Preoperative predictors of positive margins after loop electrosurgical excisional procedure-Cone.


OBJECTIVE:A LEEP-Cone may not be necessary for all patients with traditional cone indications. This study defines populations where a single pass technique with the LEEP is appropriate. METHODS:We retrospectively reviewed patients undergoing LEEP-Cone procedures performed at the University of Oklahoma Health Science Center from February of 1994 to July of 2002. Patients include those for LEEP-Cone with traditional excisional indications and those who underwent LEEP-Cone at the operating physician's discretion. Statistical analysis was used to compare preoperative factors with the resultant pathologic results. RESULTS:A total of 248 women underwent LEEP-Cone. 50.0% (33/66) of the patients with positive margins on the first pass had dysplasia or worse (CIN I-III or CA) in the second pass (top hat), compared to 6.6% (12/182) of the patients with a negative first pass (P < 0.0001). Univariate analysis found CIN III on histology and parity to be predictive of dysplasia in the top hat and two-step discrepancy to predict absence of dysplasia. On multivariate analysis, two-step discrepancy and parity remained predictive. Age >35 was the greatest percentile predictor of dysplasia in the top hat, and 91.5% of women <21 had normal top hat pathology. CONCLUSION:The retrospective data reported regarding LEEP-Cones reveal increased parity to predict dysplasia in the top hat and two-step discrepancy as a poor predictor of dysplasia in the top hat. Women under 21 years of age should have a single pass LEEP technique. The "top hat" is more appropriate as parity and age increase.


Gynecol Oncol


Gynecologic oncology


Tillmanns TD,Falkner CA,Engle DB,Wan JY,Mannel RS,Walker JL,Johnson GA,McMeekin DS,Zuna R,Gold MA




Has Abstract


2006-02-01 00:00:00














  • Rhabdomyosarcoma of the vagina in a postmenopausal woman: report of a case and review of the literature.

    abstract::Most rhabdomyosarcomas (RMSs) of the female genital tract occur in infants and young children as sarcoma botryoides. Vaginal RMS occurring in a postmenopausal woman is extremely rare. To our knowledge, only three vaginal RMSs have been reported in patients who were over 50 years of age. Herein, the first case in Taiwa...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Shy SW,Lee WH,Chen D,Ho SY

    更新日期:1995-09-01 00:00:00

  • Metastatic dermatofibrosarcoma protuberans of the vulva.

    abstract::Dermatofibrosarcoma protuberans (DFSP) of the vulva is a rare, low- to intermediate-grade sarcoma of dermal origin. This case report represents the 13th reported patient with vulvar DFSP and the first reported patient with metastatic vulvar DFSP. Although metastasis is rare, the possibility remains that the frequent r...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Soergel TM,Doering DL,O'connor D

    更新日期:1998-11-01 00:00:00

  • Expression and clinical role of long non-coding RNA in high-grade serous carcinoma.

    abstract:OBJECTIVE:To profile long non-coding RNA (lncRNA) expression at the various anatomic sites of high-grades serous carcinoma (HGSC) and in effusion-derived exosomes. METHODS:LncRNA profiling was performed on 60 HGSC specimens, including 10 ovarian tumors, 10 solid metastases and 10 malignant effusions, as well as exosom...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Filippov-Levy N,Cohen-Schussheim H,Tropé CG,Hetland Falkenthal TE,Smith Y,Davidson B,Reich R

    更新日期:2018-03-01 00:00:00

  • Placental site trophoblastic tumor: A study of 55 cases and review of the literature emphasizing factors of prognostic significance.

    abstract:OBJECTIVE:The placental site trophoblastic tumor is a rare form of gestational trophoblastic disease. Fifteen percent of reported cases have been fatal, but predicting behavior in individual patients has been challenging. METHODS:The clinical, gross and histopathological features of 55 cases and 180 cases in the liter...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Baergen RN,Rutgers JL,Young RH,Osann K,Scully RE

    更新日期:2006-03-01 00:00:00

  • Outcome of endometrial carcinoma patients with involvement of the uterine serosa.

    abstract:OBJECTIVE:The goal of this work was to evaluate the outcome of endometrial carcinoma patients undergoing primary surgery who have serosal involvement (SI). METHODS:Between 1980 and 1998, 562 women underwent primary surgery for endometrial cancer at the University of Chicago. Thirty-nine were noted to have SI. FIGO sta...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Ashman JB,Connell PP,Yamada D,Rotmensch J,Waggoner SE,Mundt AJ

    更新日期:2001-08-01 00:00:00

  • Types of pelvic exenterations: a reappraisal.

    abstract::Subgrouping of pelvic exenterations as supralevator (type I), infralevator (type II), with vulvectomy (type III), and, an added category, extended can be helpful to facilitate communication when referring to these patients. It also can facilitate a more detailed analysis of operative risk factors, complications, and r...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Magrina JF

