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Antiemetic treatment of chemotherapy-induced nausea in ovarian carcinoma patients.

Abstract：

:In a prospective, randomized, double-blind trial the combination betamethasone-dixyrazine was compared with high-dose metoclopramide as antiemetic treatment during combination chemotherapy (melphalan-doxorubicin and cisplatin) of ovarian carcinoma. Of 40 evaluable patients, 15 (38%) had previous experience with chemotherapy. Efficacy and side effects were recorded on patient and nurse questionnaires using the visual analog scale. Nausea and vomiting were prevented in 55% of the patients treated with melphalan-doxorubicin (Day 1) and in 36% of the patients treated with cisplatin (Day 2). Betamethasone-dixyrazine was superior to high-dose metoclopramide and prevented nausea in 76% compared to 32% during melphalan-doxorubicin therapy. Akathisia was noted in 21% and acute dystonic reactions in 2.6% during metoclopramide treatment but not in any case during betamethasone-dixyrazine therapy.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Sorbe B,Hallén C

doi

10.1016/0090-8258(89)90129-7

subject

Has Abstract

pub_date

1989-08-01 00:00:00

pages

141-4

issue

2

eissn

0090-8258

issn

1095-6859

pii

0090-8258(89)90129-7

journal_volume

34

pub_type

临床试验,杂志文章,随机对照试验

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