Preoperative hypoalbuminemia is an independent predictor of poor perioperative outcomes in women undergoing open surgery for gynecologic malignancies.


OBJECTIVE:To quantify the impact of preoperative hypoalbuminemia on 30-day mortality and morbidity after gynecologic cancer surgery. METHODS:Patients included in the National Surgical Quality Improvement Program (NSQIP) dataset who underwent any non-emergent surgery for gynecologic malignancy between 1/1/2008 and 12/31/2010 were identified. Analysis was conducted with albumin both as a dichotomous variable (<3.5 g/dl was defined as low albumin) and as a continuous variable to determine a clinically relevant cut-off value. RESULTS:Of the total 3171 patients identified, 2110 had preoperative albumin levels available for analysis. In addition, 279 (13.3%) of these patients had low albumin levels. According to multivariate analysis, the low albumin group had significantly higher odds of developing one or more post-operative complications (OR-2,CI: 1.47-2.73, p<0.0001), three or more complications (OR-4.1,CI: 2.31-7.1, p<0.0001), surgical complications (OR-2.39,CI: 1.59-3.58, p<0.0001), thromboembolic complications (OR-2.59,CI: 1.33-5.06, p<0.0001), pulmonary complications (OR-4.06,CI: 2.05-8.03, p<0.0001), or infectious complications (OR-1.84,CI: 1.26-2.69, p<0.0001) and a higher 30-day mortality (OR-6.52,CI: 2.51-16.95, p<0.0001). Upon subgroup analysis, this difference was not found in patients undergoing laparoscopic surgery. In patients undergoing open surgery, the probability of experiencing one or more post-operative complications increased linearly with the decrease in albumin level; however, the probability of patients experiencing three or more complications and 30-day mortality increased sharply as soon as the albumin level decreased below 3g/dl. CONCLUSION:Preoperative albumin levels <3g/dL identify a population of patients at a very high-risk of experiencing perioperative morbidity and 30-day mortality after open surgery.


Gynecol Oncol


Gynecologic oncology


Uppal S,Al-Niaimi A,Rice LW,Rose SL,Kushner DM,Spencer RJ,Hartenbach E




Has Abstract


2013-11-01 00:00:00














  • Anti-diabetic doses of metformin decrease proliferation markers in tumors of patients with endometrial cancer.

    abstract:BACKGROUND:Metformin has been associated with reduced cancer risk. The mechanisms underlying this cancer protective effect remain unknown. METHODS:"Window of opportunity" study of metformin in women with operable endometrial cancer (EC). Eleven newly diagnosed, untreated, non-diabetic patients with EC received metform...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Laskov I,Drudi L,Beauchamp MC,Yasmeen A,Ferenczy A,Pollak M,Gotlieb WH

    更新日期:2014-09-01 00:00:00

  • Targeting CD133 in an in vivo ovarian cancer model reduces ovarian cancer progression.

    abstract:OBJECTIVES:While most women with ovarian cancer will achieve complete remission after treatment, the majority will relapse within two years, highlighting the need for novel therapies. Cancer stem cells (CSC) have been identified in ovarian cancer and most other carcinomas as a small population of cells that can self-re...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Skubitz AP,Taras EP,Boylan KL,Waldron NN,Oh S,Panoskaltsis-Mortari A,Vallera DA

    更新日期:2013-09-01 00:00:00

  • Epitope recognition by anti-cathepsin D autoantibodies in endometrial cancer patients.

    abstract:OBJECTIVE:This study analyzed a model for the identification of specific epitopes recognized by autologous tumor-reactive humoral responses of endometrial cancer patients as potential markers for the monitoring of cancer. METHODS:The presence of circulating pro- and mature forms of cathepsin D and antibodies reactive ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Bosscher JR,Gerçel-Taylor C,Watkins CS,Taylor DD

    更新日期:2001-05-01 00:00:00

  • Sentinel lymph node biopsy in the management of early-stage cervical carcinoma.

