Abstract:
BACKGROUND:Ovarian cancer is the deadliest gynecologic malignancy, yet the effects on survival of modifiable pre-diagnosis lifestyle factors, such as obesity and physical activity, remain largely unexplored. Our objective was to evaluate the effect of pre-diagnosis BMI and physical activity on ovarian cancer mortality using prospectively collected data. METHODS:Data on women who developed ovarian cancer after enrollment into the NIH-AARP Diet and Health Study were analyzed. Cancer incidence was ascertained through linkage state cancer registries and consisted of 741 cases of epithelial ovarian cancer. RESULTS:Higher pre-diagnosis BMI was associated with increased overall and ovarian cancer-specific mortality. Comparing women with BMI 25-29.9, 30-34.9 and ≥ 35 to normal weight women, the HRs of overall mortality were 1.18 (95%CI 0.96-1.45), 1.05 (0.82-1.36) and 1.59 (1.14-2.18, p-trend = 0.02). The findings were similar for ovarian cancer-specific mortality comparing women with BMI ≥ 35 to normal weight women (BMI <25) with a HR of 1.47 (95%CI 1.03-2.09, p-trend 0.08). Pre-diagnosis physical activity was not associated with mortality, with HRs for overall mortality of 1.06 (95%CI 0.79-1.43), 0.94 (0.72-1.23), 0.98 (0.76-1.25), and 0.98 (0.75-1.28, p-trend = 0.91), comparing women who engaged in vigorous physical activity 1-3 times/month, 1-2 times/week, 3-4 times/week and 5 times/week, respectively, with those who never/rarely engaged in such activity. CONCLUSIONS:Women who were obese before developing ovarian cancer had increased mortality than those who were normal weight, but physical activity before diagnosis was not associated with mortality in this study population. These results suggest that maintaining a healthy weight is a powerful preventative tool.
journal_name
Gynecol Oncoljournal_title
Gynecologic oncologyauthors
Zamorano AS,Hagemann AR,Morrison L,Lee JA,Liao LM,Brinton LA,Park Y,Toriola ATdoi
10.1016/j.ygyno.2019.07.025subject
Has Abstractpub_date
2019-10-01 00:00:00pages
105-111issue
1eissn
0090-8258issn
1095-6859pii
S0090-8258(19)31449-0journal_volume
155pub_type
杂志文章abstract:BACKGROUND:Advanced gynecological surgery undertaken in a specialized gynecologic oncology unit may be associated with significant perioperative morbidity. Validated risk prediction models are available for general surgical specialties but currently not for gynecological cancer surgery. OBJECTIVE:The objective of this...
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journal_title:Gynecologic oncology
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journal_title:Gynecologic oncology
pub_type: 临床试验,杂志文章
doi:10.1006/gyno.1995.1262
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journal_title:Gynecologic oncology
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abstract::Radical vulvectomy using warm-knife and open-wound techniques was performed as the first step in a two-phase surgical approach in 274 patients with malignant vulvar tumors. Crude 5-year survival was registered in 133/223 (60%) patients. The complication rate was low and the hospitalization period was short (mean 16 da...
journal_title:Gynecologic oncology
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journal_title:Gynecologic oncology
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journal_title:Gynecologic oncology
pub_type: 杂志文章
doi:10.1016/j.ygyno.2003.07.005
更新日期:2003-11-01 00:00:00
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journal_title:Gynecologic oncology
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doi:10.1006/gyno.1994.1158
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pub_type: 杂志文章,评审
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更新日期:2014-12-01 00:00:00
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journal_title:Gynecologic oncology
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pub_type: 杂志文章
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更新日期:2008-08-01 00:00:00
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更新日期:2005-10-01 00:00:00
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更新日期:2011-07-01 00:00:00
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journal_title:Gynecologic oncology
pub_type: 临床试验,杂志文章
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更新日期:2001-11-01 00:00:00
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journal_title:Gynecologic oncology
pub_type: 杂志文章
doi:10.1016/j.ygyno.2011.11.041
更新日期:2012-04-01 00:00:00
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journal_title:Gynecologic oncology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ygyno.2009.04.023
更新日期:2009-08-01 00:00:00
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journal_title:Gynecologic oncology
pub_type: 杂志文章
doi:10.1016/0090-8258(92)90252-e
更新日期:1992-08-01 00:00:00
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journal_title:Gynecologic oncology
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2005-07-01 00:00:00
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journal_title:Gynecologic oncology
pub_type: 杂志文章
doi:10.1016/j.ygyno.2007.10.027
更新日期:2008-02-01 00:00:00