Phase II study of neoadjuvant chemotherapy with mitomycin-c, vincristine and cisplatin (MVC) in patients with stages IB2-IIB cervical carcinoma.

abstract：BACKGROUND:The simultaneous occurrence of advanced cervical cancer and a pelvic kidney is uncommonly reported. It is an interesting clinical problem because the pelvic kidney lies within the radiation field. CASE:A patient found to have bilateral pelvic kidneys and stage II-B cervical cancer underwent an anterior exen...

journal_title：Gynecologic oncology

authors： Roth TM,Woodring CT,McGehee RP

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:The aberrant expression of hepatocyte growth factor and its receptor c-Met are associated with aggressive disease and poor prognosis in a variety of human malignancies including ovarian cancer (OC). Specificity protein (Sp) transcription factors have high relevance in the signaling cascade associated with c-M...

journal_title：Gynecologic oncology

authors： Basha R,Ingersoll SB,Sankpal UT,Ahmad S,Baker CH,Edwards JR,Holloway RW,Kaja S,Abdelrahim M

更新日期：2011-07-01 00:00:00

abstract：:One of the most prevalent potential therapeutic targets for women with endometrioid endometrial cancer (EC) is the estrogen receptor (ER)/progesterone receptor (PR) pathway. Despite a high proportion of endometrioid ECs being ER and/or PR positive, endocrine therapy is only effective in a minority of women with EC and...

journal_title：Gynecologic oncology

authors： Jerzak KJ,Duska L,MacKay HJ

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the clinicopathological features of ovarian Sertoli-Leydig cell tumors (SLCTs) and to explore the reasonable therapy. METHODS:A total of 40 cases of SLCTs were retrospectively reviewed. RESULTS:The incidence of SLCTs was 0.41%, with a median age of 28 years. All tumors were confined to one ovary...

journal_title：Gynecologic oncology

authors： Gui T,Cao D,Shen K,Yang J,Zhang Y,Yu Q,Wan X,Xiang Y,Xiao Y,Guo L

更新日期：2012-11-01 00:00:00

abstract：:A phase II trial of concurrent cisplatin and 5-fluorouracil (5-FU) chemotherapy and radiation therapy (CT + RT) was conducted for the primary treatment of 12 patients with retrospective surgical FIGO stages III-IV squamous carcinoma of the vulva. Eight patients were stage III and four were stage IV. Chemotherapy was u...

journal_title：Gynecologic oncology

authors： Berek JS,Heaps JM,Fu YS,Juillard GJ,Hacker NF

更新日期：1991-09-01 00:00:00

abstract：:Toxic shock syndrome is a multisystem disease which presents with a high fever, rash, gastrointestinal symptoms, and hypotension. A 58-year-old woman presented to the emergency room with these symptoms, hypotension and tachycardia. Because of vaginal spotting a pelvic examination was performed which demonstrated vulvo...

journal_title：Gynecologic oncology

authors： Rose PG,Wilson G

更新日期：1994-02-01 00:00:00

abstract：:This study evaluated the effect ovarian weight has on the accuracy of frozen sections in serous and mucinous ovarian tumors. The study group included 294 patients who had an initial frozen section (189 serous and 105 mucinous tumors) at surgery. The pathology reports were separated into subgroups (benign, borderline, ...

journal_title：Gynecologic oncology

authors： Puls L,Heidtman E,Hunter JE,Crane M,Stafford J

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVE:The value of surgical staging of apparent early stage epithelial ovarian carcinoma (EOC) is unclear. The aim of this study was to evaluate the importance of surgical staging on the stage of disease and treatment plan. MATERIAL AND METHODS:All patients with apparent stage I EOC undergoing staging from 01/01/2...

journal_title：Gynecologic oncology

authors： Hengeveld EM,Zusterzeel PLM,Lajer H,Høgdall CK,Rosendahl M

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVES:53BP1, a critical mediator of the DNA damage response, functions by regulating the balance between homologous recombination (HR) and the more error-prone non-homologous endjoining (NHEJ). Deletion of 53BP1 in brca1 (but not brca2) null cells partially restores HR and reverses sensitivity to poly-ADP-ribose p...

journal_title：Gynecologic oncology

authors： Pennington KP,Wickramanayake A,Norquist BM,Pennil CC,Garcia RL,Agnew KJ,Taniguchi T,Welcsh P,Swisher EM

更新日期：2013-03-01 00:00:00

abstract：:This report presents 13 patients with epithelial ovarian neoplasms of low malignant potential. Ten patients had serous tumors, 1 had a mucinous tumor, and 2 had endometrioid tumors. Two had Stage I disease, 4 had Stage II disease, and 7 had Stage III disease. All were treated with melphalan. Second-look laparotomy was...

journal_title：Gynecologic oncology

authors： O'Quinn AG,Hannigan EV

更新日期：1985-06-01 00:00:00

abstract：OBJECTIVES:We aimed to evaluate whether carboplatin has a comparable efficacy with cisplatin as part of weekly concurrent chemoradiotherapy for cervical cancer (Car-RT vs. Cis-RT). METHODS:A literature search was conducted and both prospective and retrospective studies that evaluated the efficacy of Car-RT for cervica...

