Strategies in late stage cervix carcinoma.

Abstract:

:Stage IIB-IV squamous cell carcinoma of the cervix when treated by irradiation has a significant failure rate. Causes of pelvic and distant failure are discussed. New techniques employed to improve local control and decrease distant metastasis are presented. Data on morbidity, mortality, and survival will be reviewed with respect to these new strategies employed.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Krochak R

doi

10.1016/0090-8258(86)90135-6

subject

Has Abstract

pub_date

1986-03-01 00:00:00

pages

336-45

issue

3

eissn

0090-8258

issn

1095-6859

pii

0090-8258(86)90135-6

journal_volume

23

pub_type

杂志文章
  • Clinical significance of combined use of macrophage colony-stimulating factor and squamous cell carcinoma antigen as a selective diagnostic marker for squamous cell carcinoma arising in mature cystic teratoma of the ovary.

    abstract:OBJECTIVES:Mature cystic teratoma of the ovary transforms into malignant tumors, mostly squamous cell carcinomas, at an incidence of approximately 2%. Preoperative diagnosis of squamous cell carcinoma arising in mature cystic teratoma of the ovary is a difficult task. The present study aims to assess whether combined u...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.2000.5784

    authors: Suzuki M,Tamura N,Kobayashi H,Ohwada M,Terao T,Sato I

    更新日期:2000-06-01 00:00:00

  • High grade undifferentiated uterine sarcoma: surgery, treatment, and survival outcomes.

    abstract:OBJECTIVES:High grade undifferentiated uterine sarcomas (HGUS) are rare, aggressive malignancies. Data regarding management are limited. We aimed to describe disease stage, response to treatment, and survival outcomes among patients with HGUS at our institution. METHODS:We identified all patients with HGUS who receive...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2012.06.030

    authors: Tanner EJ,Garg K,Leitao MM Jr,Soslow RA,Hensley ML

    更新日期:2012-10-01 00:00:00

  • The haplotype of two FSHR polymorphisms in ovarian cancer--a potential role of ethnology in risk modification.

    abstract:OBJECTIVES:The precise role of gonadotropins in the carcinogenesis of epithelial ovarian cancer remains uncertain. Recently, the haplotype of two single nucleotide polymorphisms, Thr307Ala (rs6165) and Asn680Ser (rs6166), has been described as a risk factor for ovarian cancer in Chinese women. In this study we investig...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2008.12.011

    authors: Heubner M,Riemann K,Otterbach F,Kimmig R,Kasimir-Bauer S,Siffert W,Wimberger P

    更新日期:2009-03-01 00:00:00

  • Preoperative hypoalbuminemia is an independent predictor of poor perioperative outcomes in women undergoing open surgery for gynecologic malignancies.

    abstract:OBJECTIVE:To quantify the impact of preoperative hypoalbuminemia on 30-day mortality and morbidity after gynecologic cancer surgery. METHODS:Patients included in the National Surgical Quality Improvement Program (NSQIP) dataset who underwent any non-emergent surgery for gynecologic malignancy between 1/1/2008 and 12/3...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2013.08.011

    authors: Uppal S,Al-Niaimi A,Rice LW,Rose SL,Kushner DM,Spencer RJ,Hartenbach E

    更新日期:2013-11-01 00:00:00

  • The relationship of steroid receptor expression to nuclear DNA distribution and clinicopathological characteristics in epithelial ovarian tumors.

    abstract::Tumor specimens from 92 patients with ovarian carcinoma were analyzed for estrogen receptor (ER), progesterone receptor (PR), proliferative fraction, and ploidy. Seventy-one percent of tumors were either ER+ (greater than 5 fmole/mg protein) or PR+ (greater than 10 fmole/mg protein) with 27% of tumors overall being bo...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/s0090-8258(89)80031-9

    authors: Friedlander ML,Quinn MA,Fortune D,Foo MS,Toppila M,Hudson CN,Russell P

    更新日期:1989-02-01 00:00:00

  • Chlamydial cervicitis and cervical intraepithelial neoplasia: an immunohistochemical analysis.

