Phase II study of vinorelbine in the treatment of platinum-resistant ovarian carcinoma.

abstract：:A 75-year-old Japanese woman, who had an enlarged uterus and two nodules on the anterior vaginal wall, underwent wide excision of the anterior vaginal wall, bilateral inguinal lymphadenectomy, modified radical hysterectomy, and pelvic lymph node dissection. Her serum level of 5-S-cysteinyldopa (5-S-CD) was elevated, b...

journal_title：Gynecologic oncology

authors： Suenaga Y,Katabuchi H,Okamura H,Kageshita T,Ono T

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVES:The efficacy and safety of bevacizumab and docetaxel were evaluated in women who developed recurrent epithelial ovarian, fallopian, or peritoneal cancer within 12 months of platinum-based therapy. METHODS:Patients received docetaxel (40 mg/m(2)) on days 1 and 8 and bevacizumab (15 mg/kg) on day 1 of a 21-da...

journal_title：Gynecologic oncology

authors： Wenham RM,Lapolla J,Lin HY,Apte SM,Lancaster JM,Judson PL,Gonzalez-Bosquet J,Herschberger A,Havrilesky LJ,Secord AA

更新日期：2013-07-01 00:00:00

abstract：INTRODUCTION:Focused ultrasound under real-time MR guidance and control (MRgFUS) can be used for the thermal ablation of tissue. Currently this technique is used clinically for the noninvasive treatment of uterine leiomyomas and is in clinical evaluation for breast cancer, adenomyosis and other indications. MRgFUS is b...

journal_title：Gynecologic oncology

authors： Machtinger R,Inbar Y,Ben-Baruch G,Korach J,Rabinovici J

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:Perform a systematic review to determine the test performance of HPV mRNA testing compared to DNA testing using CIN2+ as the target condition. METHODS:We searched bibliographic databases (MEDLINE, EMBASE and Cochrane Library) from January 1996 through August 2010 using a predefined search strategy. The refer...

journal_title：Gynecologic oncology

authors： Burger EA,Kornør H,Klemp M,Lauvrak V,Kristiansen IS

更新日期：2011-03-01 00:00:00

abstract：:Ernst Wertheim was a pioneer in the history of the surgical treatment of cervical cancer. His English-language manuscript "The extended abdominal operation for carcinoma uteri (based on 500 operative cases)," which was published in 1912, detailed his standardization of the radical hysterectomy and formed the basis of ...

journal_title：Gynecologic oncology

authors： Swailes AL,Gockley A,Phaëton R,Kesterson JP

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Survivorship and quality of life issues are becoming increasingly relevant in endometrial cancer as a result of the marked increase in incidence of the disease combined with excellent and improving long term survival. OBJECTIVE:The purpose of this study was to evaluate the effect of obesity on quality of li...

journal_title：Gynecologic oncology

authors： Smits A,Lopes A,Das N,Bekkers R,Galaal K

更新日期：2014-01-01 00:00:00

abstract：:The presence of oncogenic HPV DNAs (HPV-16/18) in cervical carcinomas and their normal and metastatic pelvic lymph nodes and the expression patterns of proliferating cell nuclear antigen (PCNA) in cervical carcinomas were retrospectively studied to elucidate the possible roles of them in malignant transformation and p...

journal_title：Gynecologic oncology

authors： Park JS,Rhyu KS,Kim CJ,Kim HS,Han KT,Ahn HK,Kim SJ,Namkoong SE

更新日期：1996-03-01 00:00:00

abstract：OBJECTIVES:To determine the impact of venous thromboembolism (VTE) during primary treatment of ovarian clear cell carcinoma (OCCC) on survival. METHODS:After Institutional Review Board approval, 74 cases of OCCC were retrieved from our pathology files. Clinical and pathological data were obtained by medical record and...

journal_title：Gynecologic oncology

authors： Diaz ES,Walts AE,Karlan BY,Walsh CS

更新日期：2013-12-01 00:00:00

abstract：:Roughly one-third of patients with ataxia-telangiectasia (AT) develop malignant tumors, usually of lymphoid origin. AT patients also exhibit progeric changes. We describe three patients, between the ages of 27 and 32 years, with uterine tumors: one with a frank leiomyosarcoma and chronic T-cell leukemia, one with a mu...

journal_title：Gynecologic oncology

authors： Gatti RA,Nieberg R,Boder E

更新日期：1989-02-01 00:00:00

abstract：OBJECTIVES:To clarify the anatomy necessary for the nerve sparing Okabayashi's radical hysterectomy, we meticulously separated the blood vessels and connective tissues to preserve the pelvic splanchnic nerve, the hypogastric nerve, and the bladder branch of the inferior hypogastric plexus under magnification (x2.5) dur...

