当前位置： SCI文献检索 > GYNECOLOGIC ONCOLOGY期刊下所有文献 > The potential benefit of 6 vs. 3 cycles of chemotherapy in subsets of women with early-stage high-risk epithelial ovarian cancer: an exploratory analysis of a Gynecologic Oncology Group study.

The potential benefit of 6 vs. 3 cycles of chemotherapy in subsets of women with early-stage high-risk epithelial ovarian cancer: an exploratory analysis of a Gynecologic Oncology Group study.

Abstract：

OBJECTIVES:A prior clinical trial on early-stage high risk ovarian cancer showed a lower recurrence rate in those treated with six vs. three cycles of chemotherapy. We proposed to identify subsets of patients who may benefit from more cycles of chemotherapy. METHODS:Outcomes of patients who underwent six vs. three cycles of chemotherapy were analyzed based on clinico-pathologic factors. Kaplan-Meier estimates and Cox Regression Model were used for analyses. RESULTS:Of 427 patients (median age: 55 years), 69% had stage I disease, 30% had clear cell, 25% endometrioid, 23% serous, 7% mucinous, and 15% had other cell types. The risk of recurrence in those who had six vs. three cycles of chemotherapy was not different based on age, performance status, stage, grade of disease, presence of ascites, tumor rupture, or positive cytology. However, those with serous tumors had a significantly lower risk of recurrence after six vs. three cycles of chemotherapy (HR=0.33, CI=0.14-0.77; p=0.04) in contrast to non-serous tumors (HR=0.94, CI=0.60-1.49). Nevertheless, a test of homogeneity did not show a difference in treatment effects across cell types (p=0.285). Of those with serous tumors, the 5-year recurrence-free survival was 83% and 60% in those who received six vs. three cycles of chemotherapy, respectively (p=0.007). CONCLUSIONS:In this exploratory analysis of early-stage high risk ovarian cancer, our data suggest that six rather than three cycles of chemotherapy may decrease the recurrence of patients with serous tumors. Further studies are needed to confirm these findings.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Chan JK,Tian C,Fleming GF,Monk BJ,Herzog TJ,Kapp DS,Bell J

doi

10.1016/j.ygyno.2009.10.073

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

301-6

issue

3

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(09)00895-6

journal_volume

116

pub_type

杂志文章,随机对照试验

相关文献

GYNECOLOGIC ONCOLOGY文献大全
  • Tumor budding and E-Cadherin expression in endometrial carcinoma: are they prognostic factors in endometrial cancer?

    abstract：OBJECTIVE:To evaluate the prognostic value of tumor budding (TB) in endometrioid (EEC) and non-endometrioid endometrial cancers (NEEC) and to determine its correlation with expression of E-cadherin. METHODS:Ninety-five patients with primary endometrial carcinoma were examined statistically. All patients were diagnosed...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2011.12.433

    authors： Koyuncuoglu M,Okyay E,Saatli B,Olgan S,Akin M,Saygili U

    更新日期：2012-04-01 00:00:00

  • Impact of antibiotic treatment during platinum chemotherapy on survival and recurrence in women with advanced epithelial ovarian cancer.

    abstract：OBJECTIVE(S):To determine whether antibiotic treatment (ABX) during platinum chemotherapy (PC) for epithelial ovarian cancer (EOC) impacts progression-free survival (PFS) and overall survival (OS). STUDY DESIGN:Retrospective single institution cohort study in women with newly diagnosed stage III/IV EOC (n = 424) who u...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2020.09.010

    authors： Chambers LM,Kuznicki M,Yao M,Chichura A,Gruner M,Reizes O,Debernardo R,Rose PG,Michener C,Vargas R

    更新日期：2020-12-01 00:00:00

  • Implementation of a standardized voiding management protocol to reduce unnecessary re-catheterization - A quality improvement project.

    abstract：OBJECTIVE:To design and implement a standardized postoperative voiding management protocol that accurately identifies patients with urinary retention and reduces unnecessary re-catheterization. METHODS:A postoperative voiding management protocol was designed and implemented in patients undergoing major, inpatient, non...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2020.01.036

    authors： Brackmann M,Carballo E,Uppal S,Torski J,Reynolds RK,McLean K

    更新日期：2020-05-01 00:00:00

  • Ovarian endometrioid adenocarcinoma arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy for breast cancer: a case report.