    更新日期:1990-06-01 00:00:00

  • Novel techniques to improve split-thickness skin graft viability during vulvo-vaginal reconstruction.

    abstract:BACKGROUND:Split-thickness skin grafts are often utilized for vulvo-vaginal reconstruction. Unfortunately, infection and sloughing may occur in up to 22% of patients with standard techniques especially at irradiated recipient sites. CASES:We report seven cases of vulvo-vaginal reconstruction using split-thickness skin...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Dainty LA,Bosco JJ,McBroom JW,Winter WE 3rd,Rose GS,Elkas JC

    更新日期:2005-06-01 00:00:00

  • Polymorphisms of interleukin (IL)-1alpha, IL-1beta, IL-6, IL-10, and IL-18 and the risk of ovarian cancer.

    abstract:OBJECTIVE:Recent studies of ovarian cancer have suggested a role for inflammation in carcinogenesis. Data from a population-based case-control study in Hawaii were examined to assess the relation between polymorphisms in cytokines involved with the inflammatory response, specifically members of the interleukin (IL) fam...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Bushley AW,Ferrell R,McDuffie K,Terada KY,Carney ME,Thompson PJ,Wilkens LR,Tung KH,Ness RB,Goodman MT

    更新日期:2004-12-01 00:00:00

  • A phase 2 study of alisertib (MLN8237) in recurrent or persistent uterine leiomyosarcoma: An NRG Oncology/Gynecologic Oncology Group study 0231D.

    abstract:OBJECTIVE:This two-stage Phase II study assessed the activity of single agent alisertib in patients with recurrent/persistent uterine leiomyosarcoma (uLMS). METHODS:Eligibility criteria included histologically-confirmed, recurrent or persistent uLMS, age≥18, 1-2 prior cytotoxic regimens, and RECIST version 1.1 measura...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Hyman DM,Sill MW,Lankes HA,Piekarz R,Shahin MS,Ridgway MR,Backes F,Tenney ME,Mathews CA,Hoffman JS,Aghajanian C,Hensley ML

    更新日期:2017-01-01 00:00:00

  • Fallopian tube abnormalities in uterine serous carcinoma.

    abstract:OBJECTIVE:Uterine serous carcinoma (USC) is presumed to arise from endometrial intra-epithelial carcinoma (EIC), whereas tubo-ovarian high-grade serous carcinomas have similar precursor lesions in the Fallopian tube, i.e. serous tubal intra-epithelial carcinoma (STIC). The presence of Fallopian tube abnormalities and t...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Steenbeek MP,Bulten J,Snijders MPLM,Lombaers M,Hendriks J,van den Brand M,Kraayenbrink AA,Massuger LFAG,Sweegers S,de Hullu JA,Pijnenborg JMA,Küsters-Vandevelde HVN,Reijnen C

    更新日期:2020-08-01 00:00:00

  • Chemotherapy toxicity in gynecologic cancer patients with a body surface area (BSA)>2 m2.

    abstract:OBJECTIVES:Although many clinicians practice empiric dose reduction to prevent toxicity, it is unknown whether obese patients given chemotherapy dosed according to actual body weight (ABW) experience excess toxicity. At our institution, cancer patients receive chemotherapy dosed by ABW unless on a protocol capping dose...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Schwartz J,Toste B,Dizon DS

    更新日期:2009-07-01 00:00:00

  • The prognostic and therapeutic implications of cytologic atypia in patients with endometrial hyperplasia.

    abstract::From 1970 to 1992, 136 patients with a histologic diagnosis of endometrial hyperplasia underwent total abdominal hysterectomy at the University of Kentucky Medical Center. Slides of the curettage or biopsy specimens were reviewed and classified according to the International Society of Gynecologic Pathologists System ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Hunter JE,Tritz DE,Howell MG,DePriest PD,Gallion HH,Andrews SJ,Buckley SB,Kryscio RJ,van Nagell JR Jr

    更新日期:1994-10-01 00:00:00

  • The morbidity and utility of periaortic radiotherapy in cervical carcinoma.

    abstract::From 1971 through 1981, 81 women received 4350 to 5075 rad to the periaortic lymph nodes as part of their primary management for carcinoma of the uterine cervix. While two patients developed chronic small bowel damage, only one required surgical intervention. Five-year disease-free survival was 40%. Approximately one-...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Potish R,Adcock L,Jones T Jr,Levitt S,Prem K,Savage J,Twiggs L

    更新日期:1983-02-01 00:00:00

  • Advanced cytoreductive surgery: Asia Pacific perspective.

    abstract::The thoroughness of cytoreductive surgery is the largest contributor to survival for patients with advanced ovarian and primary peritoneal carcinoma. For many years the surgery undertaken by Gynaecologic Oncologists has been tailored to match their surgical training. Future surgical training of Gynaecologic Oncologist...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Crandon AJ,Obermair A

