HLA-DQB1 and cervical cancer in Venezuelan women.

Abstract:

BACKGROUND:Cervical cancer represents a major health problem in Venezuela as well as in other Latin American countries. High-risk human papillomavirus (HR-HPV) infection is known as the major risk factor of cervical cancer. However, whether or not a HR-HPV-infected woman progresses to cervical cancer may depend on the immune system effectors induced by viral antigens presented by her specific human leukocyte antigens (HLA) alleles. The role of the HLA system in presenting peptides to antigen-specific T-cells may be critical for genetic susceptibility and genetic resistance to cervical carcinoma. OBJECTIVE:We aimed to investigate the relationship between HLA-DQB1, HPV infection, and cervical cancer in Venezuelan women. METHODS:Blood samples and cervical swabs were obtained from 36 patients and 79 healthy controls; additional cervical biopsies were obtained from all the patients. HPV DNA was detected by PCR and HLA-DQB1 genotyping was performed using a PCR-SSP protocol. RESULTS.: A positive association with cervical cancer was observed for HLA-DQB1*0201-0202 and *0402 alleles, however after Bonferroni correction only HLA-DQB1*0402 remained statistically significant (P value = 0.004, RR = 5.067). CONCLUSION:This is the first report of HLA-DQB1 alleles associated with cervical carcinoma in Venezuelan women. Larger studies are needed to assess whether these HLA-DQB1*0201-0202 and *0402 alleles have a direct effect on disease susceptibility.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Dao DD,Sierra-Torres CH,Robazetti SC,de Gomez MN,König R,Lema C,Lester LJ,Au WW,Tyring SK

doi

10.1016/j.ygyno.2004.10.002

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

349-54

issue

2

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(04)00808-X

journal_volume

96

pub_type

杂志文章
  • An unusual case of secondary fibrosarcoma after treatment for breast cancer.

    abstract:BACKGROUND:Post-irradiation breast sarcoma is a rare and highly aggressive tumor, associated with poor prognosis. However, the mean latent periods reported for postradiation sarcomas after treatment of breast cancer ranges from 5 to 10 years. CASE:We present a rare case of fibrosarcoma of the axilla, diagnosed 23 mont...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ygyno.2006.07.014

    authors: Plotti F,Di Donato V,Zullo MA,Angioli R,Panici PB

    更新日期:2006-12-01 00:00:00

  • Debulking surgery for ovarian cancer with the Cavitron Ultrasonic Surgical Aspirator (CUSA)--a preliminary report.

    abstract::The Cavitron Ultrasonic Surgical Aspirator (CUSA) can be used to fragment and aspirate tissue precisely. The CUSA was utilized as an adjunctive procedure to standard operative techniques to optimally debulk 11 women with advanced epithelial carcinoma of the ovary. No significant intraoperative or postoperative complic...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(88)90298-3

    authors: Deppe G,Malviya VK,Malone JM Jr

    更新日期:1988-09-01 00:00:00

  • Molecular characterization of circulating tumor cells in patients with ovarian cancer improves their prognostic significance -- a study of the OVCAD consortium.

    abstract:OBJECTIVE:The study aims at identifying novel markers for circulating tumor cells (CTCs) in patients with epithelial ovarian cancer (EOC), and at evaluating their impact on outcome. METHODS:Microarray analysis comparing matched EOC tissues and peripheral blood leucocytes (N=35) was performed to identify novel CTC mark...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2012.09.021

    authors: Obermayr E,Castillo-Tong DC,Pils D,Speiser P,Braicu I,Van Gorp T,Mahner S,Sehouli J,Vergote I,Zeillinger R

    更新日期:2013-01-01 00:00:00

  • Effect of differentiation agents on expression of CA 125, alkaline phosphatase, and cytokeratins in human ovarian adenocarcinoma cells (OVCA 433).

    abstract::A number of chemical agents have been found to influence the proliferation, morphology, enzymatic activity, and antigen expression of neoplastic cells toward a more differentiated phenotype. We studied the effects of differentiating agents retinoic acid, sodium butyrate, and dibutyryl cyclic AMP on the expression of t...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(91)90356-a

    authors: Brooks SE,Timmerman J,Lau CC,Tsao SW,Knapp RC,Sheets EE

    更新日期:1991-09-01 00:00:00

  • Risk-stratification of endometrial carcinomas revisited: a combined preoperative and intraoperative scoring system for a reliable prediction of an advanced disease.

