Phase 2 trial of carboplatin plus tamoxifen in platinum-resistant ovarian cancer and primary carcinoma of the peritoneum.

abstract：:Ovarian germ cell tumors (GCTs) are rare in adults, but are more common in adolescents and young adults. Contemporary management of ovarian GCTs is evolving as collaboration among pediatric, medical, and gynecologic oncologists increases, and studies increasingly incorporate female adult patients. Despite an improved ...

journal_title：Gynecologic oncology

authors： Veneris JT,Mahajan P,Frazier AL

更新日期：2020-08-01 00:00:00

abstract：:Ovarian cancer is the leading cause of gynecologic cancer deaths in the U.S. The concept of intraperitoneal drug delivery for therapy of intraperitoneal cancers, such as ovarian cancer, arose in the 1960s. The field of intraperitoneal cisplatin therapy for ovarian cancer was initiated in the late 1970s and early 1980s...

journal_title：Gynecologic oncology

authors： Alberts DS,Markman M,Muggia F,Ozols RF,Eldermire E,Bookman MA,Chen T,Curtin J,Hess LM,Liebes L,Young RC,Trimble E

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:The purpose of this study was to survey the brachytherapy practice for cervical cancer in the United States. METHODS:The Clinical Research Committee of the American Brachytherapy Society (ABS) performed a retrospective survey of individual physicians of the ABS and American Society of Therapeutic Radiologists ...

journal_title：Gynecologic oncology

authors： Nag S,Orton C,Young D,Erickson B

更新日期：1999-04-01 00:00:00

abstract：:Epithelial ovarian carcinoma consists of not one, but several, entities. A number of subtypes exist, including high-grade and low-grade serous carcinomas, clear cell, endometrioid carcinoma and mucinous carcinoma. Historically, women with epithelial ovarian cancer have been treated similarly and "lumped" in the same c...

journal_title：Gynecologic oncology

authors： Groen RS,Gershenson DM,Fader AN

更新日期：2015-02-01 00:00:00

abstract：INTRODUCTION:Metastatic involvement of the mediastinal lymph nodes is an extremely uncommon finding in epithelial ovarian cancers. CASE REPORT:A 63-year-old woman was admitted to hospital for dyspnoea due to an anterior mediastinal mass. The surgical biopsy showed a 6-cm metastatic lymph node with a papillary pattern,...

journal_title：Gynecologic oncology

authors： Zannoni GF,Vellone VG,Distefano MG,Fadda G,Scambia G

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to define the clinical-therapeutical approach to endometrial cancer now being followed in some of the most important centers of reference for gynecological cancer in North America by means of a questionnaire. STUDY DESIGN:The questionnaire focused on four principal areas: (1) surgic...

journal_title：Gynecologic oncology

authors： Maggino T,Romagnolo C,Landoni F,Sartori E,Zola P,Gadducci A

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVE:Pelvic exenteration (PE) is an extensive surgery associated with high rates of postoperative morbidity and mortality. The absence of well-defined preoperative selection criteria to identify patients eligible for PE prompted the assessment of pre-operative predictors of 30-day major surgical complications. ME...

journal_title：Gynecologic oncology

authors： Tortorella L,Casarin J,Mara KC,Weaver AL,Multinu F,Glaser GE,Cliby WA,Scambia G,Mariani A,Kumar A

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:To evaluate the effectiveness of bevacizumab with single-agent chemotherapy for platinum-resistant ovarian cancer in a real-world setting. PATIENTS AND METHODS:We enrolled recurrent platinum-resistant ovarian cancer patients from 27 institutions. All had received bevacizumab with single-agent chemotherapy (wee...

journal_title：Gynecologic oncology

authors： Lee JY,Park JY,Park SY,Lee JW,Kim JW,Kim YB,Jeong DH,Lee KB,Kim TH,Lee IH,Choi MC,Kim KH,Kim YM,Lee YJ,Kang S,KGOG Investigators.,Pujade-Lauraine E

更新日期：2019-01-01 00:00:00

abstract：:Pretreatment serum levels of the tumor-associated antigens CA-125, tissue polypeptide antigen (TPA), carcinoembryonic antigen (CEA), and placental alkaline phosphatase (PLAP) were analyzed in 142 patients with epithelial ovarian carcinoma, and related to clinical and histopathological parameters. In a linear multiple ...

journal_title：Gynecologic oncology

authors： Tholander B,Taube A,Lindgren A,Sjöberg O,Stendahl U,Tamsen L

更新日期：1990-10-01 00:00:00

abstract：OBJECTIVE:To determine the incidence of local recurrence of vulvar squamous cell carcinoma in relation to tumor- and/or precursor lesion free pathologic margins. METHODS:Consecutive patients with primary vulvar squamous cell carcinoma surgically treated in two Dutch expert centers between 2000 and 2010 were included. ...

