Multidisciplinary approach in the management of advanced ovarian cancer patients: A personalized approach. Results from a specialized ovarian cancer unit.

abstract：:Effective cytotoxic treatment options for advanced cervical cancer are exceedingly limited. Cisplatin-based combination chemotherapy, the most commonly used cytotoxic therapy, has produced response rates ranging from 20% to 30% and overall survival of less than 10 months. Because of the minimal degree of success with ...

journal_title：Gynecologic oncology

authors： del Campo JM,Prat A,Gil-Moreno A,Pérez J,Parera M

更新日期：2008-09-01 00:00:00

abstract：:Sentinel node mapping is increasingly being utilized for endometrial cancer staging. However, only limited evidence supporting the adoption of sentinel node mapping instead of conventional lymphadenectomy is still available. Here, we aimed to review the current evidence comparing sentinel node mapping and lymphadenect...

journal_title：Gynecologic oncology

authors： Bogani G,Murgia F,Ditto A,Raspagliesi F

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:To investigate the role of Bcl-X(L) on the growth and survival of human ovarian carcinoma cells. METHODS:In this study, we enforced down-regulation of Bcl-X(L) by RNA interference in ovarian carcinoma cell lines CaOV3, SKOV3ip1 and OVCAR3 cell lines expressing various levels of Bcl-X(L). We also established ...

journal_title：Gynecologic oncology

authors： Dodier P,Piché A

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Primary appendiceal malignancy metastatic to the ovaries is a rare condition that may mimic late stage ovarian cancer. This condition is rarely diagnosed preoperatively. CASES:Three patients referred to our institution from 1994 to 1999 for presumed late stage ovarian cancer were found to have primary appen...

journal_title：Gynecologic oncology

authors： McBroom JW,Parker MF,Krivak TC,Rose GS,Crothers B

更新日期：2000-09-01 00:00:00

abstract：:Routine endocervical curettage has been advocated in the colposcopic evaluation of patients with abnormal cervical cytology. To assess the usefulness of this procedure, we reviewed the records of 518 patients referred to the Colposcopy Clinic with abnormal Pap smears. Data was reviewed retrospectively in 411 patients ...

journal_title：Gynecologic oncology

authors： Oyer R,Hanjani P

更新日期：1986-10-01 00:00:00

abstract：OBJECTIVE:The aim of this report is to describe the potential clinical utility of tracer [F-18]-Fluorodeoxyglucose (FDG) uptake, quantitated as a standardized uptake value (SUV) by positron emission tomography (PET), to evaluate treatment response to neoadjuvant chemotherapy (NAC) in advanced uterine cervical cancer. ...

journal_title：Gynecologic oncology

authors： Yoshida Y,Kurokawa T,Kawahara K,Yagihara A,Tsuchida T,Okazawa H,Fujibayashi Y,Yonekura Y,Kotsuji F

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:Self-collected HPV testing could substantially reduce disparities in cervical cancer screening, with slightly lower sensitivity compared to physician-collected specimens cross-sectionally. We aimed to evaluate the comprehensive long-term performance of self-collected HPV testing prospectively. METHODS:In 199...

journal_title：Gynecologic oncology

authors： Zhang L,Xu XQ,Hu SY,Chen F,Zhang X,Pan QJ,Zhang WH,Feng RM,Dong L,Zhang Q,Ma JF,Sauvaget C,Zhao FH,Qiao YL,Sankaranarayanan R

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:The objective of this pilot study was to determine if frailty predicts surgical complications among elderly women undergoing gynecologic oncology procedures. METHODS:A cohort of gynecologic oncology patients age ≥ 65, undergoing surgery between March and December 2011 was identified. Frailty was evaluated u...

journal_title：Gynecologic oncology

authors： Courtney-Brooks M,Tellawi AR,Scalici J,Duska LR,Jazaeri AA,Modesitt SC,Cantrell LA

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:There is a need to find agents with activity in platinum and taxane refractory ovarian cancer to be employed as second-line therapy in the malignancy. Limited clinical trial experience has suggested that gemcitabine possesses activity in this clinical setting. We wished to further define the level of activity...

journal_title：Gynecologic oncology

authors： Markman M,Webster K,Zanotti K,Kulp B,Peterson G,Belinson J

更新日期：2003-09-01 00:00:00

abstract：:A comprehensive understanding of retroperitoneal lymphatic involvement is lacking in tumors of low malignant potential. This study was undertaken to evaluate retroperitoneal lymphatic involvement in patients with ovarian tumors of low malignant potential. One hundred seventy-one patients were diagnosed with epithelial...

