Endocrine therapy in endometrial cancer: An old dog with new tricks.

abstract：:A detailed account is given of experience at a single institution with the rhomboid transposition flap used to repair the perineal defect after surgery for carcinoma of the vulva. In 13 of 15 assessable cases, the flaps healed completely or had insignificant separation of a segment of the flap. In 2 cases, more major ...

journal_title：Gynecologic oncology

authors： Helm CW,Hatch KD,Partridge EE,Shingleton HM

更新日期：1993-08-01 00:00:00

abstract：PURPOSE:To determine the relationship between chemotherapy dose modification (dose adjustment or treatment delay), overall survival (OS) and progression-free survival (PFS) for women with advanced-stage epithelial ovarian carcinoma (EOC) and primary peritoneal carcinoma (PPC) who receive carboplatin and paclitaxel. ME...

journal_title：Gynecologic oncology

authors： Olawaiye AB,Java JJ,Krivak TC,Friedlander M,Mutch DG,Glaser G,Geller M,O'Malley DM,Wenham RM,Lee RB,Bodurka DC,Herzog TJ,Bookman MA

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:Inguinal metastasis is a rare manifestation of ovarian cancer. Autopsy studies have reported inguinal metastasis in 0-3% of patients with advanced disease. CASE REPORT:We describe a 43-year-old patient with ovarian cancer limited to the adnexa who had an isolated metastasis in an enlarged inguinal lymph node...

journal_title：Gynecologic oncology

authors： Scholz HS,Lax S,Tamussino KF,Petru E

更新日期：1999-12-01 00:00:00

abstract：:Non-healing wounds represent a significant cause of morbidity and mortality for a large portion of the adult population. Wounds that fail to heal are entrapped in a self-sustaining cycle of chronic inflammation leading to the destruction of the extracellular matrix. Among cancer patients, malnutrition, radiation, phys...

journal_title：Gynecologic oncology

authors： Menke MN,Menke NB,Boardman CH,Diegelmann RF

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVES:Vaginal reconstruction following pelvic exenteration is an important aspect of the physical and psychological rehabilitation of women after radical surgery for pelvic malignancies. The choice of techniques is vast, and proper patient and surgical selection is important for obtaining satisfactory functional a...

journal_title：Gynecologic oncology

authors： Mirhashemi R,Averette HE,Lambrou N,Penalver MA,Mendez L,Ghurani G,Salom E

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to estimate the efficacy of an intensive CDP program, as well as to identify the predictors associated with lymphedema severity and response to CDP in lower limb lymphedema (LLL) after pelvic cancer therapy. METHODS:We performed a retrospective review of post-pelvic cancer LLL patie...

journal_title：Gynecologic oncology

authors： Liao SF,Li SH,Huang HY

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:To assess the role of additional biopsies performed with loop electrosurgical excisional procedure (LEEP) in predicting the likelihood of persistent high grade intraepithelial neoplasia. METHODS:Clinicopathologic data were abstracted from women who underwent excision of high grade intraepithelial lesions bet...

journal_title：Gynecologic oncology

authors： Cui Y,Sangi-Haghpeykar H,Patsner B,Bump JMM,Williams-Brown MY,Binder GL,Masand RP,Anderson ML

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:The establishment of clinical features identifying patients at a heightened risk for the development of carboplatin hypersensitivity may assist in the management of this important toxicity. Based on a previous report suggesting a history of "bee sting" allergy predicted for paclitaxel hypersensitivity, we att...

journal_title：Gynecologic oncology

authors： Markman M,Zanotti K,Kulp B,Peterson G,Markman M

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:Ovarian cancer is the leading cause of death in women with gynecologic cancer. CA125 is the commonly used biomarker in the diagnosis of ovarian cancer, but has limitations in both sensitivity and specificity. Human Epididymal secretory protein (HE4) is a promising biomarker and is included in the Risk of Ovar...

journal_title：Gynecologic oncology

authors： Stiekema A,Lok CA,Kenter GG,van Driel WJ,Vincent AD,Korse CM

更新日期：2014-03-01 00:00:00

abstract：:Malignant lipoid cell tumors of the ovary are rare lesions that are frequently associated with endocrinologic abnormalities. A case of a woman with this lesion who developed Cushing's syndrome with progression of tumor is presented. Neither aggressive medical therapy with ketoconazole nor multiagent chemotherapy was b...

