当前位置： SCI文献检索 > GYNECOLOGIC ONCOLOGY期刊下所有文献 > Global expression changes of constitutive and hormonally regulated genes during endometrial neoplastic transformation.

Global expression changes of constitutive and hormonally regulated genes during endometrial neoplastic transformation.

Abstract：

OBJECTIVE:Endometrioid endometrial carcinoma is caused by a combination of mutational events and hormonal factors. We used large-scale messenger RNA expression analysis to discover genes that distinguish neoplastic transformation and examine the patterns of tumor expression of those genes which are normally regulated during the menstrual cycle. METHODS:Expression of approximately 6000 unique genes was quantified in 4 normal (2 proliferative, 2 secretory) and 10 malignant endometria using Affymetrix Hu6800 GeneChip probe arrays. Expression differences between normal and malignant tissue groups were measured by a test of statistical significance comparing the individual t statistic for each gene to the distribution of maximum t statistics among all genes following 1001 permutations of the tissue group assignments (Permax test). Hormonally responsive genes, selected by comparison of proliferative and secretory subsets of normal endometria using a combination of filters applied to the group means and t test rankings, were then examined in the tumors. RESULTS:Fifty genes with a Permax <0.50 provided excellent discrimination between normal and malignant groups and were predominantly characterized by diminished expression levels in the cancers. We found that 100 genes which are hormonally regulated in normal tissues are expressed in a disordered and heterogeneous fashion in cancers, with tumors resembling proliferative more than secretory endometrium. CONCLUSION:Neoplastic transformation is accompanied by predominant loss of activity of many genes constitutively expressed in normal source tissues and absence of expression profiles which characterize the antitumorigenic progestin response.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Mutter GL,Baak JP,Fitzgerald JT,Gray R,Neuberg D,Kust GA,Gentleman R,Gullans SR,Wei LJ,Wilcox M

doi

10.1006/gyno.2001.6352

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

177-85

issue

2

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(01)96352-8

journal_volume

83

pub_type

杂志文章

相关文献

GYNECOLOGIC ONCOLOGY文献大全
  • Lymphopenia and its association with survival in patients with locally advanced cervical cancer.

    abstract：OBJECTIVE:To evaluate the association between lymphopenia and survival in women with cervical cancer treated with primary chemoradiation. METHODS:A single institution, retrospective analysis of patients with stage IB2-IVA cervical cancer who received upfront chemoradiation from 1998 to 2013 was performed. Complete blo...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2015.11.013

    authors： Wu ES,Oduyebo T,Cobb LP,Cholakian D,Kong X,Fader AN,Levinson KL,Tanner EJ 3rd,Stone RL,Piotrowski A,Grossman S,Roche KL

    更新日期：2016-01-01 00:00:00

  • Management of cryotherapy-ineligible women in a "screen-and-treat" cervical cancer prevention program targeting HIV-infected women in Zambia: lessons from the field.

    abstract：OBJECTIVE:We demonstrate the feasibility of implementing a referral and management system for cryotherapy-ineligible women in a "screen-and-treat" cervical cancer prevention program targeting HIV-infected women in Zambia. METHODS:We established criteria for patient referral, developed a training program for loop elect...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2008.04.031

    authors： Pfaendler KS,Mwanahamuntu MH,Sahasrabuddhe VV,Mudenda V,Stringer JS,Parham GP

    更新日期：2008-09-01 00:00:00

  • Tumor chemoconversion following surgery, chemotherapy, and normalization of serum tumor markers in a woman with a mixed type germ cell ovarian tumor.

    abstract：BACKGROUND:Malignant germ cell tumors of the ovary are often curative after conservative surgery and adjuvant chemotherapy. Persistent tumors despite normalization of serum tumor markers may represent retroconversion to benign masses, but this is rare in ovarian tumors without teratoma elements. The management in such ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.2001.6541

    authors： David YB,Weiss A,Shechtman L,Shalev E

    更新日期：2002-03-01 00:00:00

  • The efficacy of a sonographic morphology index in identifying ovarian cancer: a multi-institutional investigation.

    abstract：:Transvaginal sonography (TVS) has been shown to be the most effective means to screen for ovarian cancer. TVS is associated with a high sensitivity and specificity. However, the positive predictive value associated with TVS in the diagnosis of malignancy is low. A morphologic scoring index for use with TVS has been us...

