当前位置： SCI文献检索 > GYNECOLOGIC ONCOLOGY期刊下所有文献 > Involved-field radiation therapy for recurrent ovarian cancer: Results of a multi-institutional prospective phase II trial.

Involved-field radiation therapy for recurrent ovarian cancer: Results of a multi-institutional prospective phase II trial.

Abstract：

OBJECTIVE:To evaluate the efficacy and safety of involved-field radiation therapy (IFRT) in patients with locoregionally confined recurrent or persistent epithelial ovarian cancer. METHODS:This study included patients with recurrent epithelial ovarian cancer eligible for IFRT either during diagnosis of the recurrence or after salvage therapies. IFRT was performed at a dose of ≥45 Gy for all tumors with 10-15-mm margins as seen on standard imaging. The primary endpoint was progression-free survival (PFS); the secondary endpoints were safety, response rate, local control, and overall survival (OS). RESULTS:Thirty patients with a mean number of 5.7 metastatic lesions each were enrolled between 2014 and 2016. Seventeen were treated with 3-D conformal radiation therapy (RT) and 13 with intensity-modulated RT. IFRT was well tolerated in all patients, and acute toxicity ≥ grade 2 was not observed. One case of grade 3 abdominal pain was reported 10 months post-RT. The overall and complete response rates were 85.7% and 50%, respectively. After a median follow-up of 28 (range, 17-42) months, the median PFS was 7 months. The 2-year PFS rate was 39.3%. Six of the 16 patients who developed outfield disease progression after IFRT were successfully treated with repeat IFRT as salvage treatment. The 3-year local control and OS rates were 84.4% and 55.8%, respectively. CONCLUSIONS:Although the primary endpoint was not met, IFRT might be safe and effective for in-field tumor control in patients with persistent epithelial ovarian cancer with a limited number of metastatic foci. We plan to conduct a larger scale multi-center phase II prospective study.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Chang JS,Kim SW,Kim YJ,Kim JY,Park SY,Kim JH,Jang TK,Kim YB

doi

10.1016/j.ygyno.2018.08.012

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

39-45

issue

1

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(18)31129-6

journal_volume

151

pub_type

杂志文章,多中心研究

相关文献

GYNECOLOGIC ONCOLOGY文献大全
  • Increasing genetic counseling referral rates through bundled interventions after ovarian cancer diagnosis.

    abstract：OBJECTIVE:To increase genetic counseling referrals for patients with newly diagnosed epithelial ovarian cancer (EOC). METHODS:A practice-gap analysis was performed after measuring baseline genetic counseling referral rates to identify barriers to referral from the multidisciplinary single institution EOC care group. A...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2018.01.033

    authors： Swanson CL,Kumar A,Maharaj JM,Kemppainen JL,Thomas BC,Weinhold MR,Slaby KM,Mara KC,Wick MJ,Bakkum-Gamez JN

    更新日期：2018-04-01 00:00:00

  • Progestin and estrogen potency of combination oral contraceptives and endometrial cancer risk.

    abstract：OBJECTIVE:Using data from a case-control study of endometrial cancer, we investigated the relationship between the progestin and estrogen potency in combination oral contraceptives (OCs) and the risk of developing endometrial cancer. METHODS:Subjects included 434 endometrial cancer cases and 2,557 controls identified ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2006.03.046

    authors： Maxwell GL,Schildkraut JM,Calingaert B,Risinger JI,Dainty L,Marchbanks PA,Berchuck A,Barrett JC,Rodriguez GC

    更新日期：2006-11-01 00:00:00

  • "MECCA": a developmental, dose-intensive, non-cross-resistant platinum-based chemotherapy for advanced ovarian cancer.

    abstract：:Twenty-nine women, ages 30-58 years, with advanced ovarian carcinoma were treated with a developmental combination chemotherapy regimen consisting of mitomycin C, etoposide, cisplatin, and carboplatin (MECCA). This protocol utilized the concepts of dose intensity, front-end loading, non-cross-resistance, and synergy. ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.1996.0334

    authors： Hoskins PJ,Swenerton KD,Pike JA,McMurtrie EM,Lee N

    更新日期：1996-12-01 00:00:00

  • The prognostic significance of surgical staging for carcinoma of the endometrium.

