Transient human anti-mouse antibodies (HAMA) interference in CA 125 measurements during monitoring of ovarian cancer patients treated with murine monoclonal antibody.

Abstract:

OBJECTIVE:To investigate the influence of human anti-mouse antibodies (HAMA) on serial CA 125 measurements in serum of patients with epithelial ovarian cancer following single intraperitoneal (IP) therapy with Yttrium-90-labeled human milk fat globule 1 murine monoclonal antibody ((90)Y-muHMFG1) as part of a large international randomized phase III trial. METHODS:We monitored CA 125 concentrations in longitudinally collected serum samples from 224 patients after IP (90)Y-muHMFG1 (study group) and from 223 patients who received standard treatment (control group). Serum samples of 22 study patients with increased CA 125 concentrations were selected and subjected to affinity chromatography to study HAMA interference in CA 125 measurements. RESULTS:CA 125 serum concentrations at weeks 1, 4 and 8 were significantly higher in the study group than in the control group. In the first 8 weeks after IP (90)Y-muHMFG1 administration significantly more patients of the study group (144/224) demonstrated CA 125 concentrations above the upper limit of normal of 23 U/mL, as compared to those of the control group (37/223). Affinity chromatography of serum with high CA 125 values in the first 8 weeks confirmed HAMA interference in CA 125 measurements while after 24 weeks this HAMA interference could no longer be detected. CONCLUSIONS:This is the first study to demonstrate that clinical trials applying murine monoclonal antibodies may be flawed by a transient HAMA effect, which should be considered when monitoring ovarian cancer patients with CA 125 measurements.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Oei AL,Sweep FC,Massuger LF,Olthaar AJ,Thomas CM

doi

10.1016/j.ygyno.2008.01.025

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

199-202

issue

2

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(08)00078-4

journal_volume

109

pub_type

杂志文章,多中心研究,随机对照试验
  • Ovarian serous carcinoma presenting with mediastinal lymphadenopathy 20 months before the intraabdominal mass: role of immunohistochemistry.

    abstract:INTRODUCTION:Metastatic involvement of the mediastinal lymph nodes is an extremely uncommon finding in epithelial ovarian cancers. CASE REPORT:A 63-year-old woman was admitted to hospital for dyspnoea due to an anterior mediastinal mass. The surgical biopsy showed a 6-cm metastatic lymph node with a papillary pattern,...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2006.09.030

    authors: Zannoni GF,Vellone VG,Distefano MG,Fadda G,Scambia G

    更新日期:2007-02-01 00:00:00

  • Characterization of peripheral blood and ovarian cancer-infiltrating lymphocytes: effect of HIV infection on phenotypic expression and proliferative response.

    abstract::A study that focused on the identification of the phenotype and proliferative responses of peripheral blood and ovarian cancer-infiltrating lymphocytes in a patient with stage III ovarian cancer who had human immunodeficiency virus infection is presented. Monoclonal antibodies and flow cytometry were used to determine...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1994.1126

    authors: Guidozzi F,Reddy S,Wadee A

    更新日期:1994-05-01 00:00:00

  • Laparoscopic splenectomy for secondary cytoreduction of ovarian cancer in a woman with localized splenic recurrence.

    abstract:OBJECTIVE/BACKGROUND:Laparoscopic splenectomy is a potential surgical option for the treatment of isolated gynecologic cancer recurrence to the spleen [1-7]. The purpose of this video is to demonstrate a step-by-step approach for laparoscopic splenectomy in the setting of recurrent, oligometastatic ovarian cancer. MET...

    journal_title:Gynecologic oncology

    pub_type:

    doi:10.1016/j.ygyno.2019.12.021

    authors: Acosta-Torres S,Fader AN

    更新日期:2020-03-01 00:00:00

  • FDG-PET in the detection of recurrence of uterine cervical carcinoma following radiation therapy--tumor volume and FDG uptake value.

