Endocrine therapy in endometrial cancer: An old dog with new tricks.


:One of the most prevalent potential therapeutic targets for women with endometrioid endometrial cancer (EC) is the estrogen receptor (ER)/progesterone receptor (PR) pathway. Despite a high proportion of endometrioid ECs being ER and/or PR positive, endocrine therapy is only effective in a minority of women with EC and ultimately patients progress with resistance developing to treatment. A variety of treatment approaches with progestins, selective ER modulators (SERMs) and aromatase inhibitors (AIs) are available. Exploration of these agents is desirable given their favorable toxicity profile. Greater understanding of ER and PR biology may help identify patient populations who will derive benefit and strategies for new therapeutic options. Here we review the clinical efficacy of endocrine therapy in EC, discuss the role of ER and/or PR as prognostic biomarkers, describe disease-specific mechanisms of resistance to endocrine therapy and explore potential strategies to enhance response for the "next generation" of endocrine therapy clinical trials. We also describe the use of endocrine therapy in younger women seeking to pursue fertility sparing options for management of EC.


Gynecol Oncol


Gynecologic oncology


Jerzak KJ,Duska L,MacKay HJ




Has Abstract


2019-04-01 00:00:00














  • Application of proteomics in ovarian cancer: which sample should be used?

    abstract:OBJECTIVE:In the last decade several studies have been published using proteomics to unravel molecular pathways and to find biomarkers which can be used for diagnosis and/or prognostication in ovarian cancer. This review gives an overview of proteomic studies performed in ovarian cancer focusing on the nature of sample...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Cadron I,Van Gorp T,Timmerman D,Amant F,Waelkens E,Vergote I

    更新日期:2009-12-01 00:00:00

  • Supervised clustering of immunohistochemical markers to distinguish atypical endometrial hyperplasia from grade 1 endometrial cancer.

    abstract:OBJECTIVES:Differentiation between grade-1 endometrial cancer (EC) and atypical endometrial hyperplasia (AEH) is crucial to determine optimal surgical management. However, discrepancies exist between preoperative diagnosis of AEH and final histology. Our aim was to establish clusters of immunohistochemical markers to d...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Laas E,Ballester M,Cortez A,Gonin J,Daraï E,Graesslin O

    更新日期:2014-05-01 00:00:00

  • Retroperitoneal leiomyosarcoma: eight cases and a literature review.

    abstract::Leiomyosarcoma, a rare malignancy of smooth muscle, may arise from the retroperitoneum and present with the same vague symptoms as a malignancy of the pelvic organs. The purpose of this paper is to review eight cases of retroperitoneal leiomyosarcoma and to illustrate the presenting symptoms, prognostic indicators, an...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Todd CS,Michael H,Sutton G

    更新日期:1995-12-01 00:00:00

  • Endometrial cancer surgery in Arizona: a statewide analysis of access to care.

    abstract:OBJECTIVES:To investigate access to surgical care for endometrial cancer in Arizona. METHODS:The Arizona HealthQuery (AZHQ) data warehouse with claims information on over 7 million patients in Arizona was searched using the International Classification of Disease (ICD-9) codes and Current Procedural Terminology (CPT) ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Benjamin I,Dalton H,Qiu Y,Cayco L,Johnson WG,Balducci J

    更新日期:2011-04-01 00:00:00

  • Docetaxel plus trabectedin appears active in recurrent or persistent ovarian and primary peritoneal cancer after up to three prior regimens: a phase II study of the Gynecologic Oncology Group.

    abstract:OBJECTIVE:This study aims to estimate the activity of docetaxel 60mg/m(2) IV over 1h followed by trabectedin 1.1mg/m(2) over 3h with filgrastim, pegfilgrastim, or sargramostim every 3weeks (one cycle). METHODS:Patients with recurrent and measurable disease, acceptable organ function, PS≤2, and ≤3 prior regimens were e...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Monk BJ,Sill MW,Hanjani P,Edwards R,Rotmensch J,De Geest K,Bonebrake AJ,Walker JL

    更新日期:2011-03-01 00:00:00

  • Neoadjuvant chemotherapy in stage IB2 squamous cell carcinoma of the cervix.

    abstract::To determine the effects of neoadjuvant chemotherapy (NAC) in the management of cervical carcinoma Stage IB2 (tumor diameter > 4 cm), we reviewed 52 surgically treated patients diagnosed between January 1987 and December 1993. There were 20 patients treated with preoperative neoadjuvant chemotherapy and 32 treated by ...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Serur E,Mathews RP,Gates J,Levine P,Maiman M,Remy JC

    更新日期:1997-05-01 00:00:00

  • The role of cancer antigen 125 (CA 125) in the management of ovarian epithelial carcinomas.