journal_title：Gynecologic oncology

authors： Xue R,Cai X,Xu H,Wu S,Huang H

更新日期：2018-09-01 00:00:00

abstract：:Steroid cell tumors, not otherwise specified, are rare ovarian sex cord-stromal tumors with malignant potential. The majority of these tumors produce steroids with testosterone being the most common. A case of a 46-year-old woman who presented with sudden onset of virilization and a pelvic mass is reported. Various as...

journal_title：Gynecologic oncology

authors： Reedy MB,Richards WE,Ueland F,Uy K,Lee EY,Bryant C,van Nagell JR Jr

更新日期：1999-11-01 00:00:00

abstract：PURPOSE:Intraperitoneal (IP) therapy improves survival compared to intravenous (IV) treatment for women with newly diagnosed, optimally cytoreduced, ovarian cancer. However, the role of IP therapy in recurrent disease is unknown. Preclinical data demonstrated IP administration of the proteasome inhibitor, bortezomib pr...

journal_title：Gynecologic oncology

authors： Jandial DA,Brady WE,Howell SB,Lankes HA,Schilder RJ,Beumer JH,Christner SM,Strychor S,Powell MA,Hagemann AR,Moore KN,Walker JL,DiSilvestro PA,Duska LR,Fracasso PM,Dizon DS

更新日期：2017-05-01 00:00:00

abstract：:OBJECTIVE. A previous study has shown that Dynamic Spectral Imaging (DSI) colposcopy increases the sensitivity of the colposcopic examination in women referred with abnormal cytology. In this study we have reanalyzed the performance of DSI and conventional colposcopy for new referral conditions and for low-grade cytol...

journal_title：Gynecologic oncology

authors： Louwers JA,Zaal A,Kocken M,Berkhof J,Papagiannakis E,Snijders PJ,Meijer CJ,Verheijen RH

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:Describing the pattern of and reasons for post-operative tumor residuals in patients with advanced epithelial ovarian cancer (AOC) operated in a specialized gynecologic cancer center following a strategy of maximum upfront debulking followed by systemic chemotherapy. METHODS:All consecutive AOC-patients trea...

journal_title：Gynecologic oncology

authors： Heitz F,Harter P,Alesina PF,Walz MK,Lorenz D,Groeben H,Heikaus S,Fisseler-Eckhoff A,Schneider S,Ataseven B,Kurzeder C,Prader S,Beutel B,Traut A,du Bois A

更新日期：2016-05-01 00:00:00

abstract：:In a study of 73 patients, diagnosed with recurrent squamous cell carcinoma of the vulva between 1975 and 1990, the effect of clinical variables on the outcome was evaluated. The overall 5-year survival rate was 35.2%. Of the 73 patients, 33 (45.2%) originally had Stage I or II disease and 40 (54.8%) Stage III or IVA;...

journal_title：Gynecologic oncology

authors： Piura B,Masotina A,Murdoch J,Lopes A,Morgan P,Monaghan J

更新日期：1993-02-01 00:00:00

abstract：:Human ovarian carcinomas (n = 215) were xenotransplanted into thymus-aplastic female nu/nu mice (NMRI). Growth of transplants was defined as take-off rate, growth rapidity, and feasibility of passages. In 204 cases these growth characteristics could be correlated with survival time of the individual tumor-donor patien...

journal_title：Gynecologic oncology

authors： Kleine W

更新日期：1986-09-01 00:00:00

abstract：OBJECTIVE:ABCB1 encodes the multi-drug efflux pump P-glycoprotein (P-gp) and has been implicated in multi-drug resistance. We comprehensively evaluated this gene and flanking regions for an association with clinical outcome in epithelial ovarian cancer (EOC). METHODS:The best candidates from fine-mapping analysis of 2...

journal_title：Gynecologic oncology

authors： Johnatty SE,Beesley J,Gao B,Chen X,Lu Y,Law MH,Henderson MJ,Russell AJ,Hedditch EL,Emmanuel C,Fereday S,Webb PM,Australian Ovarian Cancer Study Group.,Goode EL,Vierkant RA,Fridley BL,Cunningham JM,Fasching PA,Beckmann

更新日期：2013-10-01 00:00:00

abstract：:Over a 20-year period, 34 patients with FIGO stage II ovarian carcinoma were treated with postoperative pelvic irradiation at the University of Michigan. Complications of radiation treatment were minimal. The overall actuarial disease-free 5-year survival was 53%. This was not significantly different for substages IIA...

journal_title：Gynecologic oncology

authors： Terada KY,Morley GW,Roberts JA

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate the risk factors and potential morbidity associated with intraoperative hypothermia (IH) during cytoreductive surgery (CRS) for advanced ovarian cancer. METHODS:Demographic and perioperative data were collected for all patients with stage IIIC-IV ovarian, fallopian...

