Mismatch repair protein expression in 1049 endometrial carcinomas, associations with body mass index, and other clinicopathologic variables.

abstract：OBJECTIVE:Epidemiologic data suggest that aberrant androgen homeostasis may promote aggressive epithelial ovarian cancer biology. Hyperandrogenism results from both obesity and expression of polymorphic androgen receptor (AR) allelotypes harboring short cytosine-adenine-guanine (CAG) repeat sequences; both have been sh...

journal_title：Gynecologic oncology

authors： Li AJ,Elmore RG,Pavelka JC,Karlan BY

更新日期：2007-12-01 00:00:00

abstract：:From September 1986 to November 1988, 38 patients with previously untreated ovarian cancer, FIGO stages III and IV, were allocated to a study testing the efficacy of high-dose platinum delivered as combined carboplatin and cisplatin. The regimen was as follows: Day 1, 250-350 mg/m2 carboplatin and 500 mg/m2 cyclophosp...

journal_title：Gynecologic oncology

authors： Bertelsen K,Bastholt L

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:Secreted protein, acidic and rich in cysteine (SPARC), is a matricellular protein that modulates cell adhesion and growth. It is thought to play a decisive role in tissue remodeling and angiogenesis. Alterations in SPARC expression have been observed in a variety of solid tumors; however, no consistent patter...

journal_title：Gynecologic oncology

authors： Paley PJ,Goff BA,Gown AM,Greer BE,Sage EH

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:To quantify the impact of preoperative hypoalbuminemia on 30-day mortality and morbidity after gynecologic cancer surgery. METHODS:Patients included in the National Surgical Quality Improvement Program (NSQIP) dataset who underwent any non-emergent surgery for gynecologic malignancy between 1/1/2008 and 12/3...

journal_title：Gynecologic oncology

authors： Uppal S,Al-Niaimi A,Rice LW,Rose SL,Kushner DM,Spencer RJ,Hartenbach E

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVES:We previously reported high rates of urinary incontinence among gynecologic cancer survivors and aimed to evaluate the effectiveness of a simple intervention for treatment of urinary incontinence in this population. METHODS:We recruited 40 gynecologic cancer survivors who reported urinary incontinence on a ...

journal_title：Gynecologic oncology

authors： Rutledge TL,Rogers R,Lee SJ,Muller CY

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:It has not been fully clarified whether alteration of Bax and other apoptosis-relating proteins of Bcl-2 and p53 is involved in endometrial carcinogenesis. METHODS:A total of 56 frozen tissues, which included 14 normal endometria, 13 endometrial hyperplasias (10 without atypia and 3 with atypia), and 29 end...

journal_title：Gynecologic oncology

authors： Sakuragi N,Salah-eldin AE,Watari H,Itoh T,Inoue S,Moriuchi T,Fujimoto S

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVES:To determine the importance of margin status and other prognostic factors associated with the recurrence and survival of patients with squamous cell vulvar carcinoma. METHODS:Data were analyzed using Kaplan-Meier methods and Cox proportional hazards regression. All slides were re-reviewed by two gynecologic...

journal_title：Gynecologic oncology

authors： Chan JK,Sugiyama V,Pham H,Gu M,Rutgers J,Osann K,Cheung MK,Berman ML,Disaia PJ

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:To identify patients with endometrial cancer at risk for hematogenous, lymphatic, or peritoneal recurrence (or combinations of them) who might potentially benefit from target-based therapies. METHODS:During a 13-year period, 915 patients had endometrial cancer managed with hysterectomy and standard adjuvant ...

journal_title：Gynecologic oncology

authors： Mariani A,Dowdy SC,Keeney GL,Long HJ,Lesnick TG,Podratz KC

更新日期：2004-10-01 00:00:00

abstract：:Nucleolar Organizer Regions (NORs) code for ribosomal RNA and are thought to be an accurate representation of the percentage of cells in S-phase. NORs are associated with nonhistone nucleoproteins, which can be stained with silver (AgNORs). An increased number of AgNORs has been observed in many malignancies. AgNORs w...

journal_title：Gynecologic oncology

authors： Chalas E,Chumas J,Barbieri R,Mann WJ

更新日期：1991-03-01 00:00:00

abstract：:Between 1975 and 1989, 896 patients were treated for endometrial carcinoma at the Massachusetts General Hospital. Thirty patients were identified from the tumor registry as having uterine papillary serous carcinomas. The survival for all patients and for groups of patients stratified on clinical and pathological param...

journal_title：Gynecologic oncology

authors： Kato DT,Ferry JA,Goodman A,Sullinger J,Scully RE,Goff BA,Fuller AF Jr,Rice LW

