A pilot randomized control trial to evaluate pelvic floor muscle training for urinary incontinence among gynecologic cancer survivors.


OBJECTIVES:We previously reported high rates of urinary incontinence among gynecologic cancer survivors and aimed to evaluate the effectiveness of a simple intervention for treatment of urinary incontinence in this population. METHODS:We recruited 40 gynecologic cancer survivors who reported urinary incontinence on a validated questionnaire. Women were randomized to either pelvic floor muscle training/behavioral therapy (treatment group) or usual care (control group). The primary outcome measure, assessed at 12 weeks post intervention, was a 40% difference in the validated Patient Global Impression of Improvement (PGI-I) score. Fisher's exact test was used to identify differences between groups for frequency data; two-sample t-test was conducted for continuous measurements. RESULTS:Mean age of this cohort was 57 (range: 37-79). The majority of the survivors had uterine cancer (60%), 18% had received radiation therapy, 95% had received surgical therapy, and 35% had received chemotherapy. At three months, 80% of the treatment and 40% of the control group reported that their urinary incontinence was "much better" or "very much better" as evaluated by the Patient Global Impression of Improvement scale (p=0.02). Brink's scores were significantly improved in the treatment group as compared to those of the controls (p<0.0001). Treatment group adherence was high; the treatment group performed exercises with an average of 22 days/month. CONCLUSIONS:Urinary incontinence negatively affects quality of life, and despite a high prevalence among gynecologic cancer survivors, it is often under-assessed and undertreated. We found a simple intervention that included pelvic floor muscle training and behavioral therapy, which significantly improved cancer survivor's urinary incontinence.


Gynecol Oncol


Gynecologic oncology


Rutledge TL,Rogers R,Lee SJ,Muller CY




Has Abstract


2014-01-01 00:00:00














  • The malignant potential of small cystic ovarian tumors in women over 50 years of age.

    abstract:OBJECTIVE:The aim of this study was to determine the risk of malignancy in cystic ovarian tumors < 10 cm in diameter in asymptomatic postmenopausal women or women >or =50 years of age. METHODS:All cystic ovarian tumors detected by transvaginal sonography screening in asymptomatic postmenopausal women or women > or =50...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Bailey CL,Ueland FR,Land GL,DePriest PD,Gallion HH,Kryscio RJ,van Nagell JR Jr

    更新日期:1998-04-01 00:00:00

  • Patient reported outcome measures among patients with vulvar cancer at various stages of treatment, recurrence, and survivorship.

    abstract:OBJECTIVE:Our goal was to pragmatically describe patient reported outcomes (PROs) in a typical clinic population of vulvar cancer patients, as prior studies of vulvar cancer PROs have examined clinical trial participants. METHODS:A prospective PRO program was implemented in the Gynecologic Oncology clinic of a tertiar...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Alimena S,Sullivan MW,Philp L,Dorney K,Hubbell H,Del Carmen MG,Goodman A,Bregar A,Growdon WB,Eisenhauer EL,Sisodia RC

    更新日期:2021-01-01 00:00:00

  • The centralization of robotic surgery in high-volume centers for endometrial cancer patients--a study of 6560 cases in the U.S.

    abstract:OBJECTIVE:To evaluate the hospital and patient factors associated with robotic surgery for endometrial cancer in the United States. METHODS:Data was obtained from the Nationwide Inpatient Sample from the year 2010. Chi-squared and multivariate analyses were used for statistical analysis. RESULTS:Of the 6560 endometri...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Chan JK,Gardner AB,Taylor K,Blansit K,Thompson CA,Brooks R,Yu X,Kapp DS

    更新日期:2015-07-01 00:00:00

  • An international assessment of ovarian cancer incidence and mortality.

    abstract:OBJECTIVE:To assess and characterize the temporal variation in ovarian cancer incidence and mortality by age within countries in the Americas, Europe, Asia, and Oceania. METHODS/MATERIALS:Data from the National Cancer Institute's Surveillance, Epidemiology, and End Results Program in the United States (U.S.) were used...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Lowe KA,Chia VM,Taylor A,O'Malley C,Kelsh M,Mohamed M,Mowat FS,Goff B

    更新日期:2013-07-01 00:00:00

  • Survival disparities in vulvar cancer patients in Commission on Cancer®-accredited facilities.

    abstract:OBJECTIVES:To investigate survival disparities and prognostic factors in vulvar cancer by age at diagnosis. METHODS:Women who underwent surgery and were diagnosed with stage I-IV vulvar cancer from 2004 to 2014 in the National Cancer Database were eligible. Proportions were compared using Chi-Square test. Survival was...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Gaulin NB,Lesnock JL,Tian C,Osei-Bonsu K,Jacobs A,Richard SD,Krivak TC,Miller EM,Shriver CD,Casablanca Y,Maxwell GL,Darcy KM

