Low-grade endometrial stromal sarcoma preoperative treatment with Depo-Lupron and Megace.

Abstract:

:A 46-year-old women presented with an inoperable low-grade endometrial stromal sarcoma. Two doses of Depo-Lupron, 7.5 mg, and Megace, 160 mg/day, were given to control uterine bleeding and shrink the tumor mass. In 9 weeks, significant reduction in the tumor occurred allowing for surgical resection. Total abdominal hysterectomy with bilateral salpingo-oophorectomy is the mainstay for primary treatment. The role of chemotherapy, radiation therapy, and hormonal therapy is poorly defined. This is a case report of neoadjuvant hormonal therapy which may improve outcomes in patients with endometrial stromal sarcomas. Additional research is needed to define the exact role of these agents.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Scribner DR Jr,Walker JL

doi

10.1006/gyno.1998.5174

subject

Has Abstract

pub_date

1998-12-01 00:00:00

pages

458-60

issue

3

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(98)95174-5

journal_volume

71

pub_type

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