    abstract:PURPOSE:We evaluated the use of positron emission tomography (PET) with fluorine-18-labeled fluoro-2-deoxy-d-glucose (FDG) in follow-up study after radiation therapy in patients with uterine cervical carcinoma. MATERIALS AND METHODS:Thirty-two studies in 25 patients were reviewed. Twenty patients were treated with ext...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2005.09.030

    authors: Sakurai H,Suzuki Y,Nonaka T,Ishikawa H,Shioya M,Kiyohara H,Katoh H,Nakayama Y,Hasegawa M,Nakano T

    更新日期:2006-03-01 00:00:00

  • Intraoperative hypothermia during primary surgical cytoreduction for advanced ovarian cancer: risk factors and associations with postoperative morbidity.

    abstract:OBJECTIVE:The objective of this study was to evaluate the risk factors and potential morbidity associated with intraoperative hypothermia (IH) during cytoreductive surgery (CRS) for advanced ovarian cancer. METHODS:Demographic and perioperative data were collected for all patients with stage IIIC-IV ovarian, fallopian...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2013.08.034

    authors: Long KC,Tanner EJ,Frey M,Leitao MM Jr,Levine DA,Gardner GJ,Sonoda Y,Abu-Rustum NR,Barakat RR,Chi DS

    更新日期:2013-12-01 00:00:00

  • Prognostic significance of hysteroscopic imaging in endometrioid endometrial adenocarcinoma.

    abstract:OBJECTIVE:The aim of this study was to relate hysteroscopic features of endometrioid endometrial adenocarcinoma to stage, grade and overall survival. METHODS:Sixty women with endometrioid adenocarcinoma underwent laparotomy and staging according to current FIGO classification. Before surgery hysteroscopy was performed...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.2001.6173

    authors: Garuti G,De Giorgi O,Sambruni I,Cellani F,Luerti M

    更新日期:2001-06-01 00:00:00

  • Glutathione S-transferase polymorphisms and ovarian cancer treatment and survival.

    abstract:OBJECTIVE:Members of the glutathione S-transferase (GST) family have been shown to have functional polymorphisms that may affect drug metabolism and influence the effects of chemotherapy and survival from cancer. GSTM1, GSTT1, and GSTP1 genotypes were evaluated for their role in ovarian cancer treatment and survival. ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2005.08.035

    authors: Beeghly A,Katsaros D,Chen H,Fracchioli S,Zhang Y,Massobrio M,Risch H,Jones B,Yu H

    更新日期:2006-02-01 00:00:00

  • The role of neoadjuvant chemotherapy in the management of patients with advanced stage ovarian cancer: survey results from members of the Society of Gynecologic Oncologists.

    abstract:OBJECTIVE:Recent randomized controlled data suggest that neoadjuvant chemotherapy (NACT) with interval debulking (ID) may produce similar overall survival and progression free survival compared to standard primary cytoreduction followed by chemotherapy. The object of our study was to assess current patterns of care amo...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2010.06.021

    authors: Dewdney SB,Rimel BJ,Reinhart AJ,Kizer NT,Brooks RA,Massad LS,Zighelboim I

    更新日期:2010-10-01 00:00:00

  • Dose-volume effects in pathologic lymph nodes in locally advanced cervical cancer.

    abstract:OBJECTIVE:In cervical cancer patients, dose-volume relationships have been demonstrated for tumor and organs-at-risk, but not for pathologic nodes. The nodal control probability (NCP) according to dose/volume parameters was investigated. MATERIAL AND METHODS:Patients with node-positive cervical cancer treated curative...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2017.12.028

    authors: Bacorro W,Dumas I,Escande A,Gouy S,Bentivegna E,Morice P,Haie-Meder C,Chargari C

    更新日期:2018-03-01 00:00:00

  • Fatal radiation hepatitis: a case report and review of the literature.

    abstract::A case of fatal radiation hepatitis occurring after treatment with 2200 rad given by the moving strip technique is presented. This fatality occurred in a 28-year-old woman with persistent ovarian carcinoma despite prolonged chemotherapy. Scans of the liver using computerized tomography, 99mTc sulfur colloid, and 99mTc...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(86)90316-1

    authors: Schacter L,Crum E,Spitzer T,Maksem J,Diwan V,Kolli S

    更新日期:1986-07-01 00:00:00

  • Single-dose actinomycin D in the treatment of postmolar trophoblastic disease.

