Potential of RASSF1A promoter methylation as biomarker for endometrial cancer: A systematic review and meta-analysis.


BACKGROUND:An epigenetic approach to explaining endometrial carcinogenesis necessitates good understanding of Ras association domain family 1 isoform A (RASSF1A) promoter methylation data from primary studies. AIMS:Differential magnitude of reported associations between RASSF1A promoter methylation and endometrial cancer (EC) prompted a meta-analysis to obtain more precise estimates. METHODS:Literature search yielded eight included articles. We calculated pooled odds ratios (OR) and 95% confidence intervals and subgrouped the data by race. Sources of heterogeneity were investigated with outlier analysis. RESULTS:The pooled ORs indicated increased risk, mostly significant. The overall effect (OR 11.46) was reflected in the European outcome (OR 15.07). However, both findings were heterogeneous (I2=57-70%) which when subjected to outlier treatment, erased heterogeneity (I2=0%) and retained significance (OR 9.85-12.66). Significance of these pre- and post-outlier outcomes were pegged at P≤0.0001. Only the Asian pre-outlier (OR 6.85) and heterogeneous (I2=82%) outcome was not significant (P=0.12) but when subjected to outlier treatment, erased heterogeneity (I2=0%) and generated significance (OR 23.74, P≤0.0001). CONCLUSIONS:Consistent increased risk associations underpinned by significance and robustness render RASSF1A with good biomarker potential for EC.


Gynecol Oncol


Gynecologic oncology


Pabalan N,Kunjantarachot A,Ruangpratheep C,Jarjanazi H,Christofolini DM,Barbosa CP,Bianco B




Has Abstract


2017-09-01 00:00:00














  • Uterine papillary serous carcinoma (UPSC): a clinicopathologic study of 30 cases.

    abstract::Between 1975 and 1989, 896 patients were treated for endometrial carcinoma at the Massachusetts General Hospital. Thirty patients were identified from the tumor registry as having uterine papillary serous carcinomas. The survival for all patients and for groups of patients stratified on clinical and pathological param...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kato DT,Ferry JA,Goodman A,Sullinger J,Scully RE,Goff BA,Fuller AF Jr,Rice LW

    更新日期:1995-12-01 00:00:00

  • Relationship of nonstaging pathological risk factors to lymph node metastasis and recurrence in clinical stage I endometrial carcinoma.

    abstract:OBJECTIVE:To determine if DNA ploidy, hormone receptors, vascular space invasion (VSI), perivascular lymphocytes (PVL), and the oncogenes HER-2/neu, p53, and bcl-2 are independent prognostic indicators for lymph node metastasis and cancer recurrence in clinical stage I endometrial carcinoma. METHODS:Among 349 patients...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Bell JG,Minnick A,Reid GC,Judis J,Brownell M

    更新日期:1997-09-01 00:00:00

  • Proceedings of a GOG workshop on intraperitoneal therapy for ovarian cancer.

    abstract::Ovarian cancer is the leading cause of gynecologic cancer deaths in the U.S. The concept of intraperitoneal drug delivery for therapy of intraperitoneal cancers, such as ovarian cancer, arose in the 1960s. The field of intraperitoneal cisplatin therapy for ovarian cancer was initiated in the late 1970s and early 1980s...

    journal_title:Gynecologic oncology

    pub_type: 共识发展会议,杂志文章


    authors: Alberts DS,Markman M,Muggia F,Ozols RF,Eldermire E,Bookman MA,Chen T,Curtin J,Hess LM,Liebes L,Young RC,Trimble E

    更新日期:2006-12-01 00:00:00

  • Contracting for professional service agreements.

    abstract::A review of several professional service agreements (PSA) of managed care organizations which contract with gynecologic oncologists in the Southern California area demonstrates several distinct patterns of practice restrictions and financial benefits which can help guide the physician who is considering signing such a...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Berman ML

    更新日期:1995-08-01 00:00:00

  • Salvage therapy in ovarian cancer: is there a role for intraperitoneal drug delivery?

    abstract::Phase 2 trials employing several antineoplastic agents have demonstrated that surgically documented responses, including complete responses, can result when patients with ovarian cancer are treated by the intraperitoneal route in the salvage setting following initial systemic chemotherapy. Activity is essentially limi...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Markman M

    更新日期:1993-10-01 00:00:00

  • Tumor reduction surgery and long-term survival in advanced ovarian cancer: a DACOVA study.

    abstract::Three hundred sixty-one patients with FIGO stage III and IV ovarian cancer were treated with cis-platinum combination chemotherapy in a Danish multicenter trial. Primary surgery was performed at 58 different departments; 32% of the patients were operated at a department associated with an oncologic center, 50% at a ge...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Bertelsen K

