"MECCA": a developmental, dose-intensive, non-cross-resistant platinum-based chemotherapy for advanced ovarian cancer.

Abstract:

:Twenty-nine women, ages 30-58 years, with advanced ovarian carcinoma were treated with a developmental combination chemotherapy regimen consisting of mitomycin C, etoposide, cisplatin, and carboplatin (MECCA). This protocol utilized the concepts of dose intensity, front-end loading, non-cross-resistance, and synergy. The median overall survival was 37 months with a 27% 5-year survival; the median failure-free survival was 15 months with a 14% 5-year failure-free rate. The predominant toxicity was hematologic and there was one toxic death (cardiac failure). The overall survival results are superior to our previous experience.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Hoskins PJ,Swenerton KD,Pike JA,McMurtrie EM,Lee N

doi

10.1006/gyno.1996.0334

subject

Has Abstract

pub_date

1996-12-01 00:00:00

pages

345-51

issue

3

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(96)90334-0

journal_volume

63

pub_type

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