Ovarian serous carcinoma presenting with mediastinal lymphadenopathy 20 months before the intraabdominal mass: role of immunohistochemistry.


INTRODUCTION:Metastatic involvement of the mediastinal lymph nodes is an extremely uncommon finding in epithelial ovarian cancers. CASE REPORT:A 63-year-old woman was admitted to hospital for dyspnoea due to an anterior mediastinal mass. The surgical biopsy showed a 6-cm metastatic lymph node with a papillary pattern, scattered psammomas and immunoreactivity for WT1, Cytokeratin 7, EMA and negative for E-cadherin, GCFDP-15, Thyroglobulin, Cytokeratin 20, Cytokeratin 5/6, CEA, Vimentin, Calretinin, TTF1. After 20 months a follow-up CT identified an ovarian mass with the same histological pattern and immunoreactivity of the mediastinal nodule. RESULTS:Immunohistochemistry, especially WT1, is useful in assessing the ovarian origin of an unusual metastasis particularly if it is the first presentation of the disease.


Gynecol Oncol


Gynecologic oncology


Zannoni GF,Vellone VG,Distefano MG,Fadda G,Scambia G




Has Abstract


2007-02-01 00:00:00














  • The prevalence of HPV16DNA in normal and pathological cervical scrapes using the polymerase chain reaction.

    abstract::Human papillomavirus (HPV) has been implicated in the development of cervical cancer. Newly developed molecular techniques have facilitated HPV identification and typing of cervical lesions. Several studies have suggested a strong correlation between HPV16 and intraepithelial cervical neoplasia. However, there is no a...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Pasetto N,Sesti F,De Santis L,Piccione E,Novelli G,Dallapiccola B

    更新日期:1992-07-01 00:00:00

  • Gynecologic oncology providers endorse practice-changing impact of communication skills training.

    abstract:OBJECTIVE:Effective communication improves patient outcomes and is crucial to good patient care. Communication skills training (CST) has been shown to improve communication skills in non-gynecologic oncology specialties. We sought to develop and test CST for gynecologic oncology (GO) providers. METHODS:We developed an...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Lefkowits C,Bevis K,Carey EC,Sheeder J,Arnold RM,Podgurski L

    更新日期:2019-06-01 00:00:00

  • Evaluation of DNA ploidy in endometrial cancer.

    abstract::We performed a study to evaluate the relationships between the surgical stage (FIGO, 1989), histological tumor grade, myometrial invasion, peritoneal cytology, lymph node metastasis and prognosis, and DNA ploidy determined by flow cytometry in paraffin-embedded blocks of resected cancer lesions from 76 patients with u...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Ikeda M,Watanabe Y,Nanjoh T,Noda K

    更新日期:1993-07-01 00:00:00

  • Increased glyceraldehyde-3-phosphate dehydrogenase gene expression in human cervical cancers.

    abstract:OBJECTIVE:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a classical glycolytic protein. A higher level of GAPDH mRNA was found in lung, pancreas, and prostate cancers, but in cervical carcinoma there have not been any reports about the level of GAPDH gene expression. So, we tried to investigate the GAPDH gene exp...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kim JW,Kim SJ,Han SM,Paik SY,Hur SY,Kim YW,Lee JM,Namkoong SE

    更新日期:1998-11-01 00:00:00

  • Flow cytometric DNA analysis of early stage adenocarcinoma of the cervix.

    abstract:OBJECTIVE:The aim of this study was to determine the utility of DNA flow cytometry as a prognostic indicator for risk of recurrence and overall survival in patients with early stage adenocarcinomas of the uterine cervix. METHODS:DNA flow cytometry was performed to determine ploidy, DNA index, and proliferative index i...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Magtibay PM,Perrone JF,Stanhope CR,Katzmann JA,Keeney GL,Li H

    更新日期:1999-11-01 00:00:00

  • Proteomic analysis of stage I endometrial cancer tissue: identification of proteins associated with oxidative processes and inflammation.

    abstract:OBJECTIVE:The present study aimed to identify differentially expressed proteins employing a high resolution mass spectrometry (MS)-based proteomic analysis of endometrial cancer cells harvested using laser microdissection. METHODS:A differential MS-based proteomic analysis was conducted from discrete epithelial cell p...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Maxwell GL,Hood BL,Day R,Chandran U,Kirchner D,Kolli VS,Bateman NW,Allard J,Miller C,Sun M,Flint MS,Zahn C,Oliver J,Banerjee S,Litzi T,Parwani A,Sandburg G,Rose S,Becich MJ,Berchuck A,Kohn E,Risinger JI,Conrad