    更新日期:1990-08-01 00:00:00

  • Frailty: an outcome predictor for elderly gynecologic oncology patients.

    abstract:OBJECTIVES:The objective of this pilot study was to determine if frailty predicts surgical complications among elderly women undergoing gynecologic oncology procedures. METHODS:A cohort of gynecologic oncology patients age ≥ 65, undergoing surgery between March and December 2011 was identified. Frailty was evaluated u...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Courtney-Brooks M,Tellawi AR,Scalici J,Duska LR,Jazaeri AA,Modesitt SC,Cantrell LA

    更新日期:2012-07-01 00:00:00

  • A case of ovarian cancer with remote metastases, with emphasis on changes in tumor marker values.

    abstract:BACKGROUND:The prognosis of cancer patients with distant metastases is extremely poor. CASE:A 51-year-old Japanese woman with Stage IIIc serous cystoadenocarcinoma of the ovary achieved complete remission. At 30 and 39 months after the initiation of therapy, solitary brain and then spleen metastases without intraperit...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Mikami M,Suzuki A,Takehara K,Komiyama S,Ishikawa M,Hirose T

    更新日期:2003-08-01 00:00:00

  • Effects of beta-carotene and other factors on outcome of cervical dysplasia and human papillomavirus infection.

    abstract::Women with histopathologically confirmed cervical intraepithelial neoplasia (CIN) were followed at 3-month intervals in a randomized double-blinded trial to evaluate the efficacy of beta-carotene to cause regression of CIN. Questionnaire data, plasma levels of micronutrients, and a cervicovaginal lavage for human papi...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Romney SL,Ho GY,Palan PR,Basu J,Kadish AS,Klein S,Mikhail M,Hagan RJ,Chang CJ,Burk RD

    更新日期:1997-06-01 00:00:00

  • Pre-operative imaging, surgery and adjuvant therapy for women diagnosed with cancer of the corpus uteri in community practice in the United States.

    abstract:INTRODUCTION:Non-Hispanic black women are less often diagnosed with endometrial cancer than are non-Hispanic white women, but are more likely to die of their disease. Reasons for this disparity in outcome are not well understood. METHODS:The Surveillance, Epidemiology, and End-Results Program data were used to sample ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Trimble EL,Harlan LC,Clegg LX,Stevens JL

    更新日期:2005-03-01 00:00:00

  • 667C>T and 1298A>C polymorphisms of MTHFR do not predict response to methotrexate in patients with gestational trophoblastic neoplasia.

    abstract:OBJECTIVE:Approximately one third of patients treated with methotrexate for gestational trophoblastic neoplasia (GTN) following a molar pregnancy are reported to develop resistance to methotrexate and need to change to different chemotherapeutic agents. Previous studies, in other clinical settings, have suggested that ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Lasecka L,Dixon PH,Molokhia M,Sharma N,Schleh A,Wang CM,Steel JH,Seckl MJ,Savage PM,Fisher RA

    更新日期:2011-12-01 00:00:00

  • Analysis of common variations in tumor-suppressor genes on chr1p36 among Caucasian women with endometriosis.

    abstract:OBJECTIVE:Epidemiological data indicate that endometriosis increases the risk of epithelial ovarian cancer (EOC), but the mechanism of cancer transition is unknown. Results from genome-wide association studies (GWAS) and transcriptome sequencing have demonstrated that genes located in the 1p36 region are important in b...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Falconer H,Sundqvist J,Xu H,Vodolazkaia A,Fassbender A,Kyama C,Bokor A,D'Hooghe TM

    更新日期:2012-11-01 00:00:00

  • The use of methylprednisolone and metoclopramide in control of emesis in patients receiving cis-platinum.

    abstract::cis-Platinum is a chemotherapeutic agent with benefits often limited by the severe gastrointestinal reactions it produces in nearly all patients. Persistent anorexia, nausea, and vomiting may continue for days after therapy and are poorly controlled by conventional antiemetics. Patients at times refuse continuation of...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Benrubi GI,Norvell M,Nuss RC,Robinson H

    更新日期:1985-07-01 00:00:00

  • Mucinous adenocarcinoma arising in rectovaginal fistulas associated with Crohn's disease.

    abstract:BACKGROUND:Crohn's disease is a chronic inflammatory disorder characterized by focal, transmural inflammation of the intestine. Gynecologic involvement, including rectovaginal fistula formation, is frequent. Case #1. A 53-year-old female with a 30-year history of Crohn's disease and numerous perirectal fistulas develop...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Moore-Maxwell CA,Robboy SJ

    更新日期:2004-04-01 00:00:00

  • ras oncogene product p21 expression and prognosis of human ovarian tumors.

