Comparison of the usefulness between a new universal grading system for epithelial ovarian cancer and the FIGO grading system.

abstract：OBJECTIVE:Incorporating topotecan into standard platinum/taxane chemotherapy for advanced ovarian cancer has been complicated by myelosuppression. This study evaluated sequential doublets of topotecan and carboplatin, followed by paclitaxel and carboplatin, in newly diagnosed advanced ovarian cancer patients. METHODS:...

journal_title：Gynecologic oncology

authors： Gordon AN,Asmar L,Messing MJ,Street DG,Pippitt CH Jr,Bailey CL,Savage J,Young JA

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVES:To identify angiogenic biomarkers associated with tumor angiogenesis and clinical outcome in high-grade serous ovarian cancer (HGSC). METHODS:51 HGSC samples were analyzed using Affymetrix HG-U133A microarray. Microvessel density (MVD) counts were determined using CD31 and CD105. Associations between mRNA e...

journal_title：Gynecologic oncology

authors： Siamakpour-Reihani S,Owzar K,Jiang C,Turner T,Deng Y,Bean SM,Horton JK,Berchuck A,Marks JR,Dewhirst MW,Alvarez Secord A

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:To determine the relationship between history of cervical dysplasia or carcinoma and the development of cervical dysplasia or adenocarcinoma in women who have a diagnosis of atypical glandular cells of undetermined significance (AGUS), favor endocervical origin, or AGUS, not otherwise specified. METHODS:A 6-...

journal_title：Gynecologic oncology

authors： Raab SS,Bishop NS,Zaleski MS

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Ovarian cancer arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy is rare. CASE:We herein report the case of a 67-year-old woman with a history of breast cancer, taking tamoxifen citrate 20 mg/day for 4 years, who underwent an operation for left ovarian tumor. The postopera...

journal_title：Gynecologic oncology

authors： Okugawa K,Hirakawa T,Ogawa S,Kaku T,Nakano H

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:To evaluate the optimal cytoreduction (OPT) rate, National Comprehensive Cancer Network (NCCN) treatment guideline compliance rate and patient outcomes for advanced stage epithelial ovarian cancer (EOC) patients at our low volume institution. METHODS:Following IRB approval, records of patients with Stage III...

journal_title：Gynecologic oncology

authors： Phippen NT,Barnett JC,Lowery WJ,Miller CR,Leath CA 3rd

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess the impact of surgical complexity on postoperative complications and mortality, according to patient's frailty (mFI) following surgery for ovarian cancer. METHODS:Patients undergoing cytoreductive surgery for ovarian cancer from 2008 to 2018 were identified from our databa...

journal_title：Gynecologic oncology

authors： Di Donato V,Di Pinto A,Giannini A,Caruso G,D'Oria O,Tomao F,Fischetti M,Perniola G,Palaia I,Muzii L,Benedetti Panici P

更新日期：2020-09-04 00:00:00

abstract：OBJECTIVE:The aim of the study was to examine whether comorbidity is an independent prognostic factor for 3129 women diagnosed with ovarian cancer from 2005 to 2011. As Performance status (PS) might capture the impact of comorbidity we addressed whether comorbidity can be explained by PS or whether comorbidity has an i...

journal_title：Gynecologic oncology

authors： Sperling C,Noer MC,Christensen IJ,Nielsen ML,Lidegaard Ø,Høgdall C

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:To assess the relationship between low-dose tamoxifen, usage and endometrial cancer in breast cancer patients. METHODS:In this case-control study, the records of the 1017 patients treated at Wilford Hall Medical Center for primary breast cancer between 1978 and 1989 were reviewed. Dose and duration of tamoxi...

journal_title：Gynecologic oncology

authors： Robinson DC,Bloss JD,Schiano MA

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:To conduct a systematic review of the literature regarding the systemic treatment of advanced uterine sarcoma and provide an evidence-based summary of the available literature. METHODS:MEDLINE, EMBASE, and the Cochrane Library databases were searched. "Uterine sarcoma," "leiomyosarcoma," "mixed mesodermal tu...

journal_title：Gynecologic oncology

authors： Kanjeekal S,Chambers A,Fung MF,Verma S

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Traditionally, hysterectomy is considered definitive therapy for cervical adenocarcinoma in situ (AIS) in women beyond childbearing. CASE:A 45-year-old gravida 2, para 2 patient presented with cervical dysplasia and on pathology review of the large loop excision procedure cervical adenocarcinoma in situ was...

journal_title：Gynecologic oncology

authors： Miller B,Dunn J,Dalrymple J,Krivak TC

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Cases of malignant ovarian tumor composed of müllerian-type epithelial tumor and malignant germ cell tumor are extremely rare. CASE:We herein report the case of a 34-year-old woman with an ovarian tumor which was composed of endometrioid adenocarcinoma (EAC), clear cell adenocarcinoma (CCC), squamous cell c...