    abstract::Studies using serological and culture techniques indicate that chlamydial infection is frequently associated with cervical intraepithelial neoplasia (CIN). This relationship was investigated by examining a series of biopsies containing normal epithelium, non-neoplastic condylomatous epithelium, and neoplastic epitheli...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(84)90163-x

    authors: Mitao M,Reumann W,Winkler B,Richart RM,Fujiwara A,Crum CP

    更新日期:1984-09-01 00:00:00

  • Prognostic features and treatment of endocervical adenocarcinoma of the cervix.

    abstract::Adenocarcinoma of the cervix represents an increasing percentage of cervical cancers as well as a controversial clinical problem. One hundred seventy-two cases of adenocarcinoma were treated at The University of Michigan Medical Center from 1970 to 1984, representing 16.8% of cervical cancers. Of this group 84 patient...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(87)90231-9

    authors: Hopkins MP,Sutton P,Roberts JA

    更新日期:1987-05-01 00:00:00

  • Surgical outcomes and national comprehensive cancer network compliance in advanced ovarian cancer surgery in a low volume military treatment facility.

    abstract:OBJECTIVE:To evaluate the optimal cytoreduction (OPT) rate, National Comprehensive Cancer Network (NCCN) treatment guideline compliance rate and patient outcomes for advanced stage epithelial ovarian cancer (EOC) patients at our low volume institution. METHODS:Following IRB approval, records of patients with Stage III...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2013.07.001

    authors: Phippen NT,Barnett JC,Lowery WJ,Miller CR,Leath CA 3rd

    更新日期:2013-10-01 00:00:00

  • Human cervical cells immortalized in vitro with oncogenic human papillomavirus DNA differentiate dysplastically in vivo.

    abstract::Human papillomavirus (HPV) types 16 and 18 are associated with cervical dysplasia and carcinoma. In vitro integration of HPV-16 or HPV-18 DNA into cultured human cervical cells results in their immortalization. In this study, in vivo differentiation of human cervical cells immortalized with recombinant HPV-16 or HPV-1...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(90)90082-v

    authors: Waggoner SE,Woodworth CD,Stoler MH,Barnes WA,Delgado G,DiPaolo JA

    更新日期:1990-09-01 00:00:00

  • Pelvic exenteration in the age of modern chemoradiation.

    abstract:BACKGROUND:To examine outcomes after pelvic exenteration in women treated with modern chemoradiation and surgical techniques. METHODS:All patients at our institution with a diagnosis of gynecologic malignancy who underwent pelvic exenteration after treatment with chemoradiation between 1/90 and 6/08 were evaluated wit...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2010.11.044

    authors: McLean KA,Zhang W,Dunsmoor-Su RF,Shah CA,Gray HJ,Swensen RE,Goff BA

    更新日期:2011-04-01 00:00:00

  • Urokinase (uPA) and PAI-1 predict survival in advanced ovarian cancer patients (FIGO III) after radical surgery and platinum-based chemotherapy.

    abstract::Fifty-one patients with advanced ovarian cancer FIGO III were studied to determine new tumor biology-oriented prognostic factors. The tumor-associated protease urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 were detected in malignant ovarian cancer tissue extracts. The concentration of both factors...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1994.1313

    authors: Kuhn W,Pache L,Schmalfeldt B,Dettmar P,Schmitt M,Jänicke F,Graeff H

    更新日期:1994-12-01 00:00:00

  • Analysis of vitamin D receptor expression and clinical correlations in patients with ovarian cancer.

    abstract:OBJECTIVE:Although the antiproliferative and differentiating properties of vitamin D have been demonstrated, its effects on cancer cells are variable. Little is known about vitamin D receptor (VDR) levels in patients with ovarian cancer. In this population we sought to determine correlations between VDR expression, cli...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2010.06.008

    authors: Silvagno F,Poma CB,Realmuto C,Ravarino N,Ramella A,Santoro N,D'Amelio P,Fuso L,Pescarmona G,Zola P

