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Predictors of optimal cytoreduction in patients with newly diagnosed advanced-stage epithelial ovarian cancer: Time to incorporate laparoscopic assessment into the standard of care.

Abstract：

:The standard management of advanced-stage ovarian cancer has been a subject of debate, and much controversy remains as to whether patients should have primary cytoreductive surgery followed by chemotherapy or neoadjuvant chemotherapy followed by interval cytoreductive surgery. In addition, there is increasing evidence that the patients who ultimately gain the most benefit from surgery are those with no residual disease at the completion of surgery (R0 resection). Therefore, to determine the best therapeutic strategy (primary cytoreductive surgery vs. neoadjuvant chemotherapy) for an individual patient, it is critically important to estimate the likelihood that primary cytoreductive surgery will leave no macroscopic residual disease. A number of studies have evaluated the use of serologic markers, such as CA-125, and imaging modalities, such as computed tomography (CT) or positron emission tomography/CT (PET/CT), to determine which patients are ideal candidates for primary cytoreductive surgery. More recently, laparoscopy has been proposed as a reliable predictor of R0 resection. In this report, we provide a review of the existing literature on the proposed criteria to predict the outcome of cytoreductive surgery and the role of laparoscopy-based scores in the management of advanced ovarian cancer.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Gómez-Hidalgo NR,Martinez-Cannon BA,Nick AM,Lu KH,Sood AK,Coleman RL,Ramirez PT

doi

10.1016/j.ygyno.2015.03.049

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

553-8

issue

3

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(15)00777-5

journal_volume

137

pub_type

杂志文章,评审

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