Voiding recovery after radical parametrectomy in cervical cancer patients: An international prospective multicentre trial - SENTIX.


OBJECTIVE:Voiding dysfunctions represent a leading morbidity after radical hysterectomy performed in patients with early-stage cervical cancer. The aim of this study was to perform ad hoc analysis of factors influencing voiding recovery in SENTIX (SENTinel lymph node biopsy in cervIX cancer) trial. METHODS:The SENTIX trial (47 sites, 18 countries) is a prospective study on sentinel lymph node biopsy without pelvic lymphadenectomy in patients with early-stage cervical cancer. Overall, the data of 300 patients were analysed. Voiding recovery was defined as the number of days from surgery to bladder catheter/epicystostomy removal or to post-voiding urine residuum ≤50 mL. RESULTS:The median voiding recovery time was three days (5th-95th percentile: 0-21): 235 (78.3%) patients recovered in <7 days and 293 (97.7%) in <30 days. Only seven (2.3%) patients recovered after >30 days. In the multivariate analysis, only previous pregnancy (p = 0.033) and type of parametrectomy (p < 0.001) significantly influenced voiding recovery >7 days post-surgery. Type-B parametrectomy was associated with a higher risk of delayed voiding recovery than type-C1 (OR = 4.69; p = 0.023 vs. OR = 3.62; p = 0.052, respectively), followed by type-C2 (OR = 5.84; p = 0.011). Both previous pregnancy and type C2 parametrectomy independently prolonged time to voiding recovery by two days. CONCLUSIONS:Time to voiding recovery is significantly related to previous pregnancy and type of parametrectomy but it is not influenced by surgical approach (open vs minimally invasive), age, or BMI. Type B parametrectomy, without direct visualisation of nerves, was associated with longer recovery than nerve-sparing type C1. Importantly, voiding dysfunctions after radical surgery are temporary, and the majority of the patients recover in less than 30 days, including patients after C2 parametrectomy.


Gynecol Oncol


Gynecologic oncology


Zapardiel I,Kocian R,Köhler C,Klat J,Germanova A,Jacob A,Bajsova S,Böhmer G,Lay L,Gil-Ibañez B,Havelka P,Kipp B,Szewczyk G,Toth R,Staringer JC,De Santiago J,Coronado PJ,Poka R,Laky R,Luyckx M,Fastrez M,Dusek L,




Has Abstract


2021-01-05 00:00:00








  • Combined PET/CT for detecting recurrent ovarian cancer limited to retroperitoneal lymph nodes.

    abstract:OBJECTIVE:To evaluate the utility of combined positron emission tomography/computed tomography (PET/CT) for detecting recurrent epithelial ovarian cancer limited to retroperitoneal adenopathy. METHODS:Fourteen patients (median age = 53 years) with rising serum CA125 levels, and negative or equivocal conventional CT im...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Bristow RE,Giuntoli RL 2nd,Pannu HK,Schulick RD,Fishman EK,Wahl RL

    更新日期:2005-11-01 00:00:00

  • Neurotropic desmoplastic melanoma: a rare vulvar malignancy.

    abstract::Melanoma represents the second most frequent vulvar malignancy, and yet is still considered to be an uncommon neoplasm. Several varieties of melanoma exist. A patient who was diagnosed with a rare subtype of melanoma as a primary vulvar process is presented here. To date, there is only one other reported case of neuro...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Byrne PR,Maiman M,Mikhail A,Harris M,Rosen Y

    更新日期:1995-02-01 00:00:00

  • A phase II study of cetuximab/paclitaxel/carboplatin for the initial treatment of advanced-stage ovarian, primary peritoneal, or fallopian tube cancer.

    abstract:OBJECTIVE:Determine the safety and efficacy of cetuximab plus paclitaxel and carboplatin as initial treatment of stage III/IV ovarian cancer. METHODS:An initial intravenous [IV] dose of cetuximab (400 mg/m(2)) was administered over 120 min followed by weekly IV infusions of cetuximab (250 mg/m(2)) administered over 60...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Konner J,Schilder RJ,DeRosa FA,Gerst SR,Tew WP,Sabbatini PJ,Hensley ML,Spriggs DR,Aghajanian CA

