Prognostic significance of hysteroscopic imaging in endometrioid endometrial adenocarcinoma.

Abstract:

OBJECTIVE:The aim of this study was to relate hysteroscopic features of endometrioid endometrial adenocarcinoma to stage, grade and overall survival. METHODS:Sixty women with endometrioid adenocarcinoma underwent laparotomy and staging according to current FIGO classification. Before surgery hysteroscopy was performed in all patients to establish the morphology of neoplasia, the extent of endometrial lining involvement, and endocervical spreading. These hysteroscopic parameters were related to overall survival, surgical stage, and grade of disease. RESULTS:First-stage carcinomas were found in 50 patients, second-stage in 4, third-stage in 3, and fourth-stage in 3 patients. Well-differentiated tumors were detected in 32, moderately differentiated in 21, and poorly differentiated in 7 patients. The cumulative 48-month probability of survival was 86.6%. The morphology of adenocarcinomas was unrelated to both their stage and their grade; no relationship to survival was found. The extent of carcinomatous spread within the endometrial cavity was significantly related to stage, grade, and survival. Endometrial lining involvement of less than 50% was associated with 100% survival, 97.1% of first-stage diseases, and 96.6% of low-grade carcinomas. These percentages dropped to 73.1, 65.3 (Fisher's exact test, P = 0.001), and 76.9% (Fisher's exact test, P = 0.035), respectively, when tumoral growth involved more than half of the endometrium. Hysteroscopy detected all carcinomas metastasizing to the cervix; in 8 patients we overdiagnosed endocervical spreading, although histology was negative. From these figures, hysteroscopy showed a sensitivity and specificity in predicting cervical spread of 100 and 87.3%, respectively. CONCLUSIONS:The extent of endometrial lining involvement in patients with endometrioid carcinoma provides preoperative information on the risk of extrauterine spread. We confirm the high accuracy of hysteroscopy in excluding cervical spread.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Garuti G,De Giorgi O,Sambruni I,Cellani F,Luerti M

doi

10.1006/gyno.2001.6173

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

408-13

issue

3

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(01)96173-6

journal_volume

81

pub_type

杂志文章
  • Malignant pericardial effusion in ovarian carcinoma cured by systemic chemotherapy.

    abstract::A case of malignant pericardial effusion in a 67-year-old patient with serous ovarian cystadenocarcinoma is presented. Pericardial effusion was treated successfully with cyclophosphamide, doxorubicin, and cisplatin. The primary tumor had previously been assumed to be sensitive to this combination by using an in vivo p...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(88)90036-4

    authors: Mäenpää J,Taina E,Erkkola R

    更新日期:1988-06-01 00:00:00

  • The significance of perineural invasion in early-stage cervical cancer.

    abstract:INTRODUCTION:Cervical cancer spreads directly and through lymphatic and vascular channels. Perineural invasion is an alternative method of spread. Several risk factors portend poor prognosis and inform management decisions regarding adjuvant therapy. OBJECTIVE:To evaluate the incidence and significance of PNI in early...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2011.08.028

    authors: Elsahwi KS,Barber E,Illuzzi J,Buza N,Ratner E,Silasi DA,Santin AD,Azodi M,Schwartz PE,Rutherford TJ

    更新日期:2011-12-01 00:00:00

  • Bone metastasis from cervix cancer.

    abstract::Among 713 patients followed after treatment for cancer of the uterine cervix, 48 (6.6%) had a metastasis to the bone. The rates of metastasis in each of the four clinical stages were 11/273 (4.0%) in stage I, 16/243 (6.6%) in stage II, 13/162 (8.0%) in stage III, and 8/35 (22.9%) in stage IV, respectively. The most fr...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(89)90853-6

    authors: Matsuyama T,Tsukamoto N,Imachi M,Nakano H

    更新日期:1989-01-01 00:00:00

  • Conservative surgical treatment in cervical cancer with 3 to 5 mm stromal invasion in the absence of confluent invasion and lymph-vascular space involvement.