journal_title：Gynecologic oncology

authors： Fujii S,Takakura K,Matsumura N,Higuchi T,Yura S,Mandai M,Baba T,Yoshioka S

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:To perform a phase I study of topically applied dihematoporphyrin ether (DHE) in the photodynamic treatment (PDT) of cervical intraepithelial neoplasia (CIN) using fixed DHE doses and application schedules, and a variable dose of 630 nm red light delivered by an argon-pumped dye laser. METHODS:Between Februa...

journal_title：Gynecologic oncology

authors： Monk BJ,Brewer C,VanNostrand K,Berns MW,McCullough JL,Tadir Y,Manetta A

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:This study investigated the expression of cellular apoptosis susceptibility protein (CAS) in serous ovarian carcinoma by immunohistochemistry and compared it with topoisomerase IIalpha (topo IIalpha), bcl-2, bcl-x, the frequency of apoptotic bodies (ABI), mitotic activity, and c-erbB-2 with regard to clinicop...

journal_title：Gynecologic oncology

authors： Brustmann H

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:The value of surgical staging of apparent early stage epithelial ovarian carcinoma (EOC) is unclear. The aim of this study was to evaluate the importance of surgical staging on the stage of disease and treatment plan. MATERIAL AND METHODS:All patients with apparent stage I EOC undergoing staging from 01/01/2...

journal_title：Gynecologic oncology

authors： Hengeveld EM,Zusterzeel PLM,Lajer H,Høgdall CK,Rosendahl M

更新日期：2019-08-01 00:00:00

abstract：:The altered expression of histocompatibility leukocyte antigens (HLA) in the development to cervical carcinoma suggests that tumor progression may be related to impaired recognition by host immune defense mechanisms. To investigate whether this phenomenon plays a role in the process of metastasis of cervical cancer, w...

journal_title：Gynecologic oncology

authors： Hilders CG,Munoz IM,Nooyen Y,Fleuren GJ

更新日期：1995-06-01 00:00:00

abstract：:Endocrine and clinicopathologic findings in a 77-year-old woman with ovarian mucinous adenofibroma of borderline malignancy are reported. The preoperative levels of testosterone, androstenedione, estrone, and estradiol in her peripheral blood were 91 ng/ml, 3.78 ng/ml, 82 pg/ml, and 35 pg/ml, respectively, abnormally ...

journal_title：Gynecologic oncology

authors： Tohya T,Mizutani H,Katabuchi H,Miyazaki K,Okamura H

更新日期：1994-08-01 00:00:00

abstract：:The Patient Protection and Affordable Care Act (ACA) was signed into law by President Barack Obama in 2010. While initial implementation of the law began shortly thereafter, the full implementation will take place over the next few years. With respect to cancer care, the act was intended to make care more accessible, ...

journal_title：Gynecologic oncology

authors： Duska LR,Engelhard CL

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:For many years, BRCA mutational status has only been considered as a predictor of ovarian cancer susceptibility and as a prognostic factor. Nonetheless, in the era of precision medicine, it has also become a predictive biomarker of response to platinum-based-chemotherapy and, more recently, to PARP-inhibitors...

journal_title：Gynecologic oncology

authors： Marchetti C,Minucci A,D'Indinosante M,Ergasti R,Arcieri M,Capoluongo ED,Pietragalla A,Caricato C,Scambia G,Fagotti A

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:Sialylation involving tumor formation and invasive behavior goes along with altered sialyltransferase (ST) activity. A potent ST inhibitor, soyasaponin I (SsaI), was discovered to selectively inhibit the cellular alpha2,3-sialyltranserase activity. In this study, we further test the effects of SsaI on modifyi...

journal_title：Gynecologic oncology

authors： Hsu CC,Lin TW,Chang WW,Wu CY,Lo WH,Wang PH,Tsai YC

更新日期：2005-02-01 00:00:00

abstract：:In a study designed to determine the merit of preserving ovarian function and childbearing capability in women with unilateral malignant ovarian tumors, the results of radical surgery (n = 86) and conservative surgery (n = 106) were compared. The mean length of survival was slightly but not significantly shorter follo...

journal_title：Gynecologic oncology

authors： Miyazaki T,Tomoda Y,Ohta M,Kano T,Mizuno K,Sakakibara K

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVE:Although there have been studies that focused on the correlation between the HPV presence of pelvic lymph nodes and pathological metastasis in patients with cervical cancer, the biologic role of HPV DNA in lymph nodes still remains uncertain. We performed this study to investigate the correlation between the ...