    abstract:OBJECTIVES:We aimed to determine the sentinel lymph node detection rates, accuracy in predicting the status of lymph node metastasis, and if pathologic ultrastaging improves the detection of micrometastases and isolated tumor cells at the time of primary surgery for cervical cancer. METHODS:A prospective, non-randomiz...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Diaz JP,Gemignani ML,Pandit-Taskar N,Park KJ,Murray MP,Chi DS,Sonoda Y,Barakat RR,Abu-Rustum NR

    更新日期:2011-03-01 00:00:00

  • Analysis of morbidity in patients with endometrial cancer: is there a commitment to offer laparoscopy?

    abstract:OBJECTIVE:Benefits of laparoscopy over laparotomy in patients with endometrial cancer (EC) are well known. As many patients with EC carry co-morbid conditions, surgery is exposing them to increased risk of complications. A review of the patients with EC recruited so far in a clinical trial comparing laparoscopy to lapa...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tozzi R,Malur S,Koehler C,Schneider A

    更新日期:2005-04-01 00:00:00

  • Chemoradiation in locally advanced cervical carcinoma: an analysis of cisplatin dosing and other clinical prognostic factors.

    abstract:OBJECTIVES:The aim of this study was to evaluate the effect of number of chemotherapy cycles and other clinical and pathologic factors on progression-free (PFS) and overall survival (OS) in patients with newly diagnosed cervical cancer. METHODS:We identified 118 patients with locally advanced cervical cancer (stages I...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Nugent EK,Case AS,Hoff JT,Zighelboim I,DeWitt LL,Trinkhaus K,Mutch DG,Thaker PH,Massad LS,Rader JS

    更新日期:2010-03-01 00:00:00

  • Metastatic endometrial cancer in lung and liver: complete and prolonged response to hormonal therapy with progestins.

    abstract::A double complete and prolonged response of metastatic endometrial carcinoma to medroxyprogesterone is reported. A 61-year-old woman with metastatic endometrial carcinoma in lung and liver achieved a complete clinical response with medroxyprogesterone lasting for 2 years. She discontinued the therapy by herself and de...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Crespo C,González-Martín A,Lastra E,García-López J,Moyano A

    更新日期:1999-02-01 00:00:00

  • Early invasive carcinoma of the cervix.

    abstract::Ninety-two patients with early invasive carcinoma of the cervix (5 mm or less) treated between July 1977 and June 1990 are reviewed. Eighty patients had squamous cell carcinomas and 12 had adenocarcinomas. The diagnosis was established by conization in 77 of 92 (83.6%) patients. Thirty-six patients (39%) had a depth o...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Jones WB,Mercer GO,Lewis JL Jr,Rubin SC,Hoskins WJ

    更新日期:1993-10-01 00:00:00

  • Phase I/II clinical safety studies of terameprocol vaginal ointment.

    abstract:OBJECTIVES:Terameprocol (M4N, EM-1421) is a novel transcription inhibitor that selectively interferes with HPV viral genes E6/E7 with Sp1-dependent promoters, and induces apoptosis by inactivation of the CDC2/cyclin B complex (maturation promoting factor) and production and phosphorylation of survivin. This trial was d...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Khanna N,Dalby R,Tan M,Arnold S,Stern J,Frazer N

    更新日期:2007-12-01 00:00:00

  • Detection of endometrial cancer via molecular analysis of DNA collected with vaginal tampons.

    abstract:OBJECTIVE:We demonstrate the feasibility of detecting EC by combining minimally-invasive specimen collection techniques with sensitive molecular testing. METHODS:Prior to hysterectomy for EC or benign indications, women collected vaginal pool samples with intravaginal tampons and underwent endometrial brushing. Specim...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Bakkum-Gamez JN,Wentzensen N,Maurer MJ,Hawthorne KM,Voss JS,Kroneman TN,Famuyide AO,Clayton AC,Halling KC,Kerr SE,Cliby WA,Dowdy SC,Kipp BR,Mariani A,Oberg AL,Podratz KC,Shridhar V,Sherman ME