journal_title：Gynecologic oncology

authors： Ohishi Y,Kaku T,Kaneki E,Wake N,Tsuneyoshi M

更新日期：2007-05-01 00:00:00

abstract：:Immunohistochemical studies were performed to investigate the prognostic significance of p53 protein expression in 46 patients with stage IIIB squamous cell carcinoma of the uterine cervix who were treated with radiation therapy alone. Tumor cells showed p53 protein expression in 29 of 46 patients. The 5-year overall ...

journal_title：Gynecologic oncology

authors： Ebara T,Mitsuhashi N,Saito Y,Sakurai H,Hasegawa M,Takahashi M,Takahashi T,Hayakawa K,Niibe H

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:The purpose of this article is to review the data, rationale, and recommendations of vaginal brachytherapy (VBT) in the post-operative treatment of endometrial cancer patients. METHODS:The authors performed a thorough review of the medical literature regarding the use of adjuvant VBT in the treatment of endo...

journal_title：Gynecologic oncology

authors： Harkenrider MM,Block AM,Siddiqui ZA,Small W Jr

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:It has been postulated that gemcitabine inhibits DNA repair, and platinum resistance is due to increased DNA repair activity. The addition of gemcitabine to platinum-based agents may have synergistic tumoricidal activity. METHODS:Retrospective chart review of all patients with recurrent, persistent, or progr...

journal_title：Gynecologic oncology

authors： Villella J,Marchetti D,Odunsi K,Rodabaugh K,Driscoll DL,Lele S

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:To investigate the role of Bcl-X(L) on the growth and survival of human ovarian carcinoma cells. METHODS:In this study, we enforced down-regulation of Bcl-X(L) by RNA interference in ovarian carcinoma cell lines CaOV3, SKOV3ip1 and OVCAR3 cell lines expressing various levels of Bcl-X(L). We also established ...

journal_title：Gynecologic oncology

authors： Dodier P,Piché A

更新日期：2006-02-01 00:00:00

abstract：:Many malignancies appear to occur with increased frequency and aggressive patterns of spread in patients seropositive for human immunodeficiency virus (HIV). The relationship between HIV infection and cervical neoplasia suggests that these patients present with more advanced disease and demonstrate poor response to th...

journal_title：Gynecologic oncology

authors： Buckley SL,Molpus K,Carr MB,Jones HW 3rd

更新日期：1993-09-01 00:00:00

abstract：OBJECTIVE:Describing the pattern of and reasons for post-operative tumor residuals in patients with advanced epithelial ovarian cancer (AOC) operated in a specialized gynecologic cancer center following a strategy of maximum upfront debulking followed by systemic chemotherapy. METHODS:All consecutive AOC-patients trea...

journal_title：Gynecologic oncology

authors： Heitz F,Harter P,Alesina PF,Walz MK,Lorenz D,Groeben H,Heikaus S,Fisseler-Eckhoff A,Schneider S,Ataseven B,Kurzeder C,Prader S,Beutel B,Traut A,du Bois A

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVES:After treatment for ovarian cancer, women want to know when they will feel 'normal' again. Our objective was to document the proportions of women with high levels of physical and emotional symptoms at the end of treatment, determine if/when they return to normal and identify groups at risk of persistent symp...

journal_title：Gynecologic oncology

authors： Beesley VL,Webber K,Nagle CM,DeFazio A,Obermair A,Williams M,Friedlander M,Webb PM,OPAL Study Group.

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVES:We sought to determine a baseline and five-year follow up sexual function score in women undergoing hysterectomy for endometrial cancer. METHODS:A cross-section of endometrial cancer patients receiving care from 2006 to 2010 was identified. Patients were surveyed during academic year 2011 using the Pelvic O...

journal_title：Gynecologic oncology

authors： Buckingham L,Haggerty A,Graul A,Morgan M,Burger R,Ko E,Andy U,Giuntoli R

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was the evaluation of endometrial histopathologic findings from 700 patients treated with tamoxifen (Tx) for breast cancer from two medical centers (United States and France). METHODS:A retrospective review of data including histologic slides from 134 hysterectomies and 566 endometrial ...

journal_title：Gynecologic oncology

authors： Deligdisch L,Kalir T,Cohen CJ,de Latour M,Le Bouedec G,Penault-Llorca F

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:A phase II trial was performed to evaluate the efficacy and safety of gefitinib in patients with persistent/recurrent endometrial cancer. METHODS:Women with histologically confirmed persistent/recurrent endometrial cancer were treated with 500mg oral gefitinib daily until progression or severe toxicity, wit...

