Sorafenib in combination with weekly topotecan in recurrent ovarian cancer, a phase I/II study of the Hoosier Oncology Group.

abstract：OBJECTIVE:We evaluated the activity and safety of the combination of topotecan, cisplatin and bevacizumab in patients with recurrent or persistent carcinoma of the cervix. METHODS:Eligible patients had persistent or recurrent cervical cancer not amenable to curative intent treatment. No prior chemotherapy for recurren...

journal_title：Gynecologic oncology

authors： Zighelboim I,Wright JD,Gao F,Case AS,Massad LS,Mutch DG,Powell MA,Thaker PH,Eisenhauer EL,Cohn DE,Valea FA,Alvarez Secord A,Lippmann LT,Dehdashti F,Rader JS

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:Oncolytic adenoviruses capable of replication selectively in tumor cells are an appealing approach for the treatment of neoplastic diseases refractory to conventional therapies. The aim of this study was to evaluate the effect of dose and scheduling of a tropism-modified, adenovirus serotype 3 receptor-target...

journal_title：Gynecologic oncology

authors： Raki M,Särkioja M,Desmond RA,Chen DT,Bützow R,Hemminki A,Kanerva A

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the utility of combined positron emission tomography/computed tomography (PET/CT) for detecting recurrent epithelial ovarian cancer limited to retroperitoneal adenopathy. METHODS:Fourteen patients (median age = 53 years) with rising serum CA125 levels, and negative or equivocal conventional CT im...

journal_title：Gynecologic oncology

authors： Bristow RE,Giuntoli RL 2nd,Pannu HK,Schulick RD,Fishman EK,Wahl RL

更新日期：2005-11-01 00:00:00

abstract：:A 46-year-old women presented with an inoperable low-grade endometrial stromal sarcoma. Two doses of Depo-Lupron, 7.5 mg, and Megace, 160 mg/day, were given to control uterine bleeding and shrink the tumor mass. In 9 weeks, significant reduction in the tumor occurred allowing for surgical resection. Total abdominal hy...

journal_title：Gynecologic oncology

authors： Scribner DR Jr,Walker JL

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:Patients with recurrent ovarian cancer were treated intraperitoneally (ip) with a replication-deficient recombinant adenovirus (ADV) containing the herpes simplex virus thymidine kinase gene. Vector delivery was followed by intravenous administration of an antiherpetic prodrug and a topoisomerase I inhibitor....

journal_title：Gynecologic oncology

authors： Hasenburg A,Tong XW,Fischer DC,Rojas-Martinez A,Nyberg-Hoffman C,Kaplan AL,Kaufman RH,Ramzy I,Aguilar-Cordova E,Kieback DG

更新日期：2001-12-01 00:00:00

abstract：OBJECTIVE:Minority and low-income cancer patients are underrepresented in clinical trials, contributing to diminished access to state-of-the-art care and disparities in cancer outcomes including survivorship issues. In cervical cancer, there is a disproportionate disease burden among minority and underserved women and ...

journal_title：Gynecologic oncology

authors： Osann K,Wenzel L,Dogan A,Hsieh S,Chase DM,Sappington S,Monk BJ,Nelson EL

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:Endometrioid endometrial carcinoma is caused by a combination of mutational events and hormonal factors. We used large-scale messenger RNA expression analysis to discover genes that distinguish neoplastic transformation and examine the patterns of tumor expression of those genes which are normally regulated d...

journal_title：Gynecologic oncology

authors： Mutter GL,Baak JP,Fitzgerald JT,Gray R,Neuberg D,Kust GA,Gentleman R,Gullans SR,Wei LJ,Wilcox M

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:Gastric-type mucinous carcinoma (GAS) is a novel variant of mucinous carcinoma of the uterine cervix. As shown in the original Japanese group description, in recent studies, GAS represents a more aggressive disease than the usual-type endocervical adenocarcinoma (UEA). Detailed clinicopathological features of...

journal_title：Gynecologic oncology

authors： Nishio S,Mikami Y,Tokunaga H,Yaegashi N,Satoh T,Saito M,Okamoto A,Kasamatsu T,Miyamoto T,Shiozawa T,Yoshioka Y,Mandai M,Kojima A,Takehara K,Kaneki E,Kobayashi H,Kaku T,Ushijima K,Kamura T

更新日期：2019-04-01 00:00:00

abstract：:Techniques for sentinel lymph node injections have varied over the years in both cervical and uterine malignancy lymph node mapping. There remains considerable variation in techniques, particularly for uterine malignancies. This review summarizes some of the techniques that have been published and are currently utiliz...

journal_title：Gynecologic oncology

authors： Abu-Rustum NR,Khoury-Collado F,Gemignani ML

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVES:To report the intermediate-term results of trans-abdominal ultrasound (TAUS)-guided brachytherapy in cervical cancer. MATERIALS AND METHODS:Ninety-two patients with cervical cancer (stage IB-IVA, according to FIGO staging), were treated by curative radiotherapy from February 2012 to June 2015. All patients ...