    更新日期:2015-04-01 00:00:00

  • MRP2 (ABCC2) and cisplatin sensitivity in hepatocytes and human ovarian carcinoma.

    abstract:OBJECTIVE:The ABC transporter MRP2 (ABCC2) can mediate cisplatin efflux, and over-expression of MRP2 has been associated with cisplatin resistance in cancer cell lines. The aim of this study was to determine the role of MRP2 in modulating cisplatin cytotoxicity in normal cells as well as the relationship between MRP2 e...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Guminski AD,Balleine RL,Chiew YE,Webster LR,Tapner M,Farrell GC,Harnett PR,Defazio A

    更新日期:2006-02-01 00:00:00

  • Human papillomavirus analysis as a prognostic marker following conization of the cervix uteri.

    abstract::Cervical intraepithelial neoplasia grade 3 (CIN 3) is treated surgically. Follow-up of these patients is important to ensure successful treatment. The present study was undertaken to determine whether human papillomavirus (HPV) testing can be used to discriminate patients who will have recurrences from those who will ...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Chua KL,Hjerpe A

    更新日期:1997-07-01 00:00:00

  • Epithelial ovarian carcinoma in patients with intersex disorders: the role of pituitary gonadotropins in ovarian tumorigenesis.

    abstract::The common epithelial tumors of the human ovary have rarely been found in the gonads of intersex patients with gonadal dysgenesis or true hermaphroditism. This report describes a patient with ovarian serous cystadenocarcinoma and mixed gonadal dysgenesis (45,X/46,XY) and reviews other reported cases. Intersex patients...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Miller DS,Teng NN,Ballon SC

    更新日期:1986-07-01 00:00:00

  • Risk-prediction model of severe postoperative complications after primary debulking surgery for advanced ovarian cancer.

    abstract:OBJECTIVES:To refine models to predict surgical morbidity and 90-day mortality after primary debulking surgery (PDS) for advanced epithelial ovarian cancer (EOC). METHODS:Women with stage IIIC/IV EOC who underwent PDS with curative intent between 1/2/2003 and 12/30/2011 were included. Patient characteristics, intraope...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kumar A,Janco JM,Mariani A,Bakkum-Gamez JN,Langstraat CL,Weaver AL,McGree ME,Cliby WA

    更新日期:2016-01-01 00:00:00

  • Carboplatin plus paclitaxel combination chemotherapy: impact of sequence of drug administration on treatment-induced neutropenia.

    abstract:OBJECTIVE:While the importance of the sequence of administration of cisplatin and paclitaxel on the degree of observed neutropenia has been documented, there is limited information available in the oncology literature to determine whether there exists sequence-dependent toxicity for the combination of carboplatin plus ...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Markman M,Elson P,Kulp B,Peterson G,Zanotti K,Webster K,Belinson J

    更新日期:2003-10-01 00:00:00

  • Treatment of resistant gestational choriocarcinoma with taxol: a report of two cases.

    abstract::Two patients with resistant gestational choriocarcinoma were treated w with Taxol after extensive prior chemotherapy including EMACO and platinum-based salvage chemotherapy. Both patients showed significant responses to Taxol. One patient relapsed in the brain and liver after treatment and died. Taxol was combined wit...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Jones WB,Schneider J,Shapiro F,Lewis JL Jr

    更新日期:1996-04-01 00:00:00

  • Comparison of bevacizumab alone or with chemotherapy in recurrent ovarian cancer patients.