    abstract：:This study is based on a retrospective review of 156 patients with endometrial carcinoma from 1978 through 1984 who underwent primary surgical evaluation. All cases were retrospectively restaged using the newly adopted FIGO surgical staging. The preoperative FIGO clinical stage distribution for this study was as follo...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/0090-8258(92)90276-o

    authors： Wolfson AH,Sightler SE,Markoe AM,Schwade JG,Averette HE,Ganjei P,Hilsenbeck SG

    更新日期：1992-05-01 00:00:00

  • Proteomic analysis of stage I endometrial cancer tissue: identification of proteins associated with oxidative processes and inflammation.

    abstract：OBJECTIVE:The present study aimed to identify differentially expressed proteins employing a high resolution mass spectrometry (MS)-based proteomic analysis of endometrial cancer cells harvested using laser microdissection. METHODS:A differential MS-based proteomic analysis was conducted from discrete epithelial cell p...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2011.02.031

    authors： Maxwell GL,Hood BL,Day R,Chandran U,Kirchner D,Kolli VS,Bateman NW,Allard J,Miller C,Sun M,Flint MS,Zahn C,Oliver J,Banerjee S,Litzi T,Parwani A,Sandburg G,Rose S,Becich MJ,Berchuck A,Kohn E,Risinger JI,Conrad

    更新日期：2011-06-01 00:00:00

  • Complete remission of gestational choriocarcinoma with choroidal metastasis treated with systemic chemotherapy alone: case report and review of literature.

    abstract：BACKGROUND:Gestational choriocarcinoma is a malignant tumor that frequently metastasizes to the highly vascularized organs such as the lung, brain, and liver via hematogenous spread. However, this tumor rarely metastasizes to the eye and only a few cases of metastasis to the choroid have been reported. CASE:A 17-year-...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,评审

    doi：10.1006/gyno.2001.6415

    authors： Ino K,Mitsui T,Nomura S,Kikkawa F,Mizutani S

    更新日期：2001-12-01 00:00:00

  • Efficacy of pegylated liposomal doxorubicin (PLD) plus carboplatin in ovarian cancer patients who recur within six to twelve months: a phase II study.

    abstract：OBJECTIVES:Pegylated liposomal doxorubicin is one of the preferred alternatives for ovarian cancer patients with early relapse (<6 months) and taxane/carboplatin for late relapse (>12 months), but the optimal therapy for the partially platinum-sensitive (6-12 months) population has not been defined. This single-arm pha...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ygyno.2009.04.037

    authors： Power P,Stuart G,Oza A,Provencher D,Bentley JR,Miller WH Jr,Pouliot JF

    更新日期：2009-09-01 00:00:00

  • Incidence of symptomatic deep venous thrombosis with epoetin alfa or darbepoetin alfa treatment of anemia in patients with ovarian or primary peritoneal cancer.

    abstract：OBJECTIVES:Recombinant epoetin alfa and darbepoetin alfa (r-HuEPO) have been shown to be safe and effective treatments for anemia, but recent reports have suggested an increased risk of thromboembolic events when these agents are used to treat chemotherapy-induced anemia among patients with breast or ovarian cancer. We...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2006.12.026

    authors： Westin SN,Skinner EN,Jonsson Funk M,Gehrig PM,Van Le L

    更新日期：2007-05-01 00:00:00

  • Placental site trophoblastic tumor: outcome of five cases including fertility preserving management.

    abstract：INTRODUCTION:Placental site trophoblastic tumor (PSTT) is a rare variant of gestational trophoblastic disease that has been re-described during the 1970s. MATERIALS AND METHODS:The patients' age at presentation, presenting symptoms, description of last pregnancy, treatment, and outcome were analyzed in five patients d...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2004.08.049

    authors： Machtinger R,Gotlieb WH,Korach J,Fridman E,Apter S,Goldenberg M,Ben-Baruch G

    更新日期：2005-01-01 00:00:00

  • Primary surgical therapy of ovarian cancer: how much and when.