journal_title：Gynecologic oncology

authors： Tharavichitkul E,Chakrabandhu S,Klunklin P,Onchan W,Jia-Mahasap B,Wanwilairat S,Tippanya D,Jayasvasti R,Sripan P,Galalae RM,Chitapanarux I

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:Tenascin is an extracellular matrix glycoprotein, relevant for embryonal and fetal development, which is reexpressed in the stroma of benign and malignant tumors. Little is known about the molecular interaction of tenascin during neoplastic transformation and tumor progression in cervical cancer. METHOD:We s...

journal_title：Gynecologic oncology

authors： Pilch H,Schäffer U,Schlenger K,Lautz A,Tanner B,Höckel M,Knapstein PG

更新日期：1999-06-01 00:00:00

abstract：OBJECTIVE:Preoperative identification of cervical stromal invasion in endometrial carcinoma is important to select patients for primary radical hysterectomy. The objective of this prospective implementation study was to assess if introduction of magnetic resonance imaging (MRI) in addition to the standardly applied end...

journal_title：Gynecologic oncology

authors： Haldorsen IS,Berg A,Werner HM,Magnussen IJ,Helland H,Salvesen OO,Trovik J,Salvesen HB

更新日期：2012-09-01 00:00:00

abstract：:A number of chemical agents have been found to influence the proliferation, morphology, enzymatic activity, and antigen expression of neoplastic cells toward a more differentiated phenotype. We studied the effects of differentiating agents retinoic acid, sodium butyrate, and dibutyryl cyclic AMP on the expression of t...

journal_title：Gynecologic oncology

authors： Brooks SE,Timmerman J,Lau CC,Tsao SW,Knapp RC,Sheets EE

更新日期：1991-09-01 00:00:00

abstract：PURPOSE:A phase II trial was conducted to evaluate the anti-tumor activity and adverse effects of capecitabine in women with measurable platinum-sensitive ovarian cancer or platinum-sensitive primary peritoneal cancer and to explore the ability of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), and th...

journal_title：Gynecologic oncology

authors： Garcia AA,Blessing JA,Lenz HJ,Darcy KM,Mannel RS,Miller DS,Husseinzadeh N,Gynecologic Oncology Group.

更新日期：2005-03-01 00:00:00

abstract：:The treatment of early vulvar carcinoma has moved toward less radical surgery with reconstruction. This report describes our preliminary experience with a mons pubis flap that is simple and appears safe, reliable, and gives excellent cosmetic and functional results following radical hemivulvectomy. Four patients have ...

journal_title：Gynecologic oncology

authors： Potkul RK,Barnes WA,Barter JF,Delgado G,Spear SL

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVES:Fractal geometry is a tool used to characterize irregularly shaped and complex figures. It can be used not only to generate biological structures (e.g., the human renal artery tree), but also to derive parameters such as the fractal dimension in order to quantify the shapes of structures. As such, it allows ...

journal_title：Gynecologic oncology

authors： Sedivy R,Windischberger C,Svozil K,Moser E,Breitenecker G

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Sertoli-Leydig cell tumors (SLCT) constitute only 0.5% of all primary ovarian neoplasms. We report a unique diagnostic method (selective laparoscopic venous sampling) and a rare case of a contralateral second primary tumor. CASE:A 14-year-old female presented with hyperandrogenic complaints and an increased...

journal_title：Gynecologic oncology

authors： White LC,Buchanan KD,O'Leary TD,Carlan SJ,Boothby R

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:Some authors have recommended the use of diagnostic laparoscopy as a pretreatment assessment step for conservative hormonal treatment in young women with endometrial cancer. The aim of this study was to determine the incidence of synchronous primary cancer of the endometrium and ovary in young women. METHODS...

journal_title：Gynecologic oncology

authors： Song T,Seong SJ,Bae DS,Suh DH,Kim DY,Lee KH,Lim MC,Lee TS

更新日期：2013-12-01 00:00:00

abstract：:Between 1964 and 1980, 1878 patients were considered for radiotherapy at the Western Infirmary, Glasgow, of whom 1673 (91.8%) had squamous tumors and 120 (6.6%) adenocarcinomas. Of these, 1505 squamous carcinomas (92.5%) and 95 (5.8%) adenocarcinomas were treated by radical radiotherapy. The treatment given to either ...

journal_title：Gynecologic oncology

authors： Davidson SE,Symonds RP,Lamont D,Watson ER

更新日期：1989-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of margin status and radiation dose in patients treated with radiation therapy (RT) for vulvar cancer. Clinical outcomes included vulvar recurrence (VR), relapse-free survival (RFS) and overall survival (OS). METHODS:We retrospectively reviewed the records of 300 patients with Stage I-...