journal_title：Gynecologic oncology

authors： Long KC,Tanner EJ,Frey M,Leitao MM Jr,Levine DA,Gardner GJ,Sonoda Y,Abu-Rustum NR,Barakat RR,Chi DS

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVES:The goal of this case review was to evaluate the influence of complete surgical versus clinical staging, including the impact of ovarian preservation, on the outcome of young patients with endometrial carcinoma. METHODS:A retrospective chart review was performed on all patients with endometrial cancer diagn...

journal_title：Gynecologic oncology

authors： Richter CE,Qian B,Martel M,Yu H,Azodi M,Rutherford TJ,Schwartz PE

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Primary non-gestational choriocarcinoma of the female genital tract has been described in the ovaries and is very unusual in other genital sites. CASE:Primary non-gestational uterine cervical choriocarcinoma was diagnosed in a patient, 32, single, without previous sexual contact nor antecedent pregnancy, ad...

journal_title：Gynecologic oncology

authors： Maestá I,Michelin OC,Traiman P,Hokama P,Rudge MV

更新日期：2005-07-01 00:00:00

abstract：:To develop a mapping strategy for improved detection of p53 allelic loss associated with ovarian carcinoma, we utilized multiple intragenic polymorphisms and single-strand conformation polymorphism (SSCP) analysis. p53 allelotype distributions were defined for 80 ovarian cancer patients from germ-line DNA. All polymor...

journal_title：Gynecologic oncology

authors： Skilling JS,Powills K,Lager DJ,Anderson B,Sorosky J,Buller RE

更新日期：1996-05-01 00:00:00

abstract：:Subgrouping of pelvic exenterations as supralevator (type I), infralevator (type II), with vulvectomy (type III), and, an added category, extended can be helpful to facilitate communication when referring to these patients. It also can facilitate a more detailed analysis of operative risk factors, complications, and r...

journal_title：Gynecologic oncology

authors： Magrina JF

更新日期：1990-06-01 00:00:00

abstract：OBJECTIVE:Cone margin status has been reported to be the most important predictor of residual disease in patients with cervical intraepithelial neoplasia (CIN) undergoing electrosurgical excisional treatment. The primary aim of this study of patients treated with electrosurgical conization was to evaluate the associati...

journal_title：Gynecologic oncology

authors： Costa S,De Nuzzo M,Infante FE,Bonavita B,Marinelli M,Rubino A,Rambelli V,Santini D,Cristiani P,Bucchi L

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to validate the role of p16(INK4a) immunocytochemistry as a marker of cervical epithelial neoplasia in cytology and biopsy samples. METHODS:During the period of 4 years a total of 501 immunocytochemistry stains in cytology and biopsy samples were performed. The cytology smears were ...

journal_title：Gynecologic oncology

authors： Kurshumliu F,Thorns C,Gashi-Luci L

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:The opioid growth factor (OGF) and its receptor, OGFr, serve as a tonically active inhibitory axis regulating cell proliferation in normal cells and a variety of cancers, including human ovarian cancer. Blockade of OGF and OGFr with the nonselective opioid receptor antagonist naltrexone (NTX) upregulates expr...

journal_title：Gynecologic oncology

authors： Donahue RN,McLaughlin PJ,Zagon IS

更新日期：2011-08-01 00:00:00

abstract：:Placement of a radiation implant in patients with cervical cancer may be difficult because of distortion of the canal by tumor or fibrosis from previous radiation. The objective of this study was to determine whether ultrasound may be useful in recognizing or preventing complications associated with placement of an in...

journal_title：Gynecologic oncology

authors： Rotmensch J,Waggoner SE,Quiet C

更新日期：1994-08-01 00:00:00

abstract：:The alpha-emitter 211At was bound to polymer microspheres with a diameter of 1.8 microns. The distributions in mice of intraperitoneally injected 211At microspheres, 90Y silicate colloid, and 32P chromic phosphate colloid were compared. The microspheres with 211At spread rapidly in the peritoneal cavity and remained m...

journal_title：Gynecologic oncology

authors： Vergote I,Larsen RH,De Vos L,Winderen M,Ellingsen T,Bjørgum J,Hoff P,Aas M,Tropé C,Nustad K

更新日期：1992-12-01 00:00:00

abstract：OBJECTIVE:The conditionally replicative adenovirus Ad5/3-Δ24 has a type-3 knob incorporated into the type-5 fiber that facilitates enhanced ovarian cancer infectivity. Preclinical studies have shown that Ad5/3-Δ24 achieves significant oncolysis and anti-tumor activity in ovarian cancer models. The purpose of this study...

journal_title：Gynecologic oncology

authors： Kim KH,Dmitriev IP,Saddekni S,Kashentseva EA,Harris RD,Aurigemma R,Bae S,Singh KP,Siegal GP,Curiel DT,Alvarez RD

更新日期：2013-09-01 00:00:00