Colorectal function preservation in posterior and total supralevator exenteration for gynecologic malignancies: an 89-patient series.

Abstract:

OBJECTIVE:The objective of this study was to analyze our experience with colorectal function preservation at the time of pelvic exenteration. METHODS:Between January 1980 and December 2001, 201 pelvic exenterations for gynecologic malignancies were performed in our hospital. Ninety-eight were supralevator exenterations and 89 were selected for this study because low colorectal anastomosis (LCRA) was performed. There were locally advanced or recurrent cancers including 50 cervical, 28 ovarian, 11 endometrial, and 3 vaginal malignancies and 5 pelvic sarcomas. RESULTS:Thirty-nine patients (44%) had a history of previous irradiation. There were were 50 posterior and 39 total exenterations. A diverting stomy and/or pelvic filling were performed respectively in 44 (49.4%) and 26 (29%) cases. The postoperative mortality rate was 4.5% (4/89). Seventeen patients experienced a colorectal anastomotic fistula (AF). AF occurred significantly more frequently in irradiated patients (14/17 = 82%). The mortality rate related to AF was 6% (1/17). Ultimately the functional colorectal anastomosis rate was 71.9%, respectively 61.5 and 80% in irradiated and nonirradiated patients. CONCLUSIONS:Colorectal function preservation in supralevator exenteration for gynecologic malignancies can be achieved safely in a majority of patients. In irradiated patients a systematically diverting stomy may result in a low mortality rate.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Moutardier V,Houvenaeghel G,Lelong B,Mokart D,Delpero JR

doi

10.1016/s0090-8258(03)00069-6

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

155-9

issue

1

eissn

0090-8258

issn

1095-6859

pii

S0090825803000696

journal_volume

89

pub_type

杂志文章
  • Relationship of margin status and radiation dose to recurrence in post-operative vulvar carcinoma.

    abstract:OBJECTIVE:To evaluate the effect of margin status and radiation dose in patients treated with radiation therapy (RT) for vulvar cancer. Clinical outcomes included vulvar recurrence (VR), relapse-free survival (RFS) and overall survival (OS). METHODS:We retrospectively reviewed the records of 300 patients with Stage I-...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2013.05.036

    authors: Viswanathan AN,Pinto AP,Schultz D,Berkowitz R,Crum CP

    更新日期:2013-09-01 00:00:00

  • The haplotype of two FSHR polymorphisms in ovarian cancer--a potential role of ethnology in risk modification.

    abstract:OBJECTIVES:The precise role of gonadotropins in the carcinogenesis of epithelial ovarian cancer remains uncertain. Recently, the haplotype of two single nucleotide polymorphisms, Thr307Ala (rs6165) and Asn680Ser (rs6166), has been described as a risk factor for ovarian cancer in Chinese women. In this study we investig...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2008.12.011

    authors: Heubner M,Riemann K,Otterbach F,Kimmig R,Kasimir-Bauer S,Siffert W,Wimberger P

    更新日期:2009-03-01 00:00:00

  • Low-grade serous carcinoma: new concepts and emerging therapies.

    abstract::For the past several years, all women with epithelial ovarian cancer have been treated identically, whether in a clinical trial or off protocol. Over the past decade, we have come to appreciate the magnitude of the heterogeneity of ovarian cancer. The development of the binary grading system for serous carcinoma was a...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ygyno.2013.05.021

    authors: Romero I,Sun CC,Wong KK,Bast RC Jr,Gershenson DM

    更新日期:2013-09-01 00:00:00

  • Loop electrocautery excisional procedure: therapeutic effectiveness as an ablation and a conization equivalent.

    abstract::This study was designed to compare the effectiveness of loop excision procedures as ablation and conization equivalents, and their use in recurrent cervical high-grade dysplasia patients. We retrospectively reviewed patients undergoing loop procedures between January 1992 and April 1994. Conization equivalents were de...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1996.0132

    authors: Gold M,Dunton CJ,Murray J,Macones G,Hanau C,Carlson JA Jr

    更新日期:1996-05-01 00:00:00

  • Push-pull theory: using mechanotransduction to achieve tissue perfusion and wound healing in complex cases.