    journal_title：Gynecologic oncology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1006/gyno.1994.1273

    authors： DePriest PD,Varner E,Powell J,Fried A,Puls L,Higgins R,Shenson D,Kryscio R,Hunter JE,Andrews SJ

    更新日期：1994-11-01 00:00:00

  • Surgical treatment of diaphragm disease correlates with improved survival in optimally debulked advanced stage ovarian cancer.

    abstract：BACKGROUND:Diaphragm involvement by ovarian cancer is often considered to be a major obstacle to successful cytoreductive surgery. Lack of evidence of survival benefit, concerns over safety and lack of experience are common justifications for this belief. In this study, we sought to evaluate the therapeutic value of di...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2005.08.027

    authors： Aletti GD,Dowdy SC,Podratz KC,Cliby WA

    更新日期：2006-02-01 00:00:00

  • Ki67 antigen immunostaining (MIB 1 monoclonal antibody) in serous ovarian tumors: index of proliferative activity with prognostic significance.

    abstract：:The purpose of this study was to evaluate the biological significance of Ki67 antigen expression in serous ovarian tumors, through the analysis of MIB 1 monoclonal antibody reactivity in cystoadenomas, borderline tumors, and invasive cystoadenocarcinomas; the correlation between this index of cell proliferation and cl...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.1995.1026

    authors： Garzetti GG,Ciavattini A,Goteri G,De Nictolis M,Stramazzotti D,Lucarini G,Biagini G

    更新日期：1995-02-01 00:00:00

  • Carboplatin/gemcitabine alternating with carboplatin/pegylated liposomal doxorubicin and carboplatin/cyclophosphamide in platinum-refractory/resistant paclitaxel - pretreated ovarian carcinoma.

    abstract：OBJECTIVE:In this phase II study the efficacy and toxicity of an alternating chemotherapy regimen was examined in platinum-resistant relapsed epithelial ovarian cancer (EOC) patients. METHODS:Forty-five patients with platinum-refractory/resistant relapsed EOC, previously treated with carboplatin+paclitaxel+/-epirubici...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2010.03.003

    authors： Pectasides D,Pectasides E,Papaxoinis G,Psyrri A,Pliarchopoulou K,Koumarianou A,Macheras A,Athanasas G,Xiros N,Economopoulos T

    更新日期：2010-07-01 00:00:00

  • HPV vaccine: A comparison of attitudes and behavioral perspectives between Latino and non-Latino women.

    abstract：OBJECTIVE:Recent scientific advances have lead to the development of a prophylactic, quadrivalent HPV vaccine conferring. We surveyed Latino and non-Latino women directly to examine what motivates them to vaccinate themselves, their daughters, and their sons. METHODS:A written survey was administered to 86 Latinas and...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2008.12.010

    authors： Watts LA,Joseph N,Wallace M,Rauh-Hain JA,Muzikansky A,Growdon WB,del Carmen MG

    更新日期：2009-03-01 00:00:00

  • Malignant acanthosis nigricans, tripe palms and the sign of Leser-Tre'lat, a hint to the diagnosis of early stage ovarian cancer: a case report and review of the literature.

    abstract：BACKGROUND:Malignant acanthosis nigricans is a mucocutaneous eruption associated with internal malignancies. Tripe palms refers to a characteristic velvety thickening of the palms, with exaggeration of normal skin markings. The sign of Leser-Tre'lat is the presence of multiple seborrheic keratoses and scattered skin ta...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2005.12.024

    authors： Kebria MM,Belinson J,Kim R,Mekhail TM

    更新日期：2006-05-01 00:00:00

  • Tumor characteristics and survival outcomes of women with tamoxifen-related uterine carcinosarcoma.

    abstract：OBJECTIVE:To examine tumor characteristics and survival outcome of women with uterine carcinosarcoma who had a history of tamoxifen use. METHODS:This is a multicenter retrospective study examining stage I-IV uterine carcinosarcoma cases based on history of tamoxifen use. Patient demographics, tumor characteristics, tr...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ygyno.2016.11.042

    authors： Matsuo K,Ross MS,Bush SH,Yunokawa M,Blake EA,Takano T,Ueda Y,Baba T,Satoh S,Shida M,Ikeda Y,Adachi S,Yokoyama T,Takekuma M,Takeuchi S,Nishimura M,Iwasaki K,Yanai S,Klobocista MM,Johnson MS,Machida H,Hasegawa K,

