A phase II trial of didemnin B (NSC No. 325319) in advanced and recurrent cervical carcinoma: a Gynecologic Oncology Group study.

abstract：OBJECTIVE:Some authors have recommended the use of diagnostic laparoscopy as a pretreatment assessment step for conservative hormonal treatment in young women with endometrial cancer. The aim of this study was to determine the incidence of synchronous primary cancer of the endometrium and ovary in young women. METHODS...

journal_title：Gynecologic oncology

authors： Song T,Seong SJ,Bae DS,Suh DH,Kim DY,Lee KH,Lim MC,Lee TS

更新日期：2013-12-01 00:00:00

abstract：:The cell line HTOA was established from a well-differentiated human ovarian serous cystadenocarcinoma. This line grew well and without interruption for 51 months and was subcultivated over 130 times. The cells were epithelial in shape, and neoplastic and pleomorphic features, a jigsaw puzzle-like arrangement, desmosom...

journal_title：Gynecologic oncology

authors： Ishiwata I,Ishiwata C,Soma M,Nozawa S,Ishikawa H

更新日期：1987-03-01 00:00:00

abstract：:To develop a mapping strategy for improved detection of p53 allelic loss associated with ovarian carcinoma, we utilized multiple intragenic polymorphisms and single-strand conformation polymorphism (SSCP) analysis. p53 allelotype distributions were defined for 80 ovarian cancer patients from germ-line DNA. All polymor...

journal_title：Gynecologic oncology

authors： Skilling JS,Powills K,Lager DJ,Anderson B,Sorosky J,Buller RE

更新日期：1996-05-01 00:00:00

abstract：:Combination chemotherapy consisting of bleomycin, vincristine, mitomycin C, and cisplatin (BOMP) was first applied to an inoperable case (57-year-old) with FIGO stage IV (T3N3 + M1B) squamous cell carcinoma of the vulva. After three courses of BOMP therapy, the patient achieved a complete response with few toxic effec...

journal_title：Gynecologic oncology

authors： Shimizu Y,Hasumi K,Masubuchi K

更新日期：1990-03-01 00:00:00

abstract：OBJECTIVE:The objective was to determine the frequency with which regression or progression of disease without treatment occurred in women diagnosed with squamous cell cervical carcinoma in situ (CIS) during pregnancy. METHODS:. A retrospective chart review of all women evaluated at the University of Iowa Colposcopy C...

journal_title：Gynecologic oncology

authors： Coppola A,Sorosky J,Casper R,Anderson B,Buller RE

更新日期：1997-11-01 00:00:00

abstract：:A total of 107 patients with carcinoma of the ovary were entered in a study combining extensive primary surgery and intensive chemotherapy. Because of evidence supporting the effectiveness of both single agent platinum (P) and the combination of cyclophosphamide and doxorubicin (CA), patients were treated with alterna...

journal_title：Gynecologic oncology

authors： Krag KJ,Canellos GP,Griffiths CT,Knapp RC,Parker LM,Welch WR,Klatt M,Andersen J

更新日期：1989-07-01 00:00:00

abstract：:Pretreatment serum levels of the tumor-associated antigens CA-125, tissue polypeptide antigen (TPA), carcinoembryonic antigen (CEA), and placental alkaline phosphatase (PLAP) were analyzed in 142 patients with epithelial ovarian carcinoma, and related to clinical and histopathological parameters. In a linear multiple ...

journal_title：Gynecologic oncology

authors： Tholander B,Taube A,Lindgren A,Sjöberg O,Stendahl U,Tamsen L

更新日期：1990-10-01 00:00:00

abstract：:Brain metastases from primary cervical carcinoma are uncommon. Only 41 cases have been reported so far in the English literature. We have seen 2 cases over the last 2 years among 481 patients with cervical cancer. Brain metastases developed 7 and 35 months after the primary diagnosis. One patient with solitary metasta...

journal_title：Gynecologic oncology

authors： Kumar L,Tanwar RK,Singh SP

更新日期：1992-09-01 00:00:00

abstract：OBJECTIVES:Uterine adenosarcomas (AS) are rare tumors composed of malignant stromal and benign epithelial components. We sought to evaluate the role of primary surgery, adjuvant treatments, and salvage therapies for patients with uterine adenosarcomas. METHODS:We identified all patients diagnosed with AS from 1990 to ...

journal_title：Gynecologic oncology

authors： Tanner EJ,Toussaint T,Leitao MM Jr,Hensley ML,Soslow RA,Gardner GJ,Jewell EL

更新日期：2013-04-01 00:00:00

abstract：:From September 1986 to November 1988, 38 patients with previously untreated ovarian cancer, FIGO stages III and IV, were allocated to a study testing the efficacy of high-dose platinum delivered as combined carboplatin and cisplatin. The regimen was as follows: Day 1, 250-350 mg/m2 carboplatin and 500 mg/m2 cyclophosp...