    abstract：BACKGROUND:Ovarian cancer arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy is rare. CASE:We herein report the case of a 67-year-old woman with a history of breast cancer, taking tamoxifen citrate 20 mg/day for 4 years, who underwent an operation for left ovarian tumor. The postopera...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,评审

    doi：10.1006/gyno.2002.6824

    authors： Okugawa K,Hirakawa T,Ogawa S,Kaku T,Nakano H

    更新日期：2002-11-01 00:00:00

  • High external parametrial dose can increase the probability of radiation proctitis in patients with uterine cervix cancer.

    abstract：OBJECTIVE:The aim of this study was to evaluate the relationship between external parametrial dose and radiation proctitis after external irradiation and high-dose-rate intracavitary (HDR-IC) brachytherapy among patients with cervical cancer. METHODS:From May 1993 through December 1996, 191 patients with stage IB-IVA ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.2000.5997

    authors： Huang EY,Lin H,Hsu HC,Wang CJ,Chen HC,Sun LM,Hsiung CY

    更新日期：2000-12-01 00:00:00

  • Human papillomavirus genotype distribution in low-grade squamous intraepithelial lesions in France and comparison with CIN2/3 and invasive cervical cancer: the EDiTH III study.

    abstract：OBJECTIVES:In the present study (EDiTH III study), the genotype-specific prevalence of HPV in low-grade squamous intraepithelial lesions (LSIL) was estimated to predict the potential benefit of HPV vaccination in France. This prevalence was compared to that previously reported in France in high-grade cervical intraepit...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ygyno.2008.04.012

    authors： Prétet JL,Jacquard AC,Saunier M,Clavel C,Dachez R,Gondry J,Pradat P,Soubeyrand B,Leocmach Y,Mougin C,Riethmuller D,EDiTH study group.

    更新日期：2008-08-01 00:00:00

  • Urolithiasis following formation of a continent urostomy: case report and review of the literature.

    abstract：BACKGROUND:Formation of urinary stones in a continent urostomy (Indiana pouch) has been described as a late complication. Management of a patient with symptomatic multiple large stones and review of the literature are outlined. CASE REPORT:A 32-year-old woman presented with recurrent urinary tract infections and pyelo...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,评审

    doi：10.1006/gyno.2000.5750

    authors： Sait K,Stuart G,Nation J,Ghatage P

    更新日期：2000-05-01 00:00:00

  • Extra-peritoneal laparoscopic para-aortic lymphadenectomy--a prospective cohort study of 293 patients with endometrial cancer.

    abstract：OBJECTIVE:To determine if extra-peritoneal laparoscopic para-aortic (PA) lymphadenectomy allows a reliable assessment of PA nodes in patients with endometrial cancer (EC). METHODS:In October of 2005, a single surgeon began performing extra-peritoneal laparoscopic PA lymphadenectomy for patients with EC. A prospective ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2008.08.021

    authors： Dowdy SC,Aletti G,Cliby WA,Podratz KC,Mariani A

    更新日期：2008-12-01 00:00:00

  • A clinical study of optical biopsy of the uterine cervix using a multispectral imaging system.

    abstract：OBJECTIVE:To present the clinical application of the multispectral imaging colposcopic system (MIS colposcopy). METHODS:MIS colposcopy was performed on 123 enrolled women. After a 3% acetic acid application, sequential images were captured, analyzed, and stored automatically. Directed biopsies were taken from distinct...

    journal_title：Gynecologic oncology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ygyno.2004.09.013

    authors： Orfanoudaki IM,Themelis GC,Sifakis SK,Fragouli DH,Panayiotides JG,Vazgiouraki EM,Koumantakis EE

    更新日期：2005-01-01 00:00:00

  • HPV vaccine: A comparison of attitudes and behavioral perspectives between Latino and non-Latino women.

