Color Doppler and duplex flow analysis for classification of breast lesions.

Abstract:

:The purpose of this study was to evaluate the differences of blood supply in benign and malignant breast tumors by color Doppler flow measurements. The study included 471 patients, 133 with carcinomas, 325 with benign breast lesions, and 13 with mastitis. An ATL UM9/HDI was used with an electronic 10-MHz linear array broadband transducer. The following flow data were analyzed: Presence of vascularity; number of tumor arteries; the mean, minimum, maximum RI index, and AB ratio; the mean, minimum, and maximum peak systolic flow velocity and the sum of all peak systolic flow velocities in each tumor. In all cancers and in most benign pathologies vascularity was found. Highly significant differences between benign and malignant were found for all quantitative flow data such as number of tumor arteries and blood flow velocity (P < 0.0001). Flow profiles analyzed by RI index and AB ratio showed a trend for increased flow resistance in malignancies. However, due to the wide overlap between benign and malignant, indices did not allow a sufficient differentiation. The study showed that standardization of the Doppler examination technique and equipment parameters is essential for vascularity assessment of tumors.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Madjar H,Sauerbrei W,Prömpeler HJ,Wolfarth R,Gufler H

doi

10.1006/gyno.1996.4585

subject

Has Abstract

pub_date

1997-03-01 00:00:00

pages

392-403

issue

3

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(96)94585-0

journal_volume

64

pub_type

临床试验,杂志文章
  • GRP78 induced by estrogen plays a role in the chemosensitivity of endometrial cancer.

    abstract:OBJECTIVE:Molecular chaperone 78 kDa glucose-regulated protein (GRP78) is a residential protein in the endoplasmic reticulum (ER) that is induced by an unfolded-protein response triggered under many kinds of stress against a cell. GRP78 is also known to act as an anti-apoptotic factor by protecting ER-stress-induced ce...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2012.04.025

    authors: Luvsandagva B,Nakamura K,Kitahara Y,Aoki H,Murata T,Ikeda S,Minegishi T

    更新日期:2012-07-01 00:00:00

  • Does debulking surgery improve survival in biologically aggressive ovarian carcinoma?

    abstract::Aggressive tumor reduction surgery has been widely used in patients with advanced stage epithelial ovarian carcinoma before initiation of cytotoxic chemotherapy. No randomized controlled trial has been carried out to confirm the benefits of such procedures. To examine the role of cytoreductive surgery in the managemen...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1997.4839

    authors: Le T,Krepart GV,Lotocki RJ,Heywood MS

    更新日期:1997-11-01 00:00:00

  • Herpes gestationis may present itself as a paraneoplastic syndrome of choriocarcinoma-a case report.

    abstract:BACKGROUND:Herpes gestationis (HG) is a rare, recurrent, pruritic, vesicobullous dermatosis occurring predominantly in pregnancy and seldom in early puerperium. Reports of the association of HG with choriocarcinoma are extremely rare and this case highlights such a possible link. CASE:This case focuses on the late pos...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/s0090-8258(03)00070-2

    authors: Djahansouzi S,Nestle-Kraemling C,Dall P,Bender HG,Hanstein B

    更新日期:2003-05-01 00:00:00

  • Placebo-controlled trial of indole-3-carbinol in the treatment of CIN.

    abstract:OBJECTIVE:Most precancerous lesions of the cervix are treated with surgery or ablative therapy. Chemoprevention, using natural and synthetic compounds, may intervene in the early precancerous stages of carcinogenesis and prevent the development of invasive disease. Our trial used indole-3-carbinol (I-3-C) administered ...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1006/gyno.2000.5847

    authors: Bell MC,Crowley-Nowick P,Bradlow HL,Sepkovic DW,Schmidt-Grimminger D,Howell P,Mayeaux EJ,Tucker A,Turbat-Herrera EA,Mathis JM