    abstract::Wound healing has evolved from gauze therapy to the use of proteomics, gene therapy, and cellular-based therapies in the short time span of 45 years. Education for health care providers has not kept pace with the logarithmic acceleration in technology development and treatment options. A patient with a non-healing wou...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ygyno.2008.07.054

    authors: Ennis WJ,Meneses P,Borhani M

    更新日期:2008-11-01 00:00:00

  • A comparison of intracavitary versus interstitial irradiation in the treatment of cervical cancer.

    abstract:OBJECTIVE:Management of locally advanced cervical cancer consists primarily of combination external and internal radiation. In order to investigate the impact of intracavitary brachytherapy versus interstitial brachytherapy on local tumor control, survival, and complications, we retrospectively reviewed the concomitant...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1997.4877

    authors: Monk BJ,Tewari K,Burger RA,Johnson MT,Montz FJ,Berman ML

    更新日期:1997-12-01 00:00:00

  • Continuous epidural infusion in gynecologic oncology patients undergoing exploratory laparotomy: The new standard for decreased postoperative pain and opioid use.

    abstract:OBJECTIVE:To compare the incidence of postoperative complications and opioid pain medication usage in gynecologic oncology patients who did and did not receive an epidural prior to undergoing exploratory laparotomy. METHODS:Retrospective cohort study of all patients undergoing exploratory laparotomy with the gynecolog...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2019.02.017

    authors: Huepenbecker SP,Cusworth SE,Kuroki LM,Lu P,Samen CDK,Woolfolk C,Deterding R,Wan L,Helsten DL,Bottros M,Mutch DG,Powell MA,Massad LS,Thaker PH

    更新日期:2019-05-01 00:00:00

  • Gonadotropin stimulation of MLS human epithelial ovarian carcinoma cells augments cell adhesion mediated by CD44 and by alpha(v)-integrin.

    abstract:OBJECTIVE:The goal of this work was to evaluate the involvement of gonadotropins in the regulation of adhesion of human epithelial ovarian carcinoma. We studied two pathways that were previously implicated in the metastatic implantation of ovarian carcinoma to the peritoneum, namely hyaluronan-CD44 and RGD-integrin med...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.2001.6512

    authors: Schiffenbauer YS,Meir G,Maoz M,Even-Ram SC,Bar-Shavit R,Neeman M

    更新日期:2002-02-01 00:00:00

  • A comparison of modified MonoPrep2 of liquid-based cytology with ThinPrep Pap test.

    abstract:OBJECTIVE:The purpose of this study is to evaluate a modified MonoPrep2 (MP) of liquid-based cytology (LBC) to search for a less expensive alternative technique usable for screening of cervical cancers. STUDY DESIGN:Cervicovaginal direct-to-vial samples from 1218 consecutive patients were processed with the modified M...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2004.05.047

    authors: Nam JH,Kim HS,Lee JS,Choi HS,Min KW,Park CS

    更新日期:2004-09-01 00:00:00

  • Endometrial squamous cell carcinoma following whole pelvic radiation therapy: response to carboplatin.

    abstract::A case of Stage IV endometrial squamous cell carcinoma occurring 8 years after a low anterior resection and whole pelvic radiation therapy for a Dukes D colon carcinoma is presented. Koilocytosis was present in the tumor. There was no evidence of human papillomavirus antigen or DNA in the tumor. The patient was treate...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1995.1167

    authors: Sorosky JI,Kaminski PF,Kreider J,Podczaski ES,Olt GJ,Zaino R

    更新日期:1995-06-01 00:00:00

  • Standardization of lower extremity quantitative lymphedema measurements and associated patient-reported outcomes in gynecologic cancers.