    abstract：:From July 1975 through December 1985, 328 patients with ovarian malignancies were treated. Of these, 302 had epithelial invasive malignancies and constitute the study group. The impact of the operative procedure, findings, and subsequent treatment is evaluated. Patients who underwent extensive debulking procedures suc...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/0090-8258(90)90277-r

    authors： Potter ME,Partridge EE,Hatch KD,Soong SJ,Austin JM,Shingleton HM

    更新日期：1991-03-01 00:00:00

  • Primary cytoreductive surgery and adjuvant hormonal monotherapy in women with advanced low-grade serous ovarian carcinoma: Reducing overtreatment without compromising survival?

    abstract：OBJECTIVES:Women with advanced-stage, low-grade serous ovarian carcinoma (LGSC) have low chemotherapy response rates and poor overall survival. Most LGSC tumors overexpress hormone receptors, which represent a potential treatment target. Our study objective was to determine the outcomes of patients with advanced-stage ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2017.07.127

    authors： Fader AN,Bergstrom J,Jernigan A,Tanner EJ 3rd,Roche KL,Stone RL,Levinson KL,Ricci S,Wethingon S,Wang TL,Shih IM,Yang B,Zhang G,Armstrong DK,Gaillard S,Michener C,DeBernardo R,Rose PG

    更新日期：2017-10-01 00:00:00

  • The prognostic significance of preoperative leukocytosis in epithelial ovarian carcinoma: a retrospective cohort study.

    abstract：OBJECTIVE:Preoperative leukocytosis is known to be a negative prognostic factor for several gynecologic malignancies, but its relationship with epithelial ovarian carcinoma (EOC) is unknown. We sought to evaluate the prognostic implications of preoperative leukocytosis for women with EOC. METHODS:We retrospectively re...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2014.01.010

    authors： So KA,Hong JH,Jin HM,Kim JW,Song JY,Lee JK,Lee NW

    更新日期：2014-03-01 00:00:00

  • Polymorphisms in genes hydroxysteroid-dehydrogenase-17b type 2 and type 4 and endometrial cancer risk.

    abstract：OBJECTIVE:Hydroxysteroid-dehydrogenase-17b (HSD17b) genes control the last step in estrogen biosynthesis. The isoenzymes HSD17b2 and HSD17b4 in the uterus preferentially catalyze the conversion of estradiol, the most potent and active form of estrogen, to estrone, the inactive form of estrogen. Endometrial adenocarcino...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2010.11.014

    authors： Karageorgi S,McGrath M,Lee IM,Buring J,Kraft P,De Vivo I

    更新日期：2011-04-01 00:00:00

  • Push-pull theory: using mechanotransduction to achieve tissue perfusion and wound healing in complex cases.

    abstract：:Wound healing has evolved from gauze therapy to the use of proteomics, gene therapy, and cellular-based therapies in the short time span of 45 years. Education for health care providers has not kept pace with the logarithmic acceleration in technology development and treatment options. A patient with a non-healing wou...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ygyno.2008.07.054

    authors： Ennis WJ,Meneses P,Borhani M

    更新日期：2008-11-01 00:00:00

  • Endometrial cancer in the oldest old: Tumor characteristics, patterns of care, and outcome.

    abstract：OBJECTIVE:Despite the fact that endometrial cancer commonly occurs in elderly women, little is known about the outcome of the oldest old, those > 80 years of age. We examined the patterns of care and outcome of the oldest old women with endometrial cancer. METHODS:An analysis of women > 65 years of age with endometrio...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2011.02.040

    authors： Wright JD,Lewin SN,Barrena Medel NI,Sun X,Burke WM,Deutsch I,Herzog TJ

    更新日期：2011-07-01 00:00:00

  • A prognostic nomogram to predict overall survival in women with recurrent ovarian cancer treated with bevacizumab and chemotherapy.

    abstract：OBJECTIVE:To develop a nomogram to predict overall survival (OS) in women with recurrent ovarian cancer treated with bevacizumab and chemotherapy. METHODS:A multicenter retrospective study was conducted. Potential prognostic variables included age; stage; grade; histology; performance status; residual disease; presenc...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ygyno.2014.01.036

    authors： Previs RA,Bevis KS,Huh W,Tillmanns T,Perry L,Moore K,Chapman J,McClung C,Kiet T,Java J,Chan J,Secord AA

    更新日期：2014-03-01 00:00:00

  • Integration and safety of fertility preservation in a breast cancer program.