    更新日期:2000-08-01 00:00:00

  • Efficacy of acupuncture in prevention of delayed chemotherapy induced nausea and vomiting in gynecologic cancer patients.

    abstract:OBJECTIVE:To compare the efficacy between acupuncture and ondansetron in the prevention of delayed chemotherapy induced nausea and vomiting (CINV). METHODS:70 patients were randomized to receive either 1) acupuncture at P6 point before chemotherapy infusion or 2) ondansetron 8 mg intravenously 30 min before chemothera...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ygyno.2014.10.025

    authors: Rithirangsriroj K,Manchana T,Akkayagorn L

    更新日期:2015-01-01 00:00:00

  • Defining the survival benefit of adjuvant pelvic radiotherapy and chemotherapy versus chemotherapy alone in stages III-IVA endometrial carcinoma.

    abstract:OBJECTIVES:To determine which patients with locoregionally advanced endometrial cancer may benefit from pelvic external beam radiotherapy (EBRT) in addition to chemotherapy compared to chemotherapy alone. METHODS:Patients with FIGO stages III-IVA endometrial carcinoma between 2004 and 2016 who underwent at least total...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2019.06.020

    authors: Xiang M,English DP,Kidd EA

    更新日期:2019-09-01 00:00:00

  • Extraperitoneal versus transperitoneal selective paraaortic lymphadenectomy in the pretreatment surgical staging of advanced cervical carcinoma (a Gynecologic Oncology Group study).

    abstract::Two-hundred and eighty-eight patients with predominately stage IIB or IIIB cervical carcinoma underwent pretreatment surgical staging including selective paraaortic lymphadenectomy (SPAL), followed by pelvic irradiation with or without paraaortic irradiation (RT). Four patients were excluded from analysis (two receive...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章

    doi:10.1016/0090-8258(89)90513-1

    authors: Weiser EB,Bundy BN,Hoskins WJ,Heller PB,Whittington RR,DiSaia PJ,Curry SL,Schlaerth J,Thigpen JT

    更新日期:1989-06-01 00:00:00

  • Placental site trophoblastic tumor: analysis of presentation, treatment, and outcome.

    abstract:OBJECTIVE:Placental-site trophoblastic tumor (PSTT) is the rarest form of gestational trophoblastic disease (GTD). A risk-adapted treatment approach has been advocated, but controversy exists as to the most important prognostic markers for this disease. Our goal was to determine the prognostic markers for patients with...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2012.12.029

    authors: Hyman DM,Bakios L,Gualtiere G,Carr C,Grisham RN,Makker V,Sonoda Y,Aghajanian C,Jewell EL

    更新日期:2013-04-01 00:00:00

  • Diagnosis of endometrial cancer in patients with postmenopausal bleeding by analysis of the lactate dehydrogenase isoenzyme activity profile in uterine fluid.

    abstract:OBJECTIVES:We have previously shown that high activity of lactate dehydrogenase (LD) isoenzymes 4 and 5 in terine aspirates is a marker for endometrial carcinoma. The purpose of this study was to identify an abnormal activity profile of LD2-5 using LD1 as an internal standard, thereby being able to dispense with measur...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2004.02.014

    authors: Niklasson O,Skude G,Marsal K,Casslén B

    更新日期:2004-05-01 00:00:00

  • Recurrent metastatic fallopian tube carcinoma in pregnancy.

    abstract:BACKGROUND:Fallopian tube cancer is the rarest of all gynecologic cancers. An extensive literature search on Medline reveals no previous case reports of fallopian tube carcinoma in association with a term pregnancy. CASE:A woman with surgical stage IIB fallopian tube carcinoma was treated with limited staging laparoto...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.2000.6097

    authors: Adolph A,Le T,Khan K,Biem S

    更新日期:2001-04-01 00:00:00

  • Inverse correlation between RASSF1A hypermethylation, KRAS and BRAF mutations in cervical adenocarcinoma.

