Potential of RASSF1A promoter methylation as biomarker for endometrial cancer: A systematic review and meta-analysis.

Abstract:

BACKGROUND:An epigenetic approach to explaining endometrial carcinogenesis necessitates good understanding of Ras association domain family 1 isoform A (RASSF1A) promoter methylation data from primary studies. AIMS:Differential magnitude of reported associations between RASSF1A promoter methylation and endometrial cancer (EC) prompted a meta-analysis to obtain more precise estimates. METHODS:Literature search yielded eight included articles. We calculated pooled odds ratios (OR) and 95% confidence intervals and subgrouped the data by race. Sources of heterogeneity were investigated with outlier analysis. RESULTS:The pooled ORs indicated increased risk, mostly significant. The overall effect (OR 11.46) was reflected in the European outcome (OR 15.07). However, both findings were heterogeneous (I2=57-70%) which when subjected to outlier treatment, erased heterogeneity (I2=0%) and retained significance (OR 9.85-12.66). Significance of these pre- and post-outlier outcomes were pegged at P≤0.0001. Only the Asian pre-outlier (OR 6.85) and heterogeneous (I2=82%) outcome was not significant (P=0.12) but when subjected to outlier treatment, erased heterogeneity (I2=0%) and generated significance (OR 23.74, P≤0.0001). CONCLUSIONS:Consistent increased risk associations underpinned by significance and robustness render RASSF1A with good biomarker potential for EC.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Pabalan N,Kunjantarachot A,Ruangpratheep C,Jarjanazi H,Christofolini DM,Barbosa CP,Bianco B

doi

10.1016/j.ygyno.2017.06.017

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

603-608

issue

3

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(17)30957-5

journal_volume

146

pub_type

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