    abstract：:Young women diagnosed with breast cancer typically face systemic treatments that may delay childbearing or permanently impair their fertility. These concerns add to the stress experienced by young cancer survivors. Timely counseling and providing fertility preservation through cryopreservation of eggs or embryos have ...

    journal_title：Gynecologic oncology

    pub_type： 社论

    doi：10.1016/j.ygyno.2011.11.028

    authors： Westphal LM,Wapnir IL

    更新日期：2012-03-01 00:00:00

  • Copy number deletion of RAD50 as predictive marker of BRCAness and PARP inhibitor response in BRCA wild type ovarian cancer.

    abstract：OBJECTIVE:To identify novel prognostic and therapeutic markers for PARP inhibitors in BRCA wild type ovarian cancer (OvCa). METHODS:BRCAness status was defined by analyzing whole-exome deep sequencing data from 220 BRCAwt OvCa cases in TCGA. Thirty-three DNA-repair genes were screened in an integrated manner for BRCA-...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2016.01.004

    authors： Zhang M,Liu G,Xue F,Edwards R,Sood AK,Zhang W,Yang D

    更新日期：2016-04-01 00:00:00

  • Radiotherapy of primary carcinoma of the vagina: management and results of different therapy schemes.

    abstract：:Three hundred and sixty-two cases of primary vaginal carcinoma were treated at the Irradiation Department of the University Clinic for Obstetrics and Gynecology, Vienna, from 1950 to 1977. As the method of choice an individually dosed, fractioned, and protracted radium-telecobalt therapy was employed. Comparing the la...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/0090-8258(85)90236-7

    authors： Kucera H,Langer M,Smekal G,Weghaupt K

    更新日期：1985-05-01 00:00:00

  • Presence of an eosinophilic infiltrate in cervical squamous carcinoma results from a type 2 immune response.

    abstract：OBJECTIVES:The presence of an eosinophilic infiltrate in patients with cervical squamous carcinoma has been shown to correlate with a worse overall survival, suggesting a less effective immune response in these cases. Since type 2 cytokines such as IL-4 and IL-5 are known to attract eosinophilic granulocytes, an immuno...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.1999.5431

    authors： van Driel WJ,Kievit-Tyson P,van den Broek LC,Zwinderman AH,Trimbos BJ,Fleuren GJ

    更新日期：1999-08-01 00:00:00

  • Risk-based stratification of carcinomas concurrently involving the endometrium and ovary.

    abstract：OBJECTIVE:Determining whether carcinomas concurrently involving endometrium and ovary are independent primary tumors (IPTs) or endometrial carcinomas with ovarian metastases (at least stage IIIA endometrial cancers, IIIA-EC) using clinicopathologic criteria is often challenging. Recent genomic studies showed that most ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2018.10.033

    authors： Turashvili G,Gómez-Hidalgo NR,Flynn J,Gonen M,Leitao MM Jr,Soslow RA,Murali R

    更新日期：2019-01-01 00:00:00

  • Complete molar pregnancy in adolescents from North and South America: Clinical presentation and risk of gestational trophoblastic neoplasia.

    abstract：OBJECTIVES:To compare complete hydatidiform mole (CHM) clinical presentation and risk factors associated with GTN development between North American and South American adolescents. METHODS:This non-concurrent cohort study was undertaken including adolescents with CHM referred to centers in North America (New England T...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2016.07.002

    authors： Soares RR,Maestá I,Colón J,Braga A,Salazar A,Charry RC,Sun SY,Goldstein DP,Berkowitz RS

    更新日期：2016-09-01 00:00:00

  • Current techniques in screening for cervical cancer in Spain: updated recommendations.

    abstract：:A population-based survey (AFRODITA Study) was conducted in Spain in order to estimate the coverage and factors associated with cervical cancer cytological screening. The results of this survey indicate that the rate of screening for cervical cancer in Spain is 75.6% in women between 18 and 65 years. This high rate of...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2008.05.013

    authors： Puig-Tintoré LM,Torné A,Alonso I

    更新日期：2008-09-01 00:00:00

  • Phase II study of ifosfamide and mesna in nonsquamous carcinoma of the cervix: a Gynecologic Oncology Group study.