journal_title：Gynecologic oncology

authors： Lee YS,Rhim CC,Lee HN,Lee KH,Park JS,Namkoong SE

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:Chimeric antigen receptor (CAR)-T cell strategies ideally target a surface antigen that is exclusively and uniformly expressed by tumors; however, no such antigen is known for high-grade serous ovarian carcinoma (HGSC). A potential solution involves combinatorial antigen targeting with AND or OR logic-gating....

journal_title：Gynecologic oncology

authors： Banville AC,Wouters MCA,Oberg AL,Goergen KM,Maurer MJ,Milne K,Ashkani J,Field E,Ghesquiere C,Jones SJM,Block MS,Nelson BH

更新日期：2021-02-01 00:00:00

abstract：:A study was undertaken to determine the potential value of involucrin immunostaining, a protein synthesized by mature squamous epithelial cells, in distinguishing benign from neoplastic lesions in cervical pathology. A total of 146 cervical biopsies were analyzed using an indirect immunoperoxidase method and polyclona...

journal_title：Gynecologic oncology

authors： Serra V,Ramirez AA,Lara C,Marzo C,Castells A,Bonilla-Musoles F

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the urinary tract dysfunction following a radical hysterectomy and to compare the baseline urodynamical parameters of women who had uterine cervical carcinoma with women who had CIN 3. METHODS:A prospective case-control study was conducted to evaluate preoperative and postoperative urinary tract...

journal_title：Gynecologic oncology

authors： Chen GD,Lin LY,Wang PH,Lee HS

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Nicaragua has some of the highest rates of cervical cancer in Latin America and the world. In 2003, the Nicaraguan Ministry of Health, the Central American Institute of Health and the Maria Luisa Ortiz Clinic combined efforts to create an effective remote rural service network, with centralized quality-contr...

journal_title：Gynecologic oncology

authors： Howe SL,Vargas DE,Granada D,Smith JK

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVE:To identify patients with endometrial cancer at risk for hematogenous, lymphatic, or peritoneal recurrence (or combinations of them) who might potentially benefit from target-based therapies. METHODS:During a 13-year period, 915 patients had endometrial cancer managed with hysterectomy and standard adjuvant ...

journal_title：Gynecologic oncology

authors： Mariani A,Dowdy SC,Keeney GL,Long HJ,Lesnick TG,Podratz KC

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:A case of primary neuroblastoma arising from the broad ligament with excellent response to neoadjuvant bleomycin, etoposide, and cisplatin (BEP) is reported. CASE:A 48-year-old woman, G0, who presented with acute renal failure, an enlarged pelvic mass, and abdominal pain was diagnosed with adult neuroblasto...

journal_title：Gynecologic oncology

authors： Milam MR,Gabel SF,Milam RA,Liu J,Ramirez PT

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVES:Sonohysterography (SHG) has been proposed as a useful tool for the surveillance of the endometrium in patients receiving tamoxifen. This study aimed to assess the value of SHG in asymptomatic patients who would have been biopsy candidates because of abnormal transvaginal ultrasound (TVUS) results. METHODS:T...

journal_title：Gynecologic oncology

authors： Bertelli G,Valenzano M,Costantini S,Rissone R,Angiolini C,Signorini A,Gustavino C

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVES:To construct a tool, using computed tomography (CT) imaging and preoperative clinical variables, to estimate successful primary cytoreduction for advanced epithelial ovarian cancer (EOC). METHODS:Women who underwent primary cytoreductive surgery for stage IIIC/IV EOC at Mayo Clinic between 1/2/2003 and 12/3...

journal_title：Gynecologic oncology

authors： Janco JM,Glaser G,Kim B,McGree ME,Weaver AL,Cliby WA,Dowdy SC,Bakkum-Gamez JN

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVES:Surgical resection of enlarged cardiophrenic lymph nodes (CPLNs) in primary treatment of advanced ovarian cancer has not been widely studied. We report on a cohort of patients undergoing CPLN resection during primary cytoreductive surgery (CRS), examining its feasibility, safety, and potential impact on clin...

journal_title：Gynecologic oncology

authors： Cowan RA,Tseng J,Murthy V,Srivastava R,Long Roche KC,Zivanovic O,Gardner GJ,Chi DS,Park BJ,Sonoda Y

更新日期：2017-11-01 00:00:00

abstract：:Fourteen patients underwent surgical debulking of diaphragmatic metastases as part of cytoreductive surgery for advanced ovarian epithelial cancer from 1983 to 1984. The surgical technique is described. Morbidity from this approach was not excessive in this small series of patients. It is suggested that this technique...

journal_title：Gynecologic oncology

authors： Deppe G,Malviya VK,Boike G,Hampton A

更新日期：1986-06-01 00:00:00