    abstract::From June 1, 1984, to May 31, 1985, 98 cases of epithelial ovarian carcinomas were assessed and followed prospectively using a new murine monoclonal antibody OC 125 which detects the antigen CA 125. Serous tumors comprised 43.7% of cases, mucinous tumors 20.4%, endometrioid tumors 16%, and other epithelial tumors 19.4...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Altaras MM,Goldberg GL,Levin W,Bloch B,Darge L,Smith JA

    更新日期:1988-05-01 00:00:00

  • Metachronous metastases from renal cell carcinoma to uterine cervix and vagina: case report and review of literature.

    abstract:BACKGROUND:Although renal cell carcinoma (RCC) is characterized with unpredictable clinical presentation, multiple genital tract metastases are still surprising and mode of spread is obscure. CASE:We report a case of RCC metastases to uterine cervix and vagina 1 year after radical nephrectomy in a 19-year-old virgin. ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Bozaci EA,Atabekoğlu C,Sertçelik A,Unlü C,Ortaç F

    更新日期:2005-10-01 00:00:00

  • A phase 2 study of alisertib (MLN8237) in recurrent or persistent uterine leiomyosarcoma: An NRG Oncology/Gynecologic Oncology Group study 0231D.

    abstract:OBJECTIVE:This two-stage Phase II study assessed the activity of single agent alisertib in patients with recurrent/persistent uterine leiomyosarcoma (uLMS). METHODS:Eligibility criteria included histologically-confirmed, recurrent or persistent uLMS, age≥18, 1-2 prior cytotoxic regimens, and RECIST version 1.1 measura...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Hyman DM,Sill MW,Lankes HA,Piekarz R,Shahin MS,Ridgway MR,Backes F,Tenney ME,Mathews CA,Hoffman JS,Aghajanian C,Hensley ML

    更新日期:2017-01-01 00:00:00

  • Pathways to a cancer-free future: A protocol for modelled evaluations to maximize the future impact of interventions on cervical cancer in Australia.

    abstract:OBJECTIVE:Australia's HPV vaccination and HPV-based cervical screening programs are changing the landscape in cervical cancer prevention. We aim to identify areas which can make the biggest further impact on cervical cancer burden. This protocol describes the first stage of a program of work called Pathways-Cervix that...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Velentzis LS,Smith MA,Simms KT,Lew JB,Hall M,Hughes S,Yuill S,Killen J,Keane A,Butler K,Darlington-Brown J,Hui H,Brotherton JML,Skinner R,Brand A,Roeske L,Heley S,Carter J,Bateson D,Frazer I,Garland SM,Guy R,H

    更新日期:2019-03-01 00:00:00

  • Combined methotrexate-dactinomycin: an effective therapy for low-risk gestational trophoblastic neoplasia.

    abstract:OBJECTIVE:The objective of this study is to examine the outcomes of combined chemotherapy using methotrexate and dactinomycin in the management of women with low-risk gestational trophoblastic neoplasia (GTN). The primary outcome is the total number of cycles of chemotherapy required to achieve a normal level of human ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Eiriksson L,Wells T,Steed H,Schepansky A,Capstick V,Hoskins P,Pike J,Swenerton K

    更新日期:2012-03-01 00:00:00

  • Novel technique for the complete staging of endometrial cancer by single-port laparoscopy.

    abstract:OBJECTIVE:Our aim was to evaluate the feasibility of a novel technique using single-port laparoscopy for the complete surgical staging of endometrial cancer. METHODS:Total hysterectomy, bilateral salpingo-oophorectomy, pelvic lymphadenectomy and para-aortic lymphadenectomy was performed using a single-port device in t...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Zapardiel I,Moreno E,Piñera A,De Santiago J

    更新日期:2016-02-01 00:00:00

  • The morbidity and utility of periaortic radiotherapy in cervical carcinoma.

    abstract::From 1971 through 1981, 81 women received 4350 to 5075 rad to the periaortic lymph nodes as part of their primary management for carcinoma of the uterine cervix. While two patients developed chronic small bowel damage, only one required surgical intervention. Five-year disease-free survival was 40%. Approximately one-...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Potish R,Adcock L,Jones T Jr,Levitt S,Prem K,Savage J,Twiggs L

    更新日期:1983-02-01 00:00:00

  • Complete molar pregnancy in adolescents from North and South America: Clinical presentation and risk of gestational trophoblastic neoplasia.

