Inverse expression of Cdk4 and p16 in epithelial ovarian tumors.

Abstract:

OBJECTIVES:The aim of this study was to elucidate the expression and the correlation of two cell cycle regulators, cdk4 and its inhibitor p16, in a series of benign, borderline, and malignant ovarian tumors and to evaluate whether their alterations correlate with clinicopathologial parameters and patients' prognosis in epithelial ovarian carcinomas. METHODS:Immunohistochemical analysis using anti-cdk4 and anti-p16 antibodies was carried out for 103 paraffin sections of ovarian tumors, and Western blot analysis and cdk4 activity assay were performed in 26 fresh ovarian tumor samples. RESULTS:The results of immunohistochemistry showed that 60.61 and 69.70% of benign, 69.57 and 56.52% of borderline, and 74.47 and 40. 43% of malignant tumors expressed cdk4 and p16, respectively, demonstrating increased cdk4 and decreased p16 expression in ovarian carcinomas. A significant inverse relationship between cdk4 and p16 expression was found. The loss of p16 expression was more correlated with G(2) and G(3) tumors in contrast with G(1) tumors. No significant correlation was observed between cdk4 expression and clinicopathological parameters. Neither cdk4 nor p16 expression has significant effects on overall survival by the Kaplan-Meier method. When the combined phenotypes of the two proteins were analyzed, patients with cdk4-positive/p16-negative expression had a reduced overall survival than other phenotypes of cdk4/p16. CONCLUSIONS:These data suggest that inverse expression of cdk4 and p16 may be involved in the development and progression of epithelial ovarian carcinomas. The combined phenotypes of cdk4 and p16 proteins could provide a useful prognostic indicator for patients with epithelial ovarian carcinoma.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Sui L,Dong Y,Ohno M,Goto M,Inohara T,Sugimoto K,Tai Y,Hando T,Tokuda M

doi

10.1006/gyno.2000.5961

subject

Has Abstract

pub_date

2000-11-01 00:00:00

pages

230-7

issue

2

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(00)95961-4

journal_volume

79

pub_type

杂志文章
  • Characterization of peripheral blood and ovarian cancer-infiltrating lymphocytes: effect of HIV infection on phenotypic expression and proliferative response.

    abstract::A study that focused on the identification of the phenotype and proliferative responses of peripheral blood and ovarian cancer-infiltrating lymphocytes in a patient with stage III ovarian cancer who had human immunodeficiency virus infection is presented. Monoclonal antibodies and flow cytometry were used to determine...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1994.1126

    authors: Guidozzi F,Reddy S,Wadee A

    更新日期:1994-05-01 00:00:00

  • Adjuvant chemotherapy for early stage endometrioid ovarian carcinoma: An analysis of the National Cancer Data Base.

    abstract:INTRODUCTION:The benefit of adjuvant chemotherapy for Stage IC grade 1 and stage IA/IB grade 2 endometrioid ovarian adenocarcinoma (EOOC) remains unclear as the NCCN guidelines recommend either observation only or adjuvant chemotherapy. Therefore, we sought to determine whether patients with stage I EOOC had improved o...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2019.11.125

    authors: Nasioudis D,Latif NA,Simpkins F,Cory L,Giuntoli RL 2nd,Haggerty AF,Morgan MA,Ko EM

    更新日期:2020-02-01 00:00:00

  • Assessment of inhibin and p53 in granulosa cell tumors of the ovary.

    abstract:OBJECTIVE:The goal of this work was to determine the cellular content of inhibin and p53 in granulosa cell tumors (GCTs). METHODS:Clinical records of 47 patients (mean age, 54 years; range, 20-85 years) presenting with GCT surgically managed at our institution were abstracted. International Federation of Gynecology st...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.2000.5774

    authors: Gebhart JB,Roche PC,Keeney GL,Lesnick TG,Podratz KC

    更新日期:2000-05-01 00:00:00

  • Persistence of human papillomavirus infection after therapeutic conization for CIN 3: is it an alarm for disease recurrence?