    更新日期：2017-02-01 00:00:00

  • PTEN expression in clear cell adenocarcinoma of the ovary.

    abstract：OBJECTIVES:In this study, we analyzed the PTEN expression in a large collection of clear cell adenocarcinomas of the ovary. Furthermore, we analyzed the expression of cyclin D1 and p27, and investigated the correlation among all these variables. METHODS:Totally, 40 clear cell adenocarcinomas were included in this stud...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2005.09.047

    authors： Hashiguchi Y,Tsuda H,Inoue T,Berkowitz RS,Mok SC

    更新日期：2006-04-01 00:00:00

  • Examining the effect of minority status and neighborhood characteristics on cervical cancer survival outcomes.

    abstract：OBJECTIVE:Understanding the factors that contribute to mortality and survival is central to health outcome research. The purpose of this study was to investigate the following: (1) differences in survival status by ethnicity and neighborhood median income level; and (2) individual- and neighborhood-level factors influe...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2010.11.041

    authors： Lim JW,Ashing-Giwa KT

    更新日期：2011-04-01 00:00:00

  • Phase II trial of gemcitabine as second-line chemotherapy of uterine leiomyosarcoma: a Gynecologic Oncology Group (GOG) Study.

    abstract：OBJECTIVE:To determine the antitumor activity and toxicity profile of gemcitabine as second-line chemotherapy in patients with recurrent or persistent uterine leiomyosarcoma (LMS). METHODS:Intravenous gemcitabine was administered over 30 min at a dose of 1000 mg/m(2) on days 1, 8, 15, with cycles repeated every 28 day...

    journal_title：Gynecologic oncology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.ygyno.2003.11.023

    authors： Look KY,Sandler A,Blessing JA,Lucci JA 3rd,Rose PG,Gynecologic Oncology Group (GOG) Study.

    更新日期：2004-02-01 00:00:00

  • Extra-peritoneal laparoscopic para-aortic lymphadenectomy--a prospective cohort study of 293 patients with endometrial cancer.

    abstract：OBJECTIVE:To determine if extra-peritoneal laparoscopic para-aortic (PA) lymphadenectomy allows a reliable assessment of PA nodes in patients with endometrial cancer (EC). METHODS:In October of 2005, a single surgeon began performing extra-peritoneal laparoscopic PA lymphadenectomy for patients with EC. A prospective ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2008.08.021

    authors： Dowdy SC,Aletti G,Cliby WA,Podratz KC,Mariani A

    更新日期：2008-12-01 00:00:00

  • Molecular characterization of circulating tumor cells in patients with ovarian cancer improves their prognostic significance -- a study of the OVCAD consortium.

    abstract：OBJECTIVE:The study aims at identifying novel markers for circulating tumor cells (CTCs) in patients with epithelial ovarian cancer (EOC), and at evaluating their impact on outcome. METHODS:Microarray analysis comparing matched EOC tissues and peripheral blood leucocytes (N=35) was performed to identify novel CTC mark...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2012.09.021

    authors： Obermayr E,Castillo-Tong DC,Pils D,Speiser P,Braicu I,Van Gorp T,Mahner S,Sehouli J,Vergote I,Zeillinger R

    更新日期：2013-01-01 00:00:00

  • An analysis of approaches to the management of endometrial cancer in North America: a CTF study.

    abstract：OBJECTIVE:The aim of this study was to define the clinical-therapeutical approach to endometrial cancer now being followed in some of the most important centers of reference for gynecological cancer in North America by means of a questionnaire. STUDY DESIGN:The questionnaire focused on four principal areas: (1) surgic...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1006/gyno.1998.4951

    authors： Maggino T,Romagnolo C,Landoni F,Sartori E,Zola P,Gadducci A

    更新日期：1998-03-01 00:00:00

  • Loop electrocautery excisional procedure: therapeutic effectiveness as an ablation and a conization equivalent.