    abstract:OBJECTIVE:Although the incidence of cervical adenocarcinoma is increasing, few genetic and epigenetic changes in its progression have been described. We hypothesized that RASSF1A methylation and KRAS and BRAF mutations may play an important role in cervical adenocarcinoma. METHODS:Archival primary carcinoma tissues (n...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2007.01.045

    authors: Kang S,Kim HS,Seo SS,Park SY,Sidransky D,Dong SM

    更新日期:2007-06-01 00:00:00

  • Melanoma of the vulva: an update.

    abstract::During the time interval 1950 through 1980, 48 patients having a mean age of 60.2 years were treated primarily for melanoma of the vulva. In all but one patient, a surgical therapeutic approach was selected, including 40 modified Basset procedures and 23 pelvic lymphadenectomies. The 5-year survival rate of the eligib...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(83)90090-2

    authors: Podratz KC,Gaffey TA,Symmonds RE,Johansen KL,O'Brien PC

    更新日期:1983-10-01 00:00:00

  • Chemotherapy and extended-field radiation therapy to para-aortic area in patients with histologically proven metastatic cervical cancer to para-aortic nodes: a phase II pilot study.

    abstract::From November 1983 to October 1992, 22 patients with invasive cervical cancer stage IB through stage IIIB with metastasis to para-aortic nodes were entered in this study. Five patients were excluded. Of 17 remaining evaluable patients, 5 (29%) were stage IB, 6 (35%) were stage IIB, and 6 (35%) were stage IIIB. Four (2...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1006/gyno.1994.1057

    authors: Husseinzadeh N,Shrake P,DeEulis T,Rowley K,Aron B

    更新日期:1994-03-01 00:00:00

  • Techniques of sentinel lymph node identification for early-stage cervical and uterine cancer.

    abstract::Techniques for sentinel lymph node injections have varied over the years in both cervical and uterine malignancy lymph node mapping. There remains considerable variation in techniques, particularly for uterine malignancies. This review summarizes some of the techniques that have been published and are currently utiliz...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ygyno.2008.07.027

    authors: Abu-Rustum NR,Khoury-Collado F,Gemignani ML

    更新日期:2008-11-01 00:00:00

  • Outcome of endometrial carcinoma patients with involvement of the uterine serosa.

    abstract:OBJECTIVE:The goal of this work was to evaluate the outcome of endometrial carcinoma patients undergoing primary surgery who have serosal involvement (SI). METHODS:Between 1980 and 1998, 562 women underwent primary surgery for endometrial cancer at the University of Chicago. Thirty-nine were noted to have SI. FIGO sta...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.2001.6189

    authors: Ashman JB,Connell PP,Yamada D,Rotmensch J,Waggoner SE,Mundt AJ

    更新日期:2001-08-01 00:00:00

  • Class II radical hysterectomy shows less morbidity and good treatment efficacy compared to class III.

    abstract::Treatment of 102 patients with cancer of the cervix by class II and III radical hysterectomy was reviewed to compare the operative morbidity and efficacy of class II radical hysterectomy for select cases. Of the 102 patients, 21 had a class II hysterectomy, whereas 81 patients had a class III hysterectomy. The class I...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(91)90078-j

    authors: Photopulos GJ,Zwaag RV

    更新日期:1991-01-01 00:00:00

  • Bleomycin, etoposide, and cisplatin combination therapy of ovarian granulosa cell tumors and other stromal malignancies: A Gynecologic Oncology Group study.

    abstract:OBJECTIVES:The objectives of this study were to assess efficacy and toxicity of the combination of bleomycin, etoposide, and cisplatin (BEP) in this Phase II trial as first-line therapy for ovarian stromal malignancies. METHODS:Patients with incompletely resected Stages II-IV or recurrent cancer underwent surgical deb...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1006/gyno.1998.5304

    authors: Homesley HD,Bundy BN,Hurteau JA,Roth LM

    更新日期:1999-02-01 00:00:00

  • Toward understanding the natural history of ovarian carcinoma development: a clinicopathological approach.