    abstract::We have previously reported that simple hysterectomy is adequate therapy for microinvasive carcinoma of the cervix with less than 3 mm stromal invasion (Yajima, A., et al, Am. J. Obstet. Gynecol. 135, 685-688, 1979). However, whether it is possible to effectively treat patients with deeper stromal invasion remained in...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1994.1219

    authors: Yaegashi N,Sato S,Inoue Y,Noda K,Yajima A

    更新日期:1994-09-01 00:00:00

  • Management of patients with metastatic gestational trophoblastic tumor.

    abstract:OBJECTIVE:This study was designed to analyze the results of treatment on patients with metastatic gestational trophoblastic tumor (metastatic GTT). METHOD:During 1996-2001, 38 cases with metastatic GTT were diagnosed and received treatment in Vali-e-Asr Hospital, Tehran, Iran. Data were gathered retrospectively and an...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2004.04.006

    authors: Ghaemmaghami F,Behtash N,Soleimani K,Hanjani P

    更新日期:2004-07-01 00:00:00

  • Recurrent metastatic fallopian tube carcinoma in pregnancy.

    abstract:BACKGROUND:Fallopian tube cancer is the rarest of all gynecologic cancers. An extensive literature search on Medline reveals no previous case reports of fallopian tube carcinoma in association with a term pregnancy. CASE:A woman with surgical stage IIB fallopian tube carcinoma was treated with limited staging laparoto...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.2000.6097

    authors: Adolph A,Le T,Khan K,Biem S

    更新日期:2001-04-01 00:00:00

  • Successful salvage of a relapsed high risk gestational trophoblastic neoplasia patient using capecitabine.

    abstract:BACKGROUND:Although most patients at high risk of Gestational Trophoblastic Neoplasia (GTN) respond to standard treatments, there is a group of patients that will die because of it. The use of new single or combination drugs in this population has become a priority. CASE REPORT:We present the case of a relapsed high r...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2007.04.002

    authors: Bianconi M,Jankilevich G,Otero S,Nassif J,Storino C

    更新日期:2007-07-01 00:00:00

  • Expression and clinical role of long non-coding RNA in high-grade serous carcinoma.

    abstract:OBJECTIVE:To profile long non-coding RNA (lncRNA) expression at the various anatomic sites of high-grades serous carcinoma (HGSC) and in effusion-derived exosomes. METHODS:LncRNA profiling was performed on 60 HGSC specimens, including 10 ovarian tumors, 10 solid metastases and 10 malignant effusions, as well as exosom...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2018.01.004

    authors: Filippov-Levy N,Cohen-Schussheim H,Tropé CG,Hetland Falkenthal TE,Smith Y,Davidson B,Reich R

    更新日期:2018-03-01 00:00:00

  • Preservation of ovarian function and reproductive ability in patients with malignant ovarian tumors.

    abstract::In a study designed to determine the merit of preserving ovarian function and childbearing capability in women with unilateral malignant ovarian tumors, the results of radical surgery (n = 86) and conservative surgery (n = 106) were compared. The mean length of survival was slightly but not significantly shorter follo...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章

    doi:10.1016/0090-8258(88)90247-8

    authors: Miyazaki T,Tomoda Y,Ohta M,Kano T,Mizuno K,Sakakibara K

    更新日期:1988-07-01 00:00:00

  • An unusual case of secondary fibrosarcoma after treatment for breast cancer.

    abstract:BACKGROUND:Post-irradiation breast sarcoma is a rare and highly aggressive tumor, associated with poor prognosis. However, the mean latent periods reported for postradiation sarcomas after treatment of breast cancer ranges from 5 to 10 years. CASE:We present a rare case of fibrosarcoma of the axilla, diagnosed 23 mont...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ygyno.2006.07.014

    authors: Plotti F,Di Donato V,Zullo MA,Angioli R,Panici PB

    更新日期:2006-12-01 00:00:00

  • Prothrombin fragment F 1 + 2 plasma concentrations in patients with gynecologic malignancies.

