Abstract：
:Two cases of peritonitis carcinomatosa with gynecological cancer, which did not respond to conventional treatment, were treated by intraperitoneal adoptive immunotherapy with allogeneic or autologous lymphokine-activated killer (LAK) cells plus interleukin-2. In case 1, reduction of acute ascites and disappearance of malignant cells from the peritoneal fluid and decreased levels of tumor markers (CA12-5 and CA19-9) were demonstrated during the treatment. In case 2, which also received additional treatment for pleuritis carcinomatosa, reduction of ascites and pleural effusion and disappearance of malignant cells from the pleural fluid were noted. In these cases allogeneic LAK therapy was well tolerated. This therapy did not prolong the patients' lives, but the findings indicate that it had appreciable local antitumor effects on peritonitis and pleuritis carcinomatosa in these patients with gynecological cancer.
journal_name
Gynecol Oncoljournal_title
Gynecologic oncologyauthors
Kamada M,Sakamoto Y,Furumoto H,Mori K,Daitoh T,Irahara M,Aono T,Nii A,Yanagawa H,Sone Sdoi
10.1016/0090-8258(89)90101-7subject
Has Abstract,Author List Incompletepub_date
1989-07-01 00:00:00pages
34-7issue
1eissn
0090-8258issn
1095-6859journal_volume
34pub_type
杂志文章abstract：OBJECTIVE:Hyperglycosylated hCG (hCG-H) is a glycosylation variant of hCG produced by cytotrophoblast cells at implantation of pregnancy and in choriocarcinoma. We investigated the biological function of hCG-H in invasion in vitro and in vivo and the use of hCG-H antibodies in blocking tumorigenesis and cancer growth i...
journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1016/j.ygyno.2005.12.047
更新日期：2006-08-01 00:00:00
abstract：OBJECTIVE:The concept of "platinum sensitivity" has been widely applied in the management of recurrent ovarian cancer. This study aimed to evaluate the applicability of this concept to recurrent endometrial cancer. PATIENTS AND METHODS:In this multicenter retrospective cohort study, the clinical data of patients with ...
journal_title：Gynecologic oncology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ygyno.2013.09.021
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:The combination ascites, pleural effusion, and elevated CA 125 are usually associated with a malignancy. CASE:A 38-year-old SLE patient consulted her physician for shortness of breath. On clinical examination, she had a tender abdomen and reduced breathing sounds. X-ray and computed tomography of the chest ...
journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1016/j.ygyno.2004.12.022
更新日期：2005-04-01 00:00:00
abstract：:Aggressive tumor reduction surgery has been widely used in patients with advanced stage epithelial ovarian carcinoma before initiation of cytotoxic chemotherapy. No randomized controlled trial has been carried out to confirm the benefits of such procedures. To examine the role of cytoreductive surgery in the managemen...
journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1006/gyno.1997.4839
更新日期：1997-11-01 00:00:00
abstract：:Non-healing wounds represent a significant cause of morbidity and mortality for a large portion of the adult population. Wounds that fail to heal are entrapped in a self-sustaining cycle of chronic inflammation leading to the destruction of the extracellular matrix. Among cancer patients, malnutrition, radiation, phys...
journal_title：Gynecologic oncology
pub_type： 杂志文章,评审
doi：10.1016/j.ygyno.2008.07.052
更新日期：2008-11-01 00:00:00
abstract：OBJECTIVES:Few studies have comprehensively tested all ovarian cancer patients for BRCA1 and BRCA2 (BRCA1/2) mutations. We sought to determine if clinically identified mutation carriers differed in clinical characteristics and outcomes from mutation carriers not identified during routine clinical care. METHODS:We incl...
journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1016/j.ygyno.2012.12.015
更新日期：2013-03-01 00:00:00
abstract：:Phase 2 trials employing several antineoplastic agents have demonstrated that surgically documented responses, including complete responses, can result when patients with ovarian cancer are treated by the intraperitoneal route in the salvage setting following initial systemic chemotherapy. Activity is essentially limi...
journal_title：Gynecologic oncology
pub_type： 杂志文章,评审
doi：10.1006/gyno.1993.1251
更新日期：1993-10-01 00:00:00
abstract：OBJECTIVE:Links between obesity, with its attendant estrogen abnormalities, and the endometrial carcinoma (EC) DNA Mismatch Repair Protein (MMR) system have recently been proposed. We investigated relationships between body mass index (BMI) and clinicopathological correlates including MMR expression in a large single i...
journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1016/j.ygyno.2014.01.017
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVE:UPSC is similar to papillary serous ovarian carcinoma in its histology and pattern of spread. The survival advantage with optimal debulking for ovarian cancer has been demonstrated. We examined our experience with UPSC. METHODS:Seventy-eight UPSC patients were seen between 1995 and 2008 at Rush University Me...
journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1016/j.ygyno.2010.11.048
更新日期：2011-06-01 00:00:00
abstract：:The ovary is a relatively frequent site of metastasis from malignant neoplasia arising elsewhere in the body, the majority of these originating from the GI tract. The best known tumor of this type is signet-ring cell adenocarcinoma (Krukenberg tumor) of gastric origin. The gall bladder and bile ducts are rare sources ...
journal_title：Gynecologic oncology
pub_type： 杂志文章,评审
doi：10.1016/0090-8258(92)90120-8
更新日期：1992-11-01 00:00:00
abstract：:The purpose of this study was to evaluate the serum tumor markers CYFRA 21-1 and squamous-cell carcinoma antigen (SCC) in the follow-up of squamous-cell cervical cancer patients. One hundred-ninety-three serum samples, which were collected pretherapeutically and during follow-up of 30 patients suffering from squamous-...
journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1006/gyno.1995.1071
更新日期：1995-03-01 00:00:00
abstract：PURPOSE:The aim of this study was to compare survival outcomes of total abdominal radical hysterectomy (TARH) versus laparoscopy-assisted radical vaginal hysterectomy (LARVH) in stage IA2-IB2 cervical cancer. METHODS:812 patients who underwent RH between 2008 and 2017 were evaluated in 3 institutions. Progression-free...
journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1016/j.ygyno.2020.09.035
更新日期：2020-12-01 00:00:00
abstract：:Thirty patients with uterine papillary serous carcinoma were treated with intravenous cisplatin, doxorubicin, and cyclophosphamide (CAP) chemotherapy, a combination with proven efficacy against ovarian carcinoma. Nineteen patients were given CAP as an adjuvant soon after surgery. Eleven patients were treated after rec...
journal_title：Gynecologic oncology
pub_type： 临床试验,杂志文章
doi：10.1006/gyno.1993.1308
更新日期：1993-12-01 00:00:00
abstract：OBJECTIVE:The conditionally replicative adenovirus Ad5/3-Δ24 has a type-3 knob incorporated into the type-5 fiber that facilitates enhanced ovarian cancer infectivity. Preclinical studies have shown that Ad5/3-Δ24 achieves significant oncolysis and anti-tumor activity in ovarian cancer models. The purpose of this study...
journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1016/j.ygyno.2013.06.003
更新日期：2013-09-01 00:00:00
abstract：OBJECTIVES:A phase II clinical trial compared docetaxel in combination with carboplatin to sequential single agent docetaxel followed by carboplatin for treatment of recurrent platinum-sensitive ovarian, peritoneal, or tubal cancer. This manuscript reports prospectively collected health-related quality of life (HRQL). ...
journal_title：Gynecologic oncology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ygyno.2011.08.015
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVE:This study sought to develop and examine preliminary validity of the NCCN-FACT Ovarian Symptom Index-18 (NFOSI-18), a new ovarian cancer-specific symptom index comprised of symptoms rated as highest priority by both oncology clinical experts and women with advanced ovarian cancer. METHODS:Fifty-one women wit...
journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1016/j.ygyno.2010.09.025
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:BRCA1 mutation carriers have a high rate of both breast and ovarian cancer. Tamoxifen is a selective estrogen receptor modulator (SERM), which is used for the treatment of primary breast cancer and for the prevention of contralateral breast cancer. Our objective is to assess if tamoxifen treatment is associat...
journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1016/j.ygyno.2009.06.012
更新日期：2009-10-01 00:00:00
abstract：PURPOSE:The goal of this study was to determine whether South African HIV-seropositive women with invasive cervical cancer present with disease that is more advanced than that of HIV-seronegative women and whether degree of immunosuppression affects the extent of disease at initial presentation. METHODS:This study is ...
journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1006/gyno.2000.5775
更新日期：2000-06-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to analyze our experience with colorectal function preservation at the time of pelvic exenteration. METHODS:Between January 1980 and December 2001, 201 pelvic exenterations for gynecologic malignancies were performed in our hospital. Ninety-eight were supralevator exenteration...
journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1016/s0090-8258(03)00069-6
更新日期：2003-04-01 00:00:00
abstract：OBJECTIVE:Our objective is to examine how selenium (Se) supplementation influences oxidative stress (malondialdehyde) and the glutathione peroxidase system in patients with ovarian cancer undergoing chemotherapy. MATERIAL:The study group included 31 patients with ovarian cancer undergoing chemotherapy receiving the dr...
