Management of patients with metastatic gestational trophoblastic tumor.


OBJECTIVE:This study was designed to analyze the results of treatment on patients with metastatic gestational trophoblastic tumor (metastatic GTT). METHOD:During 1996-2001, 38 cases with metastatic GTT were diagnosed and received treatment in Vali-e-Asr Hospital, Tehran, Iran. Data were gathered retrospectively and analyzed based on therapy and response rate. Sixteen patients initially labeled as low-risk, four as middle-risk and eighteen as high-risk patients according to FIGO scoring system (1992). Thirty-four (89.5%) patients responded to treatment; 13 to single-agent [methotrexate (MTX) or ACT] and 21 to multiagent chemotherapy [EMA/cisplatinum and etoposide (EMA-EP) or MTX, ACT-D and cyclophosphamide or chlorambucil (MAC)]. RESULTS:All low-risk patients, 2 middle-risk patients and 16 high-risk patients responded to treatment. Four cases failed to respond to therapy due to CNS involvement. CONCLUSIONS:Patients with low-risk metastatic GTT have a 100% chance to response to single-agent chemotherapy and those with high-risk disease have great chance to response to multiagent chemotherapy such as EMA-EP.


Gynecol Oncol


Gynecologic oncology


Ghaemmaghami F,Behtash N,Soleimani K,Hanjani P




Has Abstract


2004-07-01 00:00:00














  • Bilateral oophorectomy before 50 years of age is significantly associated with the metabolic syndrome and Framingham risk score: a controlled, population-based study (HUNT-2).

    abstract:OBJECTIVE:Bilateral oophorectomy (BOE) is often recommended in order to prevent cancer at hysterectomy for non-malignant diseases and when familial risk of ovarian and breast cancer has been identified. Surgical menopause increases the risk of cardiovascular mortality, however, the intervening mechanisms are not clear....

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Dørum A,Tonstad S,Liavaag AH,Michelsen TM,Hildrum B,Dahl AA

    更新日期:2008-06-01 00:00:00

  • Implementing specificity of HPV-DNA primary screening in a successful organised cervical cancer prevention programme.

    abstract:OBJECTIVE:This two-arm longitudinal study was performed within a regional organized cervical-cancer-prevention program in which HPV-DNA test is used in primary screening. The aim was to analyze the diagnostic performances of p16INK4a/Ki-67 dual-test and E6/E7-mRNA test in identifying CIN2+ lesion among HPV-DNA positive...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Zappacosta R,Caraceni D,Ciccocioppo L,Rotondo T,Capanna S,Gatta DM,D'Angelo C,Rosini S

    更新日期:2013-03-01 00:00:00

  • Parametrial invasion of uterine cervical cancer assessed by transrectal ultrasonography: preliminary report.

    abstract::Transrectal ultrasonographic examinations were performed on 30 patients with uterine cervical cancer to assess parametrial invasion. The findings were compared with data obtained by manual rectal examination. Forty-six parametria in 23 patients were histologically examined following surgery. Sensitivity, specificity, ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Aoki S,Hata T,Senoh D,Makihara K,Hata K,Takamiya O,Kitao M

    更新日期:1990-01-01 00:00:00

  • Homologous recombination deficiency real-time clinical assays, ready or not?

    abstract::Cancers with deficiencies in homologous recombination-mediated DNA repair (HRR) demonstrate improved clinical outcomes and increased survival. Approximately 50% of high-grade serous ovarian cancers (HGSOC) exhibit homologous recombination deficiency (HRD). HRD can be caused by germline or somatic mutations of genes in...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Fuh K,Mullen M,Blachut B,Stover E,Konstantinopoulos P,Liu J,Matulonis U,Khabele D,Mosammaparast N,Vindigni A

    更新日期:2020-12-01 00:00:00

  • p53 mutations and presence of HPV DNA do not correlate with radiosensitivity of gynecological cancer cell lines.

    abstract:OBJECTIVE:The correlation between p53 tumor suppressor gene mutations and the presence of high-risk human papillomavirus (HPV) DNA with the in vitro radiosensitivity of gynecological malignancies was studied in 26 cell lines derived from gynecological cancers of 23 patients. METHODS:Comparison of the intrinsic radiose...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Rantanen V,Grénman S,Kurvinen K,Hietanen S,Raitanen M,Syrjänen S

    更新日期:1998-12-01 00:00:00

  • Prognostic factors for groin node metastasis in squamous cell carcinoma of the vulva (a Gynecologic Oncology Group study)

    abstract::From 1977 to 1984 the Gynecologic Oncology Group (GOG) conducted a prospective clinical and surgical staging protocol of squamous cell carcinoma of the vulva (n = 637). The patients with superficial (5 mm or less invasion) lesions were the subject of a previous report (n = 272). The subject of this report is on factor...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Homesley HD,Bundy BN,Sedlis A,Yordan E,Berek JS,Jahshan A,Mortel R