journal_title：Gynecologic oncology

authors： Donovan JT,Otis CN,Powell JL,Cathcart HK

更新日期：1993-08-01 00:00:00

abstract：OBJECTIVE:We report a case of uterine leiomyosarcoma occurring after uterine artery embolization and review the previously published cases. We estimate the incidence of sarcoma after UAE, the mean diagnostic delay in young women undergoing this procedure and review the potential and limits of preoperative procedures in...

journal_title：Gynecologic oncology

authors： Papadia A,Salom EM,Fulcheri E,Ragni N

更新日期：2007-01-01 00:00:00

abstract：:A comprehensive understanding of retroperitoneal lymphatic involvement is lacking in tumors of low malignant potential. This study was undertaken to evaluate retroperitoneal lymphatic involvement in patients with ovarian tumors of low malignant potential. One hundred seventy-one patients were diagnosed with epithelial...

journal_title：Gynecologic oncology

authors： Leake JF,Rader JS,Woodruff JD,Rosenshein NB

更新日期：1991-08-01 00:00:00

abstract：OBJECTIVE:To identify patients with endometrial cancer at risk for hematogenous, lymphatic, or peritoneal recurrence (or combinations of them) who might potentially benefit from target-based therapies. METHODS:During a 13-year period, 915 patients had endometrial cancer managed with hysterectomy and standard adjuvant ...

journal_title：Gynecologic oncology

authors： Mariani A,Dowdy SC,Keeney GL,Long HJ,Lesnick TG,Podratz KC

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVES:In this study, we analyzed the PTEN expression in a large collection of clear cell adenocarcinomas of the ovary. Furthermore, we analyzed the expression of cyclin D1 and p27, and investigated the correlation among all these variables. METHODS:Totally, 40 clear cell adenocarcinomas were included in this stud...

journal_title：Gynecologic oncology

authors： Hashiguchi Y,Tsuda H,Inoue T,Berkowitz RS,Mok SC

更新日期：2006-04-01 00:00:00

abstract：:Uterine papillary serous carcinoma (UPSC) is an aggressive histologic subtype of endometrial cancer. Currently, no effective chemotherapy regimens exist. We report a case of complete response of a stage IV UPSC to neoadjuvant chemotherapy with Taxol and carboplatin. ...

journal_title：Gynecologic oncology

authors： Le TD,Yamada SD,Rutgers JL,DiSaia PJ

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Carcinoma of the cervix and a prolapsed uterus are common diseases in underdeveloped countries, but their association is quite rare. CASE:We report here the clinical characteristics of two Brazilian patients with carcinoma of the uterine cervix associated with a third-degree prolapsed uterus. The patients, ...

journal_title：Gynecologic oncology

authors： da Silva BB,da Costa Araújo R,Filho CP,Melo JA

更新日期：2002-02-01 00:00:00

abstract：:The radical hysterectomy is often associated with severe bladder dysfunction and colorectal motility disorders. These issues may arise as a result of damage incurred to the motor and sensory autonomic nerve supply, both of sympathetic and parasympathetic origin, that innervate the uterus, vagina, urinary bladder, and ...

journal_title：Gynecologic oncology

authors： Fujii S

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:Ras gene mutations have been identified in squamous cell carcinomas of the cervix and are associated with advanced-stage tumors. The current study was designed to determine the prevalence of c-Ki-ras mutations in invasive endocervical adenocarcinomas and associations between mutations, HPV status, and known p...

journal_title：Gynecologic oncology

authors： Koulos JP,Wright TC,Mitchell MF,Silva E,Atkinson EN,Richart RM

更新日期：1993-03-01 00:00:00

abstract：:Young women diagnosed with breast cancer typically face systemic treatments that may delay childbearing or permanently impair their fertility. These concerns add to the stress experienced by young cancer survivors. Timely counseling and providing fertility preservation through cryopreservation of eggs or embryos have ...

journal_title：Gynecologic oncology

authors： Westphal LM,Wapnir IL

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Formation of urinary stones in a continent urostomy (Indiana pouch) has been described as a late complication. Management of a patient with symptomatic multiple large stones and review of the literature are outlined. CASE REPORT:A 32-year-old woman presented with recurrent urinary tract infections and pyelo...

journal_title：Gynecologic oncology

authors： Sait K,Stuart G,Nation J,Ghatage P

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:To evaluate efficacy and safety of WF10 (TCDO iv solution) therapy in patients with late hemorrhagic radiation cystitis and proctitis in a long-term follow up. MATERIAL AND METHODS:From February 1999 to July 2001, 30 symptomatic patients with endoscopically confirmed grade 2 and 3 late hemorrhagic cystitis (...