    abstract:OBJECTIVE:The aims of this study were (1) to examine whether HPV DNA is persistently detected in the cervix after therapeutic conization for CIN 3 and (2) to explore whether a patient with persistence of HPV infection is at risk of developing recurrent disease. METHODS:Of 74 patients referred with CIN 3, 58 who were t...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.2000.5952

    authors: Nagai Y,Maehama T,Asato T,Kanazawa K

    更新日期:2000-11-01 00:00:00

  • Postsurgical surveillance of patients with FIGO stage I/II endometrial adenocarcinoma.

    abstract:OBJECTIVE:To examine the effect of postsurgical surveillance on survival of patients with FIGO stage I/II endometrial adenocarcinoma. METHODS:We examined the records of 354 patients who underwent primary surgical therapy for FIGO stage I/II endometrial adenocarcinoma. In patients who developed recurrent disease, we de...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章

    doi:10.1006/gyno.1995.1262

    authors: Berchuck A,Anspach C,Evans AC,Soper JT,Rodriguez GC,Dodge R,Robboy S,Clarke-Pearson DL

    更新日期:1995-10-01 00:00:00

  • Association between high risk papillomavirus DNA and nitric oxide release in the human uterine cervix.

    abstract:OBJECTIVE:Local cervical factors may determine the outcome of human papillomavirus (HPV) infection. Nitric oxide (NO) may be one such factor, since it is produced by uterine cervical cells and it takes part in both immunological and carcinogenic reactions. We studied the association between the presence of cervical hig...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2009.05.003

    authors: Rahkola P,Mikkola TS,Ylikorkala O,Vaisanen-Tommiska M

    更新日期:2009-08-01 00:00:00

  • Successful salvage of a relapsed high risk gestational trophoblastic neoplasia patient using capecitabine.

    abstract:BACKGROUND:Although most patients at high risk of Gestational Trophoblastic Neoplasia (GTN) respond to standard treatments, there is a group of patients that will die because of it. The use of new single or combination drugs in this population has become a priority. CASE REPORT:We present the case of a relapsed high r...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2007.04.002

    authors: Bianconi M,Jankilevich G,Otero S,Nassif J,Storino C

    更新日期:2007-07-01 00:00:00

  • Gynecologic melanomas: A clinicopathologic and molecular analysis.

    abstract:OBJECTIVE:Melanoma originating from gynecologic sites (MOGS), including the vulva, vagina, and cervix, is a rare and aggressive form of melanoma with poor long-term clinical outcome. The clinicopathologic features of vulvar and non-vulvar tumors remain relatively understudied, and in contrast to cutaneous melanomas at ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2017.08.023

    authors: Udager AM,Frisch NK,Hong LJ,Stasenko M,Johnston CM,Liu JR,Chan MP,Harms PW,Fullen DR,Orsini A,Thomas DG,Lowe L,Patel RM

    更新日期:2017-11-01 00:00:00

  • Papillary villoglandular carcinoma of the cervix.

    abstract::Three cases of papillary villoglandular carcinoma of the cervix are presented. Each patient was multiparous and presented with abnormal vaginal bleeding. The mean age at presentation was 35 years (range 28-42 years). All patients were staged as FIGO IB and underwent radical Wertheim hysterectomy and bilateral pelvic l...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(90)90437-p

    authors: Hopson L,Jones MA,Boyce CR,Tarraza HM Jr

    更新日期:1990-11-01 00:00:00

  • Cisplatin plus gemcitabine in previously treated squamous cell carcinoma of the cervix: a phase II study of the Gynecologic Oncology Group.

    abstract:OBJECTIVES:This trial was conducted to evaluate the safety and efficacy of cisplatin plus gemcitabine in previously treated squamous cell carcinoma of the cervix. SUBJECTS AND METHODS:All women had measurable histologically confirmed squamous cell cervical cancer and a GOG performance status less than or equal to 2. T...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ygyno.2005.09.009

    authors: Brewer CA,Blessing JA,Nagourney RA,McMeekin DS,Lele S,Zweizig SL

    更新日期:2006-02-01 00:00:00

  • Contracting for professional service agreements.