    abstract：:This study was designed to compare the effectiveness of loop excision procedures as ablation and conization equivalents, and their use in recurrent cervical high-grade dysplasia patients. We retrospectively reviewed patients undergoing loop procedures between January 1992 and April 1994. Conization equivalents were de...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.1996.0132

    authors： Gold M,Dunton CJ,Murray J,Macones G,Hanau C,Carlson JA Jr

    更新日期：1996-05-01 00:00:00

  • Human papillomavirus analysis as a prognostic marker following conization of the cervix uteri.

    abstract：:Cervical intraepithelial neoplasia grade 3 (CIN 3) is treated surgically. Follow-up of these patients is important to ensure successful treatment. The present study was undertaken to determine whether human papillomavirus (HPV) testing can be used to discriminate patients who will have recurrences from those who will ...

    journal_title：Gynecologic oncology

    pub_type： 临床试验,杂志文章

    doi：10.1006/gyno.1997.4753

    authors： Chua KL,Hjerpe A

    更新日期：1997-07-01 00:00:00

  • The effect of medroxyprogesterone acetate on angiogenesis in complex endometrial hyperplasia.

    abstract：OBJECTIVE:To evaluate the effect of orally administered medroxyprogesterone acetate upon angiogenesis in the myometrium of patients with complex endometrial hyperplasia. METHODS:Microvessel counts in the myometrium of consecutive patients with complex endometrial hyperplasia, treated with oral medroxyprogesterone acet...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.1998.5106

    authors： Abulafia O,Triest WE,Adcock JT,Sherer DM

    更新日期：1999-02-01 00:00:00

  • A preoperative risk-scoring system to predict lymph node metastasis in endometrial cancer and stratify patients for lymphadenectomy.

    abstract：OBJECTIVE:This study aimed to validate the preoperative scoring system adopted in the Kanagawa Cancer Center (KCC) to stratify endometrial cancer patients for lymphadenectomy according to the risk of developing lymph node metastasis (LNM). METHODS:The records of 432 and 221 uterine cancer patients treated in the KCC a...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2016.06.004

    authors： Imai K,Kato H,Katayama K,Nakanishi K,Kawano A,Iura A,Konnai K,Onose R,Hirahara F,Miyagi E

    更新日期：2016-08-01 00:00:00

  • A phase II trial of dolastatin-10 in recurrent platinum-sensitive ovarian carcinoma: a Gynecologic Oncology Group study.

    abstract：OBJECTIVE:To estimate the antitumor efficacy of dolastatin-10 in patients with measurable recurrences of platinum-sensitive ovarian carcinoma and to determine the nature and degree of toxicity of dolastatin-10 in these patients. METHODS:Patients received dolastatin-10 400 microg/m(2) intravenously every 3 weeks and tu...

    journal_title：Gynecologic oncology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/s0090-8258(03)00007-6

    authors： Hoffman MA,Blessing JA,Lentz SS,Gynecologic Oncology Group Study.

    更新日期：2003-04-01 00:00:00

  • The role of neoadjuvant chemotherapy in the management of patients with advanced stage ovarian cancer: survey results from members of the Society of Gynecologic Oncologists.

    abstract：OBJECTIVE:Recent randomized controlled data suggest that neoadjuvant chemotherapy (NACT) with interval debulking (ID) may produce similar overall survival and progression free survival compared to standard primary cytoreduction followed by chemotherapy. The object of our study was to assess current patterns of care amo...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2010.06.021

    authors： Dewdney SB,Rimel BJ,Reinhart AJ,Kizer NT,Brooks RA,Massad LS,Zighelboim I

    更新日期：2010-10-01 00:00:00

  • Monitoring cancer antigen 125 levels in induction chemotherapy for epithelial ovarian carcinoma and predicting outcome of second-look procedure.

    abstract：:A retrospective analysis of 45 patients with epithelial ovarian carcinoma who underwent second-look procedure after initial cytoreduction and platinum-based combination chemotherapy was undertaken. Each patient was evaluated for the result of CA 125 after a third course of chemotherapy, the result of CA 125 prior to s...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.1995.1121

    authors： Folk JJ,Botsford M,Musa AG

    更新日期：1995-05-01 00:00:00

  • Contribution of human papillomavirus testing by hybrid capture in the triage of women with repeated abnormal pap smears before colposcopy referral.