    更新日期:2009-08-01 00:00:00

  • The significance of peritoneal cytology in patients with carcinoma of the cervix.

    abstract::Between 1972 and 1977, 141 patients with benign gynecologic disease and 149 patients with carcinoma of the cervix were evaluated with peritoneal fluid cytology at time of celiotomy. There was no positive cytology (malignant cells) in the benign disease group. The overall incidence of positive peritoneal cytology in th...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Abu-Ghazaleh S,Johnston W,Creasman WT

    更新日期:1984-02-01 00:00:00

  • HER2/neu gene amplification determines the sensitivity of uterine serous carcinoma cell lines to AZD8055, a novel dual mTORC1/2 inhibitor.

    abstract:OBJECTIVE:To evaluate c-erbB2 gene amplification in a series of primary uterine serous carcinoma (USC) cell lines. To assess the efficacy of AZD8055, a novel dual mTORC1/2 inhibitor against primary HER2/neu amplified vs HER2/neu not amplified USC cell lines. METHODS:Twenty-two primary USC cell lines were evaluated for...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: English DP,Roque DM,Carrara L,Lopez S,Bellone S,Cocco E,Bortolomai I,Schwartz PE,Rutherford T,Santin AD

    更新日期:2013-12-01 00:00:00

  • "MECCA": a developmental, dose-intensive, non-cross-resistant platinum-based chemotherapy for advanced ovarian cancer.

    abstract::Twenty-nine women, ages 30-58 years, with advanced ovarian carcinoma were treated with a developmental combination chemotherapy regimen consisting of mitomycin C, etoposide, cisplatin, and carboplatin (MECCA). This protocol utilized the concepts of dose intensity, front-end loading, non-cross-resistance, and synergy. ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Hoskins PJ,Swenerton KD,Pike JA,McMurtrie EM,Lee N

    更新日期:1996-12-01 00:00:00

  • Human papilloma virus, vulvar dystrophy, and vulvar carcinoma: differential expression of human papillomavirus and vulvar dystrophy in the presence and absence of squamous cell carcinoma of the vulva.

    abstract::In situ hybridization (ISH) and polymerase chain reaction (PCR) for several common HPV types were performed on 41 cases of vulvar dystrophy, 19 of which were associated with previous or simultaneous invasive squamous cell carcinoma of the vulva. Three of the 19 cases (16%) of dystrophy associated with cancer were foun...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Sagerman PM,Choi YJ,Hu Y,Niedt GW

    更新日期:1996-06-01 00:00:00

  • Ovarian intraepithelial neoplasia demonstrated in patients with stage I ovarian carcinoma.

    abstract::Retrospective review of sections of ovary from 50 patients with stage I, grade 1-3, epithelial ovarian carcinoma was performed to assess presence of cellular and nuclear atypia in noncancerous tissue adjacent to the primary tumor; ovarian tissue from 50 patients undergoing incidental oophorectomy was reviewed as well....

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Plaxe SC,Deligdisch L,Dottino PR,Cohen CJ

    更新日期:1990-09-01 00:00:00

  • The prognostic significance of peritoneal seeding and size of postsurgical residual in patients with stage III epithelial ovarian cancer treated with surgery, chemotherapy, and high-dose radiotherapy.

    abstract:OBJECTIVE:The aim of this study was to retrospectively analyze the prognostic importance of age, histologic type and grade, ascites, lymph node status, size and type of postoperative residual disease, and radiation dose on disease-specific (DSS) and progression-free survival (PFS) in stage III epithelial ovarian cancer...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kapp KS,Kapp DS,Poschauko J,Stücklschweiger GF,Hackl A,Pickel H,Petru E,Winter R

    更新日期:1999-09-01 00:00:00

  • Oncologic outcome of fertility-sparing radical trachelectomy versus radical hysterectomy for stage IB1 cervical carcinoma.

    abstract:OBJECTIVE:To compare the oncologic outcomes of women who underwent a fertility-sparing radical trachelectomy (RT) to those who underwent a radical hysterectomy (RH) for stage IB1 cervical carcinoma. METHODS:We performed a case-control study of all patients with stage IB1 cervical carcinoma who underwent a vaginal or a...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Diaz JP,Sonoda Y,Leitao MM,Zivanovic O,Brown CL,Chi DS,Barakat RR,Abu-Rustum NR

    更新日期:2008-11-01 00:00:00

  • Phase II trial of CI-958 in recurrent platinum-refractory ovarian carcinoma. A Gynecologic Oncology Group Study.