更新日期：1995-12-01 00:00:00

abstract：:Adenocarcinoma originating in the endocervix may remain occult for many years. This may result in an extension to the uterine isthmus and corpus, with subsequent dissemination along the pathways of spread of uterine carcinoma, including metastasis to the ovaries. The patient described in this report had a bulky stage ...

journal_title：Gynecologic oncology

authors： Parham G,Heppard MC,DiSaia PJ

更新日期：1994-12-01 00:00:00

abstract：:An oncocytoma of the right ovary in a 22-year-old Japanese woman was examined by light and electron microscopy. The tumor was composed of oxyphilic cells with a granular cytoplasm. Electron microscopic studies revealed mitochondrial hyperplasia, a characteristic feature of the oncocyte . This may be the first report o...

journal_title：Gynecologic oncology

authors： Yoshida Y,Tenzaki T,Ishiguro T,Kawanami D,Ohshima M

更新日期：1984-05-01 00:00:00

abstract：PURPOSE:The primary goal of this trial was to evaluate the clinical activity and the toxicity of a combination of cisplatin and carboplatin for women with advanced-stage epithelial ovarian cancer. PATIENTS AND METHODS:Fifty-one consecutive evaluable patients with untreated stage III and IV epithelial ovarian cancer re...

journal_title：Gynecologic oncology

authors： Gershenson DM,Morris M,Burke TW,Levenback C,Kavanagh JJ,Fromm GL,Silva EG,Warner D,Wharton JT

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVES:The objectives of this study were twofold: to prospectively assess whether expressed intention to undergo prophylactic oophorectomy translated into uptake and to evaluate the psychological impact of the procedure in a sample of unaffected women with a strong family history of breast/ovarian cancer. METHODS:...

journal_title：Gynecologic oncology

authors： Tiller K,Meiser B,Butow P,Clifton M,Thewes B,Friedlander M,Tucker K

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Chylous ascites is an uncommon complication following para-aortic lymph node dissection in the management of gynecologic malignancies. Treatment options are serial paracentesis, medium-chain triglyceride diet, total parenteral nutrition and somatostatin as conservative management and peritoneovenous shunting...

journal_title：Gynecologic oncology

authors： Boran N,Cil AP,Tulunay G,Ozgul N,Kose MF

更新日期：2004-06-01 00:00:00

abstract：:The bad prognosis of primary Fallopian tube carcinoma (FTC) is mostly ascribed to early lymphogenous metastasis. Yet, there is a lack of information on the tumor size at which lymph node metastasis must be expected to occur. Our study was therefore designed to correlate the anatomopathologic substratum and the histolo...

journal_title：Gynecologic oncology

authors： Klein M,Rosen A,Lahousen M,Graf A,Vavra N,Beck A,Rainer A

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVE:Carcinosarcoma (CS) of the uterus or ovary is a rare, biphasic tumor comprising epithelial and mesenchymal elements, and exhibits more aggressive clinical features than its carcinoma counterpart. Four molecular subtypes of CS were recently established based on genomic aberration profiles (POLE, MSI, CNH, and ...

journal_title：Gynecologic oncology

authors： Gotoh O,Kiyotani K,Chiba T,Sugiyama Y,Takazawa Y,Nemoto K,Kato K,Tanaka N,Nomura H,Hasegawa K,Fujiwara K,Takamatsu S,Matsumura N,Noda T,Mori S

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Evidence on the incidence and risk factors for lower limb lymphedema (LLL) associated with endometrial cancer is limited. Our objective was to use data from a prospective, longitudinal gynecological cancer cohort study to determine LLL incidence up to 24 months post-diagnosis of endometrial cancer and to exp...

journal_title：Gynecologic oncology

authors： Pigott A,Obermair A,Janda M,Vagenas D,Ward LC,Reul-Hirche H,Hayes SC

更新日期：2020-08-01 00:00:00

abstract：:The aim of the present study was to compare the diagnostic accuracy of transvaginal sonography, color flow imaging, and serum CA 125 assay in pre- and postmenopausal women undergoing laparotomy for a clinical diagnosis of an adnexal mass. In 109 consecutive women, the morphology of the mass was evaluated with transvag...

journal_title：Gynecologic oncology

authors： Strigini FA,Gadducci A,Del Bravo B,Ferdeghini M,Genazzani AR

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVE:Paclitaxel is most commonly infused over 3 hs rather than the original schedule of 24 h as the briefer infusion duration results in greater convenience, similar efficacy, significantly less myelosuppression, and less cost. While differences in toxicity between 3- and 24-h infusions are well described, there i...