    abstract:OBJECTIVE:The natural history of the development of ovarian carcinoma is not known. It also remains undetermined whether ovarian carcinomas develop from benign and/or borderline malignant tumors or arise de novo from the ovarian surface epithelium. METHODS:To address these issues clinicopathologically, we reviewed the...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/s0090-8258(02)00104-x

    authors: Horiuchi A,Itoh K,Shimizu M,Nakai I,Yamazaki T,Kimura K,Suzuki A,Shiozawa I,Ueda N,Konishi I

    更新日期:2003-03-01 00:00:00

  • Does the interval from primary surgery to chemotherapy influence progression-free survival in ovarian cancer?

    abstract:OBJECTIVES:The objective of this study was to determine whether the length of the interval from primary surgery to commencement of chemotherapy has any direct effect on progression-free survival in ovarian cancer. METHODS:The progression-free survival of 472 patients enrolled in four trials who had all received platin...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.2002.6750

    authors: Flynn PM,Paul J,Cruickshank DJ,Scottish Gynaecological Cancer Trials Group.

    更新日期:2002-09-01 00:00:00

  • Clinical pharmacology of intraperitoneal cisplatin.

    abstract::The clinical pharmacology of cisplatin was determined in six patients with malignant ascites secondary to ovarian cancer, and in one patient with peritoneal mesothelioma, following intraperitoneal administration of cisplatin (25-60 mg/m2). The drug was administered in 1 liter of normal saline as a 15- to 30-min infusi...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(85)90118-0

    authors: Lopez JA,Krikorian JG,Reich SD,Smyth RD,Lee FH,Issell BF

    更新日期:1985-01-01 00:00:00

  • Neoadjuvant intraarterial chemotherapy followed by radical hysterectomy and/or radiotherapy for locally advanced cervical cancer.

    abstract:OBJECTIVES:We assessed neoadjuvant intraarterial chemotherapy (NAC) followed by radical hysterectomy and/or radiotherapy in patients with locally advanced cervical cancer. METHODS:Over 5 years, 48 consecutive women with International Federation of Gynecology and Obstetrics stage IIb-IVa cervical cancer were enrolled. ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1998.4976

    authors: Sugiyama T,Nishida T,Hasuo Y,Fujiyoshi K,Yakushiji M

    更新日期:1998-05-01 00:00:00

  • A trial of continuous-infusion vinblastine in refractory endometrial adenocarcinoma.

    abstract::Fourteen patients with refractory or metastatic adenocarcinoma of the endometrium were treated with continuous infusion vinblastine. No patient had a response. One patient had stable disease. Although well tolerated, vinblastine sulfate given by this method has no activity in this malignancy. ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(87)90279-4

    authors: Kavanagh JJ,Saul PB,Wharton JT,Rutledge FN

    更新日期:1987-02-01 00:00:00

  • Potential mechanisms for HPV vaccine-induced long-term protection.

    abstract::Human papillomaviruses (HPVs) are small double-stranded DNA viruses that infect the skin and internal squamous mucosae. These viruses were once considered to be the causal agent only of skin or genital warts--lesions of trivial significance. It turns out, however, that HPVs belong to a large virus family that includes...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ygyno.2010.04.002

    authors: Stanley M

    更新日期:2010-06-01 00:00:00

  • Consequences of universal MSI/IHC in screening ENDOMETRIAL cancer patients for Lynch syndrome.

    abstract:OBJECTIVE:Determine factors impacting the uptake of genetic counseling and results of genetic testing following universal tumor testing for Lynch syndrome in patients with endometrial cancer. METHODS:The study population consisted of two unselected cohorts of endometrial cancer patients, 408 identified retrospectively...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2014.06.009

    authors: Batte BA,Bruegl AS,Daniels MS,Ring KL,Dempsey KM,Djordjevic B,Luthra R,Fellman BM,Lu KH,Broaddus RR