    abstract::Malignant diseases have been shown to cause hypercoagulable states. Elevated prothrombin fragment F 1 + 2 plasma levels occur, when prothrombin is converted into thrombin by factor Xa. In order to evaluate the role of prothrombin fragment F 1 + 2 as an indicator for hemostatic disorders in patients with gynecologic ma...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1993.1142

    authors: Hanzal E,Tatra G

    更新日期:1993-06-01 00:00:00

  • Treatment of advanced uterine sarcoma with vincristine, actinomycin D, and cyclophosphamide.

    abstract::Between 1971 and 1979, seventy-four patients with metastatic or advanced recurrent sarcoma of uterine origin were treated with combination chemotherapy consisting of vincristine, actinomycin D, and cyclophosphamide (Cytoxan). The probability of survival at 2 and 5 years was 23 and 15%, respectively. The response rate ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(83)90078-1

    authors: Hannigan EV,Freedman RS,Elder KW,Rutledge FN

    更新日期:1983-04-01 00:00:00

  • Low-grade serous carcinoma: new concepts and emerging therapies.

    abstract::For the past several years, all women with epithelial ovarian cancer have been treated identically, whether in a clinical trial or off protocol. Over the past decade, we have come to appreciate the magnitude of the heterogeneity of ovarian cancer. The development of the binary grading system for serous carcinoma was a...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ygyno.2013.05.021

    authors: Romero I,Sun CC,Wong KK,Bast RC Jr,Gershenson DM

    更新日期:2013-09-01 00:00:00

  • Analysis of gastric-type mucinous carcinoma of the uterine cervix - An aggressive tumor with a poor prognosis: A multi-institutional study.

    abstract:OBJECTIVE:Gastric-type mucinous carcinoma (GAS) is a novel variant of mucinous carcinoma of the uterine cervix. As shown in the original Japanese group description, in recent studies, GAS represents a more aggressive disease than the usual-type endocervical adenocarcinoma (UEA). Detailed clinicopathological features of...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ygyno.2019.01.022

    authors: Nishio S,Mikami Y,Tokunaga H,Yaegashi N,Satoh T,Saito M,Okamoto A,Kasamatsu T,Miyamoto T,Shiozawa T,Yoshioka Y,Mandai M,Kojima A,Takehara K,Kaneki E,Kobayashi H,Kaku T,Ushijima K,Kamura T

    更新日期:2019-04-01 00:00:00

  • Prognostic factors for groin node metastasis in squamous cell carcinoma of the vulva (a Gynecologic Oncology Group study)

    abstract::From 1977 to 1984 the Gynecologic Oncology Group (GOG) conducted a prospective clinical and surgical staging protocol of squamous cell carcinoma of the vulva (n = 637). The patients with superficial (5 mm or less invasion) lesions were the subject of a previous report (n = 272). The subject of this report is on factor...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1993.1127

    authors: Homesley HD,Bundy BN,Sedlis A,Yordan E,Berek JS,Jahshan A,Mortel R

    更新日期:1993-06-01 00:00:00

  • The Wertheim hysterectomy: Development, modifications, and impact in the present day.

    abstract::Ernst Wertheim was a pioneer in the history of the surgical treatment of cervical cancer. His English-language manuscript "The extended abdominal operation for carcinoma uteri (based on 500 operative cases)," which was published in 1912, detailed his standardization of the radical hysterectomy and formed the basis of ...

    journal_title:Gynecologic oncology

    pub_type: 历史文章,杂志文章

    doi:10.1016/j.ygyno.2017.01.011

    authors: Swailes AL,Gockley A,Phaëton R,Kesterson JP

    更新日期:2017-04-01 00:00:00

  • Anti-Yo positive paraneoplastic cerebellar degeneration associated with ovarian carcinoma: case report and review of the literature.

    abstract::Paraneoplastic cerebellar degeneration (PCD) is a rare nonmetastatic neurological complication in cancer patients. Anti-Yo is one of the anti-onconeural antibodies found in PCD patients. It is believed that anti-Yo occurs almost always in women and is most likely associated with gynecologic or breast cancers, although...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1006/gyno.1999.5553

    authors: Cao Y,Abbas J,Wu X,Dooley J,van Amburg AL

    更新日期:1999-10-01 00:00:00

  • Surgical approach to diaphragmatic metastases from ovarian cancer.