journal_title：Gynecologic oncology

authors： Leslie KK,Sill MW,Fischer E,Darcy KM,Mannel RS,Tewari KS,Hanjani P,Wilken JA,Baron AT,Godwin AK,Schilder RJ,Singh M,Maihle NJ

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:To design and implement a standardized postoperative voiding management protocol that accurately identifies patients with urinary retention and reduces unnecessary re-catheterization. METHODS:A postoperative voiding management protocol was designed and implemented in patients undergoing major, inpatient, non...

journal_title：Gynecologic oncology

authors： Brackmann M,Carballo E,Uppal S,Torski J,Reynolds RK,McLean K

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:Overexpression of the tyrosine kinase receptor erbB-2 is important in the pathogenesis of a variety of neoplasms including ovarian cancer. As a strategy to selectively eradicate erbB-2-overexpressing tumor cells, an anti-erbB-2 single-chain immunoglobin (sFv) gene was constructed to direct expression of intra...

journal_title：Gynecologic oncology

authors： Deshane J,Cabrera G,Grim JE,Siegal GP,Pike J,Alvarez RD,Curiel DT

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVES:Women with advanced-stage, low-grade serous ovarian carcinoma (LGSC) have low chemotherapy response rates and poor overall survival. Most LGSC tumors overexpress hormone receptors, which represent a potential treatment target. Our study objective was to determine the outcomes of patients with advanced-stage ...

journal_title：Gynecologic oncology

authors： Fader AN,Bergstrom J,Jernigan A,Tanner EJ 3rd,Roche KL,Stone RL,Levinson KL,Ricci S,Wethingon S,Wang TL,Shih IM,Yang B,Zhang G,Armstrong DK,Gaillard S,Michener C,DeBernardo R,Rose PG

更新日期：2017-10-01 00:00:00

abstract：:The objective of this phase II multicenter study was to assess the efficacy and tolerance of triptorelin (a sustained-release LHRH agonist) in advanced or recurrent endometrial cancer. A total of 101 monthly intramuscular injections were administered to 24 eligible patients (median number/patient = 3; range 1-12). Mai...

journal_title：Gynecologic oncology

authors： Lhommé C,Vennin P,Callet N,Lesimple T,Achard JL,Chauvergne J,Luporsi E,Chinet-Charrot P,Coudert B,Couette JE,Guastalla JP,Lebrun D,Ispas S,Blumberg J

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:Early-phase data have demonstrated induction of antibody responses to a polyvalent vaccine conjugate (Globo-H, GM2, MUC1-TN, TF) with adjuvant OPT-821. We sought to determine if this combination decreases the hazard of progression or death compared to OPT-821 alone in patients with ovarian cancer in second/th...

journal_title：Gynecologic oncology

authors： O'Cearbhaill RE,Deng W,Chen LM,Lucci JA 3rd,Behbakht K,Spirtos NM,Muller CY,Benigno BB,Powell MA,Berry E,Tewari KS,Hanjani P,Lankes HA,Aghajanian C,Sabbatini PJ

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:This study aimed to determine if there is a causal relationship between removal of the circumflex iliac nodes distal to the external iliac nodes (CINDEIN) and postoperative lower-extremity lymphedema (POLEL) after systematic lymphadenectomy in patients with cervical cancer. METHODS:A retrospective chart revi...

journal_title：Gynecologic oncology

authors： Yamazaki H,Todo Y,Takeshita S,Ohba Y,Sudo S,Minobe S,Okamoto K,Yamashiro K,Kato H

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:The purpose of this study is to evaluate the significance of the c-Met/hepatocyte growth factor receptor expression in invasive cervical carcinoma. METHODS:Ninety-Four patients with FIGO stage 1B disease, treated primarily with surgery, were studied immunohistochemically. Of the cases, 67 were squamous carci...

journal_title：Gynecologic oncology

authors： Baykal C,Ayhan A,Al A,Yüce K,Ayhan A

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the contribution of molecular subtype to 30-day postoperative complications and 90-day mortality after primary debulking surgery (PDS) in advanced stage high-grade serous ovarian cancer (HGSOC). METHODS:Patients with stages III-IV HGSOC undergoing PDS from 1994 to 2011 with available molecular su...

journal_title：Gynecologic oncology

authors： Torres D,Kumar A,Bakkum-Gamez JN,Weaver AL,McGree ME,Wang C,Langstraat CL,Cliby WA

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:To determine the prognostic significance of the 2002 revisions of the American Joint Committee on Cancer (AJCC) Staging System for cutaneous melanoma in melanoma of the vulva and review the current surgical utilized for treatment of this neoplasm. METHODS:Demographic, surgical and outcomes data were obtained...

journal_title：Gynecologic oncology

authors： Moxley KM,Fader AN,Rose PG,Case AS,Mutch DG,Berry E,Schink JC,Kim CH,Chi DS,Moore KN

更新日期：2011-09-01 00:00:00