    更新日期:2014-08-01 00:00:00

  • Uterine sarcoma occurring in a premenopausal patient after uterine artery embolization: a case report and review of the literature.

    abstract:OBJECTIVE:We report a case of uterine leiomyosarcoma occurring after uterine artery embolization and review the previously published cases. We estimate the incidence of sarcoma after UAE, the mean diagnostic delay in young women undergoing this procedure and review the potential and limits of preoperative procedures in...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2006.08.051

    authors: Papadia A,Salom EM,Fulcheri E,Ragni N

    更新日期:2007-01-01 00:00:00

  • Human papillomavirus load in Hybrid Capture II assay: does increasing the cutoff improve the test?

    abstract:OBJECTIVE:The aim of the study was to evaluate whether the results of the Hybrid Capture II (HCII) assay for detecting high-grade squamous intraepithelial lesions (H-SIL) or cervical carcinoma can be improved by increasing the relative light units (RLU) level. STUDY DESIGN:We included 2271 women (mean age 38.7 +/- 12....

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2005.07.011

    authors: Ordi J,Alonso I,Torné A,Esteve R,Sierra E,Campo E,Puig-Tintoré LM

    更新日期:2005-11-01 00:00:00

  • Integrated analysis of HPV-mediated immune alterations in cervical cancer.

    abstract:OBJECTIVE:Human papillomavirus (HPV) infection is the primary cause of cervical cancer. HPV-mediated immune alterations are known to play crucial roles in determining viral persistence and host cell transformation. We sought to thoroughly understand HPV-directed immune alterations in cervical cancer by exploring public...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2018.01.031

    authors: Chen L,Luan S,Xia B,Liu Y,Gao Y,Yu H,Mu Q,Zhang P,Zhang W,Zhang S,Wei G,Yang M,Li K

    更新日期:2018-05-01 00:00:00

  • A pilot study of intra-arterial carboplatin in patients with recurrent carcinoma of the cervix, postradiation.

    abstract::Twelve patients with recurrent squamous cell carcinoma of the cervix restricted to the pelvis were treated with intra-arterial infusion of carboplatin. The initial carboplatin dose was 300 mg/m2, every 4 weeks, and the dose was escalated to 450 mg/m2. Myelosuppression was the dose-limiting toxicity at the 450 mg/m2 do...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章

    doi:10.1006/gyno.1994.1136

    authors: Verma S,Prefontaine M,Bertrand M,Genest P,Dahrouge S

    更新日期:1994-06-01 00:00:00

  • Screening practices and invasive cervical cancer risk in different age strata.

    abstract::Relative and population attributable risks for invasive cervical cancer in different age strata relative to screening practices have been estimated using data from a case-control study conducted since 1981 in the greater Milan area, northern Italy. A total of 548 women under 75 years of age with a histologically confi...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(90)90015-d

    authors: Parazzini F,Negri E,La Vecchia C,Bocciolone L

    更新日期:1990-07-01 00:00:00

  • A phase 2 study of alisertib (MLN8237) in recurrent or persistent uterine leiomyosarcoma: An NRG Oncology/Gynecologic Oncology Group study 0231D.

    abstract:OBJECTIVE:This two-stage Phase II study assessed the activity of single agent alisertib in patients with recurrent/persistent uterine leiomyosarcoma (uLMS). METHODS:Eligibility criteria included histologically-confirmed, recurrent or persistent uLMS, age≥18, 1-2 prior cytotoxic regimens, and RECIST version 1.1 measura...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2016.10.036

    authors: Hyman DM,Sill MW,Lankes HA,Piekarz R,Shahin MS,Ridgway MR,Backes F,Tenney ME,Mathews CA,Hoffman JS,Aghajanian C,Hensley ML

    更新日期:2017-01-01 00:00:00