journal_title：Gynecologic oncology

authors： Viswanathan AN,Pinto AP,Schultz D,Berkowitz R,Crum CP

更新日期：2013-09-01 00:00:00

abstract：:It is very rare to find endometrial cancers arising within a short period following childbirth, presumably because pregnancy has a protective effect against endometrial cancer mediated by elevated secretion of progesterone. We present the case of a 30-year-old Japanese woman with stage IIIC endometrial cancer that was...

journal_title：Gynecologic oncology

authors： Kodama J,Yoshinouchi M,Miyagi Y,Kobashi Y,Kamimura S,Okuda H,Kudo T

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:To test if TP53 hot spot mutations (HSMs) confer differential chemotherapy resistance or survival outcomes, the effects of microtubule stabilizers on human ovarian carcinoma cells (OCCs) expressing TP53 HSMs were studied in vitro. Survival outcomes of patients with high grade serous epithelial ovarian carcino...

journal_title：Gynecologic oncology

authors： Seagle BL,Yang CP,Eng KH,Dandapani M,Odunsi-Akanji O,Goldberg GL,Odunsi K,Horwitz SB,Shahabi S

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:Different Human Papilloma Virus (HPV) tests are currently used. An integrated comparison of the Amplicor, Cobas4800, PreTect HPV-Proofer and APTIMA HPV tests has not been done. METHODS:We compared the high-risk HPV detection power of these HPV tests in 528 consecutive population-based follow-up Liquid-Based ...

journal_title：Gynecologic oncology

authors： Ovestad IT,Vennestrøm U,Andersen L,Gudlaugsson E,Munk AC,Malpica A,Feng W,Voorhorst F,Janssen EA,Baak JP

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to evaluate the histological outcome of laser ring biopsies in patients with one or more smears showing cytological mild dyskaryosis where punch biopsies were not performed. The possibilities of predicting histological findings of CIN 2 and CIN 3 were analyzed. METHODS:The study com...

journal_title：Gynecologic oncology

authors： Risberg B,Andersson A,Lie KA,Nordin B,Zetterberg C

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVES:To evaluate recurrence-free survival (RFS) and overall survival (OS) for patients who underwent robotic-assisted laparoscopic hysterectomy (RALH) for uterine malignancies. METHODS:Medical records from 372 patients with uterine malignancies who underwent RALH from 3/06 to 3/09 at two institutions were review...

journal_title：Gynecologic oncology

authors： Brudie LA,Backes FJ,Ahmad S,Zhu X,Finkler NJ,Bigsby GE 4th,Cohn DE,O'Malley D,Fowler JM,Holloway RW

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVE:The purpose was to explore whether health education on symptoms of ovarian cancer would aid in early detection, by examining the relationship between symptoms, coping strategies, and timing of presentation in patients with newly diagnosed ovarian cancer. METHODS:Eighty women were included. A questionnaire co...

journal_title：Gynecologic oncology

authors： Chan YM,Ng TY,Lee PW,Ngan HY,Wong LC

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVES:Mature cystic teratoma of the ovary transforms into malignant tumors, mostly squamous cell carcinomas, at an incidence of approximately 2%. Preoperative diagnosis of squamous cell carcinoma arising in mature cystic teratoma of the ovary is a difficult task. The present study aims to assess whether combined u...

journal_title：Gynecologic oncology

authors： Suzuki M,Tamura N,Kobayashi H,Ohwada M,Terao T,Sato I

更新日期：2000-06-01 00:00:00

abstract：:The aim of the present study was to compare the diagnostic accuracy of transvaginal sonography, color flow imaging, and serum CA 125 assay in pre- and postmenopausal women undergoing laparotomy for a clinical diagnosis of an adnexal mass. In 109 consecutive women, the morphology of the mass was evaluated with transvag...

journal_title：Gynecologic oncology

authors： Strigini FA,Gadducci A,Del Bravo B,Ferdeghini M,Genazzani AR

更新日期：1996-04-01 00:00:00

abstract：:From September 1986 to November 1988, 38 patients with previously untreated ovarian cancer, FIGO stages III and IV, were allocated to a study testing the efficacy of high-dose platinum delivered as combined carboplatin and cisplatin. The regimen was as follows: Day 1, 250-350 mg/m2 carboplatin and 500 mg/m2 cyclophosp...

journal_title：Gynecologic oncology

authors： Bertelsen K,Bastholt L

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVES:The goal of this case review was to evaluate the influence of complete surgical versus clinical staging, including the impact of ovarian preservation, on the outcome of young patients with endometrial carcinoma. METHODS:A retrospective chart review was performed on all patients with endometrial cancer diagn...

journal_title：Gynecologic oncology

authors： Richter CE,Qian B,Martel M,Yu H,Azodi M,Rutherford TJ,Schwartz PE

更新日期：2009-07-01 00:00:00