    abstract::Fourteen patients underwent surgical debulking of diaphragmatic metastases as part of cytoreductive surgery for advanced ovarian epithelial cancer from 1983 to 1984. The surgical technique is described. Morbidity from this approach was not excessive in this small series of patients. It is suggested that this technique...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(86)90034-x

    authors: Deppe G,Malviya VK,Boike G,Hampton A

    更新日期:1986-06-01 00:00:00

  • A phase I study of weekly temsirolimus and topotecan in the treatment of advanced and/or recurrent gynecologic malignancies.

    abstract:OBJECTIVE:The mTOR inhibitor, temsirolimus, has clinical activity in the treatment of gynecologic malignancies, particularly endometrial cancer. We sought to determine the tolerability of the combination of weekly topotecan with weekly temsirolimus. METHODS:Women with a history of advanced or recurrent gynecologic mal...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2010.02.022

    authors: Temkin SM,Yamada SD,Fleming GF

    更新日期:2010-06-01 00:00:00

  • Metastatic dermatofibrosarcoma protuberans of the vulva.

    abstract::Dermatofibrosarcoma protuberans (DFSP) of the vulva is a rare, low- to intermediate-grade sarcoma of dermal origin. This case report represents the 13th reported patient with vulvar DFSP and the first reported patient with metastatic vulvar DFSP. Although metastasis is rare, the possibility remains that the frequent r...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1998.5173

    authors: Soergel TM,Doering DL,O'connor D

    更新日期:1998-11-01 00:00:00

  • Pre-chemotherapy hemoglobin levels and survival in patients with advanced epithelial ovarian cancer who received a first-line taxane/platinum-based regimen: results of a multicenter retrospective Italian study.

    abstract:OBJECTIVE:The aim of this retrospective multicenter study was to assess whether the pre-chemotherapy hemoglobin levels have any impact on the clinical outcome of patients with advanced epithelial ovarian cancer who received a first-line taxane/platinum-based regimen. METHODS:The study was conducted on 315 patients who...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ygyno.2005.04.012

    authors: Gadducci A,Sartori E,Landoni F,Zola P,Maggino T,Colombo N,Fanucchi A,Chiudinelli F,Lapresa M,Maria Ferrero A

    更新日期:2005-07-01 00:00:00

  • A phase II study of Hsp-7 (SGN-00101) in women with high-grade cervical intraepithelial neoplasia.

    abstract:OBJECTIVE:Approximately 2 million women worldwide are infected with high-risk human papillomaviruses (HPV), resulting in a substantial risk for the development of invasive lower genital malignancies. This study was undertaken to determine the effects of vaccination with a protein encoding a bacterial heat shock protein...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ygyno.2007.05.038

    authors: Roman LD,Wilczynski S,Muderspach LI,Burnett AF,O'Meara A,Brinkman JA,Kast WM,Facio G,Felix JC,Aldana M,Weber JS

    更新日期:2007-09-01 00:00:00

  • The role of interstitial brachytherapy using template in locally advanced gynecological malignancies.

    abstract:OBJECTIVE:Brachytherapy plays a major role in the treatment of patients with carcinoma of the cervix. However, routine intracavitary brachytherapy may not be feasible or adequate to treat locally advanced disease. The purpose of this prospective study was to assess treatment outcome for patients with locally advanced g...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.ygyno.2005.06.001

    authors: Agrawal PP,Singhal SS,Neema JP,Suryanarayan UK,Vyas RK,Rathi AK,Bahadur AK

    更新日期:2005-10-01 00:00:00

  • Immature teratoma of the ovary--an unusual case.

    abstract::A 30-year-old female was found to have a malignant immature teratoma of the ovary 14 years ago. This was treated with surgery followed by chemotherapy. Two years later, hepatic metastasis was discovered and treated with different multiple-agent chemotherapy, resulting in transformation or evolution into a mature terat...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(92)90206-x

    authors: Jumean HG,Komorowski R,Mahvi D,Anderson T

    更新日期:1992-07-01 00:00:00

  • Cloacogenic adenocarcinoma of the vulva.