    更新日期:2008-08-01 00:00:00

  • The opioid growth factor (OGF) and low dose naltrexone (LDN) suppress human ovarian cancer progression in mice.

    abstract:OBJECTIVE:The opioid growth factor (OGF) and its receptor, OGFr, serve as a tonically active inhibitory axis regulating cell proliferation in normal cells and a variety of cancers, including human ovarian cancer. Blockade of OGF and OGFr with the nonselective opioid receptor antagonist naltrexone (NTX) upregulates expr...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Donahue RN,McLaughlin PJ,Zagon IS

    更新日期:2011-08-01 00:00:00

  • The value of surgical staging in patients with apparent early stage epithelial ovarian carcinoma.

    abstract:OBJECTIVE:The value of surgical staging of apparent early stage epithelial ovarian carcinoma (EOC) is unclear. The aim of this study was to evaluate the importance of surgical staging on the stage of disease and treatment plan. MATERIAL AND METHODS:All patients with apparent stage I EOC undergoing staging from 01/01/2...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Hengeveld EM,Zusterzeel PLM,Lajer H,Høgdall CK,Rosendahl M

    更新日期:2019-08-01 00:00:00

  • A retrospective study of tamoxifen and endometrial cancer in breast cancer patients.

    abstract:OBJECTIVE:To assess the relationship between low-dose tamoxifen, usage and endometrial cancer in breast cancer patients. METHODS:In this case-control study, the records of the 1017 patients treated at Wilford Hall Medical Center for primary breast cancer between 1978 and 1989 were reviewed. Dose and duration of tamoxi...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Robinson DC,Bloss JD,Schiano MA

    更新日期:1995-11-01 00:00:00

  • Preoperative hypoalbuminemia is an independent predictor of poor perioperative outcomes in women undergoing open surgery for gynecologic malignancies.

    abstract:OBJECTIVE:To quantify the impact of preoperative hypoalbuminemia on 30-day mortality and morbidity after gynecologic cancer surgery. METHODS:Patients included in the National Surgical Quality Improvement Program (NSQIP) dataset who underwent any non-emergent surgery for gynecologic malignancy between 1/1/2008 and 12/3...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Uppal S,Al-Niaimi A,Rice LW,Rose SL,Kushner DM,Spencer RJ,Hartenbach E

    更新日期:2013-11-01 00:00:00

  • Use of complementary and alternative medicine among women with gynecologic cancers.

    abstract:OBJECTIVE:The aim of this study was to determine the prevalence and types of complementary and alternative medicine (CAM) usage by women with gynecologic cancer in an outpatient midwestern university practice. METHODS:Any patient with a gynecologic cancer seen in the outpatient clinic of the gynecologic oncology divis...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Swisher EM,Cohn DE,Goff BA,Parham J,Herzog TJ,Rader JS,Mutch DG

    更新日期:2002-03-01 00:00:00

  • Resection of recurrent ovarian or fallopian tube carcinoma involving the liver.

    abstract:OBJECTIVES:Patients who develop recurrent ovarian of fallopian tube carcinoma involving the liver often have disease refractory to chemotherapy and carry a poor prognosis. The impact of aggressive resection in this patient population is unclear. METHODS:From 1/1988 to 9/2001, 24 patients with recurrent ovarian or fall...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Yoon SS,Jarnagin WR,Fong Y,DeMatteo RP,Barakat RR,Blumgart LH,Chi DS

    更新日期:2003-11-01 00:00:00

  • Tolfenamic acid inhibits ovarian cancer cell growth and decreases the expression of c-Met and survivin through suppressing specificity protein transcription factors.

