Ovarian serous carcinoma presenting with mediastinal lymphadenopathy 20 months before the intraabdominal mass: role of immunohistochemistry.

Abstract:

INTRODUCTION:Metastatic involvement of the mediastinal lymph nodes is an extremely uncommon finding in epithelial ovarian cancers. CASE REPORT:A 63-year-old woman was admitted to hospital for dyspnoea due to an anterior mediastinal mass. The surgical biopsy showed a 6-cm metastatic lymph node with a papillary pattern, scattered psammomas and immunoreactivity for WT1, Cytokeratin 7, EMA and negative for E-cadherin, GCFDP-15, Thyroglobulin, Cytokeratin 20, Cytokeratin 5/6, CEA, Vimentin, Calretinin, TTF1. After 20 months a follow-up CT identified an ovarian mass with the same histological pattern and immunoreactivity of the mediastinal nodule. RESULTS:Immunohistochemistry, especially WT1, is useful in assessing the ovarian origin of an unusual metastasis particularly if it is the first presentation of the disease.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Zannoni GF,Vellone VG,Distefano MG,Fadda G,Scambia G

doi

10.1016/j.ygyno.2006.09.030

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

497-500

issue

2

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(06)00744-X

journal_volume

104

pub_type

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