Ovarian endometrioid adenocarcinoma arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy for breast cancer: a case report.

Abstract:

BACKGROUND:Ovarian cancer arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy is rare. CASE:We herein report the case of a 67-year-old woman with a history of breast cancer, taking tamoxifen citrate 20 mg/day for 4 years, who underwent an operation for left ovarian tumor. The postoperative histological diagnosis was endometrioid adenocarcinoma in an endometriotic cyst with a gradual transition of the degree of cellular atypia noted from typical endometriotic epithelium, to atypical endometriosis, and finally to adenocarcinoma. CONCLUSION:Tamoxifen may cause malignant transformation of endometriosis through atypical endometriosis even in the postmenopausal state. Atypical endometriosis may act as a precancerous lesion in the process of tamoxifen-induced malignant transformation of endometriosis.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Okugawa K,Hirakawa T,Ogawa S,Kaku T,Nakano H

doi

10.1006/gyno.2002.6824

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

231-4

issue

2

eissn

0090-8258

issn

1095-6859

pii

S0090825802968241

journal_volume

87

pub_type

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