    abstract:OBJECTIVE:The aberrant expression of hepatocyte growth factor and its receptor c-Met are associated with aggressive disease and poor prognosis in a variety of human malignancies including ovarian cancer (OC). Specificity protein (Sp) transcription factors have high relevance in the signaling cascade associated with c-M...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Basha R,Ingersoll SB,Sankpal UT,Ahmad S,Baker CH,Edwards JR,Holloway RW,Kaja S,Abdelrahim M

    更新日期:2011-07-01 00:00:00

  • Studies on the distribution of abnormal cells in cytological smears. VII. Cervical brush versus plastic and wooden spatulas.

    abstract::A model system of exfoliated normal human cervicovaginal squamous cells, exfoliated rodent tumor cells, and acellular, viscous, mucuslike material was used to investigate cell deposition on smear preparations made with three different instruments: plastic spatulas, wooden spatulas, and brush-tipped collectors. The tot...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Rubio CA,Kock Y,Stormby N,Porwit A

    更新日期:1990-11-01 00:00:00

  • Placental site trophoblastic tumor: analysis of presentation, treatment, and outcome.

    abstract:OBJECTIVE:Placental-site trophoblastic tumor (PSTT) is the rarest form of gestational trophoblastic disease (GTD). A risk-adapted treatment approach has been advocated, but controversy exists as to the most important prognostic markers for this disease. Our goal was to determine the prognostic markers for patients with...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Hyman DM,Bakios L,Gualtiere G,Carr C,Grisham RN,Makker V,Sonoda Y,Aghajanian C,Jewell EL

    更新日期:2013-04-01 00:00:00

  • Clinically inapparent invasive vulvar carcinoma in an area of persistent Paget's disease: a case report.

    abstract:BACKGROUND:Invasive vulvar carcinoma is reported to occur in 5 to 20% of patients with vulvar Paget's disease. We report a case in which a clinically inapparent invasive lesion was discovered on reexcision of microscopically persistent vulvar Paget's disease. CASE:A 58-year-old woman presented with a diagnosis of vulv...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Awtrey CS,Marshall DS,Soslow RA,Chi DS

    更新日期:2003-03-01 00:00:00

  • Gene expression profiling of in vitro radiation resistance in cervical carcinoma: a feasibility study.

    abstract:OBJECTIVE(S):To determine the feasibility of integrating an in vitro chemo-radiation response assay (IVRRA) with a gene microarray system to investigate the molecular patterns of expression that contribute to radiation resistance in cervical cancer. METHODS:Viable primary untreated cervical cancer specimens were obtai...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Tewari D,Monk BJ,Al-Ghazi MS,Parker R,Heck JD,Burger RA,Fruehauf JP

    更新日期:2005-10-01 00:00:00

  • Outcome of investigations for postmenopausal vaginal bleeding in women under the age of 50 years.

    abstract:OBJECTIVE:The objective of this study is to determine the incidence of endometrial cancer in young postmenopausal women presenting with vaginal bleeding. METHODS:Cross-sectional study of postmenopausal women presenting with vaginal bleeding in a gynaecological oncology centre in the United Kingdom. All women underwent...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Burbos N,Musonda P,Crocker SG,Morris EP,Duncan TJ,Nieto JJ

    更新日期:2012-04-01 00:00:00

  • Who finds cervical laser therapy painful?

    abstract::To identify women who find outpatient laser cervical surgery painful we designed a prospective observational study correlating surgical pain with multiple variables. The pain scoring systems were validated by comparing the subjective linear analogue score with an objective scoring method. The pain of surgery was compa...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Johnson N,Crompton AC

    更新日期:1994-01-01 00:00:00

  • Survival implications of staging lymphadenectomy for non-endometrioid endometrial cancers.

    abstract:PURPOSE:To determine, in patients with non-endometrioid endometrial carcinoma, 1) survival benefit associated with pelvic lymphadenectomy (LND), 2) survival benefit for para-aortic lymphadenectomy performed in addition to pelvic lymphadenectomy, and 3) association between number of lymph nodes removed and survival. ME...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Venigalla S,Chowdhry AK,Shalowitz DI