    abstract::From 1973 to 1982 single-dose (0.04 mg/kg or 1.25 mg/m2), biweekly actinomycin D was used to treat 28 women with postmolar, good-prognosis trophoblastic disease. Among the 17 patients fully evaluable for response to treatment 12 were nonmetastatic (NMTD) and 5 had lung metastases (MTD). Nine NMTD patients and 5 MTD pa...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(84)90157-4

    authors: Schlaerth JB,Morrow CP,Nalick RH,Gaddis O Jr

    更新日期:1984-09-01 00:00:00

  • Incidence of metastasis in the circumflex iliac nodes distal to the external iliac nodes in ovarian cancer.

    abstract:OBJECTIVE:The circumflex iliac nodes distal to the external iliac nodes (CINDEINs) are included in the regional lymph nodes that are commonly dissected during systematic lymphadenectomy for ovarian cancer. Because in recent years CINDEIN dissection has been reported as a significant risk factor for postoperative lower ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2012.05.031

    authors: Ohba Y,Todo Y,Akashi D,Kawaguchi S,Minobe S,Okamoto K,Kato H

    更新日期:2012-09-01 00:00:00

  • Stage IV ovarian cancer: disease site-specific rationale for postoperative treatment.

    abstract:OBJECTIVES:We aimed to define the site-specific patterns of treatment failure in stage IV ovarian cancer. METHODS:Data from all consecutive Mayo Clinic patients with stage IV epithelial ovarian cancer, from 1994 through 2003, were collected and analyzed. Statistical analyses included the chi(2) test and Kaplan-Meier c...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2008.09.010

    authors: Aletti GD,Podratz KC,Cliby WA,Gostout BS

    更新日期:2009-01-01 00:00:00

  • Overall survival results of AGO-OVAR16: A phase 3 study of maintenance pazopanib versus placebo in women who have not progressed after first-line chemotherapy for advanced ovarian cancer.

    abstract:OBJECTIVE:The AGO-OVAR16 study was designed to test the efficacy, safety, and tolerability of pazopanib maintenance after first-line chemotherapy in patients with newly diagnosed advanced ovarian cancer (AOC). METHODS:Nine hundred and forty patients with histologically confirmed AOC, International Federation of Gyneco...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ygyno.2019.08.024

    authors: Vergote I,du Bois A,Floquet A,Rau J,Kim JW,Del Campo JM,Friedlander M,Pignata S,Fujiwara K,Colombo N,Mirza MR,Monk BJ,Tsibulak I,Calvert PM,Herzog TJ,Hanker LC,Meunier J,Lee JY,Bologna A,Carrasco-Alfonso MJ,Harter

    更新日期:2019-11-01 00:00:00

  • How accurate is frozen section histology of pelvic lymph nodes in patients with endometrial cancer?

    abstract:OBJECTIVE:Recent prospective data support the trend towards systematic retroperitoneal lymphadenectomy in patients with high-risk endometrial cancer. Because para-aortic node involvement in the absence of pelvic node involvement is uncommon, a reliable finding of negative pelvic lymph nodes (PLN) at intraoperative froz...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2009.07.007

    authors: Pristauz G,Bader AA,Regitnig P,Haas J,Winter R,Tamussino K

    更新日期:2009-10-01 00:00:00

  • Pre-diagnosis body mass index, physical activity and ovarian cancer mortality.

    abstract:BACKGROUND:Ovarian cancer is the deadliest gynecologic malignancy, yet the effects on survival of modifiable pre-diagnosis lifestyle factors, such as obesity and physical activity, remain largely unexplored. Our objective was to evaluate the effect of pre-diagnosis BMI and physical activity on ovarian cancer mortality ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2019.07.025

    authors: Zamorano AS,Hagemann AR,Morrison L,Lee JA,Liao LM,Brinton LA,Park Y,Toriola AT

    更新日期:2019-10-01 00:00:00

  • Sentinel node mapping vs. lymphadenectomy in endometrial cancer: A systematic review and meta-analysis.