    abstract：OBJECTIVE:Recent scientific advances have lead to the development of a prophylactic, quadrivalent HPV vaccine conferring. We surveyed Latino and non-Latino women directly to examine what motivates them to vaccinate themselves, their daughters, and their sons. METHODS:A written survey was administered to 86 Latinas and...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2008.12.010

    authors： Watts LA,Joseph N,Wallace M,Rauh-Hain JA,Muzikansky A,Growdon WB,del Carmen MG

    更新日期：2009-03-01 00:00:00

  • The anterior Obturator Artery Perforator (aOAP) flap: surgical anatomy and application of a method for vulvar reconstruction.

    abstract：OBJECTIVE:Vulvar reconstruction following oncologic resection is challenging. Some flaps used for reconstruction can show adverse characteristics such as excessive tissue bulk or increased distance to the defect. Region of the sulcus genitofemoralis is of thin and pliable tissue proximate to the vulva. Vasculature and ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2010.08.033

    authors： O'Dey DM,Bozkurt A,Pallua N

    更新日期：2010-12-01 00:00:00

  • Identification and validation of a prognostic proteomic signature for cervical cancer.

    abstract：OBJECTIVE:To date, The Cancer Genome Atlas (TCGA) has provided the most extensive molecular characterization of invasive cervical cancer (ICC). Analysis of reverse phase protein array (RPPA) data from TCGA samples showed that cervical cancers could be stratified into 3 clusters exhibiting significant differences in sur...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2019.08.021

    authors： Rader JS,Pan A,Corbin B,Iden M,Lu Y,Vellano CP,Akbani R,Mills GB,Simpson P

    更新日期：2019-11-01 00:00:00

  • HPV subtypes and immunological parameters of cervical cancer in Iceland during two time periods, 1958-1960 and 1995-1996.

    abstract：OBJECTIVE:Cervical cancer is a disease caused in part by an infection with an oncogenic subtype of human papillomavirus (HPV). In this study we analysed all cervical cancer samples diagnosed in Iceland during two periods, 1958-1960 and 1995-1996, and asked whether significant changes in viral or immunological parameter...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/s0090-8258(03)00053-2

    authors： Mikaelsdottir EK,Benediktsdottir KR,Olafsdottir K,Arnadottir T,Ragnarsson GB,Olafsson K,Sigurdsson K,Kristjansdottir GS,Imsland AK,Ogmundsdottir HM,Rafnar T

    更新日期：2003-04-01 00:00:00

  • Differential induction of apoptosis by tumor necrosis factor-related apoptosis-inducing ligand in human ovarian carcinoma cells.

    abstract：OBJECTIVES:In this study, we examine the sensitivity of a panel of ovarian carcinoma cells, which includes four primary ovarian cancer cell samples, and four normal ovarian epithelium samples to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). We also examine the intracellular regulation of TRAIL-mediat...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2004.03.029

    authors： Lane D,Cartier A,L'Espérance S,Côté M,Rancourt C,Piché A

    更新日期：2004-06-01 00:00:00

  • The influence of surgical staging on the evaluation and treatment of patients with cervical carcinoma.

    abstract：:Ninety-six patients with cervical cancer underwent surgical staging prior to radiation therapy. An equal number of patients were explored by transperitoneal and extraperitoneal surgery. Three different extraperitoneal approaches were utilized. All patients had bilateral paraaortic lymphadenectomy and selective pelvic ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/0090-8258(86)90028-4

    authors： LaPolla JP,Schlaerth JB,Gaddis O,Morrow CP

    更新日期：1986-06-01 00:00:00

  • Does para-aortic irradiation reduce the risk of distant metastasis in advanced cervical cancer? A systematic review and meta-analysis of randomized clinical trials.

    abstract：PURPOSE:To evaluate the impact of the extension of the radiotherapy field cranially toward para-aortic lymph nodes (EF-RT) in advanced cervical cancer. MATERIALS AND METHODS:A systematic search of databases (PubMed, CENTRAL, Clinical Trials) was performed and included studies that were published between 1960 and Novem...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ygyno.2016.11.044

    authors： Sapienza LG,Gomes MJL,Calsavara VF,Leitao MM Jr,Baiocchi G

    更新日期：2017-02-01 00:00:00

  • Heparanase expression correlates with poor survival in metastatic ovarian carcinoma.