    abstract:OBJECTIVE:The aim of this study is to develop a risk-scoring system for predicting lymph node and distant metastasis in endometrial carcinoma. METHODS:A total of 1166 patients, treated at a single institution between 1-2007 and 12-2013, were included in the study. The association of stage IIIC-IV disease with demograp...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2015.01.545

    authors: Tuomi T,Pasanen A,Luomaranta A,Leminen A,Bützow R,Loukovaara M

    更新日期:2015-04-01 00:00:00

  • Ultrasound guidance for placement of difficult intracavitary implants.

    abstract::Placement of a radiation implant in patients with cervical cancer may be difficult because of distortion of the canal by tumor or fibrosis from previous radiation. The objective of this study was to determine whether ultrasound may be useful in recognizing or preventing complications associated with placement of an in...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1994.1186

    authors: Rotmensch J,Waggoner SE,Quiet C

    更新日期:1994-08-01 00:00:00

  • Induction of death receptor ligand-mediated apoptosis in epithelial ovarian carcinoma: The search for sensitizing agents.

    abstract:OBJECTIVE:To assess the abilities of cisplatin, paclitaxel, and flexible heteroarotinoid (Flex-Het) compound (SHetA2) to sensitize ovarian cancer cells to induction of the extrinsic apoptosis pathway by death receptor ligands, tumor necrosis factor alpha (TNFalpha), and TNF-related apoptosis-inducing ligand (TRAIL). S...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2009.09.007

    authors: Moxley KM,Chengedza S,Benbrook DM

    更新日期:2009-12-01 00:00:00

  • Malignant acanthosis nigricans, tripe palms and the sign of Leser-Tre'lat, a hint to the diagnosis of early stage ovarian cancer: a case report and review of the literature.

    abstract:BACKGROUND:Malignant acanthosis nigricans is a mucocutaneous eruption associated with internal malignancies. Tripe palms refers to a characteristic velvety thickening of the palms, with exaggeration of normal skin markings. The sign of Leser-Tre'lat is the presence of multiple seborrheic keratoses and scattered skin ta...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2005.12.024

    authors: Kebria MM,Belinson J,Kim R,Mekhail TM

    更新日期:2006-05-01 00:00:00

  • Anti-Yo positive paraneoplastic cerebellar degeneration associated with ovarian carcinoma: case report and review of the literature.

    abstract::Paraneoplastic cerebellar degeneration (PCD) is a rare nonmetastatic neurological complication in cancer patients. Anti-Yo is one of the anti-onconeural antibodies found in PCD patients. It is believed that anti-Yo occurs almost always in women and is most likely associated with gynecologic or breast cancers, although...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1006/gyno.1999.5553

    authors: Cao Y,Abbas J,Wu X,Dooley J,van Amburg AL

    更新日期:1999-10-01 00:00:00

  • Facts, misconceptions, and myths about cancer. What do patients with gynecological cancer and the female public at large know?

    abstract:UNLABELLED:Misconceptions about cancer may increase the level of fear in the general public and render coping more difficult in cancer patients. The aim of this survey was to study the level of knowledge and misconceptions. MATERIALS AND METHODS:A questionnaire comprising 27 questions related to cancer etiology, treat...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1997.4626

    authors: Carlsson ME,Strang PM

    更新日期:1997-04-01 00:00:00

  • Carboplatin-paclitaxel compared to Carboplatin-Paclitaxel-Bevacizumab in advanced or recurrent endometrial cancer: MITO END-2 - A randomized phase II trial.