    更新日期:2010-10-01 00:00:00

  • Adjuvant chemotherapy with cisplatin, doxorubicin, and cyclophosphamide (PAC) for early-stage high-risk endometrial cancer: a preliminary analysis.

    abstract::Between October 1985 and January 1989, 33 patients with stage I (31) or clinically occult stage II (2) endometrial cancer at a high risk for recurrence were entered in a prospective study evaluating adjuvant cisplatin, doxorubicin, and cyclophosphamide (PAC) chemotherapy. Eligibility criteria included grade 2 tumors w...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(90)90063-q

    authors: Stringer CA,Gershenson DM,Burke TW,Edwards CL,Gordon AN,Wharton JT

    更新日期:1990-09-01 00:00:00

  • HER2/neu gene amplification determines the sensitivity of uterine serous carcinoma cell lines to AZD8055, a novel dual mTORC1/2 inhibitor.

    abstract:OBJECTIVE:To evaluate c-erbB2 gene amplification in a series of primary uterine serous carcinoma (USC) cell lines. To assess the efficacy of AZD8055, a novel dual mTORC1/2 inhibitor against primary HER2/neu amplified vs HER2/neu not amplified USC cell lines. METHODS:Twenty-two primary USC cell lines were evaluated for...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2013.08.033

    authors: English DP,Roque DM,Carrara L,Lopez S,Bellone S,Cocco E,Bortolomai I,Schwartz PE,Rutherford T,Santin AD

    更新日期:2013-12-01 00:00:00

  • Endometrial clear cell carcinoma metastatic to the paranasal sinuses: a case report and review of the literature.

    abstract:BACKGROUND:Paranasal sinus metastasis following endometrial carcinoma is extremely rare and a reflection of disseminated disease. CASE:We report a case of a 72-year-old woman who presented ethmoid and sphenoid sinus metastasis, 14 months after total abdominal hysterectomy and bilateral salpingo-oophorectomy due to an ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ygyno.2004.04.005

    authors: Ilvan S,Akyildiz EU,Calay Z,Celikoyar M,Sahinler I

    更新日期:2004-07-01 00:00:00

  • Clinicopathologic features of villoglandular papillary adenocarcinoma of the uterine cervix.

    abstract:OBJECTIVES:The objectives of this study are to analyze the clinicopathologic features of villoglandular papillary adenocarcinoma (VGPA) of the uterine cervix and to discuss the management thereof. We examined 13 patients with VGPA. METHODS:Clinical profiles, including patient age, clinical stage, surgical procedure, a...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ygyno.2003.10.020

    authors: Utsugi K,Shimizu Y,Akiyama F,Umezawa S,Hasumi K

    更新日期:2004-01-01 00:00:00

  • Pilomatricoma-like endometrioid adenosquamous carcinoma of the ovary with neuroendocrine differentiation.

    abstract::A case of high-grade endometrioid adenosquamous carcinoma of the ovary showing pilomatricoma-like areas and neuroendocrine differentiation is presented. The pilomatricoma-like areas were strongly positive for cytokeratin and vimentin, whereas the poorly differentiated areas of the tumor were positive for cytokeratin, ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1996.0142

    authors: Fang J,Keh P,Katz L,Rao MS

    更新日期:1996-05-01 00:00:00

  • Detection of beta-subunit human chorionic gonadotropin mRNA in the peripheral blood of patients with nonmetastatic gestational trophoblastic disease.