    abstract::Sentinel node mapping is increasingly being utilized for endometrial cancer staging. However, only limited evidence supporting the adoption of sentinel node mapping instead of conventional lymphadenectomy is still available. Here, we aimed to review the current evidence comparing sentinel node mapping and lymphadenect...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.ygyno.2019.03.254

    authors: Bogani G,Murgia F,Ditto A,Raspagliesi F

    更新日期:2019-06-01 00:00:00

  • Malignant mixed mullerian tumor arising in extragenital endometriosis: report of a case and review of the literature.

    abstract::A primary malignant mixed Mullerian tumor (MMMT) was found in the wall of the rectum of a 67-year-old female. The uterus, fallopian tubes, and ovaries had been previously excised for benign disease. The tumor was associated with foci of benign endometriosis. A literature review of extragenital MMMTs indicates that the...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(86)90228-3

    authors: Chumas JC,Thanning L,Mann WJ

    更新日期:1986-02-01 00:00:00

  • Combined methotrexate-dactinomycin: an effective therapy for low-risk gestational trophoblastic neoplasia.

    abstract:OBJECTIVE:The objective of this study is to examine the outcomes of combined chemotherapy using methotrexate and dactinomycin in the management of women with low-risk gestational trophoblastic neoplasia (GTN). The primary outcome is the total number of cycles of chemotherapy required to achieve a normal level of human ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2011.10.036

    authors: Eiriksson L,Wells T,Steed H,Schepansky A,Capstick V,Hoskins P,Pike J,Swenerton K

    更新日期:2012-03-01 00:00:00

  • Mucinous neoplasm in the cervix associated with a mucinous neoplasm in the ovary and concurrent bilateral sex cord tumors with annular tubules: immunohistochemical study.

    abstract::The patient described synchronous mucinous tumors of the cervix and ovary and concurrent annular tubules, but without the classical stigmata of Peutz-Jeghers syndrome. The cervical tumor was an invasive mucinous adenocarcinoma with mixed components of minimal deviation and less-well-differentiated endometrioid morphol...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(91)90040-c

    authors: Matseoane S,Moscovic E,Williams S,Huang JC

    更新日期:1991-12-01 00:00:00

  • Costs of treatment and outcomes associated with second-line therapy and greater for relapsed ovarian cancer.

    abstract:OBJECTIVES:Most women with epithelial ovarian cancer (EOC) will develop disease progression or recurrence with resistance to platinum therapy. We report overall costs and treatment outcomes associated with topotecan or gemcitabine administration in platinum- and paclitaxel-resistant EOC patients. METHODS:Patients who ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2004.01.014

    authors: Prasad M,Ben-Porat L,Hoppe B,Aghajanian C,Sabbatini P,Chi DS,Hensley ML

    更新日期:2004-04-01 00:00:00

  • The "real-life" variability of CA-125 in ovarian cancer patients.

    abstract:BACKGROUND:The serum CA-125 antigen value has proven to be useful in predicting changes that affect prognosis and management of ovarian cancer; however, interpreting variations in the tumor marker is still not well-defined. Our goal was to further understand the analytical variability of CA-125 in a conventional hospit...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2006.02.010

    authors: Tso E,Elson P,Vanlente F,Markman M

    更新日期:2006-10-01 00:00:00

  • Global expression changes of constitutive and hormonally regulated genes during endometrial neoplastic transformation.

    abstract:OBJECTIVE:Endometrioid endometrial carcinoma is caused by a combination of mutational events and hormonal factors. We used large-scale messenger RNA expression analysis to discover genes that distinguish neoplastic transformation and examine the patterns of tumor expression of those genes which are normally regulated d...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.2001.6352

    authors: Mutter GL,Baak JP,Fitzgerald JT,Gray R,Neuberg D,Kust GA,Gentleman R,Gullans SR,Wei LJ,Wilcox M

    更新日期:2001-11-01 00:00:00

  • Mucinous adenofibroma of the ovary: case report of the endocrinologic findings.