    abstract:OBJECTIVE:Increased Vascular Endothelial Growth Factor Receptor (VEGF) expression in endometrial cancer (EC) is associated with a poor prognosis. Preliminary clinical data reported Bevacizumab effectiveness in EC both as single agent and in combination with chemotherapy. METHODS:In a phase II trial, patients with adva...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ygyno.2019.10.013

    authors: Lorusso D,Ferrandina G,Colombo N,Pignata S,Pietragalla A,Sonetto C,Pisano C,Lapresa MT,Savarese A,Tagliaferri P,Lombardi D,Cinieri S,Breda E,Sabatucci I,Sabbatini R,Conte C,Cecere SC,Maltese G,Scambia G

    更新日期:2019-12-01 00:00:00

  • Does adjuvant chemotherapy dose modification have an impact on the outcome of patients diagnosed with advanced stage ovarian cancer? An NRG Oncology/Gynecologic Oncology Group study.

    abstract:PURPOSE:To determine the relationship between chemotherapy dose modification (dose adjustment or treatment delay), overall survival (OS) and progression-free survival (PFS) for women with advanced-stage epithelial ovarian carcinoma (EOC) and primary peritoneal carcinoma (PPC) who receive carboplatin and paclitaxel. ME...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ygyno.2018.07.021

    authors: Olawaiye AB,Java JJ,Krivak TC,Friedlander M,Mutch DG,Glaser G,Geller M,O'Malley DM,Wenham RM,Lee RB,Bodurka DC,Herzog TJ,Bookman MA

    更新日期:2018-10-01 00:00:00

  • Conservative surgical treatment in cervical cancer with 3 to 5 mm stromal invasion in the absence of confluent invasion and lymph-vascular space involvement.

    abstract::We have previously reported that simple hysterectomy is adequate therapy for microinvasive carcinoma of the cervix with less than 3 mm stromal invasion (Yajima, A., et al, Am. J. Obstet. Gynecol. 135, 685-688, 1979). However, whether it is possible to effectively treat patients with deeper stromal invasion remained in...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1994.1219

    authors: Yaegashi N,Sato S,Inoue Y,Noda K,Yajima A

    更新日期:1994-09-01 00:00:00

  • Distribution of intraperitoneally injected microspheres labeled with the alpha-emitter astatine (211At) compared with phosphorus (32P) and yttrium (90Y) colloids in mice.

    abstract::The alpha-emitter 211At was bound to polymer microspheres with a diameter of 1.8 microns. The distributions in mice of intraperitoneally injected 211At microspheres, 90Y silicate colloid, and 32P chromic phosphate colloid were compared. The microspheres with 211At spread rapidly in the peritoneal cavity and remained m...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(92)90140-e

    authors: Vergote I,Larsen RH,De Vos L,Winderen M,Ellingsen T,Bjørgum J,Hoff P,Aas M,Tropé C,Nustad K

    更新日期:1992-12-01 00:00:00

  • Racial disparities in survival in malignant germ cell tumors of the ovary.

    abstract:OBJECTIVE:To investigate racial disparities with respect to adjuvant treatment and survival in patients presenting with malignant ovarian germ cell tumors (OGCT). METHODS:The National Cancer Database (NCDB) was used to identify women diagnosed with OGCT. Demographic data were abstracted, including stratification by ra...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2016.01.006

    authors: Hinchcliff E,Rauh-Hain JA,Clemmer JT,Diver E,Hall T,Stall J,Growdon W,Clark R,Schorge J

    更新日期:2016-03-01 00:00:00

  • Concordance of DNA ploidy pattern as measured by flow cytometry in primary, metastatic, and persistent ovarian carcinoma.

    abstract::In an attempt to evaluate the stability of DNA content in ovarian carcinoma, 66 tumor specimens from 25 patients with stage III disease were analyzed by flow cytometry. For all patients, both primary tumor and omental metastasis were available, and for 16 patients the persistent tumor found at second-look operation wa...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1996.0027

    authors: Zanetta GM,Keeney GL,Kimlinger TK,Katzmann JA,Podratz KC

    更新日期:1996-02-01 00:00:00

  • Prognostic value of endocervical sampling following loop excision of high grade intraepithelial neoplasia.