    abstract:OBJECTIVE:The aim of this study was to detect beta-subunit human chorionic gonadotropin (beta(h)CG) mRNA in the peripheral blood samples of patients with nonmetastatic gestational trophoblastic disease (GTD) undergoing hysterectomy. METHODS:Heparinized peripheral blood samples were obtained from four patients with non...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.2002.6716

    authors: Suzuka K,Matsui H,Iitsuka Y,Sekiya S

    更新日期:2002-07-01 00:00:00

  • Feasibility study comparing docetaxel-cisplatin versus docetaxel-carboplatin as first-line chemotherapy for ovarian cancer.

    abstract:OBJECTIVE:To determine the feasibility of docetaxel-cisplatin combination therapy compared with docetaxel-carboplatin combination therapy as first-line chemotherapy for patients with ovarian cancer. METHODS:Fifty patients with International Federation of Gynecology and Obstetrics stage Ic-IV ovarian cancer who underwe...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.ygyno.2005.11.020

    authors: Minagawa Y,Kigawa J,Kanamori Y,Itamochi H,Terakawa N,Okada M,Kitada F

    更新日期:2006-06-01 00:00:00

  • Flow-cytometric DNA analysis of early stage adenocarcinoma of the cervix.

    abstract:OBJECTIVE:The purpose of this study was to determine the utility of DNA flow cytometry as a prognostic indicator for risk of recurrence and overall survival in patients with early stage adenocarcinomas of the uterine cervix. METHODS:DNA flow cytometry was performed to determine ploidy, DNA index, and proliferative ind...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1999.5520

    authors: Magtibay PM,Perrone JF,Stanhope CR,Katzmann JA,Keeney GL,Li H

    更新日期:1999-10-01 00:00:00

  • Southwest Oncology Group Trial S9912: intraperitoneal cisplatin and paclitaxel plus intravenous paclitaxel and pegylated liposomal doxorubicin as primary chemotherapy of small-volume residual stage III ovarian cancer.

    abstract:OBJECTIVE:While primary cisplatin-based intraperitoneal chemotherapy has been shown to favorably impact survival in small-volume residual advanced ovarian cancer, there is a need to develop strategies that improve the effectiveness of this approach. METHODS:A multi-center phase 2 trial was conducted that added intrave...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ygyno.2009.04.023

    authors: Smith HO,Moon J,Wilczynski SP,Tiersten AD,Hannigan EV,Robinson WR,Rivkin SE,Anderson GL,Liu PY,Markman M

    更新日期:2009-08-01 00:00:00

  • BARD1, a possible biomarker for breast and ovarian cancer.

    abstract::Breast cancer is the leading cause of cancer death in women. Ovarian cancer, although less frequent, is detected very late, and survival is correlated to early detection. Therefore, better methods for early detection would help to increase the number of survivors. The incidence of young women diagnosed with breast can...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ygyno.2009.10.079

    authors: Irminger-Finger I

    更新日期:2010-05-01 00:00:00

  • Low expression of long noncoding XLOC_010588 indicates a poor prognosis and promotes proliferation through upregulation of c-Myc in cervical cancer.

    abstract:OBJECTIVE:The identification and investigation of cancer-associated long non-coding RNAs are important for understanding the molecular biology of cancer. The aim of the present study was to examine the expression pattern of lncRNA XLOC_010588 in cervical cancer and to evaluate its biological role and clinical significa...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2014.03.555

    authors: Liao LM,Sun XY,Liu AW,Wu JB,Cheng XL,Lin JX,Zheng M,Huang L

    更新日期:2014-06-01 00:00:00

  • Co-expression patterns of chimeric antigen receptor (CAR)-T cell target antigens in primary and recurrent ovarian cancer.

    abstract:OBJECTIVE:Chimeric antigen receptor (CAR)-T cell strategies ideally target a surface antigen that is exclusively and uniformly expressed by tumors; however, no such antigen is known for high-grade serous ovarian carcinoma (HGSC). A potential solution involves combinatorial antigen targeting with AND or OR logic-gating....

