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Neoadjuvant bleomycin, etoposide, and cisplatin in adult neuroblastoma arising from the broad ligament of the uterus.

Abstract：

BACKGROUND:A case of primary neuroblastoma arising from the broad ligament with excellent response to neoadjuvant bleomycin, etoposide, and cisplatin (BEP) is reported. CASE:A 48-year-old woman, G0, who presented with acute renal failure, an enlarged pelvic mass, and abdominal pain was diagnosed with adult neuroblastoma arising from the broad ligament of the uterus. She received three cycles of neoadjuvant therapy consisting of bleomycin, etoposide, and cisplatin (BEP) given every 3 weeks and had an excellent initial response. She then underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and appendectomy, with pathologic analysis revealing small residual disease on the broad ligament of the uterus and omentum. The patient died of recurrent disease 20 months after her initial diagnosis. CONCLUSIONS:The clinical management of cancer in the broad ligament of the uterus must be tailored to the pathologic diagnosis. Although our patient had an excellent initial response to BEP, further study is needed to identify a treatment that can reduce recurrences and improve clinical outcomes.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Milam MR,Gabel SF,Milam RA,Liu J,Ramirez PT

doi

10.1016/j.ygyno.2007.06.027

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

350-4

issue

2

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(07)00400-3

journal_volume

107

pub_type

杂志文章

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