journal_title：Gynecologic oncology

authors： Te Grootenhuis NC,Pouwer AW,de Bock GH,Hollema H,Bulten J,van der Zee AGJ,de Hullu JA,Oonk MHM

更新日期：2019-08-01 00:00:00

abstract：:Monoclonal antibody rp-28 directed against the ras gene product p21 has been studied to evaluate ras p21 expression in malignant and benign ovarian tissues. Some ovarian carcinomas of serous and mucinous cystadenocarcinomas, undifferentiated adenocarcinomas, and clear cell carcinomas demonstrated intense staining of r...

journal_title：Gynecologic oncology

authors： Yaginuma Y,Yamashita K,Kuzumaki N,Fujita M,Shimizu T

更新日期：1992-07-01 00:00:00

abstract：OBJECTIVE:To investigate the neutrophil-to-lymphocyte ratio (NLR) from peripheral blood, a general measure of inflammation, in ovarian cancer. METHODS:White cell counts and CA125 levels before treatment, tumor features, and questionnaire data on 519 women with ovarian cancer at two Boston hospitals were recorded. Coun...

journal_title：Gynecologic oncology

authors： Williams KA,Labidi-Galy SI,Terry KL,Vitonis AF,Welch WR,Goodman A,Cramer DW

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVES:To estimate the frequency of abnormal surveillance cytology leading to high-grade dysplasia after surgical management for high-grade vulvar intraepithelial neoplasia (VIN) and vulvar cancer and to determine whether prior hysterectomy reduces this risk. METHODS:Women who underwent surgery for high-grade VIN ...

journal_title：Gynecologic oncology

authors： Buchanan TR,Zamorano AS,Massad LS,Liu J,Thaker PH,Powell MA,Mutch DG,Kuroki LM

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Human papillomavirus type 16 variants have been described and may have different biologic activities: this has implications for the design of HPV vaccines. OBJECTIVES:The aim of this study was to see if the HPV16 variant E-G 131 can be detected in women with preinvasive disease and to consider the histologi...

journal_title：Gynecologic oncology

authors： Etherington IJ,Ellis JR,Luesley DM,Moffitt DD,Young LS

更新日期：1999-01-01 00:00:00

abstract：:Approximately 20,000 women are diagnosed with ovarian cancer in the United States each year, and some 12,000 women die because of it. Epithelial ovarian cancer, the most common histopathologic type, is uncommon before age 40 years, after which incidence rates increase steeply until age 70-79 years and then decrease so...

journal_title：Gynecologic oncology

authors： Whittemore AS

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVE:Reduced Selenium-Binding Protein 1 (SELENBP1) expression was recently shown in multiple cancers. There is little information on the expression and function of SELENBP1 in cancer progression. In order to develop a better understanding of the role of SELENBP1 in ovarian cancer, our objective was to determine if...

journal_title：Gynecologic oncology

authors： Stammer K,Edassery SL,Barua A,Bitterman P,Bahr JM,Hales DB,Luborsky JL

更新日期：2008-04-01 00:00:00

abstract：:The cell line HTOA was established from a well-differentiated human ovarian serous cystadenocarcinoma. This line grew well and without interruption for 51 months and was subcultivated over 130 times. The cells were epithelial in shape, and neoplastic and pleomorphic features, a jigsaw puzzle-like arrangement, desmosom...

journal_title：Gynecologic oncology

authors： Ishiwata I,Ishiwata C,Soma M,Nozawa S,Ishikawa H

更新日期：1987-03-01 00:00:00

abstract：:The records of 125 patients with nonmucinous invasive ovarian adenocarcinoma who underwent cytoreductive surgery, cisplatin-based combination chemotherapy, and second-look laparotomy were analyzed to correlate pre-second-look serum CA-125 levels with the size of residual ovarian cancer. The majority of patients with n...

journal_title：Gynecologic oncology

authors： Patsner B,Orr JW Jr,Mann WJ Jr,Taylor PT,Partridge E,Allmen T

更新日期：1990-06-01 00:00:00

abstract：:Relative and population attributable risks for invasive cervical cancer in different age strata relative to screening practices have been estimated using data from a case-control study conducted since 1981 in the greater Milan area, northern Italy. A total of 548 women under 75 years of age with a histologically confi...

journal_title：Gynecologic oncology

authors： Parazzini F,Negri E,La Vecchia C,Bocciolone L

更新日期：1990-07-01 00:00:00

abstract：:Favorable responses to hexamethylmelamine (HMM) have been documented in untreated as well as in alkylating agent-resistant ovarian epithelial adenocarcinoma (OvCa). Platinum-based combination therapy for OvCa has been used since 1976. Eighteen patients with OvCa were treated with HMM as salvage therapy between Februar...