journal_title：Gynecologic oncology

authors： Jennens R,Rischin D,Yuen K,Toner G,Millward M

更新日期：2003-10-01 00:00:00

abstract：:Copyright ...

journal_title：Gynecologic oncology

authors： Posner JB

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVE:The goal of this work was to evaluate the involvement of gonadotropins in the regulation of adhesion of human epithelial ovarian carcinoma. We studied two pathways that were previously implicated in the metastatic implantation of ovarian carcinoma to the peritoneum, namely hyaluronan-CD44 and RGD-integrin med...

journal_title：Gynecologic oncology

authors： Schiffenbauer YS,Meir G,Maoz M,Even-Ram SC,Bar-Shavit R,Neeman M

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:To investigate the influence of human anti-mouse antibodies (HAMA) on serial CA 125 measurements in serum of patients with epithelial ovarian cancer following single intraperitoneal (IP) therapy with Yttrium-90-labeled human milk fat globule 1 murine monoclonal antibody ((90)Y-muHMFG1) as part of a large inte...

journal_title：Gynecologic oncology

authors： Oei AL,Sweep FC,Massuger LF,Olthaar AJ,Thomas CM

更新日期：2008-05-01 00:00:00

abstract：:The COVID-19 pandemic has challenged our ability to provide timely surgical care for our patients. In response, the U.S. Surgeon General, the American College of Srugeons, and other surgical professional societies recommended postponing elective surgical procedures and proceeding cautiously with cancer procedures that...

journal_title：Gynecologic oncology

authors： Fader AN,Huh WK,Kesterson J,Pothuri B,Wethington S,Wright JD,Bakkum-Gamez JN,Soliman PT,Sinno AK,Leitao M,Martino MA,Karam A,Rossi E,Brown J,Blank S,Burke W,Goff B,Yamada SD,Uppal S,Dowdy SC

更新日期：2020-08-01 00:00:00

abstract：:Cyclin D1 is a critical gene controlling the G1 phase progression through the cell cycle. Alterations of cyclin D1 have been demonstrated in a variety of cancer types. We recently reported that increased cyclin D1 expression is associated with malignancy also in ovarian tumors. Three human ovarian cancer cell lines (S...

journal_title：Gynecologic oncology

authors： Cagnoli M,Barbieri F,Bruzzo C,Alama A

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:Debate continues about optimal management of patients with node-positive stage I cervical cancer. Our objective was to determine if patient outcomes are affected by radical hysterectomy in the modern era of adjuvant chemoradiation. METHODS:Cervical cancer patients diagnosed from 2000 to 2008 were identified....

journal_title：Gynecologic oncology

authors： Ziebarth AJ,Smith H,Killian ME,Nguyen NA,Durst JK,Subramaniam A,Kim KH,Leath CA 3rd,Straughn JM Jr,Alvarez RD

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:Endometrial cancer (EC) is a rare condition in young women. The objective of this study was to evaluate the risk of pelvic lymph node (LN) metastasis in young women with EC who are candidates for conservative management. METHODS:Using the SEER database, a population-based analysis was conducted to identify w...

journal_title：Gynecologic oncology

authors： Gonthier C,Douhnai D,Koskas M

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVES:The presence of an eosinophilic infiltrate in patients with cervical squamous carcinoma has been shown to correlate with a worse overall survival, suggesting a less effective immune response in these cases. Since type 2 cytokines such as IL-4 and IL-5 are known to attract eosinophilic granulocytes, an immuno...

journal_title：Gynecologic oncology

authors： van Driel WJ,Kievit-Tyson P,van den Broek LC,Zwinderman AH,Trimbos BJ,Fleuren GJ

更新日期：1999-08-01 00:00:00

abstract：INTRODUCTION:Focused ultrasound under real-time MR guidance and control (MRgFUS) can be used for the thermal ablation of tissue. Currently this technique is used clinically for the noninvasive treatment of uterine leiomyomas and is in clinical evaluation for breast cancer, adenomyosis and other indications. MRgFUS is b...

journal_title：Gynecologic oncology

authors： Machtinger R,Inbar Y,Ben-Baruch G,Korach J,Rabinovici J

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:The hepatocyte growth factor (HGF) receptor c-Met plays an important role in tumor dissemination by activating mitogenic signaling pathways. The goal of this study was to investigate immunohistochemical (IHC) staining patterns of HGF and c-Met in endometrioid endometrial cancer (EC) and uterine serous cancer ...

journal_title：Gynecologic oncology

authors： Bishop EA,Lengyel ER,Yamada SD,Montag A,Temkin SM

更新日期：2011-04-01 00:00:00