Treatment for fertility and risk of ovarian tumors of borderline malignancy.

abstract：:Two postmenopausal patients with stage I adenocarcinoma of the endometrium who were managed with a combined laparoscopic and vaginal approach are presented. Surgical-pathologic staging was performed laparoscopically, with exploration of the abdomen and procurement of peritoneal cytology and pelvic and para-aortic lymp...

journal_title：Gynecologic oncology

authors： Childers JM,Surwit EA

更新日期：1992-04-01 00:00:00

abstract：OBJECTIVE:To test whether platelets could increase invasion potential and initiate EMT in ovarian cancer cells via a TGF-β signaling pathway. METHODS:Blood samples were collected in 69 patients with ovarian cancer, 16 patients with benign ovarian tumor and 64 healthy donors. SK-OV-3 and OVCAR-3 ovarian cancer cells we...

journal_title：Gynecologic oncology

authors： Guo Y,Cui W,Pei Y,Xu D

更新日期：2019-06-01 00:00:00

abstract：:Clear cell carcinoma of the ovary accounts for 2 to 3% of all epithelial ovarian neoplasms. Patient profiles, pathological characteristics, and results of treatment are reviewed for 59 patients. The median age was 51. Disease extent at diagnosis was as follows: stage I, 18 patients (31%); stage II, 20 patients (34%); ...

journal_title：Gynecologic oncology

authors： Crozier MA,Copeland LJ,Silva EG,Gershenson DM,Stringer CA

更新日期：1989-11-01 00:00:00

abstract：OBJECTIVES:Platinum-containing chemotherapeutic drugs have high response rates yet are known to cause hypersensitivity reactions. Attempts have been made to rechallenge allergic patients with prolonged desensitization infusion regimens. CASE:A female with advanced peritoneal cancer went into remission after six cycles...

journal_title：Gynecologic oncology

authors： McElroy TM,Gruenigen VE,Waggoner SE

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:Current therapy for cervical cancer includes radiation therapy. Retinoic acid (RA) can increase the sensitivity of cervical cancer cell lines to radiation. The mechanism of this sensitization may not involve the p53 protein because the human papillomavirus (HPV) E6 protein, which is present in the majority of...

journal_title：Gynecologic oncology

authors： Tillmanns TD,Kamelle SA,Guruswamy S,Gould NS,Rutledge TL,Benbrook DM

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:We wished to compare the cost-effectiveness of three chemotherapy regimens for treatment of recurrent platinum-sensitive ovarian cancer. METHODS:A Markov decision tree was constructed comparing three chemotherapy regimens: (1) carboplatin alone (C); (2) paclitaxel/carboplatin (PC); (3) gemcitabine/carboplati...

journal_title：Gynecologic oncology

authors： Havrilesky LJ,Secord AA,Kulasingam S,Myers E

更新日期：2007-11-01 00:00:00

abstract：:The steroid receptor content of the primary endometrial cancer of 22 patients who were treated for recurrent or advanced disease has been measured and correlated with response to medroxyprogesterone acetate. No patient with a progesterone receptor (PR)-negative tumor responded and only 2 patients with PR-positive tumo...

journal_title：Gynecologic oncology

authors： Quinn MA,Cauchi M,Fortune D

更新日期：1985-07-01 00:00:00

abstract：OBJECTIVE:Mismatch repair (MMR) deficiency and Bethesda panel microsatellite instability (MSI) are increasingly analyzed to identify tumors that might benefit from immune checkpoint inhibitors, but tumor heterogeneity is a potential obstacle for such analyses. In ovarian cancer, data on intratumoral heterogeneity of MM...

journal_title：Gynecologic oncology

authors： Fraune C,Rosebrock J,Simon R,Hube-Magg C,Makrypidi-Fraune G,Kluth M,Büscheck F,Höflmayer D,Schmalfeldt B,Müller V,Wölber L,Witzel I,Paluchowski P,Wilke C,Heilenkötter U,von Leffern I,Clauditz TS,Wilczak W,Sauter G,S

更新日期：2020-03-01 00:00:00

abstract：:A patient with three synchronous, Stage I neoplasms of the ovary, kidney, and lung, who underwent resection of all lesions at the same operative procedure, is presented. The incidence of multiple primary malignancies and the prognosis for Stage I cancers of the ovary, kidney, and lung are reviewed. ...

journal_title：Gynecologic oncology

authors： Ringler GE,Senekjian EK,Smith FL,Little AG,Clinton S,Stephens JK

更新日期：1989-04-01 00:00:00

abstract：:Two cases with squamous cell carcinoma of the cervix stage IIB with primary tumor mass about 2 X 2 X 2 cm were treated with primary chemotherapy of cis-platinum, 20 micrograms/m2 body surface intravenously daily for 5 consecutive days. Papanicolaou smear turned negative after two courses of chemotherapy in both cases....