    更新日期:2011-06-01 00:00:00

  • Platelets promote invasion and induce epithelial to mesenchymal transition in ovarian cancer cells by TGF-β signaling pathway.

    abstract:OBJECTIVE:To test whether platelets could increase invasion potential and initiate EMT in ovarian cancer cells via a TGF-β signaling pathway. METHODS:Blood samples were collected in 69 patients with ovarian cancer, 16 patients with benign ovarian tumor and 64 healthy donors. SK-OV-3 and OVCAR-3 ovarian cancer cells we...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Guo Y,Cui W,Pei Y,Xu D

    更新日期:2019-06-01 00:00:00

  • Novel techniques to improve split-thickness skin graft viability during vulvo-vaginal reconstruction.

    abstract:BACKGROUND:Split-thickness skin grafts are often utilized for vulvo-vaginal reconstruction. Unfortunately, infection and sloughing may occur in up to 22% of patients with standard techniques especially at irradiated recipient sites. CASES:We report seven cases of vulvo-vaginal reconstruction using split-thickness skin...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Dainty LA,Bosco JJ,McBroom JW,Winter WE 3rd,Rose GS,Elkas JC

    更新日期:2005-06-01 00:00:00

  • Solitary recurrent metastasis of epithelial ovarian cancer in the spleen.

    abstract::In epithelial ovarian cancer, solitary metastasis to and recurrences in the parenchyma of the spleen are rare in the absence of apparent disease in other sites. We report four patients who developed isolated, solitary splenic parenchymal recurrences of their epithelial ovarian adenocarcinomas and underwent a splenecto...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Farias-Eisner R,Braly P,Berek JS

    更新日期:1993-03-01 00:00:00

  • Metastatic cervical carcinoma to the breast.

    abstract::Metastatic disease to the breast is often an unexpected diagnosis in a female who presents with a breast mass. The most important factor suggesting the appropriate diagnosis is a history of cancer. Correlation of mammographic and ultrasonographic findings may also raise the possibility of a metastatic mass. A well-def...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Younathan CM,Steinbach BG,DeBose CD

    更新日期:1992-05-01 00:00:00

  • Studies on the distribution of abnormal cells in cytological smears. VII. Cervical brush versus plastic and wooden spatulas.

    abstract::A model system of exfoliated normal human cervicovaginal squamous cells, exfoliated rodent tumor cells, and acellular, viscous, mucuslike material was used to investigate cell deposition on smear preparations made with three different instruments: plastic spatulas, wooden spatulas, and brush-tipped collectors. The tot...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Rubio CA,Kock Y,Stormby N,Porwit A

    更新日期:1990-11-01 00:00:00

  • Primary cytoreductive surgery and adjuvant hormonal monotherapy in women with advanced low-grade serous ovarian carcinoma: Reducing overtreatment without compromising survival?

    abstract:OBJECTIVES:Women with advanced-stage, low-grade serous ovarian carcinoma (LGSC) have low chemotherapy response rates and poor overall survival. Most LGSC tumors overexpress hormone receptors, which represent a potential treatment target. Our study objective was to determine the outcomes of patients with advanced-stage ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Fader AN,Bergstrom J,Jernigan A,Tanner EJ 3rd,Roche KL,Stone RL,Levinson KL,Ricci S,Wethingon S,Wang TL,Shih IM,Yang B,Zhang G,Armstrong DK,Gaillard S,Michener C,DeBernardo R,Rose PG

    更新日期:2017-10-01 00:00:00

  • Reconstructive surgery following resection of primary vulvar cancers.

    abstract:OBJECTIVE:This study describes the surgical treatment and follow-up of 213 patients with primary vulvar cancer; particular attention is given to reconstructive surgical procedures. METHODS:The clinical and pathological parameters of the patients were recorded according to standardized procedures, and the data concerni...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Weikel W,Hofmann M,Steiner E,Knapstein PG,Koelbl H

    更新日期:2005-10-01 00:00:00

  • The efficacy of concurrent weekly carboplatin with radiotherapy in the treatment of cervical cancer: A meta-analysis.

    abstract:OBJECTIVES:We aimed to evaluate whether carboplatin has a comparable efficacy with cisplatin as part of weekly concurrent chemoradiotherapy for cervical cancer (Car-RT vs. Cis-RT). METHODS:A literature search was conducted and both prospective and retrospective studies that evaluated the efficacy of Car-RT for cervica...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,meta分析,评审


    authors: Xue R,Cai X,Xu H,Wu S,Huang H

    更新日期:2018-09-01 00:00:00

  • Endocrine therapy in endometrial cancer: An old dog with new tricks.