    更新日期:2020-04-01 00:00:00

  • Aberrant expression and mutations of TGF-beta receptor type II gene in endometrial cancer.

    abstract:OBJECTIVE:Transforming growth factor beta (TGF-beta) is a multifunctional cytokine that strongly inhibits epithelial cell growth. Disabling of TGF-beta signaling is thought to be involved in development of a variety of tumors in which abnormal expression or function of TGF-beta receptor plays critical roles. In the pre...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Sakaguchi J,Kyo S,Kanaya T,Maida Y,Hashimoto M,Nakamura M,Yamada K,Inoue M

    更新日期:2005-09-01 00:00:00

  • Uterine sarcoma occurring in a premenopausal patient after uterine artery embolization: a case report and review of the literature.

    abstract:OBJECTIVE:We report a case of uterine leiomyosarcoma occurring after uterine artery embolization and review the previously published cases. We estimate the incidence of sarcoma after UAE, the mean diagnostic delay in young women undergoing this procedure and review the potential and limits of preoperative procedures in...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Papadia A,Salom EM,Fulcheri E,Ragni N

    更新日期:2007-01-01 00:00:00

  • Role of PET or PET/CT in the post-therapy surveillance of uterine sarcoma.

    abstract:OBJECTIVE:To evaluate the clinical accuracy and clinical impact of positron emission tomography (PET) or positron emission tomography/computed tomography (PET/CT) in detecting and treating tumor recurrence in patients with treated uterine sarcoma. METHODS:Results of 36 patients who underwent PET or PET/CT in post-ther...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Park JY,Kim EN,Kim DY,Suh DS,Kim JH,Kim YM,Kim YT,Nam JH

    更新日期:2008-05-01 00:00:00

  • MicroRNA miR-886-5p inhibits apoptosis by down-regulating Bax expression in human cervical carcinoma cells.

    abstract:OBJECTIVE:MicroRNA (miRNA) plays an essential role in the progression of a variety of cancers, but its role in cervical cancer progression is not well defined. We aimed to test whether special miRNAs and their target mRNAs contribute to cervical cancer progression. METHODS:The expression profiles of 1145 microRNAs in ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Li JH,Xiao X,Zhang YN,Wang YM,Feng LM,Wu YM,Zhang YX

    更新日期:2011-01-01 00:00:00

  • PTEN expression in clear cell adenocarcinoma of the ovary.

    abstract:OBJECTIVES:In this study, we analyzed the PTEN expression in a large collection of clear cell adenocarcinomas of the ovary. Furthermore, we analyzed the expression of cyclin D1 and p27, and investigated the correlation among all these variables. METHODS:Totally, 40 clear cell adenocarcinomas were included in this stud...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Hashiguchi Y,Tsuda H,Inoue T,Berkowitz RS,Mok SC

    更新日期:2006-04-01 00:00:00

  • Vascular endothelial growth factor (VEGF) up-regulates epidermal growth factor receptor (EGF-R) in cervical cancer in vitro: this action is mediated through HPV-E6 in HPV-positive cancers.

    abstract:OBJECTIVES:Epidermal Growth Factor Receptor (EGF-R) up-regulation in cervical cancer cells leads to an increase in cell proliferative Insulin-like Growth Factor II (IGF-II) and Vascular Endothelial Growth Factor (VEGF) and a decrease of the anti-proliferative IGF-binding protein-3 (IGF-BP3). The objectives for this stu...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Mathur RS,Mathur SP

    更新日期:2005-04-01 00:00:00

  • Pembrolizumab in patients with programmed death ligand 1-positive advanced ovarian cancer: Analysis of KEYNOTE-028.

    abstract:OBJECTIVE:To evaluate safety, tolerability, and antitumor activity of pembrolizumab monotherapy in patients with programmed death ligand 1 (PD-L1)-expressing advanced ovarian cancer enrolled in the multicohort, phase Ib KEYNOTE-028 trial. METHODS:Key inclusion criteria were age ≥18 years; advanced ovarian epithelial, ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Varga A,Piha-Paul S,Ott PA,Mehnert JM,Berton-Rigaud D,Morosky A,Yang P,Ruman J,Matei D

    更新日期:2019-02-01 00:00:00

  • Treatment options for advanced endometrial carcinoma.

    abstract:OBJECTIVE:Endometrial carcinoma is the most common malignancy of the female reproductive tract. Most cases are diagnosed at an early stage due to the appearance of symptoms such as postmenopausal bleeding. However, endometrial carcinoma carries a poor prognosis when it recurs after previous definitive treatment or when...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Dizon DS

    更新日期:2010-05-01 00:00:00

  • Moving forward with actionable therapeutic targets and opportunities in endometrial cancer: A NCI clinical trials planning meeting report.