journal_title：Gynecologic oncology

authors： Kim DS,Moon H,Kang KJ

更新日期：1985-09-01 00:00:00

abstract：OBJECTIVE:To assess the safety and efficacy of pegylated liposomal doxorubicin (PLD), carboplatin, plus bevacizumab in patients with ovarian, fallopian tube, or primary peritoneal cancer. METHODS:Patients with platinum-sensitive, recurrent disease received PLD 30 mg/m(2) and carboplatin area under the curve (AUC) 5 on...

journal_title：Gynecologic oncology

authors： del Carmen MG,Micha J,Small L,Street DG,Londhe A,McGowan T

更新日期：2012-09-01 00:00:00

abstract：:Iatrogenic immune suppression following renal transplantation is frequently associated with certain neoplasms, including vulvar carcinoma. We describe a patient with a vulvar carcinoma less than 1 mm depth of invasion and less than 3 mm superficial spread 12 years after renal transplantation. A simple vulvectomy was p...

journal_title：Gynecologic oncology

authors： Volgger B,Marth C,Zeimet A,Müller-Holzner E,Ruth N,Dapunt O

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVE:Currently available tumor markers for ovarian cancer are still inadequate in both sensitivity and specificity to be used for population-based screening. Artificial neural network (ANN) as a modeling tool has demonstrated its ability to assimilate information from multiple sources and to detect subtle and comp...

journal_title：Gynecologic oncology

authors： Zhang Z,Yu Y,Xu F,Berchuck A,van Haaften-Day C,Havrilesky LJ,de Bruijn HW,van der Zee AG,Woolas RP,Jacobs IJ,Skates S,Chan DW,Bast RC Jr

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:Recent studies of ovarian cancer have suggested a role for inflammation in carcinogenesis. Data from a population-based case-control study in Hawaii were examined to assess the relation between polymorphisms in cytokines involved with the inflammatory response, specifically members of the interleukin (IL) fam...

journal_title：Gynecologic oncology

authors： Bushley AW,Ferrell R,McDuffie K,Terada KY,Carney ME,Thompson PJ,Wilkens LR,Tung KH,Ness RB,Goodman MT

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVES:Lymph node status is an important prognostic factor in patients with squamous cell carcinoma (SCC) of the vulva. Complete inguinofemoral lymph node dissection (ILND) is accompanied by a high morbidity. Sentinel lymph node biopsy (SLNB) was established for less invasive lymph node (LN) staging. The aim of thi...

journal_title：Gynecologic oncology

authors： Johann S,Klaeser B,Krause T,Mueller MD

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVES:We have previously shown that high activity of lactate dehydrogenase (LD) isoenzymes 4 and 5 in terine aspirates is a marker for endometrial carcinoma. The purpose of this study was to identify an abnormal activity profile of LD2-5 using LD1 as an internal standard, thereby being able to dispense with measur...

journal_title：Gynecologic oncology

authors： Niklasson O,Skude G,Marsal K,Casslén B

更新日期：2004-05-01 00:00:00

abstract：:From 1980 to 1987, 30 patients with FIGO clinical Stage II carcinoma of the endometrium were treated with 5000 cGy preoperative pelvic radiation therapy at Thomas Jefferson University Hospital. Patients with gross cervical disease received additional intracavitary irradiation with a tandem and ovoids for a combined to...

journal_title：Gynecologic oncology

authors： Reisinger SA,Staros EB,Feld R,Mohiuddin M,Lewis GC

更新日期：1992-05-01 00:00:00

abstract：PURPOSE:To evaluate the impact of the extension of the radiotherapy field cranially toward para-aortic lymph nodes (EF-RT) in advanced cervical cancer. MATERIALS AND METHODS:A systematic search of databases (PubMed, CENTRAL, Clinical Trials) was performed and included studies that were published between 1960 and Novem...

journal_title：Gynecologic oncology

authors： Sapienza LG,Gomes MJL,Calsavara VF,Leitao MM Jr,Baiocchi G

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:To quantify the effect of race/ethnicity on risk of complete and partial molar pregnancy. METHODS:We conducted a cross-sectional study including women who were followed for complete or partial mole and those who had a live singleton birth in a teaching hospital in the northeastern United States between 2000 ...

journal_title：Gynecologic oncology

authors： Melamed A,Gockley AA,Joseph NT,Sun SY,Clapp MA,Goldstein DP,Berkowitz RS,Horowitz NS

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:Approximately one third of patients treated with methotrexate for gestational trophoblastic neoplasia (GTN) following a molar pregnancy are reported to develop resistance to methotrexate and need to change to different chemotherapeutic agents. Previous studies, in other clinical settings, have suggested that ...

journal_title：Gynecologic oncology

authors： Lasecka L,Dixon PH,Molokhia M,Sharma N,Schleh A,Wang CM,Steel JH,Seckl MJ,Savage PM,Fisher RA

