the gynecologic oncology divis...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Swisher EM,Cohn DE,Goff BA,Parham J,Herzog TJ,Rader JS,Mutch DG

    更新日期:2002-03-01 00:00:00

  • Outcome of investigations for postmenopausal vaginal bleeding in women under the age of 50 years.

    abstract:OBJECTIVE:The objective of this study is to determine the incidence of endometrial cancer in young postmenopausal women presenting with vaginal bleeding. METHODS:Cross-sectional study of postmenopausal women presenting with vaginal bleeding in a gynaecological oncology centre in the United Kingdom. All women underwent...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Burbos N,Musonda P,Crocker SG,Morris EP,Duncan TJ,Nieto JJ

    更新日期:2012-04-01 00:00:00

  • Prevention of venous thromboembolism in gynecologic oncology surgery.

    abstract::Gynecologic oncology patients are at a high-risk of postoperative venous thromboembolism and these events are a source of major morbidity and mortality. Given the availability of prophylaxis regimens, a structured comprehensive plan for prophylaxis is necessary to care for this population. There are many prophylaxis s...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Barber EL,Clarke-Pearson DL

    更新日期:2017-02-01 00:00:00

  • Molecular characterization of circulating tumor cells in patients with ovarian cancer improves their prognostic significance -- a study of the OVCAD consortium.

    abstract:OBJECTIVE:The study aims at identifying novel markers for circulating tumor cells (CTCs) in patients with epithelial ovarian cancer (EOC), and at evaluating their impact on outcome. METHODS:Microarray analysis comparing matched EOC tissues and peripheral blood leucocytes (N=35) was performed to identify novel CTC mark...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Obermayr E,Castillo-Tong DC,Pils D,Speiser P,Braicu I,Van Gorp T,Mahner S,Sehouli J,Vergote I,Zeillinger R

    更新日期:2013-01-01 00:00:00

  • Primary appendiceal malignancy mimicking advanced stage ovarian carcinoma: a case series.

    abstract:BACKGROUND:Primary appendiceal malignancy metastatic to the ovaries is a rare condition that may mimic late stage ovarian cancer. This condition is rarely diagnosed preoperatively. CASES:Three patients referred to our institution from 1994 to 1999 for presumed late stage ovarian cancer were found to have primary appen...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: McBroom JW,Parker MF,Krivak TC,Rose GS,Crothers B

    更新日期:2000-09-01 00:00:00

  • Parametrial angiomyolipoma with multicystic change.

    abstract:BACKGROUND:Angiomyolipoma is a distinctive benign neoplasm of the renal origin. Rare extrarenal instances of angiomyolipoma have been documented at various body sites. A case of extrarenal angiomyolipoma arising from the parametrial soft tissues is described in the present report. CASE:A woman, age 40 years, presented...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Chopra R,Al-Mulhim AR,Hashish H

    更新日期:2003-07-01 00:00:00

  • Multicystic benign mesothelioma of the peritoneum presenting as postmenopausal bleeding and a solitary pelvic cyst--a case report.

    abstract:BACKGROUND:All non-invasive diagnostic algorithms suffer from diagnostic uncertainty in discriminating benign from malignant adnexal masses. CASE:We present a case where the identification of a large solitary multiloculated pelvic cyst in a woman with postmenopausal bleeding was shown to be multifocal multicystic beni...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Varma R,Wallace R

    更新日期:2004-01-01 00:00:00

  • Nibrin is a marker of clinical outcome in patients with advanced serous ovarian cancer treated in the phase III OVA-301 trial.

    abstract:OBJECTIVE:This study investigated the relationship between 13 proteins involved in DNA damage and the outcomes of patients with recurrent ovarian cancer (ROC). PATIENTS AND METHODS:Immunohistochemistry staining was performed in 114 diagnostic samples from patients with serous ROC who participated in the OVA-301 study,...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Monk BJ,Kaye SB,Poveda A,Herzog TJ,Aracil M,Nieto A,Badri N,Parekh TV,Tanović A,Galmarini CM

    更新日期:2014-01-01 00:00:00

  • Monitoring cancer antigen 125 levels in induction chemotherapy for epithelial ovarian carcinoma and predicting outcome of second-look procedure.

    abstract::A retrospective analysis of 45 patients with epithelial ovarian carcinoma who underwent second-look procedure after initial cytoreduction and platinum-based combination chemotherapy was undertaken. Each patient was evaluated for the result of CA 125 after a third course of chemotherapy, the result of CA 125 prior to s...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Folk JJ,Botsford M,Musa AG

    更新日期:1995-05-01 00:00:00

  • Expression of multidrug resistance-1 protein inversely correlates with paclitaxel response and survival in ovarian cancer patients: a study in serial samples.

    abstract:OBJECTIVES:The role of MDR1 in clinical paclitaxel resistance remains poorly characterized. This study sought to identify the incidence and significance of P-glycoprotein (P-gp) over-expression on survival, tumor response to paclitaxel and the effect of prior cytotoxic exposure on P-gp expression in patients with paire...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Penson RT,Oliva E,Skates SJ,Glyptis T,Fuller AF Jr,Goodman A,Seiden MV

    更新日期:2004-04-01 00:00:00

  • Conservative surgery in stage I adult type granulosa cells tumors of the ovary: Results from the MITO-9 study.