    abstract::The incidence of endometrial cancer (EC) in the U.S. has been rising, from an estimated annual incidence of 49,560 in 2013 to 61,380 in 2017. Meanwhile, the SEER-based relative survival of women with EC in the U.S. has remained flat [82.3% from 1987 to 1989, 82.8% from 2007 to 2013] and our recent increased understand...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Lheureux S,McCourt C,Rimel BJ,Duska L,Fleming G,Mackay H,Mutch D,Temkin SM,Lynn J,Kohn EC

    更新日期:2018-02-22 00:00:00

  • Genetic variants in HLA-DP/DQ contribute to risk of cervical cancer: a two-stage study in Chinese women.

    abstract:OBJECTIVE:Human leukocyte antigens (HLA) play an important role in presenting virus antigens to immune cells that are responsible for the clearance of virus-infected cells and tumor cells. Herein, we evaluated whether genetic variants of HLA-DP and HLA-DQ are associated with cervical cancer risk. METHODS:We genotyped ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Jiang J,Li N,Shen Y,Liu J,Liu L,Du J,Lei Y,Wen Y,Yang L,Guo L,Zhang K,Qiang F,Wang S,Hu Z,Dai M,Shen H

    更新日期:2013-05-01 00:00:00

  • Reconstructive surgery following resection of primary vulvar cancers.

    abstract:OBJECTIVE:This study describes the surgical treatment and follow-up of 213 patients with primary vulvar cancer; particular attention is given to reconstructive surgical procedures. METHODS:The clinical and pathological parameters of the patients were recorded according to standardized procedures, and the data concerni...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Weikel W,Hofmann M,Steiner E,Knapstein PG,Koelbl H

    更新日期:2005-10-01 00:00:00

  • Cadherins, catenins and cell cycle regulators: impact on survival in a Gynecologic Oncology Group phase II endometrial cancer trial.

    abstract:OBJECTIVE:We evaluated the clinical relevance of catenins, cadherins and cell cycle regulators in stage IV or recurrent endometrial carcinoma in a multi-center phase II trial (GOG protocol #119). METHODS:Tissue microarrays of metastatic or recurrent (n=42) tumor were developed and immunohistochemistry was performed. A...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Singh M,Darcy KM,Brady WE,Clubwala R,Weber Z,Rittenbach JV,Akalin A,Whitney CW,Zaino R,Ramirez NC,Leslie KK

    更新日期:2011-11-01 00:00:00

  • Phase II study of vinorelbine in the treatment of platinum-resistant ovarian carcinoma.

    abstract:OBJECTIVE:The purpose of this phase II study was to evaluate on an intent-to-treat basis the activity and toxicity of single-agent vinorelbine (VRL) as second-line chemotherapy of patients with platinum-resistant ovarian cancer. Platinum-resistant disease was defined as disease refractory to or relapsing within 12 mont...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Sørensen P,Høyer M,Jakobsen A,Malmström H,Havsteen H,Bertelsen K

    更新日期:2001-04-01 00:00:00

  • Adjuvant chemotherapy in early uterine sarcoma.

    abstract::Nine years' experience with early uterine sarcoma is reviewed. In addition to hysterectomy and radiotherapy, 34 patients received adjunctive chemotherapy; 67 patients received no adjunctive chemotherapy. Seventeen patients who received chemotherapy received combination vincristine, 1.5 mg/m2 weekly; actinomycin D, 0.5...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Hannigan EV,Freedman RS,Rutledge FN

    更新日期:1983-02-01 00:00:00

  • Risk of cardiovascular disease in women with BRCA1 and BRCA2 mutations.

    abstract:OBJECTIVE:Estimate the prevalence of cardiovascular disease risk factors and endpoints in women with BRCA mutations. METHODS:Women, age 40 and older, with BRCA mutations identified in Kaiser Permanente Northern California completed a questionnaire and underwent a lipid and fasting glucose panel. Bivariable analysis of...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Powell CB,Alabaster A,Armstrong MA,Stoller N,Raine-Bennett T

    更新日期:2018-12-01 00:00:00

  • Survival of women diagnosed with malignant, mixed mullerian tumors of the ovary (OMMMT).

    abstract:OBJECTIVE:To analyze the survival of women with malignant, mixed mullerian tumors of the ovary (OMMMT) compared to women with epithelial ovarian cancer (EOC). METHODS:Data from the Surveillance, Epidemiology and End Results (SEER) Program on 14025 women diagnosed with primary invasive ovarian cancer between 1988 and 1...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Barnholtz-Sloan JS,Morris R,Malone JM Jr,Munkarah AR

    更新日期:2004-05-01 00:00:00

  • The role of preoperative computerized tomography (CT) scan of the pelvis and groin in the management of clinically early staged vulva squamous cell carcinoma.