journal_title：Gynecologic oncology

authors： Bertelsen K,Bastholt L

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Primary cancer of the vulva is not common, constituting only 3-5% of all gynecologic malignancies and <1% of all cancer in the female. Metastatic tumors of the vulva are even more unusual, constituting only 5-8% of all vulvar cancers. CASE:A 32-year-old female underwent total mastectomy with axillary lymph ...

journal_title：Gynecologic oncology

authors： Sheen-Chen SM,Eng HL,Huang CC

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:Caregiver burden, quality of life (QOL) and unmet needs are poorly understood, particularly at the end of life. We explored these issues in caregivers of women with ovarian cancer. PATIENTS AND METHODS:The Australian Ovarian Cancer Study (AOCS) is a prospective population-based study of women newly diagnosed w...

journal_title：Gynecologic oncology

authors： Butow PN,Price MA,Bell ML,Webb PM,deFazio A,Australian Ovarian Cancer Study Group.,Australian Ovarian Cancer Study Quality Of Life Study Investigators.,Friedlander M

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVE:Ovarian cancer is most frequently diagnosed at a late stage with a poor prognosis. No markers for early diagnosis have been established. Aberrantly methylated DNA appears as a promising molecular cancer marker. The aim of this study was to analyze the methylation status of the proapoptotic cancer related gene...

journal_title：Gynecologic oncology

authors： Häfner N,Diebolder H,Jansen L,Hoppe I,Dürst M,Runnebaum IB

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:Previous studies suggest that differences in molecular features of endometrial cancers between racial groups may contribute to the poorer survival in Blacks. The objective of this investigation was to determine whether gene expression among endometrial cancers is different between Blacks and Whites. METHODS:...

journal_title：Gynecologic oncology

authors： Maxwell GL,Allard J,Gadisetti CV,Litzi T,Casablanca Y,Chandran U,Darcy KM,Levine DA,Berchuck A,Hamilton CA,Conrads TP,Risinger JI

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:Endometrioid endometrial carcinoma is caused by a combination of mutational events and hormonal factors. We used large-scale messenger RNA expression analysis to discover genes that distinguish neoplastic transformation and examine the patterns of tumor expression of those genes which are normally regulated d...

journal_title：Gynecologic oncology

authors： Mutter GL,Baak JP,Fitzgerald JT,Gray R,Neuberg D,Kust GA,Gentleman R,Gullans SR,Wei LJ,Wilcox M

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:To examine the DNA methyltransferase (DNMT) mRNA and protein levels in endometrioid and serous cancers and to study the relationship between DNA methyltransferase expression and endometrial cancer development. METHODS:Normal endometrium, Grade I and Grade III endometrioid carcinoma tissues and cell lines, as...

journal_title：Gynecologic oncology

authors： Xiong Y,Dowdy SC,Xue A,Shujuan J,Eberhardt NL,Podratz KC,Jiang SW

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVES:Determinants of endometrial cancer grade have not been precisely defined, however, cell cycle control is considered to be integrally involved in endometrial cancer development. TP53 and MDM2 are essential components for cell cycle arrest and apoptosis. Polymorphisms in these genes cause TP53 inactivation and...

journal_title：Gynecologic oncology

authors： Ashton KA,Proietto A,Otton G,Symonds I,McEvoy M,Attia J,Gilbert M,Hamann U,Scott RJ

更新日期：2009-04-01 00:00:00

abstract：:To determine the morbidity associated with delivery of intraperitoneal chemotherapy via subcutaneous semipermanent infusion catheters, we analyzed the data on 227 patients treated from April 1985 through December 1989. A total of 249 catheters were inserted and used to administer chemotherapy in these patients. There ...

journal_title：Gynecologic oncology

authors： Davidson SA,Rubin SC,Markman M,Jones WB,Hakes TB,Reichman B,Almadrones L,Chapman D,Lewis JL Jr,Hoskins WJ

更新日期：1991-05-01 00:00:00

abstract：OBJECTIVE:We report a case of uterine leiomyosarcoma occurring after uterine artery embolization and review the previously published cases. We estimate the incidence of sarcoma after UAE, the mean diagnostic delay in young women undergoing this procedure and review the potential and limits of preoperative procedures in...

journal_title：Gynecologic oncology

authors： Papadia A,Salom EM,Fulcheri E,Ragni N

更新日期：2007-01-01 00:00:00

abstract：:From 1970 to 1992, 136 patients with a histologic diagnosis of endometrial hyperplasia underwent total abdominal hysterectomy at the University of Kentucky Medical Center. Slides of the curettage or biopsy specimens were reviewed and classified according to the International Society of Gynecologic Pathologists System ...