    abstract:OBJECTIVE:To assess the role of additional biopsies performed with loop electrosurgical excisional procedure (LEEP) in predicting the likelihood of persistent high grade intraepithelial neoplasia. METHODS:Clinicopathologic data were abstracted from women who underwent excision of high grade intraepithelial lesions bet...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2017.01.007

    authors: Cui Y,Sangi-Haghpeykar H,Patsner B,Bump JMM,Williams-Brown MY,Binder GL,Masand RP,Anderson ML

    更新日期:2017-03-01 00:00:00

  • Presentation of cervical cancer.

    abstract::To determine how patients with invasive cervical cancer present and whether presentation affects disease-free survival (DFS), a review of 81 patients treated for cervical cancer by the Division of Gynecologic Oncology and Pelvic Surgery at the Southern California Permanente Medical Group between January 1, 1986, and D...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(91)90229-x

    authors: Pretorius R,Semrad N,Watring W,Fotheringham N

    更新日期:1991-07-01 00:00:00

  • Importance of serum sialic acid and lactate dehydrogenase in diagnosis and treatment monitoring of cervical cancer patients.

    abstract::In an attempt to establish a blood-based biochemical index for diagnosis of cervical cancer and treatment monitoring of patients suffering from the disease, serum levels of total sialic acid (TSA), lipid-bound sialic acid (LSA), and lactate dehydrogenase were estimated by highly specific spectrophotometric methods. Se...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1993.1214

    authors: Patel PS,Rawal GN,Balar DB

    更新日期:1993-09-01 00:00:00

  • Adjuvant chemotherapy for early stage endometrioid ovarian carcinoma: An analysis of the National Cancer Data Base.

    abstract:INTRODUCTION:The benefit of adjuvant chemotherapy for Stage IC grade 1 and stage IA/IB grade 2 endometrioid ovarian adenocarcinoma (EOOC) remains unclear as the NCCN guidelines recommend either observation only or adjuvant chemotherapy. Therefore, we sought to determine whether patients with stage I EOOC had improved o...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2019.11.125

    authors: Nasioudis D,Latif NA,Simpkins F,Cory L,Giuntoli RL 2nd,Haggerty AF,Morgan MA,Ko EM

    更新日期:2020-02-01 00:00:00

  • Elevated nm23 protein expression is correlated with diminished progression-free survival in patients with epithelial ovarian carcinoma.

    abstract:OBJECTIVES:The role of the candidate metastasis-suppressor gene nm23-H1 first characterized in breast cancer remains controversial, with both metastasis suppression and disease progression being linked to elevated nm23-H1 gene expression in different human tumor types. We sought to characterize (1) the pattern and inte...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1996.0056

    authors: Srivatsa PJ,Cliby WA,Keeney GL,Dodson MK,Suman VJ,Roche PC,Podratz KC

    更新日期:1996-03-01 00:00:00

  • The role of cancer antigen 125 (CA 125) in the management of ovarian epithelial carcinomas.

    abstract::From June 1, 1984, to May 31, 1985, 98 cases of epithelial ovarian carcinomas were assessed and followed prospectively using a new murine monoclonal antibody OC 125 which detects the antigen CA 125. Serous tumors comprised 43.7% of cases, mucinous tumors 20.4%, endometrioid tumors 16%, and other epithelial tumors 19.4...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(88)90042-x

    authors: Altaras MM,Goldberg GL,Levin W,Bloch B,Darge L,Smith JA

    更新日期:1988-05-01 00:00:00

  • Angiogenesis in endometrial carcinoma: Therapies and biomarkers, current options, and future perspectives.

    abstract::Endometrial carcinoma is the most common gynecologic malignancy and the fourth most prevalent cancer in women in the modern world. Despite a relatively high chance of surgical cure, for patients with advanced or recurrent disease there are few therapeutic options. Angiogenesis has been extensively studied ever since v...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ygyno.2020.12.016

    authors: Berger AA,Dao F,Levine DA

    更新日期:2020-12-26 00:00:00

  • p53 mutations and presence of HPV DNA do not correlate with radiosensitivity of gynecological cancer cell lines.