    abstract：OBJECTIVE:To analyze the expression of Heparanase, an enzyme involved in cancer metastasis and angiogenesis, in ovarian and breast carcinoma cells in effusions. METHODS:Heparanase protein expression was analyzed in malignant effusions from ovarian (=200) and breast (=41) carcinoma patients using immunocytochemistry. T...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2006.08.045

    authors： Davidson B,Shafat I,Risberg B,Ilan N,Trope' CG,Vlodavsky I,Reich R

    更新日期：2007-02-01 00:00:00

  • Bone metastasis from cervix cancer.

    abstract：:Among 713 patients followed after treatment for cancer of the uterine cervix, 48 (6.6%) had a metastasis to the bone. The rates of metastasis in each of the four clinical stages were 11/273 (4.0%) in stage I, 16/243 (6.6%) in stage II, 13/162 (8.0%) in stage III, and 8/35 (22.9%) in stage IV, respectively. The most fr...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/0090-8258(89)90853-6

    authors： Matsuyama T,Tsukamoto N,Imachi M,Nakano H

    更新日期：1989-01-01 00:00:00

  • Human cervical cells immortalized in vitro with oncogenic human papillomavirus DNA differentiate dysplastically in vivo.

    abstract：:Human papillomavirus (HPV) types 16 and 18 are associated with cervical dysplasia and carcinoma. In vitro integration of HPV-16 or HPV-18 DNA into cultured human cervical cells results in their immortalization. In this study, in vivo differentiation of human cervical cells immortalized with recombinant HPV-16 or HPV-1...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/0090-8258(90)90082-v

    authors： Waggoner SE,Woodworth CD,Stoler MH,Barnes WA,Delgado G,DiPaolo JA

    更新日期：1990-09-01 00:00:00

  • Pelvic sidewall adenocarcinoma after definitive therapy for cervical adenocarcinoma in situ.

    abstract：BACKGROUND:Traditionally, hysterectomy is considered definitive therapy for cervical adenocarcinoma in situ (AIS) in women beyond childbearing. CASE:A 45-year-old gravida 2, para 2 patient presented with cervical dysplasia and on pathology review of the large loop excision procedure cervical adenocarcinoma in situ was...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2005.06.044

    authors： Miller B,Dunn J,Dalrymple J,Krivak TC

    更新日期：2005-11-01 00:00:00

  • A follow-up study of patients with cervical cancer after resection, with special emphasis on the incidence of second primary cancers.

    abstract：:The causes of death in long-term survivors after resection of cervical cancer were investigated in a follow-up study of 375 women, focusing especially on the postoperative development of second primary cancers. The 5- and 10-year overall survival rates were 75.0 and 66.0%, respectively, in cases that showed frank inva...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.1995.1011

    authors： Tominaga K,Koyama Y,Sasagawa M,Obata N,Kamata H,Yamaguchi E,Nagai M

    更新日期：1995-01-01 00:00:00

  • Small cell carcinoma of the gynecologic tract: a multifaceted spectrum of lesions.

    abstract：OBJECTIVE:Small cell carcinoma (SmCC) of the female genital tract constitutes a diagnostic and clinical challenge given its rarity and the lack of standardized therapeutic approaches. Here we review the morphological, clinical and molecular features of gynecologic SmCCs and discuss potential areas for future research. ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ygyno.2014.05.017

    authors： Atienza-Amores M,Guerini-Rocco E,Soslow RA,Park KJ,Weigelt B

    更新日期：2014-08-01 00:00:00

  • Improved therapeutic index of lower dose topotecan chemotherapy in recurrent ovarian cancer.

    abstract：OBJECTIVE:Topotecan (1.5 mg/m(2)) administered daily for 5 consecutive days of a 21-day cycle is an established chemotherapeutic regimen in recurrent ovarian cancer. However, noncumulative myelosuppression has limited its use by many clinicians. We sought to determine whether a lower dose of topotecan could provide com...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.2001.6365

    authors： Rodriguez M,Rose PG

    更新日期：2001-11-01 00:00:00

  • A phase II trial of dolastatin-10 in recurrent platinum-sensitive ovarian carcinoma: a Gynecologic Oncology Group study.

    abstract：OBJECTIVE:To estimate the antitumor efficacy of dolastatin-10 in patients with measurable recurrences of platinum-sensitive ovarian carcinoma and to determine the nature and degree of toxicity of dolastatin-10 in these patients. METHODS:Patients received dolastatin-10 400 microg/m(2) intravenously every 3 weeks and tu...

    journal_title：Gynecologic oncology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/s0090-8258(03)00007-6

    authors： Hoffman MA,Blessing JA,Lentz SS,Gynecologic Oncology Group Study.