    abstract:OBJECTIVES:The objectives of this study were twofold: (1) to estimate the anti-tumor efficacy of CI-958 in patients with measurable platinum-resistant ovarian cancer; (2) to determine the nature and degree of toxicity of CI-958 in these patients. METHODS:Patients received CI-958 560 mg/m(2) intravenously every 3 weeks...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Hoffman MA,Blessing JA,Morgan M

    更新日期:2000-12-01 00:00:00

  • HPV vaccination against cervical cancer in women above 25 years of age: key considerations and current perspectives.

    abstract:OBJECTIVE:Vaccination of young women (15-25 years of age) against human papillomavirus (HPV) has been shown to be very efficacious in preventing the development of moderate or severe cervical precancerous lesions associated with HPV-16 or -18. As the highest rates of new infections with high-risk (i.e., oncogenic) HPV ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Castellsagué X,Schneider A,Kaufmann AM,Bosch FX

    更新日期:2009-12-01 00:00:00

  • Overexpression of gelsolin in human cervical carcinoma and its clinicopathological significance.

    abstract:OBJECTIVES:Cervical carcinoma is the second most common cause of death from gynecological cancers worldwide. Knowledge of the molecular mechanisms underlying the tumorigenesis of cervical cancer cell, except human papilloma virus infection, is limited. METHODS:A microarray was used to study the differential expression...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Liao CJ,Wu TI,Huang YH,Chang TC,Wang CS,Tsai MM,Hsu CY,Tsai MH,Lai CH,Lin KH

    更新日期:2011-01-01 00:00:00

  • Uterine papillary serous carcinoma (UPSC): a clinicopathologic study of 30 cases.

    abstract::Between 1975 and 1989, 896 patients were treated for endometrial carcinoma at the Massachusetts General Hospital. Thirty patients were identified from the tumor registry as having uterine papillary serous carcinomas. The survival for all patients and for groups of patients stratified on clinical and pathological param...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kato DT,Ferry JA,Goodman A,Sullinger J,Scully RE,Goff BA,Fuller AF Jr,Rice LW

    更新日期:1995-12-01 00:00:00

  • Treatment of cervical intraepithelial neoplasia with the carbon dioxide laser.

    abstract::Between 1978 and 1983, one hundred and forty-six patients with CIN I-III were treated with the carbon dioxide laser and 129 have been followed for 6 to 58 months. The remission rate was 92.2% after one treatment and 98.4% after two treatments. All persistent lesions were detected within 8 weeks after treatment. After ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Tsukamoto N

    更新日期:1985-07-01 00:00:00

  • GRP78 induced by estrogen plays a role in the chemosensitivity of endometrial cancer.

    abstract:OBJECTIVE:Molecular chaperone 78 kDa glucose-regulated protein (GRP78) is a residential protein in the endoplasmic reticulum (ER) that is induced by an unfolded-protein response triggered under many kinds of stress against a cell. GRP78 is also known to act as an anti-apoptotic factor by protecting ER-stress-induced ce...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Luvsandagva B,Nakamura K,Kitahara Y,Aoki H,Murata T,Ikeda S,Minegishi T

    更新日期:2012-07-01 00:00:00

  • Ovarian preservation during the surgical treatment of early stage endometrial cancer: a nation-wide study conducted by the Korean Gynecologic Oncology Group.

    abstract:OBJECTIVES:The objective of this study was to determine whether ovarian preservation is feasible in younger endometrial cancer patients. METHODS:Endometrial cancer patients who underwent ovary-saving surgery were recruited from the tumor registries of 14 tertiary hospitals under the influence of the Korean Gynecologic...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Lee TS,Kim JW,Kim TJ,Cho CH,Ryu SY,Ryu HS,Kim BG,Lee KH,Kim YM,Kang SB,Korean Gynecologic Oncology Group.

    更新日期:2009-10-01 00:00:00

  • Association between high risk papillomavirus DNA and nitric oxide release in the human uterine cervix.

    abstract:OBJECTIVE:Local cervical factors may determine the outcome of human papillomavirus (HPV) infection. Nitric oxide (NO) may be one such factor, since it is produced by uterine cervical cells and it takes part in both immunological and carcinogenic reactions. We studied the association between the presence of cervical hig...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Rahkola P,Mikkola TS,Ylikorkala O,Vaisanen-Tommiska M

    更新日期:2009-08-01 00:00:00

  • Costs of treatment and outcomes associated with second-line therapy and greater for relapsed ovarian cancer.

    abstract:OBJECTIVES:Most women with epithelial ovarian cancer (EOC) will develop disease progression or recurrence with resistance to platinum therapy. We report overall costs and treatment outcomes associated with topotecan or gemcitabine administration in platinum- and paclitaxel-resistant EOC patients. METHODS:Patients who ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Prasad M,Ben-Porat L,Hoppe B,Aghajanian C,Sabbatini P,Chi DS,Hensley ML

    更新日期:2004-04-01 00:00:00