    abstract：OBJECTIVE:The purpose of this work was to evaluate the ability of testing for high-risk human papillomavirus (HPV) types using the hybrid capture technique to predict the presence of cervical intraepithelial neoplasia (CIN) II,III in patients with repeated atypical squamous cells of undetermined significance (ASCUS) an...

    journal_title：Gynecologic oncology

    pub_type： 临床试验,杂志文章

    doi：10.1006/gyno.2000.5929

    authors： Fait G,Kupferminc MJ,Daniel Y,Geva E,Ron IG,Lessing JB,Bar-Am A

    更新日期：2000-11-01 00:00:00

  • The additional value of endometrial sampling in the early detection of endometrial cancer in women with Lynch syndrome.

    abstract：OBJECTIVE:Based on previous studies, standard gynecological screening consisting of annual transvaginal ultrasonography (TVU) was added with endometrial sampling in women with Lynch syndrome (LS). The aim of this study was to evaluate the additional value of endometrial sampling in detecting (pre)malignancies of the en...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2013.05.032

    authors： Helder-Woolderink JM,De Bock GH,Sijmons RH,Hollema H,Mourits MJ

    更新日期：2013-11-01 00:00:00

  • Risk of malignancy index in the preoperative evaluation of patients with adnexal masses.

    abstract：OBJECTIVE:The aim of this study was to evaluate the use of a Risk of Malignancy Index (RMI) in primary evaluation of patients with adnexal masses. METHODS:The RMI is based on menopausal status, ultrasonographic findings, and serum CA 125 level. A cutoff level of 200 was chosen as the threshold for referral for central...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/s0090-8258(03)00192-6

    authors： Andersen ES,Knudsen A,Rix P,Johansen B

    更新日期：2003-07-01 00:00:00

  • FGFR2 mutations are rare across histologic subtypes of ovarian cancer.

    abstract：OBJECTIVE:Ovarian cancer is the leading cause of death from gynecologic malignancies in the Western world. Fibroblast growth factor receptor (FGFR) signaling has been implicated to play a role in ovarian tumorigenesis. Mutational activation of one member of this receptor family, FGFR2, is a frequent event in endometrio...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2009.12.002

    authors： Byron SA,Gartside MG,Wellens CL,Goodfellow PJ,Birrer MJ,Campbell IG,Pollock PM

    更新日期：2010-04-01 00:00:00

  • Venous thromboembolism during primary treatment of ovarian clear cell carcinoma is associated with decreased survival.

    abstract：OBJECTIVES:To determine the impact of venous thromboembolism (VTE) during primary treatment of ovarian clear cell carcinoma (OCCC) on survival. METHODS:After Institutional Review Board approval, 74 cases of OCCC were retrieved from our pathology files. Clinical and pathological data were obtained by medical record and...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2013.09.005

    authors： Diaz ES,Walts AE,Karlan BY,Walsh CS

    更新日期：2013-12-01 00:00:00

  • Prognostic factors of Krukenberg's tumor.

    abstract：OBJECTIVE:The aim of this study was to determine prognostic factors of metachronous Krukenberg's tumors of gastric origin, thereby helping to establish a therapeutic plan for this rare entity. METHODS:Thirty-four female patients who underwent curative resection of gastric carcinoma from 1987 through 1996 and subsequen...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.2001.6210

    authors： Kim HK,Heo DS,Bang YJ,Kim NK

    更新日期：2001-07-01 00:00:00

  • Methylation in host and viral genes as marker of aggressiveness in cervical lesions: Analysis in 543 unscreened women.

    abstract：OBJECTIVE:The present study aimed to evaluate the association between altered methylation and histologically confirmed high grade cervical intraepithelial neoplasia (hgCIN). METHODS:Methylation levels in selected host (CADM1, MAL, DAPK1) and HPV (L1_I, L1_II, L2) genes were measured by pyrosequencing in DNA samples ob...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2018.08.031

    authors： Fiano V,Trevisan M,Fasanelli F,Grasso C,Marabese F,da Graça Bicalho M,de Carvalho NS,Maestri CA,Merletti F,Sacerdote C,De Marco L,Gillio-Tos A

    更新日期：2018-11-01 00:00:00