    更新日期:1993-06-01 00:00:00

  • Phase II study of vinorelbine in the treatment of platinum-resistant ovarian carcinoma.

    abstract:OBJECTIVE:The purpose of this phase II study was to evaluate on an intent-to-treat basis the activity and toxicity of single-agent vinorelbine (VRL) as second-line chemotherapy of patients with platinum-resistant ovarian cancer. Platinum-resistant disease was defined as disease refractory to or relapsing within 12 mont...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Sørensen P,Høyer M,Jakobsen A,Malmström H,Havsteen H,Bertelsen K

    更新日期:2001-04-01 00:00:00

  • Conservative surgical treatment in cervical cancer with 3 to 5 mm stromal invasion in the absence of confluent invasion and lymph-vascular space involvement.

    abstract::We have previously reported that simple hysterectomy is adequate therapy for microinvasive carcinoma of the cervix with less than 3 mm stromal invasion (Yajima, A., et al, Am. J. Obstet. Gynecol. 135, 685-688, 1979). However, whether it is possible to effectively treat patients with deeper stromal invasion remained in...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Yaegashi N,Sato S,Inoue Y,Noda K,Yajima A

    更新日期:1994-09-01 00:00:00

  • Metastatic endometrial cancer in lung and liver: complete and prolonged response to hormonal therapy with progestins.

    abstract::A double complete and prolonged response of metastatic endometrial carcinoma to medroxyprogesterone is reported. A 61-year-old woman with metastatic endometrial carcinoma in lung and liver achieved a complete clinical response with medroxyprogesterone lasting for 2 years. She discontinued the therapy by herself and de...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Crespo C,González-Martín A,Lastra E,García-López J,Moyano A

    更新日期:1999-02-01 00:00:00

  • Characterization of human cervical precancerous tissue through the fourier transform infrared microscopy with mapping method.

    abstract:OBJECTIVE:The aim of this study was to evaluate directly the utility of Fourier transform infrared microscopy (FTIR-MC) in detecting cervical precancer by comparison with the pathological examination of biopsy tissue. METHODS:Cervical biopsy specimens were obtained from the outpatient department at Kaohsiung Municipal...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Chang JI,Huang YB,Wu PC,Chen CC,Huang SC,Tsai YH

    更新日期:2003-12-01 00:00:00

  • Laparoscopic splenectomy for secondary cytoreduction of ovarian cancer in a woman with localized splenic recurrence.

    abstract:OBJECTIVE/BACKGROUND:Laparoscopic splenectomy is a potential surgical option for the treatment of isolated gynecologic cancer recurrence to the spleen [1-7]. The purpose of this video is to demonstrate a step-by-step approach for laparoscopic splenectomy in the setting of recurrent, oligometastatic ovarian cancer. MET...

    journal_title:Gynecologic oncology



    authors: Acosta-Torres S,Fader AN

    更新日期:2020-03-01 00:00:00

  • Carcinoma of the cervix in association with uterine prolapse.

    abstract:BACKGROUND:Carcinoma of the cervix and a prolapsed uterus are common diseases in underdeveloped countries, but their association is quite rare. CASE:We report here the clinical characteristics of two Brazilian patients with carcinoma of the uterine cervix associated with a third-degree prolapsed uterus. The patients, ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: da Silva BB,da Costa Araújo R,Filho CP,Melo JA

    更新日期:2002-02-01 00:00:00

  • Fibroblasts stimulate human ovarian cancer cell invasion and expression of 72-kDa gelatinase A (MMP-2).

    abstract:OBJECTIVE:The host-tumor interactions and tumor stroma may participate in the regulation of invasive behavior of tumor cells. In order to better understand the human ovarian cancer invasion we explored the possibility that normal fibroblasts could participate in the control of the spread of human ovarian cancer. RESUL...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Westerlund A,Hujanen E,Puistola U,Turpeenniemi-Hujanen T

    更新日期:1997-10-01 00:00:00

  • Role of integrins in invasion of endometrial cancer cell lines.

    abstract:OBJECTIVE:The objective of this study was to determine whether there is a link between integrins and components of the plasminogen system, regarding tumor cell invasion to the artificial extracellular matrix. METHODS:Immunocytochemistry was performed with antibodies directed against integrins alpha2beta1, alpha4beta1,...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Prifti S,Zourab Y,Koumouridis A,Bohlmann M,Strowitzki T,Rabe T