    更新日期:2018-06-01 00:00:00

  • Introduction of transperitoneal lymphadenectomy in a gynecologic oncology center: analysis of 650 laparoscopic pelvic and/or paraaortic transperitoneal lymphadenectomies.

    abstract:OBJECTIVE:Lymphadenectomy is an integral part of staging and treatment of gynecologic malignancies. We evaluated the feasibility and oncologic value of laparoscopic transperitoneal pelvic and paraaortic lymphadenectomy in correlation to complication rate and body mass index. METHODS:Between August 1994 and September 2...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Köhler C,Klemm P,Schau A,Possover M,Krause N,Tozzi R,Schneider A

    更新日期:2004-10-01 00:00:00

  • Intraepithelial neoplasia in the vulvar region.

    abstract::From 1978 to 1982, 49 patients with intraepithelial neoplasia in the vulvar region were included in a prospective investigation. The main purpose was to evaluate the effect of treatment by local excision with a free margin of 2 mm and to estimate the importance of colposcopy. In 28% of the patients, the disease recurr...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Andreasson B,Bock JE

    更新日期:1985-07-01 00:00:00

  • Consolidation paclitaxel is more cost-effective than bevacizumab following upfront treatment of advanced epithelial ovarian cancer.

    abstract:INTRODUCTION:Randomized trials have demonstrated significant improvements in progression-free survival (PFS) with consolidation paclitaxel (P) and bevacizumab (B) following cytoreduction and adjuvant carboplatin/paclitaxel (CP) for advanced epithelial ovarian cancer (EOC). We sought to evaluate the cost-effectiveness (...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Lesnock JL,Farris C,Krivak TC,Smith KJ,Markman M

    更新日期:2011-09-01 00:00:00

  • Intermediate-term results of trans-abdominal ultrasound (TAUS)-guided brachytherapy in cervical cancer.

    abstract:OBJECTIVES:To report the intermediate-term results of trans-abdominal ultrasound (TAUS)-guided brachytherapy in cervical cancer. MATERIALS AND METHODS:Ninety-two patients with cervical cancer (stage IB-IVA, according to FIGO staging), were treated by curative radiotherapy from February 2012 to June 2015. All patients ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Tharavichitkul E,Chakrabandhu S,Klunklin P,Onchan W,Jia-Mahasap B,Wanwilairat S,Tippanya D,Jayasvasti R,Sripan P,Galalae RM,Chitapanarux I

    更新日期:2018-03-01 00:00:00

  • Preoperative predictors of positive margins after loop electrosurgical excisional procedure-Cone.

    abstract:OBJECTIVE:A LEEP-Cone may not be necessary for all patients with traditional cone indications. This study defines populations where a single pass technique with the LEEP is appropriate. METHODS:We retrospectively reviewed patients undergoing LEEP-Cone procedures performed at the University of Oklahoma Health Science C...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Tillmanns TD,Falkner CA,Engle DB,Wan JY,Mannel RS,Walker JL,Johnson GA,McMeekin DS,Zuna R,Gold MA

    更新日期:2006-02-01 00:00:00

  • Fatty acid composition of lysophosphatidic acid and lysophosphatidylinositol in plasma from patients with ovarian cancer and other gynecological diseases.

    abstract:OBJECTIVE:We previously reported that plasma levels of total lysophosphatidic acid (LPA) represented a potential biomarker for ovarian cancer and other gynecological cancers [1]. However, total LPA is composed of different LPA species with distinct fatty acid chains. The major objective of the current study, therefore,...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Shen Z,Wu M,Elson P,Kennedy AW,Belinson J,Casey G,Xu Y

    更新日期:2001-10-01 00:00:00

  • Utility of pre-operative serum CA-125 in the management of uterine papillary serous carcinoma.