    abstract:OBJECTIVES:To compare complete hydatidiform mole (CHM) clinical presentation and risk factors associated with GTN development between North American and South American adolescents. METHODS:This non-concurrent cohort study was undertaken including adolescents with CHM referred to centers in North America (New England T...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Soares RR,Maestá I,Colón J,Braga A,Salazar A,Charry RC,Sun SY,Goldstein DP,Berkowitz RS

    更新日期:2016-09-01 00:00:00

  • Bcl-X(L) is functionally non-equivalent for the regulation of growth and survival in human ovarian cancer cells.

    abstract:OBJECTIVE:To investigate the role of Bcl-X(L) on the growth and survival of human ovarian carcinoma cells. METHODS:In this study, we enforced down-regulation of Bcl-X(L) by RNA interference in ovarian carcinoma cell lines CaOV3, SKOV3ip1 and OVCAR3 cell lines expressing various levels of Bcl-X(L). We also established ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Dodier P,Piché A

    更新日期:2006-02-01 00:00:00

  • Second primary malignancy in endometrial carcinoma patients.

    abstract::An epidemiologic study of multiple primary malignant neoplasms in endometrial cancer patients in Israel is presented. During the 7-year period of the study, 104 patients (10.3%) out of 1007 patients diagnosed as having endometrial cancer had another primary cancer. There was a significant difference in the incidence o...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Schwartz Z,Ohel G,Birkenfeld A,Anteby SO,Schenker JG

    更新日期:1985-09-01 00:00:00

  • Paratubal borderline serous tumors.

    abstract:BACKGROUND:While ovarian borderline tumors are common, their fallopian tube counterparts are extremely rare. We describe the first case of a serous borderline paratubal tumor with a review of the literature on paratubal and tubal low malignant potential tumors. CASE:A 26 year-old woman presented with acute onset of sh...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Seamon LG,Holt CN,Suarez A,Richardson DL,Carlson MJ,O'Malley DM

    更新日期:2009-04-01 00:00:00

  • Correlation of CA125 and CA19-9 serum levels with clinical course and second-look findings in patients with ovarian carcinoma.

    abstract::CA125 and CA19-9 levels were serially evaluated in blood samples from 21 patients during and after integrated surgical and chemotherapeutic treatment for ovarian carcinoma. Serial measurement of CA125 and CA19-9 correlated with clinical course of disease in 89.7 and 72.7% of instances, respectively. The decrease of se...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Fioretti P,Gadducci A,Ferdeghini M,Bartolini T,Bianchi R,Facchini V

    更新日期:1987-11-01 00:00:00

  • Mullerian inhibiting substance reduction of colony growth of human gynecologic cancers in a stem cell assay.

    abstract::Mullerian Inhibiting Substance (MIS), a fetal testicular product that causes regression of the Mullerian duct in the male mammalian embryo, was evaluated for its antitumor effect on the premise that a substance active against this genital precursor in the fetus might also be active against tumors derived from these ti...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Fuller AF Jr,Krane IM,Budzik GP,Donahoe PK

    更新日期:1985-10-01 00:00:00

  • Cancer-associated stroma significantly contributes to the mesenchymal subtype signature of serous ovarian cancer.

    abstract:OBJECTIVE:Mesenchymal (MES) subtype of high-grade serous ovarian cancer (HGSOC) is associated with worse outcomes including survival and resectability compared with other molecular subtypes. Molecular subtypes have historically been derived from 'tumor', consisting of both cancer and stromal cells. We sought to determi...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Zhang Q,Wang C,Cliby WA

    更新日期:2019-02-01 00:00:00

  • High external parametrial dose can increase the probability of radiation proctitis in patients with uterine cervix cancer.

    abstract:OBJECTIVE:The aim of this study was to evaluate the relationship between external parametrial dose and radiation proctitis after external irradiation and high-dose-rate intracavitary (HDR-IC) brachytherapy among patients with cervical cancer. METHODS:From May 1993 through December 1996, 191 patients with stage IB-IVA ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Huang EY,Lin H,Hsu HC,Wang CJ,Chen HC,Sun LM,Hsiung CY

    更新日期:2000-12-01 00:00:00

  • A phase I pharmacokinetic study of intraperitoneal bortezomib and carboplatin in patients with persistent or recurrent ovarian cancer: An NRG Oncology/Gynecologic Oncology Group study.

    abstract:PURPOSE:Intraperitoneal (IP) therapy improves survival compared to intravenous (IV) treatment for women with newly diagnosed, optimally cytoreduced, ovarian cancer. However, the role of IP therapy in recurrent disease is unknown. Preclinical data demonstrated IP administration of the proteasome inhibitor, bortezomib pr...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Jandial DA,Brady WE,Howell SB,Lankes HA,Schilder RJ,Beumer JH,Christner SM,Strychor S,Powell MA,Hagemann AR,Moore KN,Walker JL,DiSilvestro PA,Duska LR,Fracasso PM,Dizon DS