journal_title：Gynecologic oncology

authors： Veerasarn V,Boonnuch W,Kakanaporn C

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the urinary tract dysfunction following a radical hysterectomy and to compare the baseline urodynamical parameters of women who had uterine cervical carcinoma with women who had CIN 3. METHODS:A prospective case-control study was conducted to evaluate preoperative and postoperative urinary tract...

journal_title：Gynecologic oncology

authors： Chen GD,Lin LY,Wang PH,Lee HS

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVE:Brachytherapy plays a major role in the treatment of patients with carcinoma of the cervix. However, routine intracavitary brachytherapy may not be feasible or adequate to treat locally advanced disease. The purpose of this prospective study was to assess treatment outcome for patients with locally advanced g...

journal_title：Gynecologic oncology

authors： Agrawal PP,Singhal SS,Neema JP,Suryanarayan UK,Vyas RK,Rathi AK,Bahadur AK

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVES:A previously reported phase 2 trial suggested substantial clinical activity associated with the combination of a platinum agent and tamoxifen in the treatment of platinum-resistant ovarian cancer. We wished to confirm or refute this observation in a patient population with well-characterized platinum-resista...

journal_title：Gynecologic oncology

authors： Markman M,Webster K,Zanotti K,Peterson G,Kulp B,Belinson J

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVES:The PI3K/AKT/mTOR pathway is frequently overactivated in endometrial cancer (EC). We assessed the efficacy of ABTL0812, a novel first-in-class molecule presenting a unique mechanism of action inhibiting this pathway. METHODS:We investigated the effects of ABTL0812 on proliferation, cell death and modulation...

journal_title：Gynecologic oncology

authors： Felip I,Moiola CP,Megino-Luque C,Lopez-Gil C,Cabrera S,Solé-Sánchez S,Muñoz-Guardiola P,Megias-Roda E,Pérez-Montoyo H,Alfon J,Yeste-Velasco M,Santacana M,Dolcet X,Reques A,Oaknin A,Rodríguez-Freixinos V,Lizcano JM,Domèn

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess the impact of surgical complexity on postoperative complications and mortality, according to patient's frailty (mFI) following surgery for ovarian cancer. METHODS:Patients undergoing cytoreductive surgery for ovarian cancer from 2008 to 2018 were identified from our databa...

journal_title：Gynecologic oncology

authors： Di Donato V,Di Pinto A,Giannini A,Caruso G,D'Oria O,Tomao F,Fischetti M,Perniola G,Palaia I,Muzii L,Benedetti Panici P

更新日期：2020-09-04 00:00:00

abstract：OBJECTIVE:The primary objective of the study was to prospectively assess quality of life (QOL) among women at increased risk of ovarian cancer who are undergoing risk-reducing salpingo-oophorectomy (RRSO) or serial screening. METHODS:Women at increased risk of ovarian cancer who were undergoing RRSO were recruited int...

journal_title：Gynecologic oncology

authors： Fang CY,Cherry C,Devarajan K,Li T,Malick J,Daly MB

更新日期：2009-03-01 00:00:00

abstract：:A new cell line, CUMC-3, has been derived from an invasive nonkeratinizing squamous cell carcinoma of the uterine cervix in a 32-year-old patient. It has been maintained in long-term culture for 59 months, and passaged over 310 times. Monolayer-cultured cells were polygonal in shape, showing a pavement-like arrangemen...

journal_title：Gynecologic oncology

authors： Kim JW,Cho YH,Lyu MS,Lee CG,Jung JK,Kim SJ,Namkoong SE

更新日期：1995-04-01 00:00:00

abstract：PURPOSE:To examine the differentially expressed cancer-related genes in two morphologically different uterine cervical carcinoma cell lines derived from the same patient by an Affymetrix Human Cancer G110 Array carrying 1700 cancer-associated genes. In addition, to investigate specific gene expression depending on hist...

journal_title：Gynecologic oncology

authors： Fujimoto T,Nishikawa A,Iwasaki M,Akutagawa N,Teramoto M,Kudo R

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:This study sought to develop and examine preliminary validity of the NCCN-FACT Ovarian Symptom Index-18 (NFOSI-18), a new ovarian cancer-specific symptom index comprised of symptoms rated as highest priority by both oncology clinical experts and women with advanced ovarian cancer. METHODS:Fifty-one women wit...

journal_title：Gynecologic oncology

authors： Jensen SE,Rosenbloom SK,Beaumont JL,Abernethy A,Jacobsen PB,Syrjala K,Cella D

更新日期：2011-02-01 00:00:00