journal_title：Gynecologic oncology

authors： Leake JF,Rader JS,Woodruff JD,Rosenshein NB

更新日期：1991-08-01 00:00:00

abstract：OBJECTIVE:To determine the relationship between history of cervical dysplasia or carcinoma and the development of cervical dysplasia or adenocarcinoma in women who have a diagnosis of atypical glandular cells of undetermined significance (AGUS), favor endocervical origin, or AGUS, not otherwise specified. METHODS:A 6-...

journal_title：Gynecologic oncology

authors： Raab SS,Bishop NS,Zaleski MS

更新日期：1999-09-01 00:00:00

abstract：:A study that focused on the identification of the phenotype and proliferative responses of peripheral blood and ovarian cancer-infiltrating lymphocytes in a patient with stage III ovarian cancer who had human immunodeficiency virus infection is presented. Monoclonal antibodies and flow cytometry were used to determine...

journal_title：Gynecologic oncology

authors： Guidozzi F,Reddy S,Wadee A

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the sensitivity of sentinel node (SN) ultrastaging and to define parameters that may reduce the overall false-negative rate in women with early-stage cervical cancer. METHODS:We analyzed data from a large retrospective multicenter cohort group with FIGO stages IA-IIB cervical cancer in whom at le...

journal_title：Gynecologic oncology

authors： Cibula D,Abu-Rustum NR,Dusek L,Slama J,Zikán M,Zaal A,Sevcik L,Kenter G,Querleu D,Jach R,Bats AS,Dyduch G,Graf P,Klat J,Meijer CJ,Mery E,Verheijen R,Zweemer RP

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:The goal of this work was to evaluate the involvement of gonadotropins in the regulation of adhesion of human epithelial ovarian carcinoma. We studied two pathways that were previously implicated in the metastatic implantation of ovarian carcinoma to the peritoneum, namely hyaluronan-CD44 and RGD-integrin med...

journal_title：Gynecologic oncology

authors： Schiffenbauer YS,Meir G,Maoz M,Even-Ram SC,Bar-Shavit R,Neeman M

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:BRCA1 mutation carriers have a high rate of both breast and ovarian cancer. Tamoxifen is a selective estrogen receptor modulator (SERM), which is used for the treatment of primary breast cancer and for the prevention of contralateral breast cancer. Our objective is to assess if tamoxifen treatment is associat...

journal_title：Gynecologic oncology

authors： Vicus D,Rosen B,Lubinski J,Domchek S,Kauff ND,Lynch HT,Isaacs C,Tung N,Sun P,Narod SA,Hereditary Ovarian Cancer Clinical Study Group.

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:The presence of cardiac metastasis from cervical carcinoma is extremely rare. The diagnosis is made almost exclusively postmortem. There are few cases of premortem diagnosis, and it is believed that when cardiac metastasis are found in vivo, the prognosis is extremely poor. Due to the rarity of this conditio...

journal_title：Gynecologic oncology

authors： Lemus JF,Abdulhay G,Sobolewski C,Risch VR

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to examine the clinicopathologic correlates of T-regulatory (T(reg)) cell infiltration in serous ovarian cancers and to define gene signatures associated with high T(reg)s. METHODS:Tumor infiltrating T(reg) and cytotoxic T-cells (CTLs) were quantitated in 232 primary serous ov...

journal_title：Gynecologic oncology

authors： Barnett JC,Bean SM,Whitaker RS,Kondoh E,Baba T,Fujii S,Marks JR,Dressman HK,Murphy SK,Berchuck A

更新日期：2010-03-01 00:00:00

abstract：:Wound healing has evolved from gauze therapy to the use of proteomics, gene therapy, and cellular-based therapies in the short time span of 45 years. Education for health care providers has not kept pace with the logarithmic acceleration in technology development and treatment options. A patient with a non-healing wou...

journal_title：Gynecologic oncology

authors： Ennis WJ,Meneses P,Borhani M

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:To evaluate incidence, indications, and outcome of hysterectomy in women presenting with gestational trophoblastic disease. METHODS:A prospective observational study using a standardized protocol for registration, assessment, and treatment of gestational trophoblastic disease. A total of 5976 consecutive new...

journal_title：Gynecologic oncology

authors： Pisal N,North C,Tidy J,Hancock B

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVES:The goal of this work was to test the hypotheses that S-phase fraction (SPF) by DNA labeling index (SPF-LI) would predict the course of the disease for ovarian/peritoneal carcinomas and that SPF-LI would correlate better with pathologic classification and outcome than SPF by DNA flow cytometry (SPF-F). METH...