    abstract:INTRODUCTION:Vulvar squamous cell carcinoma (VSCC) commonly metastasises through groin lymphatics. However, the use of pre-operative imaging in detecting inguinal nodal metastasis before staging surgery or to triage patients for sentinel node biopsy remains unclear. Here, we investigated if pre-operative CT scan, the i...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Pounds R,O'Neill D,Subba K,Garg A,Scerif M,Leong E,Nevin J,Kehoe S,Yap J

    更新日期:2020-05-01 00:00:00

  • Prognostic value of pathologic features and DNA analysis in endometrial carcinoma.

    abstract::In a series of 38 nonmetastasizing and 29 metastasizing endometrial cancers, histologic subtype, aneuploidy, nuclear grade, and depth of myometrial invasion were the features most distinctly separating these two groups of patients. The most important factor was histologic type: papillary, papillary serous, adenosquamo...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Symonds DA

    更新日期:1990-12-01 00:00:00

  • Implementing specificity of HPV-DNA primary screening in a successful organised cervical cancer prevention programme.

    abstract:OBJECTIVE:This two-arm longitudinal study was performed within a regional organized cervical-cancer-prevention program in which HPV-DNA test is used in primary screening. The aim was to analyze the diagnostic performances of p16INK4a/Ki-67 dual-test and E6/E7-mRNA test in identifying CIN2+ lesion among HPV-DNA positive...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Zappacosta R,Caraceni D,Ciccocioppo L,Rotondo T,Capanna S,Gatta DM,D'Angelo C,Rosini S

    更新日期:2013-03-01 00:00:00

  • Molecular evidence linking primary cancer of the fallopian tube to BRCA1 germline mutations.

    abstract:OBJECTIVES:BRCA1 and BRCA2 germline mutations increase the risk of ovarian and breast cancer. Fallopian tube cancer has occasionally been observed in breast-ovarian cancer families. At our family cancer clinic we recently encountered two cases of Fallopian tube cancer within two families harboring a BRCA1 germline muta...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Zweemer RP,van Diest PJ,Verheijen RH,Ryan A,Gille JJ,Sijmons RH,Jacobs IJ,Menko FH,Kenemans P

    更新日期:2000-01-01 00:00:00

  • Analysis of morbidity in patients with endometrial cancer: is there a commitment to offer laparoscopy?

    abstract:OBJECTIVE:Benefits of laparoscopy over laparotomy in patients with endometrial cancer (EC) are well known. As many patients with EC carry co-morbid conditions, surgery is exposing them to increased risk of complications. A review of the patients with EC recruited so far in a clinical trial comparing laparoscopy to lapa...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tozzi R,Malur S,Koehler C,Schneider A

    更新日期:2005-04-01 00:00:00

  • Types of pelvic exenterations: a reappraisal.

    abstract::Subgrouping of pelvic exenterations as supralevator (type I), infralevator (type II), with vulvectomy (type III), and, an added category, extended can be helpful to facilitate communication when referring to these patients. It also can facilitate a more detailed analysis of operative risk factors, complications, and r...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Magrina JF

    更新日期:1990-06-01 00:00:00

  • Gynecologic melanomas: A clinicopathologic and molecular analysis.

    abstract:OBJECTIVE:Melanoma originating from gynecologic sites (MOGS), including the vulva, vagina, and cervix, is a rare and aggressive form of melanoma with poor long-term clinical outcome. The clinicopathologic features of vulvar and non-vulvar tumors remain relatively understudied, and in contrast to cutaneous melanomas at ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Udager AM,Frisch NK,Hong LJ,Stasenko M,Johnston CM,Liu JR,Chan MP,Harms PW,Fullen DR,Orsini A,Thomas DG,Lowe L,Patel RM

    更新日期:2017-11-01 00:00:00

  • MRP2 (ABCC2) and cisplatin sensitivity in hepatocytes and human ovarian carcinoma.

    abstract:OBJECTIVE:The ABC transporter MRP2 (ABCC2) can mediate cisplatin efflux, and over-expression of MRP2 has been associated with cisplatin resistance in cancer cell lines. The aim of this study was to determine the role of MRP2 in modulating cisplatin cytotoxicity in normal cells as well as the relationship between MRP2 e...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Guminski AD,Balleine RL,Chiew YE,Webster LR,Tapner M,Farrell GC,Harnett PR,Defazio A

    更新日期:2006-02-01 00:00:00

  • Use of V-Y flap for vulvar reconstruction.

    abstract::Less extensive surgical treatment has become possible for limited vulvar cancer. However, primary closure is advisable only when the defect is minimal and tissue replacement is always needed in radical excisions. Local flaps are always considered the first choice because of their characteristics of similarity to the r...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Tateo A,Tateo S,Bernasconi C,Zara C

    更新日期:1996-08-01 00:00:00