journal_title：Gynecologic oncology

authors： Stehman FB,Ehrlich CE,Callangan MF

更新日期：1984-02-01 00:00:00

abstract：OBJECTIVE:Cone margin status has been reported to be the most important predictor of residual disease in patients with cervical intraepithelial neoplasia (CIN) undergoing electrosurgical excisional treatment. The primary aim of this study of patients treated with electrosurgical conization was to evaluate the associati...

journal_title：Gynecologic oncology

authors： Costa S,De Nuzzo M,Infante FE,Bonavita B,Marinelli M,Rubino A,Rambelli V,Santini D,Cristiani P,Bucchi L

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVE:We demonstrate the feasibility of implementing a referral and management system for cryotherapy-ineligible women in a "screen-and-treat" cervical cancer prevention program targeting HIV-infected women in Zambia. METHODS:We established criteria for patient referral, developed a training program for loop elect...

journal_title：Gynecologic oncology

authors： Pfaendler KS,Mwanahamuntu MH,Sahasrabuddhe VV,Mudenda V,Stringer JS,Parham GP

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Endometrial polyps are the most common endometrial pathology described in association with postmenopausal tamoxifen exposure. It is generally accepted that the occurrence of malignancy in endometrial polyps among healthy women is up to 0.5%. However, no one has yet described the incidence of this malignant t...

journal_title：Gynecologic oncology

authors： Cohen I,Bernheim J,Azaria R,Tepper R,Sharony R,Beyth Y

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy between acupuncture and ondansetron in the prevention of delayed chemotherapy induced nausea and vomiting (CINV). METHODS:70 patients were randomized to receive either 1) acupuncture at P6 point before chemotherapy infusion or 2) ondansetron 8 mg intravenously 30 min before chemothera...

journal_title：Gynecologic oncology

authors： Rithirangsriroj K,Manchana T,Akkayagorn L

更新日期：2015-01-01 00:00:00

abstract：:Thirty-two patients with Stage III or IV epithelial ovarian cancer and residual tumor volumes in excess of 2 cm in diameter after initial debulking were treated with platinum and cyclophosphamide chemotherapy. Twenty-seven patients (84%) received at least six courses of chemotherapy. Six patients developed grade 3 or ...

journal_title：Gynecologic oncology

authors： Gallion HH,van Nagell JR,Donaldson ES,Hanson MB,Kryscio RJ

更新日期：1987-06-01 00:00:00

abstract：OBJECTIVE:To assess the role of additional biopsies performed with loop electrosurgical excisional procedure (LEEP) in predicting the likelihood of persistent high grade intraepithelial neoplasia. METHODS:Clinicopathologic data were abstracted from women who underwent excision of high grade intraepithelial lesions bet...

journal_title：Gynecologic oncology

authors： Cui Y,Sangi-Haghpeykar H,Patsner B,Bump JMM,Williams-Brown MY,Binder GL,Masand RP,Anderson ML

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:The ovarian yolk sac tumor (OYST) is a very rare malignancy arising in young women. Our objective was to determine whether an early decline in serum alpha-fetoprotein (AFP) during chemotherapy has a prognostic impact. METHODS:This retrospective study is based on prospectively recorded OYST cases at Gustave ...

journal_title：Gynecologic oncology

authors： de la Motte Rouge T,Pautier P,Genestie C,Rey A,Gouy S,Leary A,Haie-Meder C,Kerbrat P,Culine S,Fizazi K,Lhommé C

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:The purpose of this article is to review the data, rationale, and recommendations of vaginal brachytherapy (VBT) in the post-operative treatment of endometrial cancer patients. METHODS:The authors performed a thorough review of the medical literature regarding the use of adjuvant VBT in the treatment of endo...

journal_title：Gynecologic oncology

authors： Harkenrider MM,Block AM,Siddiqui ZA,Small W Jr

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVES:Terameprocol (M4N, EM-1421) is a novel transcription inhibitor that selectively interferes with HPV viral genes E6/E7 with Sp1-dependent promoters, and induces apoptosis by inactivation of the CDC2/cyclin B complex (maturation promoting factor) and production and phosphorylation of survivin. This trial was d...

journal_title：Gynecologic oncology

authors： Khanna N,Dalby R,Tan M,Arnold S,Stern J,Frazer N

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:To determine the proportion of endometrial cancer patients who can be safely prescribed community/home based unsupervised exercise. A better understanding of the physical dysfunction secondary to comorbidities among endometrial cancer patients would assist clinicians in delineating which patients to send to m...

journal_title：Gynecologic oncology

authors： Zhang X,Haggerty AF,Brown JC,Giuntoli R 2nd,Lin L,Simpkins F,Dean LT,Ko E,Morgan MA,Schmitz KH

更新日期：2015-10-01 00:00:00