    abstract：:A phase II trial of ifosfamide (IFX) and mesna was conducted by the GOG in patients with recurrent or advanced nonsquamous carcinoma of the cervix. A starting dose of 1.5 g/m2 IFX iv daily for 5 days and 300 mg/m2 mesna iv every 4 hr with three doses daily after IFX were given. In patients who had received prior radio...

    journal_title：Gynecologic oncology

    pub_type： 临床试验,杂志文章

    doi：10.1006/gyno.1993.1084

    authors： Sutton GP,Blessing JA,DiSaia PJ,McGuire WP

    更新日期：1993-04-01 00:00:00

  • Endometrial response to endogenous hormones after pelvic irradiation for genital malignancies.

    abstract：:Two cases are presented which demonstrate histologically an endometrial response to endogenous hormones after pelvic teletherapy and brachytherapy in patients who have undergone lateral ovarian transposition. Reasons for such a response are briefly discussed. ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/0090-8258(90)90118-5

    authors： Larson JE,Whitney CW,Zaino R,Kaminski P,Podczaski E,Mortel R

    更新日期：1990-01-01 00:00:00

  • High cyclooxygenase-2 expression in cervical adenocarcinomas.

    abstract：OBJECTIVE:The purpose of this study was to examine the relationships between cyclooxygenase-2 (COX-2) expression and prognostic factors in cervical carcinomas. METHODS:We studied COX-2 expression in 53 women with cervical cancers, including 35 squamous cell carcinomas (SCCs), 1 adenosquamous cell carcinoma (ASCC), and...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/s0090-8258(02)00066-5

    authors： Chen YJ,Wang LS,Wang PH,Lai CR,Yen MS,Ng HT,Yuan CC

    更新日期：2003-03-01 00:00:00

  • POSTN/TGFBI-associated stromal signature predicts poor prognosis in serous epithelial ovarian cancer.

    abstract：OBJECTIVE:To identify molecular prognosticators and therapeutic targets for high-grade serous epithelial ovarian cancers (EOCs) using genetic analyses driven by biologic features of EOC pathogenesis. METHODS:Ovarian tissue samples (n = 172; 122 serous EOCs, 30 other EOCs, 20 normal/benign) collected prospectively from...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2013.12.021

    authors： Karlan BY,Dering J,Walsh C,Orsulic S,Lester J,Anderson LA,Ginther CL,Fejzo M,Slamon D

    更新日期：2014-02-01 00:00:00

  • Robotically assisted laparoscopic hysterectomy versus total abdominal hysterectomy and lymphadenectomy for endometrial cancer.

    abstract：OBJECTIVE:To compare surgical morbidity and clinical-pathologic factors for patients with endometrial cancer (EC) undergoing robotic-assisted laparoscopic hysterectomy (RALH) versus total abdominal hysterectomy (TAH) with aortic and/or pelvic lymphadenectomy (LA). METHODS:During the first 14 months of a robotics surgi...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2008.08.025

    authors： DeNardis SA,Holloway RW,Bigsby GE 4th,Pikaart DP,Ahmad S,Finkler NJ

    更新日期：2008-12-01 00:00:00

  • An unusual case of secondary fibrosarcoma after treatment for breast cancer.

    abstract：BACKGROUND:Post-irradiation breast sarcoma is a rare and highly aggressive tumor, associated with poor prognosis. However, the mean latent periods reported for postradiation sarcomas after treatment of breast cancer ranges from 5 to 10 years. CASE:We present a rare case of fibrosarcoma of the axilla, diagnosed 23 mont...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ygyno.2006.07.014

    authors： Plotti F,Di Donato V,Zullo MA,Angioli R,Panici PB

    更新日期：2006-12-01 00:00:00

  • Direct laparoscopic venous sampling to diagnose a small Sertoli-Leydig tumor.

    abstract：BACKGROUND:Sertoli-Leydig cell tumors (SLCT) constitute only 0.5% of all primary ovarian neoplasms. We report a unique diagnostic method (selective laparoscopic venous sampling) and a rare case of a contralateral second primary tumor. CASE:A 14-year-old female presented with hyperandrogenic complaints and an increased...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/s0090-8258(03)00405-0

    authors： White LC,Buchanan KD,O'Leary TD,Carlan SJ,Boothby R

    更新日期：2003-10-01 00:00:00