journal_title：Gynecologic oncology

authors： Meyer JS,Gersell DJ,Yim S

更新日期：2001-06-01 00:00:00

abstract：:There have been nine cases reported in the English literature in which the finding of malignant cells on cervical/vaginal cytology led to the diagnosis of primary gastric cancer. We report on a patient with gastric carcinoma, metastatic to the cervix, in which the diagnosis was suspected by the finding of signet ring ...

journal_title：Gynecologic oncology

authors： McGill F,Adachi A,Karimi N,Wadler S,Kim ES,Greston WM,Kleiner GJ

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:To evaluate, from a societal perspective, the cost-effectiveness of adding bevacizumab to first-line therapy based on outcomes from the GOG-218 and ICON-7 trials. METHODS:A three-state Markov model was used. The time horizon was until the death of 99% of the initial cohort of 1000 individuals. Costs and qual...

journal_title：Gynecologic oncology

authors： Mehta DA,Hay JW

更新日期：2014-03-01 00:00:00

abstract：:Didemnin B was administered to 24 women with recurrent squamous cell cervical carcinoma. The initial dose was 4.2 mg/m2, intravenously, repeated every 28 days. Twenty-three patients were evaluable for toxicity and twenty-one for response. Toxicity was mild, consisting mainly of nausea and vomiting. There were no objec...

journal_title：Gynecologic oncology

authors： Jacobs AJ,Blessing JA,Munoz A

更新日期：1992-03-01 00:00:00

abstract：:To develop a mapping strategy for improved detection of p53 allelic loss associated with ovarian carcinoma, we utilized multiple intragenic polymorphisms and single-strand conformation polymorphism (SSCP) analysis. p53 allelotype distributions were defined for 80 ovarian cancer patients from germ-line DNA. All polymor...

journal_title：Gynecologic oncology

authors： Skilling JS,Powills K,Lager DJ,Anderson B,Sorosky J,Buller RE

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVE:We demonstrate the feasibility of implementing a referral and management system for cryotherapy-ineligible women in a "screen-and-treat" cervical cancer prevention program targeting HIV-infected women in Zambia. METHODS:We established criteria for patient referral, developed a training program for loop elect...

journal_title：Gynecologic oncology

authors： Pfaendler KS,Mwanahamuntu MH,Sahasrabuddhe VV,Mudenda V,Stringer JS,Parham GP

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:Lymph node status in early-stage vulvar cancer can be accurately assessed by the sentinel-node (SN) procedure. Molecular techniques, such as DNA-methylation assay, might improve SN assessment. In this study, we selected methylation markers for vulvar cancer and determined if these methylation markers were sui...

journal_title：Gynecologic oncology

authors： Oonk MH,Eijsink JJ,Volders HH,Hollema H,Wisman GB,Schuuring E,van der Zee AG

更新日期：2012-05-01 00:00:00

abstract：:Twenty-five patients underwent adjunctive extrafascial hysterectomy 14-60 days following completion of external and intracavitary irradiation for bulky carcinoma of the uterine cervix. Review of the operative histopathology and correlation with subsequent patient outcomes suggests that morphologically persistent cance...

journal_title：Gynecologic oncology

authors： Russell AH,Burt AR,Ek M,Russell KJ,Cain JM,Greer BE,Tamimi HK,Figge DC

更新日期：1987-10-01 00:00:00

abstract：OBJECTIVES:The presence of disseminated tumor cells (DTC) in breast cancer patients is associated with poor prognosis. However, there are limited data about the prevalence and prognostic impact of DTC in patients with gynecological tumors. The aim of this study was to evaluate the presence of DTC in the bone marrow (BM...

journal_title：Gynecologic oncology

authors： Fehm T,Becker S,Bachmann C,Beck V,Gebauer G,Banys M,Wallwiener D,Solomayer EF

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:The value of surgical staging of apparent early stage epithelial ovarian carcinoma (EOC) is unclear. The aim of this study was to evaluate the importance of surgical staging on the stage of disease and treatment plan. MATERIAL AND METHODS:All patients with apparent stage I EOC undergoing staging from 01/01/2...

journal_title：Gynecologic oncology

authors： Hengeveld EM,Zusterzeel PLM,Lajer H,Høgdall CK,Rosendahl M

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:The opioid growth factor (OGF) and its receptor, OGFr, serve as a tonically active inhibitory axis regulating cell proliferation in normal cells and a variety of cancers, including human ovarian cancer. Blockade of OGF and OGFr with the nonselective opioid receptor antagonist naltrexone (NTX) upregulates expr...

journal_title：Gynecologic oncology

authors： Donahue RN,McLaughlin PJ,Zagon IS

更新日期：2011-08-01 00:00:00