    abstract:BACKGROUND:To compare the efficacy of chemotherapy (C) combined with bevacizumab (Bev) versus Bev alone in recurrent, heavily pretreated epithelial ovarian cancer (EOC). METHODS:A multicenter analysis of patients treated from 2004 to 2011 was performed. Demographic, treatment, response, and adverse event information w...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Fuh KC,Secord AA,Bevis KS,Huh W,ElNaggar A,Blansit K,Previs R,Tillmanns T,Kapp DS,Chan JK

    更新日期:2015-12-01 00:00:00

  • The immune response in pregnancy and in cancer is active and supportive of placental and tumor cell growth not their destruction.

    abstract::While many investigators have described the biochemical and physiological similarities between tumor cells and trophoblast cells, in this discourse we will compare primarily their leucocytes, which constitute a large portion of the tumor and its microenvironment as well as the placenta and its microenvironment. There ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Beaman KD,Dambaeva S,Katara GK,Kulshrestha A,Gilman-Sachs A

    更新日期:2017-06-01 00:00:00

  • A prospective phase II study of chemoradiation followed by adjuvant chemotherapy for FIGO stage I-IIIA (1988) uterine papillary serous carcinoma of the endometrium.

    abstract:OBJECTIVE:To prospectively evaluate tumor control, survival, and toxic effects in patients with International Federation of Gynecology and Obstetrics (1988) stage I-IIIA papillary serous carcinoma of the endometrium treated with concurrent chemoradiation and adjuvant chemotherapy. METHODS:Thirty-two patients were enro...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Jhingran A,Ramondetta LM,Bodurka DC,Slomovitz BM,Brown J,Levy LB,Garcia ME,Eifel PJ,Lu KH,Burke TW

    更新日期:2013-05-01 00:00:00

  • Incidence of symptomatic deep venous thrombosis with epoetin alfa or darbepoetin alfa treatment of anemia in patients with ovarian or primary peritoneal cancer.

    abstract:OBJECTIVES:Recombinant epoetin alfa and darbepoetin alfa (r-HuEPO) have been shown to be safe and effective treatments for anemia, but recent reports have suggested an increased risk of thromboembolic events when these agents are used to treat chemotherapy-induced anemia among patients with breast or ovarian cancer. We...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Westin SN,Skinner EN,Jonsson Funk M,Gehrig PM,Van Le L

    更新日期:2007-05-01 00:00:00

  • Diagnosis of endometrial cancer in patients with postmenopausal bleeding by analysis of the lactate dehydrogenase isoenzyme activity profile in uterine fluid.

    abstract:OBJECTIVES:We have previously shown that high activity of lactate dehydrogenase (LD) isoenzymes 4 and 5 in terine aspirates is a marker for endometrial carcinoma. The purpose of this study was to identify an abnormal activity profile of LD2-5 using LD1 as an internal standard, thereby being able to dispense with measur...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Niklasson O,Skude G,Marsal K,Casslén B

    更新日期:2004-05-01 00:00:00

  • Evaluation of the scalene lymph nodes in primary and recurrent cervical carcinoma.

    abstract::Open biopsy of the left scalene lymph nodes has been utilized to identify distant spread of cervical carcinoma in selected groups of patients who do not have other clinical evidence of disseminated disease. Twenty-one patients with primary cervical carcinoma and histologically proven para-aortic lymph node metastases ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Burke TW,Heller PB,Hoskins WJ,Weiser EB,Nash JD,Park RC

    更新日期:1987-11-01 00:00:00

  • Malignant melanoma of the vulva: an extension of cutaneous melanoma?

    abstract:OBJECTIVE:To determine the prognostic significance of the 2002 revisions of the American Joint Committee on Cancer (AJCC) Staging System for cutaneous melanoma in melanoma of the vulva and review the current surgical utilized for treatment of this neoplasm. METHODS:Demographic, surgical and outcomes data were obtained...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Moxley KM,Fader AN,Rose PG,Case AS,Mutch DG,Berry E,Schink JC,Kim CH,Chi DS,Moore KN

    更新日期:2011-09-01 00:00:00

  • Prognostic value of pre-treatment human papilloma virus DNA status in cervical cancer.