    abstract::Primary adenocarcinoma of the vulva is rare, and cloagocenic adenocarcinoma of the vulva is extremely rare. Here we report a vulvar tumor characterized by columnar cells with prominent brush border and the presence of goblet cells and endocrine cells, presenting the tubulovillous pattern and mucin histochemistry of en...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1999.5433

    authors: Willén R,Békássy,Carlén B,Bozoky B,Cajander S

    更新日期:1999-08-01 00:00:00

  • Transcript expression in endometrial cancers from Black and White patients.

    abstract:OBJECTIVE:Previous studies suggest that differences in molecular features of endometrial cancers between racial groups may contribute to the poorer survival in Blacks. The objective of this investigation was to determine whether gene expression among endometrial cancers is different between Blacks and Whites. METHODS:...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2013.04.017

    authors: Maxwell GL,Allard J,Gadisetti CV,Litzi T,Casablanca Y,Chandran U,Darcy KM,Levine DA,Berchuck A,Hamilton CA,Conrads TP,Risinger JI

    更新日期:2013-07-01 00:00:00

  • A phase II trial of docetaxel and bevacizumab in recurrent ovarian cancer within 12 months of prior platinum-based chemotherapy.

    abstract:OBJECTIVES:The efficacy and safety of bevacizumab and docetaxel were evaluated in women who developed recurrent epithelial ovarian, fallopian, or peritoneal cancer within 12 months of platinum-based therapy. METHODS:Patients received docetaxel (40 mg/m(2)) on days 1 and 8 and bevacizumab (15 mg/kg) on day 1 of a 21-da...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2013.04.049

    authors: Wenham RM,Lapolla J,Lin HY,Apte SM,Lancaster JM,Judson PL,Gonzalez-Bosquet J,Herschberger A,Havrilesky LJ,Secord AA

    更新日期:2013-07-01 00:00:00

  • Vascular endothelial growth factor (VEGF) and ovarian carcinoma cell supernatant activate signal transducers and activators of transcription (STATs) via VEGF receptor-2 (KDR) in human hemopoietic progenitor cells.

    abstract:OBJECTIVE:To investigate the STATs signaling pathway activated by VEGF in human hemopoietic progenitor cells. METHODS:CD34(+) hemopoietic progenitor cells, which isolated from umbilical cord blood, were treated with VEGF or culture supernatant of ovarian carcinoma cell line which could secrete large amount of VEGF, ph...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2004.03.038

    authors: Ye F,Chen HZ,Xie X,Ye DF,Lu WG,Ding ZM

    更新日期:2004-07-01 00:00:00

  • Sentinel lymph node biopsy in the management of early-stage cervical carcinoma.

    abstract:OBJECTIVES:We aimed to determine the sentinel lymph node detection rates, accuracy in predicting the status of lymph node metastasis, and if pathologic ultrastaging improves the detection of micrometastases and isolated tumor cells at the time of primary surgery for cervical cancer. METHODS:A prospective, non-randomiz...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2010.12.334

    authors: Diaz JP,Gemignani ML,Pandit-Taskar N,Park KJ,Murray MP,Chi DS,Sonoda Y,Barakat RR,Abu-Rustum NR

    更新日期:2011-03-01 00:00:00

  • Increased glyceraldehyde-3-phosphate dehydrogenase gene expression in human cervical cancers.

    abstract:OBJECTIVE:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a classical glycolytic protein. A higher level of GAPDH mRNA was found in lung, pancreas, and prostate cancers, but in cervical carcinoma there have not been any reports about the level of GAPDH gene expression. So, we tried to investigate the GAPDH gene exp...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1998.5195

    authors: Kim JW,Kim SJ,Han SM,Paik SY,Hur SY,Kim YW,Lee JM,Namkoong SE

    更新日期:1998-11-01 00:00:00