    abstract::Practice changing standardization of lower extremity lymphedema quantitative measurements with integrated patient reported outcomes will likely refine and redefine the optimal risk-reduction strategies to diminish the devastating limb-related dysfunction and morbidity associated with treatment of gynecologic cancers. ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ygyno.2020.10.026

    authors: Russo S,Walker JL,Carlson JW,Carter J,Ward LC,Covens A,Tanner EJ 3rd,Armer JM,Ridner S,Hayes S,Taghian AG,Brunelle C,Lopez-Acevedo M,Davidson BA,Schaverien MV,Ghamande SA,Bernas M,Cheville AL,Yost KJ,Schmitz K,Coy

    更新日期:2021-02-01 00:00:00

  • Mucinous adenofibroma of the ovary: case report of the endocrinologic findings.

    abstract::Endocrine and clinicopathologic findings in a 77-year-old woman with ovarian mucinous adenofibroma of borderline malignancy are reported. The preoperative levels of testosterone, androstenedione, estrone, and estradiol in her peripheral blood were 91 ng/ml, 3.78 ng/ml, 82 pg/ml, and 35 pg/ml, respectively, abnormally ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1994.1197

    authors: Tohya T,Mizutani H,Katabuchi H,Miyazaki K,Okamura H

    更新日期:1994-08-01 00:00:00

  • Reproducibility in the assessment of postmenopausal ovaries with transvaginal ultrasound.

    abstract:OBJECTIVE:The goal of this study was to evaluate the interexaminer variation in the assessment of postmenopausal ovaries using transvaginal ultrasound (TVU). METHODS:One hundred eighty-eight cancer screening trial participants undergoing TVU were reassessed by a second TVU examination. RESULTS:Although first examiner...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.2000.5785

    authors: Modugno F,Weissfeld JL,Hill LM

    更新日期:2000-05-01 00:00:00

  • Endometrial cancer presentation is associated with social determinants of health in a public healthcare system: A population-based cohort study.

    abstract:OBJECTIVE:Delay in diagnosis of endometrial cancer may be associated with disease progression and impact management and outcomes. Social and cultural barriers influence recognition of symptoms and self-advocacy in seeking care. Associations between social determinants of health (SDH) and disease presentation have been ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2020.04.693

    authors: Helpman L,Pond GR,Elit L,Anderson LN,Seow H

    更新日期:2020-07-01 00:00:00

  • Endometrial adenocarcinoma: clinical outcome in 881 patients and analysis of 146 patients whose deaths were due to endometrial cancer.

    abstract::Throughout 1970-1975, 881 patients were treated at Departments I and II of Obstetrics and Gynecology, Helsinki University Central Hospital. They were treated mainly by using surgery and/or radiotherapy combined with adjuvant progestin therapy. The over-all uncorrected 5-year survival rate was 72.2% and corrected rate ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(86)90059-4

    authors: Tiitinen A,Forss M,Aho I,Vesterinen E,Nieminen U

    更新日期:1986-09-01 00:00:00

  • Radiation therapy for elderly patient with squamous cell carcinoma of the uterine cervix.

    abstract:OBJECTIVE:The purpose of this study was to profile cervical squamous cell carcinoma in elderly patients undergoing radiation therapy and to study the treatment outcome and side effects of therapy. MATERIALS AND METHODS:A retrospective analysis was carried out from the records of 380 patients with squamous cell carcino...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1999.5722

    authors: Sakurai H,Mitsuhashi N,Takahashi M,Yamakawa M,Akimoto T,Hayakawa K,Niibe H

    更新日期:2000-04-01 00:00:00

  • Patient reported outcomes of a randomized, placebo-controlled trial of bevacizumab in the front-line treatment of ovarian cancer: a Gynecologic Oncology Group Study.

    abstract:PURPOSE:To analyze quality of life (QOL) in a randomized, placebo-controlled phase III trial concluding that the addition of concurrent and maintenance bevacizumab (Arm 3) to carboplatin and paclitaxel prolongs progression-free survival in front-line treatment of advanced ovarian cancer compared to chemotherapy alone (...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ygyno.2012.11.038

    authors: Monk BJ,Huang HQ,Burger RA,Mannel RS,Homesley HD,Fowler J,Greer BE,Boente M,Liang SX,Wenzel L