    更新日期：2003-04-01 00:00:00

  • Push-pull theory: using mechanotransduction to achieve tissue perfusion and wound healing in complex cases.

    abstract：:Wound healing has evolved from gauze therapy to the use of proteomics, gene therapy, and cellular-based therapies in the short time span of 45 years. Education for health care providers has not kept pace with the logarithmic acceleration in technology development and treatment options. A patient with a non-healing wou...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ygyno.2008.07.054

    authors： Ennis WJ,Meneses P,Borhani M

    更新日期：2008-11-01 00:00:00

  • Clinical audit in gynecological cancer surgery: development of a risk scoring system to predict adverse events.

    abstract：BACKGROUND:Advanced gynecological surgery undertaken in a specialized gynecologic oncology unit may be associated with significant perioperative morbidity. Validated risk prediction models are available for general surgical specialties but currently not for gynecological cancer surgery. OBJECTIVE:The objective of this...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2009.08.004

    authors： Kondalsamy-Chennakesavan S,Bouman C,De Jong S,Sanday K,Nicklin J,Land R,Obermair A

    更新日期：2009-12-01 00:00:00

  • Ovarian steroid cell tumors, not otherwise specified: a case report and literature review.

    abstract：:Steroid cell tumors, not otherwise specified, are rare ovarian sex cord-stromal tumors with malignant potential. The majority of these tumors produce steroids with testosterone being the most common. A case of a 46-year-old woman who presented with sudden onset of virilization and a pelvic mass is reported. Various as...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,评审

    doi：10.1006/gyno.1999.5549

    authors： Reedy MB,Richards WE,Ueland F,Uy K,Lee EY,Bryant C,van Nagell JR Jr

    更新日期：1999-11-01 00:00:00

  • Prospective evaluation of prognostic significance of the tumor-free distance from uterine serosa in surgically staged endometrial adenocarcinoma.

    abstract：OBJECTIVE:To determine if tumor-free distance (TFD) from the uterine serosa predicts surgicopathologic factors and outcome in surgically staged endometrial cancer, and to compare TFD with the traditional estimate of depth of myometrial invasion (DOI). METHODS:Patients who underwent complete surgical staging for primar...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2008.09.009

    authors： Schwab KV,O'Malley DM,Fowler JM,Copeland LJ,Cohn DE

    更新日期：2009-01-01 00:00:00

  • Association of obesity with survival in patients with endometrial cancer.

    abstract：BACKGROUND:Obesity confers an overall increased risk for development of endometrial cancer. However there are conflicting reports regarding the effect of obesity on patients' overall and disease specific survival. The purpose of this study was to evaluate the effect of obesity on survival in women with endometrial canc...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2019.03.258

    authors： Van Arsdale A,Miller DT,Kuo DY,Isani S,Sanchez L,Nevadunsky NS

    更新日期：2019-07-01 00:00:00

  • Concurrent cisplatin and 5-fluorouracil chemotherapy and radiation therapy for advanced-stage squamous carcinoma of the vulva.

    abstract：:A phase II trial of concurrent cisplatin and 5-fluorouracil (5-FU) chemotherapy and radiation therapy (CT + RT) was conducted for the primary treatment of 12 patients with retrospective surgical FIGO stages III-IV squamous carcinoma of the vulva. Eight patients were stage III and four were stage IV. Chemotherapy was u...

    journal_title：Gynecologic oncology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0090-8258(91)90345-6

    authors： Berek JS,Heaps JM,Fu YS,Juillard GJ,Hacker NF

    更新日期：1991-09-01 00:00:00