    更新日期:2002-01-01 00:00:00

  • Class III NSRH: oncological outcome in 170 cervical cancer patients.

    abstract:OBJECTIVE:To analyze local recurrence rate (LRR), morbidities and oncologic outcome of class III nerve-sparing radical hysterectomy. PATIENTS AND METHODS:170 consecutive class III NSRH cases were performed. Nineteen patients were addressed directly to surgery whilst neoadjuvant chemotherapy was administered in 151 pat...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Ditto A,Martinelli F,Hanozet F,Reato C,Solima E,Zanaboni F,Grijuela B,Carcangiu M,Haeusler E,Raspagliesi F

    更新日期:2010-11-01 00:00:00

  • Role of toll-like receptors in cervical, endometrial and ovarian cancers: a review.

    abstract:OBJECTIVE:The Toll-like receptors (TLRs) have been implicated in inflammation, innate immunity and cancer. The goal of this paper is to review the available published research about Toll-like receptors and their roles in gynecologic malignancies. METHODS:A Medline search was conducted and published articles from the l...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Husseinzadeh N,Davenport SM

    更新日期:2014-11-01 00:00:00

  • Fertility-sparing options for early stage cervical cancer.

    abstract:OBJECTIVE:To review the literature on fertility-sparing options for women with early stage cervical cancer and outline patient selection criteria, operative, oncologic, and pregnancy outcomes. METHODS:The literature was searched using MEDLINE (OVID: 1950 through October 2009) and EMBASE (OVID: 1988 through October 200...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Gien LT,Covens A

    更新日期:2010-05-01 00:00:00

  • Urinary gonadotropin fragment, a new tumor marker. II. Differentiating a benign from a malignant pelvic mass.

    abstract::We examined the efficacy of CA125 and urinary gonadotropin fragment (UGF) measurements for differentiating benign from malignant pelvic masses. CA125, at a cutoff of greater than or equal to 35 U/ml, detected 82% (n = 71) of ovarian malignancies, but also falsely detected 14% of (n = 332) patients with benign pelvic m...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Cole LA,Nam JH,Chambers JT,Schwartz PE

    更新日期:1990-03-01 00:00:00

  • Gestational trophoblastic disease in women aged 50 or more.

    abstract::Twenty cases of gestational trophoblastic disease in women aged 50 or more are reported. The lesions were 7 hydatidiform mole (35%), 8 invasive mole (40%), and 5 choriocarcinoma (25%). The most common presenting symptom was abnormal vaginal bleeding. Three choriocarcinoma patients were postmenopausal and all of them h...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Tsukamoto N,Iwasaka T,Kashimura Y,Uchino H,Kashimura M,Matsuyama T

    更新日期:1985-01-01 00:00:00

  • Long-term survival in an ovarian cancer patient with brain metastases.

    abstract:BACKGROUND:Central nervous system (CNS) metastases from ovarian adenocarcinoma are uncommon. The long-term prognosis for these patients is poor, with studies reporting a mean survival of less than 12 months. CASE:We present a case involving a 57-year-old woman diagnosed and treated for primary ovarian cancer in 1994. ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Micha JP,Goldstein BH,Hunter JV,Rettenmaier MA,Brown JV

    更新日期:2004-03-01 00:00:00

  • Bolus mitomycin C and 5-FU with sequential radiation for poor-prognosis locally advanced cervical cancer.

    abstract::Forty patients with locally advanced cervical carcinoma were entered into a protocol utilizing the bolus administration of both mitomycin C (10 or 15 mg) on Day 1 and 5-fluorouracil (400 mg) on Day 1-5 followed by sequential pelvic irradiation on Day 6 between September 1980 and October 1985. All patients had poor-pro...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,评审


    authors: Denehy TR,Eastman R,SanFilippo L,Gregori CA,Breen JL

    更新日期:1996-01-01 00:00:00

  • Radical vaginal trachelectomy after supracervical hysterectomy.

    abstract:BACKGROUND:Radical vaginal trachelectomy (RVT) is an acceptable approach when applied toward a select group of patients with early stage cervical carcinoma. It is less invasive, can maintain fertility, and can be ideal in patients with significant comorbid factors compared to abdominal approaches. A small subset of pat...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Mendez LE,Penalver M,McCreath W,Bejarano P,Angioli R

    更新日期:2002-06-01 00:00:00

  • Carcinoma of the cervix with extensive endometrial and myometrial involvement.

    abstract::Verrucous carcinoma is a rare variant of epidermoid carcinoma with distinct clinical and histopathologic features. To date, 31 cases have been reported in the cervix. They are typically slow-growing, locally invasive tumors with low potential for lymphatic metastasis and appear to be radioresistant. We report a case w...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: de Jesus M,Tang W,Sadjadi M,Belmonte AH,Poon TP