    abstract::One of the most prevalent potential therapeutic targets for women with endometrioid endometrial cancer (EC) is the estrogen receptor (ER)/progesterone receptor (PR) pathway. Despite a high proportion of endometrioid ECs being ER and/or PR positive, endocrine therapy is only effective in a minority of women with EC and...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Jerzak KJ,Duska L,MacKay HJ

    更新日期:2019-04-01 00:00:00

  • Intraepithelial neoplasia in the vulvar region.

    abstract::From 1978 to 1982, 49 patients with intraepithelial neoplasia in the vulvar region were included in a prospective investigation. The main purpose was to evaluate the effect of treatment by local excision with a free margin of 2 mm and to estimate the importance of colposcopy. In 28% of the patients, the disease recurr...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Andreasson B,Bock JE

    更新日期:1985-07-01 00:00:00

  • Urinary tract dysfunction after radical hysterectomy for cervical cancer.

    abstract:OBJECTIVES:To evaluate the urinary tract dysfunction following a radical hysterectomy and to compare the baseline urodynamical parameters of women who had uterine cervical carcinoma with women who had CIN 3. METHODS:A prospective case-control study was conducted to evaluate preoperative and postoperative urinary tract...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Chen GD,Lin LY,Wang PH,Lee HS

    更新日期:2002-05-01 00:00:00

  • Electronic patient-reported symptom monitoring in patients recovering from ambulatory minimally invasive gynecologic surgery: A prospective pilot study.

    abstract:OBJECTIVE:To evaluate the feasibility of an electronic symptom-tracking platform for patients recovering from ambulatory surgery. METHOD:We assessed user response to an electronic system designed to self-report symptoms. Endpoints included compliance, postoperative symptoms, patient satisfaction. An 8-item symptom inv...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Zivanovic O,Chen LY,Vickers A,Straubhar A,Baser R,Veith M,Aiken N,Carter J,Curran K,Simon B,Mueller J,Jewell E,Chi DS,Sonoda Y,Abu-Rustum NR,Leitao MM Jr

    更新日期:2020-10-01 00:00:00

  • Presence of an eosinophilic infiltrate in cervical squamous carcinoma results from a type 2 immune response.

    abstract:OBJECTIVES:The presence of an eosinophilic infiltrate in patients with cervical squamous carcinoma has been shown to correlate with a worse overall survival, suggesting a less effective immune response in these cases. Since type 2 cytokines such as IL-4 and IL-5 are known to attract eosinophilic granulocytes, an immuno...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: van Driel WJ,Kievit-Tyson P,van den Broek LC,Zwinderman AH,Trimbos BJ,Fleuren GJ

    更新日期:1999-08-01 00:00:00

  • Primary appendiceal malignancy mimicking advanced stage ovarian carcinoma: a case series.

    abstract:BACKGROUND:Primary appendiceal malignancy metastatic to the ovaries is a rare condition that may mimic late stage ovarian cancer. This condition is rarely diagnosed preoperatively. CASES:Three patients referred to our institution from 1994 to 1999 for presumed late stage ovarian cancer were found to have primary appen...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: McBroom JW,Parker MF,Krivak TC,Rose GS,Crothers B

    更新日期:2000-09-01 00:00:00

  • DNA flow cytometry and morphometry as prognostic indicators in advanced ovarian cancer: a step forward in predicting the clinical outcome.

    abstract::In 74 patients with advanced ovarian cancer, the value of DNA flow cytometry and morphometry was evaluated and compared with histological grading and clinical outcome. By means of both DNA flow cytometry and morphometry a clear distinction was found between a favorable group of 15 patients, with a median survival of m...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Rodenburg CJ,Cornelisse CJ,Hermans J,Fleuren GJ

    更新日期:1988-02-01 00:00:00

  • Multicellular spheroids in ovarian cancer metastases: Biology and pathology.

    abstract::Epithelial ovarian cancer (EOC) has a relatively high mortality rate ( approximately 55%). One of the presiding causes is that the current chemotherapeutic regimes are unable to achieve sustained remission, despite frequently producing a positive response at first treatment. One of the reasons that EOC is difficult to...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Shield K,Ackland ML,Ahmed N,Rice GE

    更新日期:2009-04-01 00:00:00

  • Use of CA 125 to monitor patients with ovarian epithelial carcinomas.

    abstract::The CA 125 radioimmunoassay has been increasingly used to monitor the course of patients with ovarian epithelial carcinomas. The purpose of this report is to describe our experience in the use of this assay and to better define its clinical utility. Fifty-one patients had serum CA 125 follow-up during primary chemothe...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Podczaski E,Whitney C,Manetta A,Larson JE,Kirk J,Stevens CW,Lyter J,Mortel R