    更新日期:2017-05-01 00:00:00

  • Conservative management of early stage cervical cancer: is there a role for less radical surgery?

    abstract:OBJECTIVES:The utility of parametrial resection in women with early stage cervical cancer is controversial. In patients with favorable pathologic characteristics such as tumor size <2cm and the absence of lymphovascular space invasion, the rate of parametrial involvement is very low. More conservative surgical approach...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Schmeler KM,Frumovitz M,Ramirez PT

    更新日期:2011-03-01 00:00:00

  • Diagnosis of endometrial cancer in patients with postmenopausal bleeding by analysis of the lactate dehydrogenase isoenzyme activity profile in uterine fluid.

    abstract:OBJECTIVES:We have previously shown that high activity of lactate dehydrogenase (LD) isoenzymes 4 and 5 in terine aspirates is a marker for endometrial carcinoma. The purpose of this study was to identify an abnormal activity profile of LD2-5 using LD1 as an internal standard, thereby being able to dispense with measur...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Niklasson O,Skude G,Marsal K,Casslén B

    更新日期:2004-05-01 00:00:00

  • The additional value of endometrial sampling in the early detection of endometrial cancer in women with Lynch syndrome.

    abstract:OBJECTIVE:Based on previous studies, standard gynecological screening consisting of annual transvaginal ultrasonography (TVU) was added with endometrial sampling in women with Lynch syndrome (LS). The aim of this study was to evaluate the additional value of endometrial sampling in detecting (pre)malignancies of the en...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Helder-Woolderink JM,De Bock GH,Sijmons RH,Hollema H,Mourits MJ

    更新日期:2013-11-01 00:00:00

  • Detection of beta-subunit human chorionic gonadotropin mRNA in the peripheral blood of patients with nonmetastatic gestational trophoblastic disease.

    abstract:OBJECTIVE:The aim of this study was to detect beta-subunit human chorionic gonadotropin (beta(h)CG) mRNA in the peripheral blood samples of patients with nonmetastatic gestational trophoblastic disease (GTD) undergoing hysterectomy. METHODS:Heparinized peripheral blood samples were obtained from four patients with non...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Suzuka K,Matsui H,Iitsuka Y,Sekiya S

    更新日期:2002-07-01 00:00:00

  • The results of treatment of epithelial ovarian cancer after centralisation of primary surgery. Results from North Jutland, Denmark.

    abstract:OBJECTIVE:The study was performed to evaluate the results of treatment of ovarian carcinoma after the introduction of centralised primary surgery in the County of North Jutland, Denmark. METHOD:Prospective study of consecutive cases of ovarian cancer undergoing primary surgical treatment at the Gynecologic Oncologic C...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Soegaard Andersen E,Knudsen A,Svarrer T,Lund B,Nielsen K,Grove A,Tetsche M

    更新日期:2005-12-01 00:00:00

  • Differential induction of apoptosis by tumor necrosis factor-related apoptosis-inducing ligand in human ovarian carcinoma cells.

    abstract:OBJECTIVES:In this study, we examine the sensitivity of a panel of ovarian carcinoma cells, which includes four primary ovarian cancer cell samples, and four normal ovarian epithelium samples to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). We also examine the intracellular regulation of TRAIL-mediat...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Lane D,Cartier A,L'Espérance S,Côté M,Rancourt C,Piché A

    更新日期:2004-06-01 00:00:00

  • Molecular evidence linking primary cancer of the fallopian tube to BRCA1 germline mutations.

    abstract:OBJECTIVES:BRCA1 and BRCA2 germline mutations increase the risk of ovarian and breast cancer. Fallopian tube cancer has occasionally been observed in breast-ovarian cancer families. At our family cancer clinic we recently encountered two cases of Fallopian tube cancer within two families harboring a BRCA1 germline muta...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Zweemer RP,van Diest PJ,Verheijen RH,Ryan A,Gille JJ,Sijmons RH,Jacobs IJ,Menko FH,Kenemans P

    更新日期:2000-01-01 00:00:00

  • Pilomatricoma-like endometrioid adenosquamous carcinoma of the ovary with neuroendocrine differentiation.

    abstract::A case of high-grade endometrioid adenosquamous carcinoma of the ovary showing pilomatricoma-like areas and neuroendocrine differentiation is presented. The pilomatricoma-like areas were strongly positive for cytokeratin and vimentin, whereas the poorly differentiated areas of the tumor were positive for cytokeratin, ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Fang J,Keh P,Katz L,Rao MS

    更新日期:1996-05-01 00:00:00