    更新日期:1990-02-01 00:00:00

  • Cardiac metastasis from carcinoma of the cervix: report of two cases.

    abstract:BACKGROUND:The presence of cardiac metastasis from cervical carcinoma is extremely rare. The diagnosis is made almost exclusively postmortem. There are few cases of premortem diagnosis, and it is believed that when cardiac metastasis are found in vivo, the prognosis is extremely poor. Due to the rarity of this conditio...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Lemus JF,Abdulhay G,Sobolewski C,Risch VR

    更新日期:1998-06-01 00:00:00

  • Malignant ovarian tumor composed of endometrioid adenocarcinoma, clear cell adenocarcinoma, squamous cell carcinoma, yolk sac tumor and immature teratoma with prominent neuroectodermal and rhabdomyosarcomatous differentiation: a case study.

    abstract:BACKGROUND:Cases of malignant ovarian tumor composed of müllerian-type epithelial tumor and malignant germ cell tumor are extremely rare. CASE:We herein report the case of a 34-year-old woman with an ovarian tumor which was composed of endometrioid adenocarcinoma (EAC), clear cell adenocarcinoma (CCC), squamous cell c...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Ohishi Y,Kaku T,Kaneki E,Wake N,Tsuneyoshi M

    更新日期:2007-05-01 00:00:00

  • Predictive biomarkers of platinum and taxane resistance using the transcriptomic data of 1816 ovarian cancer patients.

    abstract:OBJECTIVE:The first-line chemotherapy for ovarian cancer is based on a combination of platinum and taxane. To date, no reliable predictive biomarker has been recognized that is capable of identifying patients with pre-existing resistance to these agents. Here, we have established an integrated database and identified t...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Fekete JT,Ősz Á,Pete I,Nagy GR,Vereczkey I,Győrffy B

    更新日期:2020-03-01 00:00:00

  • A multicenter phase II study with triptorelin (sustained-release LHRH agonist) in advanced or recurrent endometrial carcinoma: a French anticancer federation study.

    abstract::The objective of this phase II multicenter study was to assess the efficacy and tolerance of triptorelin (a sustained-release LHRH agonist) in advanced or recurrent endometrial cancer. A total of 101 monthly intramuscular injections were administered to 24 eligible patients (median number/patient = 3; range 1-12). Mai...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Lhommé C,Vennin P,Callet N,Lesimple T,Achard JL,Chauvergne J,Luporsi E,Chinet-Charrot P,Coudert B,Couette JE,Guastalla JP,Lebrun D,Ispas S,Blumberg J

    更新日期:1999-11-01 00:00:00

  • Surgical treatment of diaphragm disease correlates with improved survival in optimally debulked advanced stage ovarian cancer.

    abstract:BACKGROUND:Diaphragm involvement by ovarian cancer is often considered to be a major obstacle to successful cytoreductive surgery. Lack of evidence of survival benefit, concerns over safety and lack of experience are common justifications for this belief. In this study, we sought to evaluate the therapeutic value of di...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Aletti GD,Dowdy SC,Podratz KC,Cliby WA

    更新日期:2006-02-01 00:00:00

  • A phase I pharmacokinetic study of intraperitoneal bortezomib and carboplatin in patients with persistent or recurrent ovarian cancer: An NRG Oncology/Gynecologic Oncology Group study.

    abstract:PURPOSE:Intraperitoneal (IP) therapy improves survival compared to intravenous (IV) treatment for women with newly diagnosed, optimally cytoreduced, ovarian cancer. However, the role of IP therapy in recurrent disease is unknown. Preclinical data demonstrated IP administration of the proteasome inhibitor, bortezomib pr...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Jandial DA,Brady WE,Howell SB,Lankes HA,Schilder RJ,Beumer JH,Christner SM,Strychor S,Powell MA,Hagemann AR,Moore KN,Walker JL,DiSilvestro PA,Duska LR,Fracasso PM,Dizon DS

    更新日期:2017-05-01 00:00:00

  • Preoperative pathologic findings associated with residual disease at radical hysterectomy in women with stage IA2 cervical cancer.

    abstract:OBJECTIVE:To correlate findings on pathologic examination of loop electroexcisional procedure (LEEP) or cone biopsy specimens with residual disease in radical hysterectomy specimens in patients with stage IA2 cervical cancer to determine whether a subset of such patients may be eligible for conservative, fertility-spar...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Suri A,Frumovitz M,Milam MR,dos Reis R,Ramirez PT

    更新日期:2009-01-01 00:00:00