journal_title：Gynecologic oncology

authors： Hunter JE,Tritz DE,Howell MG,DePriest PD,Gallion HH,Andrews SJ,Buckley SB,Kryscio RJ,van Nagell JR Jr

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:Our objective was to determine the rate of BRCA1/2 deficiency in platinum-sensitive and platinum-resistant tumors from a cohort of unselect patients with advanced epithelial ovarian cancer (EOH). METHODS:BRCA1/2 mutation analysis was performed in 29 patients with platinum-sensitive EOC and 24 patients with p...

journal_title：Gynecologic oncology

authors： Dann RB,DeLoia JA,Timms KM,Zorn KK,Potter J,Flake DD 2nd,Lanchbury JS,Krivak TC

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:This study was conducted to determine the objective response of trimetrexate in patients with advanced or recurrent leiomyosarcoma of the uterus. METHODS:Eligibility was restricted to patients with measurable disease who had received no more than one prior chemotherapy regimen, who had adequate bone marrow, ...

journal_title：Gynecologic oncology

authors： Smith HO,Blessing JA,Vaccarello L

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy and toxicity of interferon-alpha-2b (IFN-alpha) and cisplatin given concomitantly with radiation therapy (RT) in the treatment of locally advanced cervical carcinoma. MATERIALS AND METHODS:Twenty-one patients with stage bulky Ib-IIIb (Ib, 2; IIa, 2; IIb, 8; IIIb, 9) cervical carcinoma ...

journal_title：Gynecologic oncology

authors： Stock RG,Dottino P,Jennings TS,Terk M,DeWyngaert JK,Beddoe AM,Cohen C

更新日期：1997-12-01 00:00:00

abstract：:Three cases of papillary villoglandular carcinoma of the cervix are presented. Each patient was multiparous and presented with abnormal vaginal bleeding. The mean age at presentation was 35 years (range 28-42 years). All patients were staged as FIGO IB and underwent radical Wertheim hysterectomy and bilateral pelvic l...

journal_title：Gynecologic oncology

authors： Hopson L,Jones MA,Boyce CR,Tarraza HM Jr

更新日期：1990-11-01 00:00:00

abstract：OBJECTIVE:To compare the incidence of postoperative complications and opioid pain medication usage in gynecologic oncology patients who did and did not receive an epidural prior to undergoing exploratory laparotomy. METHODS:Retrospective cohort study of all patients undergoing exploratory laparotomy with the gynecolog...

journal_title：Gynecologic oncology

authors： Huepenbecker SP,Cusworth SE,Kuroki LM,Lu P,Samen CDK,Woolfolk C,Deterding R,Wan L,Helsten DL,Bottros M,Mutch DG,Powell MA,Massad LS,Thaker PH

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:Epidermal Growth Factor Receptor (EGF-R) up-regulation in cervical cancer cells leads to an increase in cell proliferative Insulin-like Growth Factor II (IGF-II) and Vascular Endothelial Growth Factor (VEGF) and a decrease of the anti-proliferative IGF-binding protein-3 (IGF-BP3). The objectives for this stu...

journal_title：Gynecologic oncology

authors： Mathur RS,Mathur SP

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:Our aim was to evaluate the feasibility of a novel technique using single-port laparoscopy for the complete surgical staging of endometrial cancer. METHODS:Total hysterectomy, bilateral salpingo-oophorectomy, pelvic lymphadenectomy and para-aortic lymphadenectomy was performed using a single-port device in t...

journal_title：Gynecologic oncology

authors： Zapardiel I,Moreno E,Piñera A,De Santiago J

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:The presence of metastases to regional lymph nodes (LN) is the single most important risk factor in endometrial cancer. Advances in molecular biology have provided more sensitive methods for detecting micrometastasis. This was a pilot study to determine whether cytokeratin staining of LN from endometrial canc...

journal_title：Gynecologic oncology

authors： Gonzalez Bosquet J,Keeney GL,Mariani A,Webb MJ,Cliby WA

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:The objective was to describe trends over time in key factors surrounding end-of-life care on a gynecologic oncology service at a tertiary cancer center. METHODS:Patients with gynecologic cancers who were hospitalized and died at our institution between 1992 and 1997 were identified using institutional datab...

journal_title：Gynecologic oncology

authors： Dalrymple JL,Levenback C,Wolf JK,Bodurka DC,Garcia M,Gershenson DM

更新日期：2002-05-01 00:00:00

abstract：:Fifty patients with cervical cancer were treated with radical hysterectomy and lymphadenectomy followed by postoperative radiation therapy for high risk factors (nodal metastases, lymphvascular space invasion, close or involved margins) at the University of Alabama at Birmingham Medical Center from 1969 to 1984. Fifte...

journal_title：Gynecologic oncology

authors： Barter JF,Soong SJ,Shingleton HM,Hatch KD,Orr JW Jr

更新日期：1989-03-01 00:00:00