    abstract::A review of several professional service agreements (PSA) of managed care organizations which contract with gynecologic oncologists in the Southern California area demonstrates several distinct patterns of practice restrictions and financial benefits which can help guide the physician who is considering signing such a...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1995.1204

    authors: Berman ML

    更新日期:1995-08-01 00:00:00

  • Clinically inapparent invasive vulvar carcinoma in an area of persistent Paget's disease: a case report.

    abstract:BACKGROUND:Invasive vulvar carcinoma is reported to occur in 5 to 20% of patients with vulvar Paget's disease. We report a case in which a clinically inapparent invasive lesion was discovered on reexcision of microscopically persistent vulvar Paget's disease. CASE:A 58-year-old woman presented with a diagnosis of vulv...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/s0090-8258(02)00007-0

    authors: Awtrey CS,Marshall DS,Soslow RA,Chi DS

    更新日期:2003-03-01 00:00:00

  • A clinical study of optical biopsy of the uterine cervix using a multispectral imaging system.

    abstract:OBJECTIVE:To present the clinical application of the multispectral imaging colposcopic system (MIS colposcopy). METHODS:MIS colposcopy was performed on 123 enrolled women. After a 3% acetic acid application, sequential images were captured, analyzed, and stored automatically. Directed biopsies were taken from distinct...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.ygyno.2004.09.013

    authors: Orfanoudaki IM,Themelis GC,Sifakis SK,Fragouli DH,Panayiotides JG,Vazgiouraki EM,Koumantakis EE

    更新日期:2005-01-01 00:00:00

  • Transcript expression in endometrial cancers from Black and White patients.

    abstract:OBJECTIVE:Previous studies suggest that differences in molecular features of endometrial cancers between racial groups may contribute to the poorer survival in Blacks. The objective of this investigation was to determine whether gene expression among endometrial cancers is different between Blacks and Whites. METHODS:...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2013.04.017

    authors: Maxwell GL,Allard J,Gadisetti CV,Litzi T,Casablanca Y,Chandran U,Darcy KM,Levine DA,Berchuck A,Hamilton CA,Conrads TP,Risinger JI

    更新日期:2013-07-01 00:00:00

  • Effectiveness of serotonin-receptor antagonist antiemetic therapy over successive courses of carboplatin-based chemotherapy.

    abstract:PURPOSE:There are extremely limited data available in the general oncology or gynecologic cancer literature to document the effectiveness of antiemetic therapy over multiple courses of cytotoxic chemotherapy. METHODS:To examine this highly clinically relevant issue, we analyzed the complete treatment course of patient...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.2002.6656

    authors: Markman MR,Peterson G,Kulp B,Markman M

    更新日期:2002-06-01 00:00:00

  • Pilomatricoma-like endometrioid adenosquamous carcinoma of the ovary with neuroendocrine differentiation.

    abstract::A case of high-grade endometrioid adenosquamous carcinoma of the ovary showing pilomatricoma-like areas and neuroendocrine differentiation is presented. The pilomatricoma-like areas were strongly positive for cytokeratin and vimentin, whereas the poorly differentiated areas of the tumor were positive for cytokeratin, ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1996.0142

    authors: Fang J,Keh P,Katz L,Rao MS

    更新日期:1996-05-01 00:00:00

  • Alterations in SPARC and VEGF immunoreactivity in epithelial ovarian cancer.

    abstract:OBJECTIVE:Secreted protein, acidic and rich in cysteine (SPARC), is a matricellular protein that modulates cell adhesion and growth. It is thought to play a decisive role in tissue remodeling and angiogenesis. Alterations in SPARC expression have been observed in a variety of solid tumors; however, no consistent patter...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.2000.5894

    authors: Paley PJ,Goff BA,Gown AM,Greer BE,Sage EH

    更新日期:2000-09-01 00:00:00

  • Frozen section diagnoses of 578 ovarian tumors made by pathologists with and without expertise on gynecologic pathology.