    abstract::Monoclonal antibody rp-28 directed against the ras gene product p21 has been studied to evaluate ras p21 expression in malignant and benign ovarian tissues. Some ovarian carcinomas of serous and mucinous cystadenocarcinomas, undifferentiated adenocarcinomas, and clear cell carcinomas demonstrated intense staining of r...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Yaginuma Y,Yamashita K,Kuzumaki N,Fujita M,Shimizu T

    更新日期:1992-07-01 00:00:00

  • Feasibility, safety and clinical outcomes of cardiophrenic lymph node resection in advanced ovarian cancer.

    abstract:OBJECTIVES:Surgical resection of enlarged cardiophrenic lymph nodes (CPLNs) in primary treatment of advanced ovarian cancer has not been widely studied. We report on a cohort of patients undergoing CPLN resection during primary cytoreductive surgery (CRS), examining its feasibility, safety, and potential impact on clin...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Cowan RA,Tseng J,Murthy V,Srivastava R,Long Roche KC,Zivanovic O,Gardner GJ,Chi DS,Park BJ,Sonoda Y

    更新日期:2017-11-01 00:00:00

  • Plasmin modulators, aprotinin and anti-catalytic plasmin antibody, efficiently inhibit destruction of bovine vascular endothelial cells by choriocarcinoma cells.

    abstract::The interaction of human gestational choriocarcinoma cell line, SMT-cc1, with bovine vascular endothelial cells, CPAE, was examined in an in vitro coculture model. SMT-cc1 cells have urokinase-type plasminogen activator (uPA) on their cell surface, and more than half of the cell-associated uPA is enzymatically inactiv...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Sugimura M,Kobayashi H,Terao T

    更新日期:1994-03-01 00:00:00

  • Vulval Keratoacanthoma: a case report.

    abstract:BACKGROUND:Vulval Keratoacanthoma (KA) is very rare and its differential diagnosis from the commonly occurring Vulval Squamous Cell Carcinoma (SCC) is important to avoid overtreatment. CASE:A case of Vulval KA in a 79-year-old lady is reported. She presented with a 9-mm firm raised lesion on the antero-lateral left si...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Nascimento MC,Cominos D,Davies NJ,Obermair A

    更新日期:2005-05-01 00:00:00

  • Parametrial angiomyolipoma with multicystic change.

    abstract:BACKGROUND:Angiomyolipoma is a distinctive benign neoplasm of the renal origin. Rare extrarenal instances of angiomyolipoma have been documented at various body sites. A case of extrarenal angiomyolipoma arising from the parametrial soft tissues is described in the present report. CASE:A woman, age 40 years, presented...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Chopra R,Al-Mulhim AR,Hashish H

    更新日期:2003-07-01 00:00:00

  • Advanced vulvar carcinoma treated with internal iliac arterial embolization therapy after radiotherapy.

    abstract::Two patients with vulvar carcinoma are reported who were treated with internal iliac transcatheter arterial embolization and radiotherapy. Patient 1 had T3N3M0 vulvar carcinoma. The lesion remaining after radiotherapy was treated by bilateral internal iliac arterial embolization. Vulvectomy was then performed, and the...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Harima Y,Shiraishi T,Harima K,Tanaka Y

    更新日期:1990-10-01 00:00:00

  • Increased risk of secondary uterine leiomyosarcoma in hereditary retinoblastoma.

    abstract:OBJECTIVE:In the US, second non-ocular malignancies are the primary cause of death in retinoblastoma survivors with the germline RB1 mutation. Soft tissue sarcomas are one of the most likely malignancies to pose a risk to these patients, with leiomyosarcoma (LMS) being the most common subtype. As our cohort is followed...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Francis JH,Kleinerman RA,Seddon JM,Abramson DH

    更新日期:2012-02-01 00:00:00

  • Quantitative metabolic parameters measured on F-18 FDG PET/CT predict survival after relapse in patients with relapsed epithelial ovarian cancer.

    abstract:OBJECTIVE:This study aimed to evaluate the prognostic value of quantitative metabolic parameters measured on F-18 FDG PET/CT (FDG PET/CT) at the time of the first relapse in patients with relapsed epithelial ovarian cancer (EOC). METHODS:Fifty-six relapsed EOC patients were retrospectively included. Quantitative metab...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kim CY,Jeong SY,Chong GO,Son SH,Jung JH,Kim DH,Lee SW,Ahn BC,Lee J

    更新日期:2015-03-01 00:00:00

  • Tolfenamic acid inhibits ovarian cancer cell growth and decreases the expression of c-Met and survivin through suppressing specificity protein transcription factors.