    abstract:OBJECTIVE:The correlation between p53 tumor suppressor gene mutations and the presence of high-risk human papillomavirus (HPV) DNA with the in vitro radiosensitivity of gynecological malignancies was studied in 26 cell lines derived from gynecological cancers of 23 patients. METHODS:Comparison of the intrinsic radiose...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1998.5194

    authors: Rantanen V,Grénman S,Kurvinen K,Hietanen S,Raitanen M,Syrjänen S

    更新日期:1998-12-01 00:00:00

  • The role of MicroRNA molecules and MicroRNA-regulating machinery in the pathogenesis and progression of epithelial ovarian cancer.

    abstract::MicroRNA molecules are small, single-stranded RNA molecules that function to regulate networks of genes. They play important roles in normal female reproductive tract biology, as well as in the pathogenesis and progression of epithelial ovarian cancer. DROSHA, DICER, and Argonaute proteins are components of the microR...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ygyno.2017.08.027

    authors: Wang X,Ivan M,Hawkins SM

    更新日期:2017-11-01 00:00:00

  • Are self-collected samples comparable to physician-collected cervical specimens for human papillomavirus DNA testing? A systematic review and meta-analysis.

    abstract:OBJECTIVE:To compare the detection rate of genital human papillomavirus (HPV) infection in self- and physician-obtained samples. DESIGN:Systematic review and meta-analysis. DATA SOURCES:Studies published between 1966 and November 2005 identified through Medline and Embase that compared both sampling methods. MAIN OU...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.ygyno.2007.01.023

    authors: Petignat P,Faltin DL,Bruchim I,Tramèr MR,Franco EL,Coutlée F

    更新日期:2007-05-01 00:00:00

  • Transient human anti-mouse antibodies (HAMA) interference in CA 125 measurements during monitoring of ovarian cancer patients treated with murine monoclonal antibody.

    abstract:OBJECTIVE:To investigate the influence of human anti-mouse antibodies (HAMA) on serial CA 125 measurements in serum of patients with epithelial ovarian cancer following single intraperitoneal (IP) therapy with Yttrium-90-labeled human milk fat globule 1 murine monoclonal antibody ((90)Y-muHMFG1) as part of a large inte...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ygyno.2008.01.025

    authors: Oei AL,Sweep FC,Massuger LF,Olthaar AJ,Thomas CM

    更新日期:2008-05-01 00:00:00

  • Bolus mitomycin C and 5-FU with sequential radiation for poor-prognosis locally advanced cervical cancer.

    abstract::Forty patients with locally advanced cervical carcinoma were entered into a protocol utilizing the bolus administration of both mitomycin C (10 or 15 mg) on Day 1 and 5-fluorouracil (400 mg) on Day 1-5 followed by sequential pelvic irradiation on Day 6 between September 1980 and October 1985. All patients had poor-pro...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,评审

    doi:10.1006/gyno.1996.0013

    authors: Denehy TR,Eastman R,SanFilippo L,Gregori CA,Breen JL

    更新日期:1996-01-01 00:00:00

  • Completed versus aborted radical hysterectomy for node-positive stage IB cervical cancer in the modern era of chemoradiation therapy.

    abstract:OBJECTIVE:Debate continues about optimal management of patients with node-positive stage I cervical cancer. Our objective was to determine if patient outcomes are affected by radical hysterectomy in the modern era of adjuvant chemoradiation. METHODS:Cervical cancer patients diagnosed from 2000 to 2008 were identified....

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2012.03.046

    authors: Ziebarth AJ,Smith H,Killian ME,Nguyen NA,Durst JK,Subramaniam A,Kim KH,Leath CA 3rd,Straughn JM Jr,Alvarez RD

    更新日期:2012-07-01 00:00:00

  • Pathological characteristics of cervical adenocarcinoma in a multi-center US-based study.

    abstract:OBJECTIVE:Difficulties in detecting cervical adenocarcinoma early are well known. We report a detailed pathology review of cervical adenocarcinoma subtypes, comparing growth patterns and appearance of non-neoplastic epithelium to inform possible clues for disease progression and early detection. METHODS:This analysis ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ygyno.2006.03.049

    authors: Wang SS,Sherman ME,Silverberg SG,Carreon JD,Lacey JV Jr,Zaino R,Kurman RJ,Hildesheim A

    更新日期:2006-11-01 00:00:00