    更新日期:1989-05-01 00:00:00

  • Sensitivity to Fas-mediated apoptosis in high-risk HPV-positive human cervical cancer cells: relationship with Fas, caspase-8, and Bid.

    abstract:OBJECTIVE:Binding of Fas ligand or agonistic anti-Fas antibody to the death receptor Fas can activate a caspase-cascade resulting in apoptosis. In the present study, the functionality of the Fas pathway was studied in human cervical cancer cells with different HPV and p53 status. METHODS:HeLa (HPV-18 positive), CaSki,...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Hougardy BM,van der Zee AG,van den Heuvel FA,Timmer T,de Vries EG,de Jong S

    更新日期:2005-05-01 00:00:00

  • Inverse expression of Cdk4 and p16 in epithelial ovarian tumors.

    abstract:OBJECTIVES:The aim of this study was to elucidate the expression and the correlation of two cell cycle regulators, cdk4 and its inhibitor p16, in a series of benign, borderline, and malignant ovarian tumors and to evaluate whether their alterations correlate with clinicopathologial parameters and patients' prognosis in...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Sui L,Dong Y,Ohno M,Goto M,Inohara T,Sugimoto K,Tai Y,Hando T,Tokuda M

    更新日期:2000-11-01 00:00:00

  • Chemotherapy followed by radiotherapy versus radiotherapy alone in locally advanced cervical cancer: a randomized study.

    abstract::Between August 1990 and January 1992, 184 patients with squamous cell carcinoma of the cervix, FIGO stage IIB-IVA, were randomized to receive either two cycles of bleomycin, ifosfamide-mesna, and cis-platinum (BIP) chemotherapy (CT) followed by radiotherapy (RT) ("CT-RT group," n = 94) or RT alone (RT group, n = 90). ...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,随机对照试验,评审


    authors: Kumar L,Kaushal R,Nandy M,Biswal BM,Kumar S,Kriplani A,Singh R,Rath GK,Kochupillai V

    更新日期:1994-09-01 00:00:00

  • Does neoadjuvant chemotherapy impair long-term survival for ovarian cancer patients? A nationwide Danish study.

    abstract:OBJECTIVE:In Denmark, the proportion of women with ovarian cancer treated with neoadjuvant chemotherapy (NACT) has increased, and the use of NACT varies among center hospitals. We aimed to evaluate the impact of first-line treatment on surgical outcome and median overall survival (MOS). METHODS:All patients treated in...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Fagö-Olsen CL,Ottesen B,Kehlet H,Antonsen SL,Christensen IJ,Markauskas A,Mosgaard BJ,Ottosen C,Soegaard CH,Soegaard-Andersen E,Hoegdall C

    更新日期:2014-02-01 00:00:00

  • Platinum-based neoadjuvant chemotherapy and interval surgical cytoreduction for advanced ovarian cancer: a meta-analysis.

    abstract:OBJECTIVE:To determine the overall survival and relative effect of multiple prognostic variables in cohorts of patients with advanced-stage ovarian cancer treated with platinum-based neoadjuvant chemotherapy in lieu of primary cytoreductive surgery. METHODS:Twenty-two cohorts of patients with Stage III and IV ovarian ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,meta分析


    authors: Bristow RE,Chi DS

    更新日期:2006-12-01 00:00:00

  • Invasive adenocarcinoma of the cervix following LLETZ (large loop excision of the transformation zone) for adenocarcinoma in situ.

    abstract::Adenocarcinoma in situ (AIS) of the cervix is a controversial entity which is being encountered with increasing frequency. Current critical issues in its management are the safety of uterine preservation in younger patients and the use of LLETZ conization. A 28-year-old patient was diagnosed with AIS and managed with ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kennedy AW,elTabbakh GH,Biscotti CV,Wirth S

    更新日期:1995-08-01 00:00:00

  • The efficacy of complex decongestive physiotherapy (CDP) and predictive factors of response to CDP in lower limb lymphedema (LLL) after pelvic cancer treatment.

    abstract:OBJECTIVE:The aim of this study was to estimate the efficacy of an intensive CDP program, as well as to identify the predictors associated with lymphedema severity and response to CDP in lower limb lymphedema (LLL) after pelvic cancer therapy. METHODS:We performed a retrospective review of post-pelvic cancer LLL patie...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Liao SF,Li SH,Huang HY

    更新日期:2012-06-01 00:00:00