    abstract:OBJECTIVE:Frozen section is an important diagnostic tool to determine the nature of the ovarian masses intraoperatively. The optimal surgical treatment can be achieved by classifying the masses as benign, borderline and malignant. The aim of this retrospective study was to evaluate the accuracy of frozen section diagno...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2011.06.030

    authors: Bige O,Demir A,Saygili U,Gode F,Uslu T,Koyuncuoglu M

    更新日期:2011-10-01 00:00:00

  • Phase II trial of etoposide in leiomyosarcoma of the uterus: a Gynecologic Oncology Group study.

    abstract::Twenty-eight patients with advanced, persistent or recurrent leiomyosarcoma of the uterus not previously exposed to cytotoxic drugs were entered into a study of single-agent intravenous etoposide 100 mg/m2 daily for 3 days every 3 weeks. No complete or partial responses were observed. Thirteen patients demonstrated st...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章

    doi:10.1006/gyno.1996.0289

    authors: Thigpen T,Blessing JA,Yordan E,Valea F,Vaccarello L

    更新日期:1996-10-01 00:00:00

  • A need for laparoscopic evaluation of patients with endometrial carcinoma selected for conservative treatment.

    abstract:BACKGROUND:The aim of this paper was to report two cases of extrauterine disease in patients with early stage endometrial cancer (EC) who desired fertility-sparing management. CASES:Two patients presenting an apparent early stage EC and desiring conservative management. The two patients, aged 35 and 36 years old, had ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ygyno.2004.09.034

    authors: Morice P,Fourchotte V,Sideris L,Gariel C,Duvillard P,Castaigne D

    更新日期:2005-01-01 00:00:00

  • Progestin and estrogen potency of combination oral contraceptives and endometrial cancer risk.

    abstract:OBJECTIVE:Using data from a case-control study of endometrial cancer, we investigated the relationship between the progestin and estrogen potency in combination oral contraceptives (OCs) and the risk of developing endometrial cancer. METHODS:Subjects included 434 endometrial cancer cases and 2,557 controls identified ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2006.03.046

    authors: Maxwell GL,Schildkraut JM,Calingaert B,Risinger JI,Dainty L,Marchbanks PA,Berchuck A,Barrett JC,Rodriguez GC

    更新日期:2006-11-01 00:00:00

  • The presence of tumor-infiltrating FOXP3+ lymphocytes correlates with intratumoral angiogenesis in endometrial cancer.

    abstract:OBJECTIVES:CD4(+)CD25(+) regulatory T-cells (Tregs), that express the transcription factor FOXP3, suppress effector T-cell populations and can enable tumour cells to evade the host immune response. In this study, we investigated the numbers of FOXP3(+) Tregs in the normal and malignat endometrium and examined potential...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2008.04.021

    authors: Giatromanolaki A,Bates GJ,Koukourakis MI,Sivridis E,Gatter KC,Harris AL,Banham AH

    更新日期:2008-08-01 00:00:00

  • Analysis of common variations in tumor-suppressor genes on chr1p36 among Caucasian women with endometriosis.

    abstract:OBJECTIVE:Epidemiological data indicate that endometriosis increases the risk of epithelial ovarian cancer (EOC), but the mechanism of cancer transition is unknown. Results from genome-wide association studies (GWAS) and transcriptome sequencing have demonstrated that genes located in the 1p36 region are important in b...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2012.08.013

    authors: Falconer H,Sundqvist J,Xu H,Vodolazkaia A,Fassbender A,Kyama C,Bokor A,D'Hooghe TM

    更新日期:2012-11-01 00:00:00

  • Application of proteomics in ovarian cancer: which sample should be used?