    abstract:OBJECTIVE:Although the relationship between human papilloma virus (HPV) and cervical cancer is well established, the prognostic value of HPV status has not been determined, largely because previous studies have yielded conflicting results. This study aimed to investigate the prognostic value of pre-treatment HPV DNA fo...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Chong GO,Lee YH,Han HS,Lee HJ,Park JY,Hong DG,Lee YS,Cho YL

    更新日期:2018-01-01 00:00:00

  • Involved-field radiation therapy for recurrent ovarian cancer: Results of a multi-institutional prospective phase II trial.

    abstract:OBJECTIVE:To evaluate the efficacy and safety of involved-field radiation therapy (IFRT) in patients with locoregionally confined recurrent or persistent epithelial ovarian cancer. METHODS:This study included patients with recurrent epithelial ovarian cancer eligible for IFRT either during diagnosis of the recurrence ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Chang JS,Kim SW,Kim YJ,Kim JY,Park SY,Kim JH,Jang TK,Kim YB

    更新日期:2018-10-01 00:00:00

  • Establishment and characterization of ovarian endometrioid carcinoma cell line.

    abstract::Ascitic fluid was obtained from a patient with ovarian endometrioid carcinoma. The cells obtained from the fluid were cultured in Eagle's minimum essential medium containing 15% fetal calf serum at 37 degrees C under humidified 5% CO2 and 95% air. Epithelial colonies grew rapidly in the primary culture and we were abl...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Uehara S,Abe H,Hoshiai H,Yajima A,Suzuki M

    更新日期:1984-03-01 00:00:00

  • The implementation of critical pathways in gynecologic oncology in a managed care setting: a cost analysis.

    abstract:OBJECTIVES:The aim of the study is to determine whether critical pathways can be implemented at an academic institution to limit cost, without compromising patient satisfaction and quality of care. PATIENTS AND METHODS:Patients undergoing a hysterectomy with either cervical or endometrial cancer were placed on specifi...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Ghosh K,Downs LS,Padilla LA,Murray KP,Twiggs LB,Letourneau CM,Carson LF

    更新日期:2001-11-01 00:00:00

  • The prescription or proscription of exercise in endometrial cancer care.

    abstract:OBJECTIVE:To determine the proportion of endometrial cancer patients who can be safely prescribed community/home based unsupervised exercise. A better understanding of the physical dysfunction secondary to comorbidities among endometrial cancer patients would assist clinicians in delineating which patients to send to m...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Zhang X,Haggerty AF,Brown JC,Giuntoli R 2nd,Lin L,Simpkins F,Dean LT,Ko E,Morgan MA,Schmitz KH

    更新日期:2015-10-01 00:00:00

  • Lymph node metastasis probability in young patients eligible for conservative management of endometrial cancer.

    abstract:OBJECTIVE:Endometrial cancer (EC) is a rare condition in young women. The objective of this study was to evaluate the risk of pelvic lymph node (LN) metastasis in young women with EC who are candidates for conservative management. METHODS:Using the SEER database, a population-based analysis was conducted to identify w...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Gonthier C,Douhnai D,Koskas M

    更新日期:2020-04-01 00:00:00

  • A phase II trial of high-dose mitoxantrone, carboplatin, and cyclophosphamide with autologous bone marrow rescue for recurrent epithelial ovarian carcinoma: analysis of risk factors for clinical outcome.

    abstract::Despite high initial response rates to platinum-based chemotherapy, most patients with advanced ovarian carcinoma die of drug-resistant disease. Drug resistance can be overcome in the hematologic malignancies and lymphomas with high-dose therapy and bone marrow transplantation (BMT) when used early, suggesting that th...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Stiff P,Bayer R,Camarda M,Tan S,Dolan J,Potkul R,Loutfi S,Kinch L,Sosman J,Peace D

    更新日期:1995-06-01 00:00:00