    abstract:OBJECTIVE:To evaluate the usefulness of pre-operative serum CA-125 in the management of women diagnosed with uterine papillary serous carcinoma (UPSC). We hypothesized that elevated pre-operative levels of serum CA-125 correlate with higher disease stage and poorer prognosis. METHODS:Patients diagnosed with UPSC and m...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Olawaiye AB,Rauh-Hain JA,Withiam-Leitch M,Rueda B,Goodman A,del Carmen MG

    更新日期:2008-09-01 00:00:00

  • Sentinel lymph node biopsy in the management of early-stage cervical carcinoma.

    abstract:OBJECTIVES:We aimed to determine the sentinel lymph node detection rates, accuracy in predicting the status of lymph node metastasis, and if pathologic ultrastaging improves the detection of micrometastases and isolated tumor cells at the time of primary surgery for cervical cancer. METHODS:A prospective, non-randomiz...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Diaz JP,Gemignani ML,Pandit-Taskar N,Park KJ,Murray MP,Chi DS,Sonoda Y,Barakat RR,Abu-Rustum NR

    更新日期:2011-03-01 00:00:00

  • Tumor budding and E-Cadherin expression in endometrial carcinoma: are they prognostic factors in endometrial cancer?

    abstract:OBJECTIVE:To evaluate the prognostic value of tumor budding (TB) in endometrioid (EEC) and non-endometrioid endometrial cancers (NEEC) and to determine its correlation with expression of E-cadherin. METHODS:Ninety-five patients with primary endometrial carcinoma were examined statistically. All patients were diagnosed...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Koyuncuoglu M,Okyay E,Saatli B,Olgan S,Akin M,Saygili U

    更新日期:2012-04-01 00:00:00

  • Clinical outcomes in patients with isolated serous tubal intraepithelial carcinoma (STIC): A comprehensive review.

    abstract::OBJECTIVE. Serous tubal intraepithelial carcinoma (STIC) is currently considered the precursor lesion of pelvic (i.e., ovarian or peritoneal) high-grade serous carcinoma. The incidence of STIC has been reported to range from 0.6% to 7% in BRCA mutations carriers. However, the clinical outcome of patients with 'isolate...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Patrono MG,Iniesta MD,Malpica A,Lu KH,Fernandez RO,Salvo G,Ramirez PT

    更新日期:2015-12-01 00:00:00

  • TP53 hot spot mutations in ovarian cancer: selective resistance to microtubule stabilizers in vitro and differential survival outcomes from The Cancer Genome Atlas.

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    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Seagle BL,Yang CP,Eng KH,Dandapani M,Odunsi-Akanji O,Goldberg GL,Odunsi K,Horwitz SB,Shahabi S

    更新日期:2015-07-01 00:00:00

  • Increased serum levels of 5-S-cysteinyldopa and intercellular adhesion molecule-1 in a patient with a uterine amelanotic metastasis from a primary vaginal malignant melanoma.

    abstract::A 75-year-old Japanese woman, who had an enlarged uterus and two nodules on the anterior vaginal wall, underwent wide excision of the anterior vaginal wall, bilateral inguinal lymphadenectomy, modified radical hysterectomy, and pelvic lymph node dissection. Her serum level of 5-S-cysteinyldopa (5-S-CD) was elevated, b...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Suenaga Y,Katabuchi H,Okamura H,Kageshita T,Ono T

    更新日期:1999-01-01 00:00:00

  • Immunization with adenoviral vectors carrying recombinant IL-12 and E7 enhanced the antitumor immunity to human papillomavirus 16-associated tumor.

    abstract:OBJECTIVE:Human papillomavirus (HPV) infection play a significant role in cervical carcinogenesis, and HPV oncoprotein E7 has important functions in the formation and maintenance of cervical cancers. Interleukin-12 (IL-12) has been reported to induce cellular immune responses, and has also been demonstrated to suppress...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Jin HS,Park EK,Lee JM,NamKoong SE,Kim DG,Lee YJ,Jun HJ,Han BD,Bae SM,Ahn WS

    更新日期:2005-05-01 00:00:00