Abstract:
OBJECTIVE:We sought to determine whether DNA ploidy correlates with the four molecular subgroups of endometrial carcinoma (EC) as determined using ProMisE (Proactive Molecular Risk Classifier for Endometrial Cancer). METHODS:90 cases of EC previously characterized by clinicopathological parameters, outcomes, and ProMisE molecular subgroup (POLE EDM, MMR-D, p53 wt or p53 abn) were assessed for DNA ploidy using image cytometry. Associations of ploidy with traditional clinicopathological parameters were also tested. RESULTS:Abnormal DNA ploidy status differed amongst the ProMisE groups (p<0.001) and was found in 80.9% (17/21) of p53 abn, 37.0% (10/27) of p53 wt, 28.6% (4/14) of POLE EDM and 14.3% (4/28) of MMR-D. Abnormal DNA content was significantly associated with lower BMI (p=0.034) and grade 3 tumors (p=0.001). In the entire cohort, abnormal DNA content was significantly associated with worse progression free survival (p=0.0094) but not disease specific survival (p=0.249) or overall survival (p=0.187). When examining ploidy within each of the ProMisE groups, abnormal DNA content correlated with worse overall survival (p=0.041) and progression free survival (p=0.011) in the MMR-D group. No statistically significant relationship was seen in the remaining 3 groups. CONCLUSION:Abnormal DNA ploidy status did correlate with the molecular subgroups of EC; abnormal DNA content was seen in the large majority of p53 abn cases. Abnormal ploidy however was also seen in smaller numbers in the p53 wt, POLE EDM and MMR-D groups; therefore abnormal DNA content was not a specific marker for any one molecular group. The addition of ploidy to the ProMisE molecular categories conferred additional prognostic value within the MMR-D group, which merits further study.
journal_name
Gynecol Oncoljournal_title
Gynecologic oncologyauthors
Proctor L,Pradhan M,Leung S,Cheng A,Lee CH,Soslow RA,Gilks CB,Talhouk A,McAlpine JM,Danielsen HE,Hoang LNdoi
10.1016/j.ygyno.2017.06.020subject
Has Abstractpub_date
2017-09-01 00:00:00pages
596-602issue
3eissn
0090-8258issn
1095-6859pii
S0090-8258(17)30961-7journal_volume
146pub_type
杂志文章abstract:OBJECTIVE:The purpose of this study is to evaluate the significance of the c-Met/hepatocyte growth factor receptor expression in invasive cervical carcinoma. METHODS:Ninety-Four patients with FIGO stage 1B disease, treated primarily with surgery, were studied immunohistochemically. Of the cases, 67 were squamous carci...
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pub_type: 杂志文章
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doi:10.1006/gyno.1999.5506
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journal_title:Gynecologic oncology
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journal_title:Gynecologic oncology
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pub_type: 杂志文章,多中心研究
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journal_title:Gynecologic oncology
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更新日期:1998-03-01 00:00:00
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更新日期:2004-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.ygyno.2004.10.002
更新日期:2005-02-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2018-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1006/gyno.1999.5573
更新日期:1999-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1006/gyno.1993.1059
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更新日期:2018-12-01 00:00:00
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更新日期:2007-12-01 00:00:00
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更新日期:2019-02-01 00:00:00
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doi:10.1016/0090-8258(90)90343-j
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-08-01 00:00:00
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更新日期:2012-09-01 00:00:00
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doi:10.1006/gyno.1999.5588
更新日期:1999-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1006/gyno.1998.5194
更新日期:1998-12-01 00:00:00
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更新日期:2007-01-01 00:00:00