    abstract:OBJECTIVE:In the last decade several studies have been published using proteomics to unravel molecular pathways and to find biomarkers which can be used for diagnosis and/or prognostication in ovarian cancer. This review gives an overview of proteomic studies performed in ovarian cancer focusing on the nature of sample...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ygyno.2009.09.005

    authors: Cadron I,Van Gorp T,Timmerman D,Amant F,Waelkens E,Vergote I

    更新日期:2009-12-01 00:00:00

  • Is aspirin use associated with a decreased risk of ovarian cancer? A systematic review and meta-analysis of observational studies with dose-response analysis.

    abstract:OBJECTIVE:Currently available epidemiologic evidences concerning the chemopreventive effect of aspirin on ovarian cancer are inconsistent. Therefore, we aimed to further explore the association by synthesizing evidence from population-based studies. METHODS:We searched PubMed, EMBASE, Web of Science, and Scopus using ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.ygyno.2016.04.543

    authors: Zhang D,Bai B,Xi Y,Wang T,Zhao Y

    更新日期:2016-08-01 00:00:00

  • Comparison of human chorionic gonadotropin regression in molar pregnancies and post-molar nonmetastatic gestational trophoblastic neoplasia.

    abstract::The rate of regression of the beta subunit of human chorionic gonadotropin in patients successfully treated by single-agent chemotherapy with methotrexate (MTX) for postmolar nonmetastatic gestational trophoblastic neoplasia (NMGTN) has not previously been described. In 21 patients with NMGTN treated with MTX, the rat...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章

    doi:10.1016/0090-8258(88)90150-3

    authors: Rotmensch J,Rosenshein NB,Block BS

    更新日期:1988-01-01 00:00:00

  • The role of secondary cytoreductive surgery for recurrent ovarian cancer.

    abstract:OBJECTIVE:The aim of this study was to assess the survival benefit of salvage surgical cytoreduction in patients with recurrent ovarian cancer and compare the surgical outcome with salvage chemotherapy alone. METHODS:Seventy-five patients with recurrent ovarian cancer were reviewed for possible benefits of salvage the...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ygyno.2004.11.057

    authors: Güngör M,Ortaç F,Arvas M,Kösebay D,Sönmezer M,Köse K

    更新日期:2005-04-01 00:00:00

  • Resveratrol inhibits ovarian cancer cell adhesion to peritoneal mesothelium in vitro by modulating the production of α5β1 integrins and hyaluronic acid.

    abstract:OBJECTIVE:Resveratrol (Res) is known to inhibit adhesion of numerous malignancies though its effect on an adherence of ovarian cancer cells to peritoneal mesothelium remains undefined. METHODS:To address this issue, ovarian cancer cells (A2780, OVCAR-3, SKOV-3) were subjected to Res (10, 50, 100 μM), and then their ad...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2014.06.022

    authors: Mikuła-Pietrasik J,Sosińska P,Książek K

    更新日期:2014-09-01 00:00:00

  • Incidence and risk factors for lower limb lymphedema associated with endometrial cancer: Results from a prospective, longitudinal cohort study.

    abstract:BACKGROUND:Evidence on the incidence and risk factors for lower limb lymphedema (LLL) associated with endometrial cancer is limited. Our objective was to use data from a prospective, longitudinal gynecological cancer cohort study to determine LLL incidence up to 24 months post-diagnosis of endometrial cancer and to exp...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2020.04.702

    authors: Pigott A,Obermair A,Janda M,Vagenas D,Ward LC,Reul-Hirche H,Hayes SC

    更新日期:2020-08-01 00:00:00

  • Participation of the general gynecologist in surgical staging of endometrial cancer: analysis of cost and perioperative outcomes.

    abstract:OBJECTIVE:To compare the cost and perioperative outcomes of endometrial cancer staging when the procedure is performed by a gynecologic oncologist alone or when a general gynecologist participates in the procedure. METHODS:A retrospective analysis was performed on a series of women with clinical stage I endometrial ca...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2006.05.019

    authors: Hoekstra A,Singh DK,Garb M,Arekapudi S,Rademaker A,Lurain JR

    更新日期:2006-12-01 00:00:00