    abstract:OBJECTIVE:The aberrant expression of hepatocyte growth factor and its receptor c-Met are associated with aggressive disease and poor prognosis in a variety of human malignancies including ovarian cancer (OC). Specificity protein (Sp) transcription factors have high relevance in the signaling cascade associated with c-M...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Basha R,Ingersoll SB,Sankpal UT,Ahmad S,Baker CH,Edwards JR,Holloway RW,Kaja S,Abdelrahim M

    更新日期:2011-07-01 00:00:00

  • Predictive and prognostic angiogenic markers in a gynecologic oncology group phase II trial of bevacizumab in recurrent and persistent ovarian or peritoneal cancer.

    abstract:OBJECTIVE:Potential predictive/prognostic angiogenic markers were prospectively examined in a phase II trial of bevacizumab in epithelial ovarian cancer (EOC)/primary peritoneal cancer (PPC). METHODS:Recurrent/persistent EOC/PPC patients were treated with bevacizumab (15 mg/kg IV q21days) until disease progression. Va...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Han ES,Burger RA,Darcy KM,Sill MW,Randall LM,Chase D,Parmakhtiar B,Monk BJ,Greer BE,Connelly P,Degeest K,Fruehauf JP

    更新日期:2010-12-01 00:00:00

  • Analysis of gastric-type mucinous carcinoma of the uterine cervix - An aggressive tumor with a poor prognosis: A multi-institutional study.

    abstract:OBJECTIVE:Gastric-type mucinous carcinoma (GAS) is a novel variant of mucinous carcinoma of the uterine cervix. As shown in the original Japanese group description, in recent studies, GAS represents a more aggressive disease than the usual-type endocervical adenocarcinoma (UEA). Detailed clinicopathological features of...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Nishio S,Mikami Y,Tokunaga H,Yaegashi N,Satoh T,Saito M,Okamoto A,Kasamatsu T,Miyamoto T,Shiozawa T,Yoshioka Y,Mandai M,Kojima A,Takehara K,Kaneki E,Kobayashi H,Kaku T,Ushijima K,Kamura T

    更新日期:2019-04-01 00:00:00

  • Effect of recombinant human tumor necrosis factor on A2774 human ovarian cancer cell line: potentiation of mitoxantrone cytotoxicity.

    abstract::Recombinant human tumor necrosis factor (rHuTNF) is a macrophage-secretory protein with antitumor activity. In vivo and in vitro cytotoxicity studies have been carried out to test the effectiveness of rHuTNF alone or in combination with chemotherapeutic agents. We have evaluated the direct cytotoxic effect of rHuTNF o...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Vigani A,Chiara S,Miglietta L,Repetto L,Conte PF,Cimoli G,Morelli L,Billi G,Parodi S,Russo P

    更新日期:1991-04-01 00:00:00

  • Regional lymph node recurrence following local excision for microinvasive vulvar carcinoma.

    abstract::A case of microinvasive squamous cell carcinoma of the vulva is reported in which regional lymph node recurrence was noted after excisional therapy. Review of the initial pathology revealed only 0.72 mm of invasion. The results of a literature survey regarding microinvasive vulvar carcinoma are discussed. ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Atamdede F,Hoogerland D

    更新日期:1989-07-01 00:00:00

  • Endocrine therapy in endometrial cancer: An old dog with new tricks.

    abstract::One of the most prevalent potential therapeutic targets for women with endometrioid endometrial cancer (EC) is the estrogen receptor (ER)/progesterone receptor (PR) pathway. Despite a high proportion of endometrioid ECs being ER and/or PR positive, endocrine therapy is only effective in a minority of women with EC and...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Jerzak KJ,Duska L,MacKay HJ

    更新日期:2019-04-01 00:00:00

  • Contribution of human papillomavirus testing by hybrid capture in the triage of women with repeated abnormal pap smears before colposcopy referral.

    abstract:OBJECTIVE:The purpose of this work was to evaluate the ability of testing for high-risk human papillomavirus (HPV) types using the hybrid capture technique to predict the presence of cervical intraepithelial neoplasia (CIN) II,III in patients with repeated atypical squamous cells of undetermined significance (ASCUS) an...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Fait G,Kupferminc MJ,Daniel Y,Geva E,Ron IG,Lessing JB,Bar-Am A

    更新日期:2000-11-01 00:00:00

  • Radical hysterectomy followed by tailored postoperative therapy in the treatment of stage IB2 cervical cancer: feasibility and indications for adjuvant therapy.

    abstract:OBJECTIVE:To determine the outcome, complications and likelihood of requiring adjuvant therapy of patients with stage IB2 cervical cancer treated with primary radical hysterectomy and lymph node dissection. METHODS:Clinical and pathologic data between 1985 and 1999 were reviewed. Associations between clinical and path...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Yessaian A,Magistris A,Burger RA,Monk BJ

    更新日期:2004-07-01 00:00:00