更新日期：2011-12-01 00:00:00

abstract：:CA125 and CA19-9 levels were serially evaluated in blood samples from 21 patients during and after integrated surgical and chemotherapeutic treatment for ovarian carcinoma. Serial measurement of CA125 and CA19-9 correlated with clinical course of disease in 89.7 and 72.7% of instances, respectively. The decrease of se...

journal_title：Gynecologic oncology

authors： Fioretti P,Gadducci A,Ferdeghini M,Bartolini T,Bianchi R,Facchini V

更新日期：1987-11-01 00:00:00

abstract：OBJECTIVE:Heredity is a major cause of ovarian cancer and during recent years the contribution from germline mismatch repair (MMR) gene mutations linked to Lynch syndrome has gradually been recognized. METHODS:We characterized clinical features, tumor morphology and mismatch repair defects in all ovarian cancers ident...

journal_title：Gynecologic oncology

authors： Ketabi Z,Bartuma K,Bernstein I,Malander S,Grönberg H,Björck E,Holck S,Nilbert M

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:To investigate differences in local tumour staging between clinical examination and MRI and differences between FIGO 2009, FIGO 2018 and TNM in patients with primary cervical cancer undergoing definitive radio-chemotherapy. METHODS:Patients from the prospective observational multi-centre study "EMBRACE" were...

journal_title：Gynecologic oncology

authors： Knoth J,Pötter R,Jürgenliemk-Schulz IM,Haie-Meder C,Fokdal L,Sturdza A,Hoskin P,Mahantshetty U,Segedin B,Bruheim K,Wiebe E,Rai B,Cooper R,van der Steen-Banasik E,van Limbergen E,Pieters BR,Sundset M,Tan LT,Nout RA,T

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the utility of DNA flow cytometry as a prognostic indicator for risk of recurrence and overall survival in patients with early stage adenocarcinomas of the uterine cervix. METHODS:DNA flow cytometry was performed to determine ploidy, DNA index, and proliferative index i...

journal_title：Gynecologic oncology

authors： Magtibay PM,Perrone JF,Stanhope CR,Katzmann JA,Keeney GL,Li H

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:We wanted to identify genes up-regulated in ovarian tumors that might serve as early markers for ovarian cancer. One promising focus is the family of genes that encode secreted proteases, which play essential roles in tumor invasion and metastasis. Kallikrein 10 (KLK10) is a member of the kallikrein family of...

journal_title：Gynecologic oncology

authors： Shvartsman HS,Lu KH,Lee J,Lillie J,Deavers MT,Clifford S,Wolf JK,Mills GB,Bast RC Jr,Gershenson DM,Schmandt R

更新日期：2003-07-01 00:00:00

abstract：:A case of fatal radiation hepatitis occurring after treatment with 2200 rad given by the moving strip technique is presented. This fatality occurred in a 28-year-old woman with persistent ovarian carcinoma despite prolonged chemotherapy. Scans of the liver using computerized tomography, 99mTc sulfur colloid, and 99mTc...

journal_title：Gynecologic oncology

authors： Schacter L,Crum E,Spitzer T,Maksem J,Diwan V,Kolli S

更新日期：1986-07-01 00:00:00

abstract：:Uterine leiomyosarcoma is the most common type of uterine sarcoma. It is an extremely aggressive malignancy associated with a poor overall prognosis. Women affected may vary in age, but are most often diagnosed in their perimenopausal years. Presenting symptoms may be vague and mimic other benign uterine conditions. P...

journal_title：Gynecologic oncology

authors： Roberts ME,Aynardi JT,Chu CS

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:To compare the survival experience of women with a BRCA1 mutation who enrolled in an ovarian cancer screening program with that of women who opted for preventive oophorectomy. METHODS:We followed 1964 women with a BRCA1 mutation and two ovaries intact in a prospective study. No women had ovarian cancer or ha...

journal_title：Gynecologic oncology

authors： Gronwald J,Lubinski J,Huzarski T,Cybulski C,Menkiszak J,Siołek M,Stawicka M,Sun P,Kim SJ,Kotsopoulos J,Narod SA

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to determine the efficacy of a low-dose oral granisetron plus intravenous dexamethasone prophylactic antiemetic regimen in patients receiving carboplatin-based chemotherapy. PATIENTS AND METHODS:Patients with gynecologic malignancies being treated with either single-agent carb...

journal_title：Gynecologic oncology

authors： Markman M,Kennedy A,Webster K,Kulp B,Peterson G,Belinson J

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVES:The search for effective systemic chemotherapy for endometrial cancer is ongoing. Complete responses to current drugs or regimens are infrequent, and overall survival for patients with disease not amenable to surgery or radiation therapy is poor. Dactinomycin has proven activity against a wide variety of sol...

journal_title：Gynecologic oncology

authors： Moore DH,Blessing JA,Dunton C,Buller RE,Reid GC

更新日期：1999-12-01 00:00:00