journal_title：Gynecologic oncology
pub_type： 临床试验,杂志文章
doi：10.1016/j.ygyno.2003.12.013
更新日期：2004-05-01 00:00:00
abstract：:Objective. Thegoal of this study was to determine the influence of LVSI (lymphvascular space involvement) on the risk of lymph node metastases from endometrial cancer.Methods. All patients with surgically staged endometrial cancer from 1998 to 2000 were identified from divisional databases. The influence of LVSI on th...
journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1006/gyno.2002.6825
更新日期：2002-12-01 00:00:00
abstract：:A retrospective evaluation of 87 cases of uterine sarcoma treated during 1965-1980 at two Swedish hospitals has been made. Adjuvant postoperative radiotherapy has been compared with adjuvant chemotherapy. Various types of combination treatments were also evaluated. Both types of adjuvant therapy seem to reduce the fai...
journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1016/0090-8258(85)90209-4
更新日期：1985-03-01 00:00:00
abstract：OBJECTIVE:Previous studies by the Gynecologic Oncology Group have demonstrated a 7% response rate with bolus etoposide as second-line therapy in nonsquamous cell carcinoma of the cervix. Prolonged oral etoposide, which exploits the schedule dependency of this agent, has demonstrated increased activity in squamous carci...
journal_title：Gynecologic oncology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/s0090-8258(03)00079-9
更新日期：2003-05-01 00:00:00
abstract：OBJECTIVE:To compare the validities of magnetic resonance imaging (MRI) and (18)F-fluoro-deoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) in preoperative evaluation of uterine carcinosarcoma. METHODS:Pathologic results of primary tumor lesions and paraaortic and pelvic lymph node (LN) a...
journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1016/j.ygyno.2016.01.009
更新日期：2016-03-01 00:00:00
abstract：:A case of Stage IIIC primary ovarian leiomyosarcoma in a premenopausal woman with multiple recurrences alive and well 7 years after diagnosis is presented. In addition to the typical light microscopic, immunohistochemical, and electron microscopic features of ovarian leiomyosarcoma, the tumor was progesterone receptor...
journal_title：Gynecologic oncology
pub_type： 杂志文章,评审
doi：10.1006/gyno.1997.4824
更新日期：1997-09-01 00:00:00
abstract：:Gynecologic oncology patients are at a high-risk of postoperative venous thromboembolism and these events are a source of major morbidity and mortality. Given the availability of prophylaxis regimens, a structured comprehensive plan for prophylaxis is necessary to care for this population. There are many prophylaxis s...
journal_title：Gynecologic oncology
pub_type： 杂志文章,评审
doi：10.1016/j.ygyno.2016.11.036
更新日期：2017-02-01 00:00:00
abstract：:After standard management of stage III-IV ovarian cancer patients by surgical reduction of tumor mass and subsequent cisplatin-based combination chemotherapy, eradication of residual intraabdominal disease remains a major clinical problem. In an effort to increase response to therapy without adding marrow toxicity, af...
journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1016/0090-8258(90)90304-4
更新日期：1990-04-01 00:00:00
abstract：:Episiotomy scar tumor implantation arising from a cervical carcinoma is rare. This report details a patient who developed an episiotomy implant from a "microinvasive" adenocarcinoma of the cervix 5 months following vaginal delivery. The implant behaved as a primary focus for metastases to the inguinal lymph nodes. Des...
journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1006/gyno.1995.0025
更新日期：1995-11-01 00:00:00
abstract：:In a study of 73 patients, diagnosed with recurrent squamous cell carcinoma of the vulva between 1975 and 1990, the effect of clinical variables on the outcome was evaluated. The overall 5-year survival rate was 35.2%. Of the 73 patients, 33 (45.2%) originally had Stage I or II disease and 40 (54.8%) Stage III or IVA;...
journal_title：Gynecologic oncology
pub_type： 杂志文章,评审
doi：10.1006/gyno.1993.1032
更新日期：1993-02-01 00:00:00
abstract：OBJECTIVE:To estimate the antitumor efficacy of dolastatin-10 in patients with measurable recurrences of platinum-sensitive ovarian carcinoma and to determine the nature and degree of toxicity of dolastatin-10 in these patients. METHODS:Patients received dolastatin-10 400 microg/m(2) intravenously every 3 weeks and tu...
journal_title：Gynecologic oncology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/s0090-8258(03)00007-6
更新日期：2003-04-01 00:00:00