    abstract:OBJECTIVE:About 30% of Adult type granulosa cell tumors of the ovary (AGCTs) are diagnosed in fertile age. In stage I, conservative surgery (fertility-sparing surgery, FSS), either unilateral salpingo-oophorectomy (USO) or cystectomy are possible options. The aim of this study is to compare oncological outcomes of FSS ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Bergamini A,Cormio G,Ferrandina G,Lorusso D,Giorda G,Scarfone G,Bocciolone L,Raspagliesi F,Tateo S,Cassani C,Savarese A,Breda E,De Giorgi U,Mascilini F,Candiani M,Kardhashi A,Biglia N,Perrone AM,Pignata S,Mangili G

    更新日期:2019-08-01 00:00:00

  • Hexamethylmelamine as first-line chemotherapy in the treatment of advanced or recurrent carcinoma of the endometrium: a phase II trial of the Gynecologic Oncology Group.

    abstract::Thirty-eight patients with advanced or recurrent carcinoma of the endometrium who had received no prior chemotherapy were placed on study by the Gynecologic Oncology Group. One was deemed histologically ineligible. Three patients had insufficient trials to evaluate response. Of the remaining 34 who received hexamethyl...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Thigpen JT,Blessing JA,Ball H,Hanjani P,Manetta A,Homesley H

    更新日期:1988-11-01 00:00:00

  • Primary mucinous cystoadenocarcinoma of the retroperitoneum: two cases.

    abstract::Two cases of primary retroperitoneal mucinous cystoadenocarcinoma of the ovarian type are reported. Both tumors occurred in females with bilateral normal ovaries and contained benign, borderline, and malignant mucinous epithelium. Full-thickness infiltration of the cyst wall was not found. In addition to surgery, one ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Tenti P,Carnevali L,Tateo S,Durola R

    更新日期:1994-11-01 00:00:00

  • Human papillomavirus analysis as a prognostic marker following conization of the cervix uteri.

    abstract::Cervical intraepithelial neoplasia grade 3 (CIN 3) is treated surgically. Follow-up of these patients is important to ensure successful treatment. The present study was undertaken to determine whether human papillomavirus (HPV) testing can be used to discriminate patients who will have recurrences from those who will ...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Chua KL,Hjerpe A

    更新日期:1997-07-01 00:00:00

  • Ovarian cancer tumor infiltrating T-regulatory (T(reg)) cells are associated with a metastatic phenotype.

    abstract:OBJECTIVE:The objective of this study was to examine the clinicopathologic correlates of T-regulatory (T(reg)) cell infiltration in serous ovarian cancers and to define gene signatures associated with high T(reg)s. METHODS:Tumor infiltrating T(reg) and cytotoxic T-cells (CTLs) were quantitated in 232 primary serous ov...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Barnett JC,Bean SM,Whitaker RS,Kondoh E,Baba T,Fujii S,Marks JR,Dressman HK,Murphy SK,Berchuck A

    更新日期:2010-03-01 00:00:00

  • Isolated recurrence at the residual uterine cervix after abdominal radical trachelectomy for early cervical cancer.

    abstract:BACKGROUND:We report an isolated recurrence at the residual cervix shortly after abdominal radical trachelectomy for cervical cancer. CASE:A 34-year-old woman underwent radical abdominal trachelectomy and pelvic lymphadenectomy for FIGO stage IB1 squamous cell cervical cancer. The tumor measured 10 mm in maximum diame...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Bader AA,Tamussino KF,Moinfar F,Bjelic-Radisic V,Winter R

    更新日期:2005-12-01 00:00:00

  • Ovarian serous carcinoma presenting with mediastinal lymphadenopathy 20 months before the intraabdominal mass: role of immunohistochemistry.

    abstract:INTRODUCTION:Metastatic involvement of the mediastinal lymph nodes is an extremely uncommon finding in epithelial ovarian cancers. CASE REPORT:A 63-year-old woman was admitted to hospital for dyspnoea due to an anterior mediastinal mass. The surgical biopsy showed a 6-cm metastatic lymph node with a papillary pattern,...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Zannoni GF,Vellone VG,Distefano MG,Fadda G,Scambia G

    更新日期:2007-02-01 00:00:00

  • How accurate is frozen section histology of pelvic lymph nodes in patients with endometrial cancer?

    abstract:OBJECTIVE:Recent prospective data support the trend towards systematic retroperitoneal lymphadenectomy in patients with high-risk endometrial cancer. Because para-aortic node involvement in the absence of pelvic node involvement is uncommon, a reliable finding of negative pelvic lymph nodes (PLN) at intraoperative froz...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Pristauz G,Bader AA,Regitnig P,Haas J,Winter R,Tamussino K

    更新日期:2009-10-01 00:00:00

  • Conservative management in primary genital lymphomas: the role of chemotherapy.

    abstract:BACKGROUND:The female genital lymphomas are an extremely rare disease accounting for less than 0.5% of gynecological cancers and for 1.5% of all NHL. Because of their low incidence there is no widely accepted consensus on its treatment. Literature data support a radiotherapy-based treatment in case of primary genital l...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Signorelli M,Maneo A,Cammarota S,Isimbaldi G,Garcia Parra R,Perego P,Maria Pogliani E,Mangioni C

    更新日期:2007-02-01 00:00:00

  • Human papillomavirus load in Hybrid Capture II assay: does increasing the cutoff improve the test?

    abstract:OBJECTIVE:The aim of the study was to evaluate whether the results of the Hybrid Capture II (HCII) assay for detecting high-grade squamous intraepithelial lesions (H-SIL) or cervical carcinoma can be improved by increasing the relative light units (RLU) level. STUDY DESIGN:We included 2271 women (mean age 38.7 +/- 12....

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Ordi J,Alonso I,Torné A,Esteve R,Sierra E,Campo E,Puig-Tintoré LM

    更新日期:2005-11-01 00:00:00