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2020.12.005

    authors: Banville AC,Wouters MCA,Oberg AL,Goergen KM,Maurer MJ,Milne K,Ashkani J,Field E,Ghesquiere C,Jones SJM,Block MS,Nelson BH

    更新日期:2021-02-01 00:00:00

  • Update on novel therapeutic agents for cervical cancer.

    abstract::Effective cytotoxic treatment options for advanced cervical cancer are exceedingly limited. Cisplatin-based combination chemotherapy, the most commonly used cytotoxic therapy, has produced response rates ranging from 20% to 30% and overall survival of less than 10 months. Because of the minimal degree of success with ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ygyno.2008.04.016

    authors: del Campo JM,Prat A,Gil-Moreno A,Pérez J,Parera M

    更新日期:2008-09-01 00:00:00

  • Intraperitoneal chemotherapy: analysis of complications with an implanted subcutaneous port and catheter system.

    abstract::To determine the morbidity associated with delivery of intraperitoneal chemotherapy via subcutaneous semipermanent infusion catheters, we analyzed the data on 227 patients treated from April 1985 through December 1989. A total of 249 catheters were inserted and used to administer chemotherapy in these patients. There ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(91)90266-8

    authors: Davidson SA,Rubin SC,Markman M,Jones WB,Hakes TB,Reichman B,Almadrones L,Chapman D,Lewis JL Jr,Hoskins WJ

    更新日期:1991-05-01 00:00:00

  • Retinoblastoma protein expression in endometrial hyperplasia and carcinoma.

    abstract::The retinoblastoma (RB) gene was the first defined tumor suppressor gene. While originally described in retinoblastoma, more recently alterations in RB have been described in a number of other human neoplasms and there has been a suggestion that alteration of RB may play a significant role in the development of endome...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1997.4664

    authors: Niemann TH,Yilmaz AG,McGaughy VR,Vaccarello L

    更新日期:1997-05-01 00:00:00

  • Intraoperative hypothermia during primary surgical cytoreduction for advanced ovarian cancer: risk factors and associations with postoperative morbidity.

    abstract:OBJECTIVE:The objective of this study was to evaluate the risk factors and potential morbidity associated with intraoperative hypothermia (IH) during cytoreductive surgery (CRS) for advanced ovarian cancer. METHODS:Demographic and perioperative data were collected for all patients with stage IIIC-IV ovarian, fallopian...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2013.08.034

    authors: Long KC,Tanner EJ,Frey M,Leitao MM Jr,Levine DA,Gardner GJ,Sonoda Y,Abu-Rustum NR,Barakat RR,Chi DS

    更新日期:2013-12-01 00:00:00

  • Robotically assisted laparoscopic hysterectomy versus total abdominal hysterectomy and lymphadenectomy for endometrial cancer.

    abstract:OBJECTIVE:To compare surgical morbidity and clinical-pathologic factors for patients with endometrial cancer (EC) undergoing robotic-assisted laparoscopic hysterectomy (RALH) versus total abdominal hysterectomy (TAH) with aortic and/or pelvic lymphadenectomy (LA). METHODS:During the first 14 months of a robotics surgi...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2008.08.025

    authors: DeNardis SA,Holloway RW,Bigsby GE 4th,Pikaart DP,Ahmad S,Finkler NJ

    更新日期:2008-12-01 00:00:00

  • Fertility-sparing surgery for treatment of non-epithelial ovarian cancer: Oncological and reproductive outcomes in a prospective nationwide population-based cohort study.

    abstract:OBJECTIVE:To compare the oncologic outcome of women who underwent fertility-sparing surgery (FSS) vs. radical surgery (RS) for treatment of NEOC in a prospective, nationwide, population-based study and report on the reproductive outcomes in women after FSS. METHODS:Using the Swedish Quality Register for Gynecological ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ygyno.2019.08.017

    authors: Johansen G,Dahm-Kähler P,Staf C,Flöter Rådestad A,Rodriguez-Wallberg KA

    更新日期:2019-11-01 00:00:00