    abstract::Endocrine and clinicopathologic findings in a 77-year-old woman with ovarian mucinous adenofibroma of borderline malignancy are reported. The preoperative levels of testosterone, androstenedione, estrone, and estradiol in her peripheral blood were 91 ng/ml, 3.78 ng/ml, 82 pg/ml, and 35 pg/ml, respectively, abnormally ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1994.1197

    authors: Tohya T,Mizutani H,Katabuchi H,Miyazaki K,Okamura H

    更新日期:1994-08-01 00:00:00

  • Prothrombin fragment F 1 + 2 plasma concentrations in patients with gynecologic malignancies.

    abstract::Malignant diseases have been shown to cause hypercoagulable states. Elevated prothrombin fragment F 1 + 2 plasma levels occur, when prothrombin is converted into thrombin by factor Xa. In order to evaluate the role of prothrombin fragment F 1 + 2 as an indicator for hemostatic disorders in patients with gynecologic ma...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1993.1142

    authors: Hanzal E,Tatra G

    更新日期:1993-06-01 00:00:00

  • Nongestational pure ovarian choriocarcinoma with contralateral teratoma.

    abstract:BACKGROUND:Nongestational pure ovarian choriocarcinoma is a rare malignancy with only 29 cases described to date. CASE:We describe a case associated with mature cystic teratoma of the contralateral ovary. Details of all 30 cases including clinical features, associations, surgicopathological findings, operative procedu...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1006/gyno.2000.6043

    authors: Goswami D,Sharma K,Zutshi V,Tempe A,Nigam S

    更新日期:2001-02-01 00:00:00

  • HPV subtypes and immunological parameters of cervical cancer in Iceland during two time periods, 1958-1960 and 1995-1996.

    abstract:OBJECTIVE:Cervical cancer is a disease caused in part by an infection with an oncogenic subtype of human papillomavirus (HPV). In this study we analysed all cervical cancer samples diagnosed in Iceland during two periods, 1958-1960 and 1995-1996, and asked whether significant changes in viral or immunological parameter...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/s0090-8258(03)00053-2

    authors: Mikaelsdottir EK,Benediktsdottir KR,Olafsdottir K,Arnadottir T,Ragnarsson GB,Olafsson K,Sigurdsson K,Kristjansdottir GS,Imsland AK,Ogmundsdottir HM,Rafnar T

    更新日期:2003-04-01 00:00:00

  • Cell kinetics: a prognostic marker in epithelial ovarian cancer.

    abstract::The proliferative activities (3H-thymidine labeling index, LI) of 72 primary ovarian cancers and 76 metastatic lesions from untreated patients were evaluated. Overall, median LI values for primary and metastatic lesions were similar (7.8 vs 7.0%), but cell kinetics significantly differed in metastases from different s...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0090-8258(89)90003-6

    authors: Silvestrini R,Daidone MG,Bolis G,Fontanelli R,Landoni F,Andreola S,Colombi R

    更新日期:1989-10-01 00:00:00

  • Comparison of the usefulness between a new universal grading system for epithelial ovarian cancer and the FIGO grading system.

    abstract:OBJECTIVE:The aim of this study was to compare the usefulness of a new universal grading system for ovarian cancer proposed by Shimizu et al. (Cancer 82 (1998), 893; Gynecol. Oncol. 70 (1998), 2) with that of the FIGO grading system as a prognostic factor of ovarian cancer. METHODS:We reviewed all paraffin-embedded ti...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/s0090-8258(03)00133-1

    authors: Ishioka Si,Sagae S,Terasawa K,Sugimura M,Nishioka Y,Tsukada K,Kudo R

    更新日期:2003-06-01 00:00:00

  • A clinicopathological analysis of 40 cases of ovarian Sertoli-Leydig cell tumors.

    abstract:OBJECTIVE:To evaluate the clinicopathological features of ovarian Sertoli-Leydig cell tumors (SLCTs) and to explore the reasonable therapy. METHODS:A total of 40 cases of SLCTs were retrospectively reviewed. RESULTS:The incidence of SLCTs was 0.41%, with a median age of 28 years. All tumors were confined to one ovary...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2012.07.114

    authors: Gui T,Cao D,Shen K,Yang J,Zhang Y,Yu Q,Wan X,Xiang Y,Xiao Y,Guo L

    更新日期:2012-11-01 00:00:00