    更新日期:2013-03-01 00:00:00

  • The NCI-MATCH trial and precision medicine in gynecologic cancers.

    abstract::The Precision Medicine Initiative is a National Cancer Institute (NCI) driven interdisciplinary collaborative effort to test the feasibility of trials incorporating genomic profiling when choosing patient therapies. The goal of the initiative is to generate the scientific evidence needed to move the concept of precisi...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ygyno.2018.01.008

    authors: Barroilhet L,Matulonis U

    更新日期:2018-03-01 00:00:00

  • Margin status revisited in vulvar squamous cell carcinoma.

    abstract:OBJECTIVE:To determine the incidence of local recurrence of vulvar squamous cell carcinoma in relation to tumor- and/or precursor lesion free pathologic margins. METHODS:Consecutive patients with primary vulvar squamous cell carcinoma surgically treated in two Dutch expert centers between 2000 and 2010 were included. ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ygyno.2019.05.010

    authors: Te Grootenhuis NC,Pouwer AW,de Bock GH,Hollema H,Bulten J,van der Zee AGJ,de Hullu JA,Oonk MHM

    更新日期:2019-08-01 00:00:00

  • Second primary malignancy in endometrial carcinoma patients.

    abstract::An epidemiologic study of multiple primary malignant neoplasms in endometrial cancer patients in Israel is presented. During the 7-year period of the study, 104 patients (10.3%) out of 1007 patients diagnosed as having endometrial cancer had another primary cancer. There was a significant difference in the incidence o...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(85)90005-8

    authors: Schwartz Z,Ohel G,Birkenfeld A,Anteby SO,Schenker JG

    更新日期:1985-09-01 00:00:00

  • Phase II trial of CI-958 in recurrent platinum-refractory ovarian carcinoma. A Gynecologic Oncology Group Study.

    abstract:OBJECTIVES:The objectives of this study were twofold: (1) to estimate the anti-tumor efficacy of CI-958 in patients with measurable platinum-resistant ovarian cancer; (2) to determine the nature and degree of toxicity of CI-958 in these patients. METHODS:Patients received CI-958 560 mg/m(2) intravenously every 3 weeks...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1006/gyno.2000.5984

    authors: Hoffman MA,Blessing JA,Morgan M

    更新日期:2000-12-01 00:00:00

  • Sentinel node mapping vs. lymphadenectomy in endometrial cancer: A systematic review and meta-analysis.

    abstract::Sentinel node mapping is increasingly being utilized for endometrial cancer staging. However, only limited evidence supporting the adoption of sentinel node mapping instead of conventional lymphadenectomy is still available. Here, we aimed to review the current evidence comparing sentinel node mapping and lymphadenect...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.ygyno.2019.03.254

    authors: Bogani G,Murgia F,Ditto A,Raspagliesi F

    更新日期:2019-06-01 00:00:00

  • Increased risk of secondary uterine leiomyosarcoma in hereditary retinoblastoma.

    abstract:OBJECTIVE:In the US, second non-ocular malignancies are the primary cause of death in retinoblastoma survivors with the germline RB1 mutation. Soft tissue sarcomas are one of the most likely malignancies to pose a risk to these patients, with leiomyosarcoma (LMS) being the most common subtype. As our cohort is followed...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2011.10.019

    authors: Francis JH,Kleinerman RA,Seddon JM,Abramson DH

    更新日期:2012-02-01 00:00:00

  • Primary invasive vaginal carcinoma treated with radiotherapy: analysis of prognostic factors.

    abstract::Between 1965 and 1988, 125 patients with primary invasive vaginal carcinoma were treated with radiation therapy at the Center of Oncology in Kraków. Twenty-two superficial stage I patients received radium or cesium intracavitary radiation alone. The remaining 11 patients with stage I disease whose lesions were either ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1996.0004

    authors: Urbański K,Kojs Z,Reinfuss M,Fabisiak W

    更新日期:1996-01-01 00:00:00

  • Evaluation of pegylated liposomal doxorubicin (Doxil) as second-line chemotherapy of squamous cell carcinoma of the cervix: a phase II study of the Gynecologic Oncology Group.

    abstract:OBJECTIVE:Doxorubicin has reported activity in advanced and recurrent cervical cancer but hematologic toxicity has limited its use in some combinations. To determine the level of activity and potential for use in future combinations, a phase II trial of pegylated liposomal doxorubicin as second-line therapy in advanced...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ygyno.2005.11.048

    authors: Rose PG,Blessing JA,Lele S,Abulafia O

    更新日期:2006-08-01 00:00:00

  • A clinicopathological analysis of 40 cases of ovarian Sertoli-Leydig cell tumors.

    abstract:OBJECTIVE:To evaluate the clinicopathological features of ovarian Sertoli-Leydig cell tumors (SLCTs) and to explore the reasonable therapy. METHODS:A total of 40 cases of SLCTs were retrospectively reviewed. RESULTS:The incidence of SLCTs was 0.41%, with a median age of 28 years. All tumors were confined to one ovary...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2012.07.114

    authors: Gui T,Cao D,Shen K,Yang J,Zhang Y,Yu Q,Wan X,Xiang Y,Xiao Y,Guo L

    更新日期:2012-11-01 00:00:00

  • Quality of laparoscopic radical hysterectomy in developing countries: a comparison of surgical and oncologic outcomes between a comprehensive cancer center in the United States and a cancer center in Colombia.

    abstract:OBJECTIVE:To help determine whether global collaborations for prospective gynecologic surgery trials should include hospitals in developing countries, we compared surgical and oncologic outcomes of patients undergoing laparoscopic radical hysterectomy at a large comprehensive cancer center in the United States and a ca...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2012.01.007

    authors: Pareja R,Nick AM,Schmeler KM,Frumovitz M,Soliman PT,Buitrago CA,Borrero M,Angel G,Reis RD,Ramirez PT

    更新日期:2012-05-01 00:00:00

  • PD-1 blockade in recurrent or metastatic cervical cancer: Data from cemiplimab phase I expansion cohorts and characterization of PD-L1 expression in cervical cancer.

    abstract:OBJECTIVES:To characterize the safety, tolerability, and anti-tumor activity of cemiplimab as monotherapy or in combination with hypofractionated radiation therapy (hfRT) in patients with recurrent or metastatic cervical cancer. To determine the association between histology and programmed death-ligand 1 (PD-L1) expres...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2020.08.026

    authors: Rischin D,Gil-Martin M,González-Martin A,Braña I,Hou JY,Cho D,Falchook GS,Formenti S,Jabbour S,Moore K,Naing A,Papadopoulos KP,Baranda J,Fury W,Feng M,Stankevich E,Li J,Yama-Dang NA,Yoo SY,Lowy I,Mathias M,Fury

    更新日期:2020-11-01 00:00:00

  • Management of high-grade stage I adenocarcinoma of the endometrium: hysterectomy following low dose external beam pelvic irradiation.

    abstract::Sixty-eight patients with FIGO stage I, grade 2 or 3 adenocarcinoma of the endometrium were treated according to a protocol involving 10 Gy external pelvic irradiation, prompt hysterectomy with surgical staging, and postoperative therapy individualized according to surgical-pathologic findings. Five-year survival for ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(86)90222-2

    authors: Shimm DS,Wang CC,Fuller AF Jr,Nelson JH Jr,Nikrui N,Young RH,Scully RE

    更新日期:1986-02-01 00:00:00

  • Primary vaginal melanoma: improved survival with radical pelvic surgery.

    abstract::Primary vaginal melanoma is an aggressive and rare gynecological malignancy with < 150 reported cases to date. Historically, patients with this disease have a poor prognosis for all types of treatment. In several studies containing small numbers of patients conservative therapy often has been recommended. Eight patien...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章

    doi:10.1006/gyno.1994.1283

    authors: Van Nostrand KM,Lucci JA 3rd,Schell M,Berman ML,Manetta A,DiSaia PJ

    更新日期:1994-11-01 00:00:00